{"id":"https://openalex.org/W7224538538","doi":"https://doi.org/10.26434/chemrxiv.15011260/v1","title":"Chemical Editing of DNA-Mediated Nanoparticle Superlattices through a CRISPR-inspired Strategy","display_name":"Chemical Editing of DNA-Mediated Nanoparticle Superlattices through a CRISPR-inspired Strategy","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224538538","doi":"https://doi.org/10.26434/chemrxiv.15011260/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15011260/v1","doi":"https://doi.org/10.26434/chemrxiv.15011260/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15011260/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15011260/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15011260/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034937079","display_name":"Elad Arad","orcid":"https://orcid.org/0000-0002-0802-0079","observed_orcids":["https://orcid.org/0000-0002-0802-0079"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elad Arad","raw_affiliation_strings":["Columbia University in the City of New York","Department of Chemical Engineering"],"raw_orcid":"https://orcid.org/0000-0002-0802-0079","affiliations":[{"raw_affiliation_string":"Columbia University in the City of New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023668760","display_name":"Dayoung Gloria Lee","orcid":"https://orcid.org/0000-0002-3956-0203","observed_orcids":["https://orcid.org/0000-0002-3956-0203"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dayoung Gloria Lee","raw_affiliation_strings":["Columbia University in the City of New York","Department of Chemical Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University in the City of New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147155338","display_name":"Mannat Vikramaditya Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mannat Vikramaditya Jain","raw_affiliation_strings":["Columbia University in the City of New York","Department of Applied Physics and Applied Mathematics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University in the City of New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Applied Physics and Applied Mathematics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059672842","display_name":"Einat Nativ\u2010Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Einat Nativ-Roth","raw_affiliation_strings":["Ben-Gurion University of the Negev","Ilse Katz Institute for Nanoscale Science and Technology (IKI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben-Gurion University of the Negev","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Ilse Katz Institute for Nanoscale Science and Technology (IKI","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079893941","display_name":"Oleg Gang","orcid":"https://orcid.org/0000-0001-5534-3121","observed_orcids":["https://orcid.org/0000-0001-5534-3121"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]},{"id":"https://openalex.org/I4390039222","display_name":"Center for Functional Nanomaterials","ror":"https://ror.org/035xqz322","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672","https://openalex.org/I4390039222"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Oleg Gang","raw_affiliation_strings":["Brookhaven National Laboratory (BNL","Center for Functional Nanomaterials (CFN","Center for Nanomedicine Institute for Basic Science (IBS) Seoul","Columbia University in the City of New York","Department of Applied Physics and Applied Mathematics","Department of Chemical Engineering","Department of Nano Biomedical Engineering (NanoBME) Advanced Science Institute","Yonsei University Seoul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brookhaven National Laboratory (BNL","institution_ids":["https://openalex.org/I200870766"]},{"raw_affiliation_string":"Center for Functional Nanomaterials (CFN","institution_ids":["https://openalex.org/I4390039222"]},{"raw_affiliation_string":"Center for Nanomedicine Institute for Basic Science (IBS) Seoul","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Columbia University in the City of New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Applied Physics and Applied Mathematics","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Department of Nano Biomedical Engineering (NanoBME) Advanced Science Institute","institution_ids":[]},{"raw_affiliation_string":"Yonsei University Seoul","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cas9","display_name":"Cas9","score":0.8209999799728394},{"id":"https://openalex.org/keywords/crispr-cas12a","display_name":"CRISPR/Cas12a","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dna-origami","display_name":"DNA origami","score":0.6039999723434448},{"id":"https://openalex.org/keywords/post-assembly-modification","display_name":"post-assembly modification","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-linkers","display_name":"DNA linkers","score":0.527999997138977},{"id":"https://openalex.org/keywords/dna-nanotechnology","display_name":"DNA nanotechnology","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.6762999892234802},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5708000063896179},{"id":"https://openalex.org/C129275984","wikidata":"https://www.wikidata.org/wiki/Q602847","display_name":"DNA nanotechnology","level":3,"score":0.5601000189781189},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5304999947547913},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5112000107765198},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.4729999899864197},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42329999804496765},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.39980000257492065},{"id":"https://openalex.org/C195116880","wikidata":"https://www.wikidata.org/wiki/Q4859565","display_name":"Sticky and blunt ends","level":4,"score":0.392300009727478},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.3815000057220459},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.3499000072479248},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3483999967575073},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.328900009393692},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.323199987411499},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C64452783","wikidata":"https://www.wikidata.org/wiki/Q1524945","display_name":"Ternary operation","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.29499998688697815},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.29440000653266907},{"id":"https://openalex.org/C139425391","wikidata":"https://www.wikidata.org/wiki/Q2726733","display_name":"Molecular machine","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C70636015","wikidata":"https://www.wikidata.org/wiki/Q4300350","display_name":"Molecular biophysics","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C84211826","wikidata":"https://www.wikidata.org/wiki/Q5260078","display_name":"Deoxyribozyme","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2639000117778778},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C3044715","wikidata":"https://www.wikidata.org/wiki/Q3952437","display_name":"Bond cleavage","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C26856880","wikidata":"https://www.wikidata.org/wiki/Q910150","display_name":"Self-assembly","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C178213299","wikidata":"https://www.wikidata.org/wiki/Q44424","display_name":"Chemical bond","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15011260/v1","doi":"https://doi.org/10.26434/chemrxiv.15011260/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15011260/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15011260/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15011260/v1","doi":"https://doi.org/10.26434/chemrxiv.15011260/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15011260/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15011260/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1285306620","display_name":null,"funder_award_id":"SC0012704","funder_id":"https://openalex.org/F4320338289","funder_display_name":"Brookhaven National Laboratory"},{"id":"https://openalex.org/G241279073","display_name":null,"funder_award_id":"DE\u2010SC0012704","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3262563802","display_name":null,"funder_award_id":"DE- SC0012704","funder_id":"https://openalex.org/F4320338289","funder_display_name":"Brookhaven National Laboratory"},{"id":"https://openalex.org/G357145406","display_name":null,"funder_award_id":"DE-SC-0012704","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5765906131","display_name":null,"funder_award_id":"SC0012704.","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7463374569","display_name":null,"funder_award_id":"SC0012704","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320338289","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224538538.pdf","grobid_xml":"https://content.openalex.org/works/W7224538538.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1515870710","https://openalex.org/W2002589841","https://openalex.org/W2009963235","https://openalex.org/W2024080095","https://openalex.org/W2025026952","https://openalex.org/W2036887984","https://openalex.org/W2045435533","https://openalex.org/W2050915030","https://openalex.org/W2056909801","https://openalex.org/W2059132797","https://openalex.org/W2073900740","https://openalex.org/W2078484807","https://openalex.org/W2082015621","https://openalex.org/W2117123165","https://openalex.org/W2123314710","https://openalex.org/W2165869860","https://openalex.org/W2280780597","https://openalex.org/W2314186264","https://openalex.org/W2327500409","https://openalex.org/W2329213810","https://openalex.org/W2492012250","https://openalex.org/W2528783366","https://openalex.org/W2588186673","https://openalex.org/W2695110627","https://openalex.org/W2774954425","https://openalex.org/W2943515348","https://openalex.org/W2963086271","https://openalex.org/W2975050399","https://openalex.org/W2998147254","https://openalex.org/W3000134507","https://openalex.org/W3011810033","https://openalex.org/W3023064176","https://openalex.org/W3044567272","https://openalex.org/W3162221541","https://openalex.org/W3171129376","https://openalex.org/W3203808599","https://openalex.org/W4281296332","https://openalex.org/W4283362586","https://openalex.org/W4316466738","https://openalex.org/W4317437864","https://openalex.org/W4389879763","https://openalex.org/W4392753178","https://openalex.org/W4396669166","https://openalex.org/W4401107823","https://openalex.org/W4402103091","https://openalex.org/W4403886937","https://openalex.org/W4413115729","https://openalex.org/W7115558000","https://openalex.org/W7203464287","https://openalex.org/W7203953132","https://openalex.org/W7213250537"],"related_works":["https://openalex.org/W2270731812","https://openalex.org/W2339230070","https://openalex.org/W2397125745","https://openalex.org/W3096831554","https://openalex.org/W3003229472","https://openalex.org/W1804284596","https://openalex.org/W2327500409","https://openalex.org/W4238351110","https://openalex.org/W4240863311","https://openalex.org/W1985469579"],"abstract_inverted_index":{"Biological":[0],"systems":[1],"employ":[2],"molecular":[3,42,115],"machinery":[4],"to":[5,18,29,44,93,133,209],"organize":[6,45],"matter":[7],"into":[8,24,48,119],"functional":[9],"structures":[10],"and":[11,90,107,123],"dynamically":[12],"modify":[13,31],"their":[14,36,175],"organization":[15,219],"in":[16],"response":[17],"external":[19],"signals.":[20],"Translating":[21],"such":[22,66],"capabilities":[23],"synthetic":[25],"nanomaterials":[26,217],"requires":[27],"strategies":[28],"selectively":[30,94,163,195,222],"the":[32,167,178,206],"interactions":[33],"that":[34,63],"define":[35],"structure.":[37],"DNAbased":[38],"assembly":[39,208],"exploits":[40],"sequence-specific":[41,185],"recognition":[43],"nanoscale":[46],"components":[47],"prescribed":[49],"architectures,":[50],"yet":[51],"post-assembly":[52,211],"modification":[53,80,187],"of":[54,74,81,125,145,158,188],"structural":[55],"DNA":[56,75,96,147,189,202],"bonds":[57,190],"remains":[58],"challenging.":[59],"Here,":[60],"we":[61],"demonstrate":[62],"enzymatic":[64,226],"reactions,":[65],"as":[67,191],"DNA-backbone":[68],"covalent":[69],"scission":[70],"using":[71],"CRISPRmediated":[72],"editing":[73],"linkers,":[76],"provide":[77],"targeted":[78],"chemical":[79,143,186],"assembled":[82,135],"3D":[83],"nanomaterials.":[84,198],"Guide":[85],"RNAs":[86],"(gRNAs)":[87],"direct":[88],"Cas9":[89,162],"Cas12a":[91],"nucleases":[92],"cleave":[95],"duplexes":[97],"linking":[98],"nanoparticles":[99],"within":[100,155,177],"ordered":[101],"superlattices.":[102],"Fluorescence":[103],"measurements,":[104],"optical":[105],"microscopy,":[106],"timeresolved":[108],"small-angle":[109],"X-ray":[110],"scattering":[111],"(SAXS)":[112],"reveal":[113],"how":[114],"bond":[116],"cleavage":[117,144],"propagates":[118],"domain":[120],"erosion,":[121],"fragmentation,":[122],"loss":[124],"long-range":[126],"lattice":[127],"order.":[128],"We":[129],"extend":[130],"this":[131],"strategy":[132,193],"superlattices":[134],"from":[136],"DNA-origami":[137,159],"frames,":[138],"demonstrating":[139],"programmable":[140],"disassembly":[141,151],"through":[142,224],"interframe":[146],"linkages.":[148],"Importantly,":[149],"sequence-selective":[150],"can":[152,220],"be":[153,221],"realized":[154],"mixed":[156],"populations":[157],"lattices,":[160],"where":[161],"disrupts":[164],"lattices":[165,173],"containing":[166],"recognized":[168],"linker":[169],"sequence,":[170],"while":[171],"non-targeted":[172],"retain":[174],"structure":[176],"same":[179],"reaction":[180],"environment.":[181],"These":[182],"results":[183],"establish":[184],"a":[192,214],"for":[194],"transforming":[196],"DNA-based":[197],"This":[199],"approach":[200],"extends":[201],"programmability":[203],"beyond":[204],"encoding":[205],"initial":[207],"directing":[210],"transformations,":[212],"providing":[213],"pathway":[215],"toward":[216],"whose":[218],"modified":[223],"guided":[225],"processes,":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}