{"id":"https://openalex.org/W7224533932","doi":"https://doi.org/10.7759/cureus.118763","title":"Long-Term Phosphodiesterase Type 5 (PDE5) Inhibitor Therapy and Serum Uric Acid Levels in Men With Erectile Dysfunction: A Retrospective Analysis","display_name":"Long-Term Phosphodiesterase Type 5 (PDE5) Inhibitor Therapy and Serum Uric Acid Levels in Men With Erectile Dysfunction: A Retrospective Analysis","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224533932","doi":"https://doi.org/10.7759/cureus.118763"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.118763","doi":"https://doi.org/10.7759/cureus.118763","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.118763","pdf_url":"https://www.cureus.com/articles/539016-long-term-phosphodiesterase-type-5-pde5-inhibitor-therapy-and-serum-uric-acid-levels-in-men-with-erectile-dysfunction-a-retrospective-analysis.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7224533932"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/539016-long-term-phosphodiesterase-type-5-pde5-inhibitor-therapy-and-serum-uric-acid-levels-in-men-with-erectile-dysfunction-a-retrospective-analysis.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083285039","display_name":"Ahmed Al Saeedi","orcid":"https://orcid.org/0000-0002-9841-7589","observed_orcids":["https://orcid.org/0000-0002-9841-7589"]},"institutions":[{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Ahmed Al Saeedi","raw_affiliation_strings":[". Urology , Hamad Medical Corporation , Doha , QAT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Urology , Hamad Medical Corporation , Doha , QAT","institution_ids":["https://openalex.org/I49828101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001202853","display_name":"\u00d6nder Cang\u00fcven","orcid":"https://orcid.org/0000-0002-1010-0609","observed_orcids":["https://orcid.org/0000-0002-1010-0609"]},"institutions":[{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Onder Canguven","raw_affiliation_strings":[". Urology , Hamad Medical Corporation , Doha , QAT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Urology , Hamad Medical Corporation , Doha , QAT","institution_ids":["https://openalex.org/I49828101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014152307","display_name":"Yaser M Ata","orcid":"https://orcid.org/0000-0001-6261-0523","observed_orcids":["https://orcid.org/0000-0001-6261-0523"]},"institutions":[{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Yaser M Ata","raw_affiliation_strings":[". Urology , Hamad Medical Corporation , Doha , QAT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Urology , Hamad Medical Corporation , Doha , QAT","institution_ids":["https://openalex.org/I49828101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093018784","display_name":"Khalid Jassim Alkubaisi","orcid":"https://orcid.org/0009-0001-2834-1371","observed_orcids":["https://orcid.org/0009-0001-2834-1371"]},"institutions":[{"id":"https://openalex.org/I179948855","display_name":"Istanbul Ayd\u0131n University","ror":"https://ror.org/00qsyw664","country_code":"TR","type":"education","lineage":["https://openalex.org/I179948855"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Khalid AlKubaisi","raw_affiliation_strings":[". Urology , Istanbul Ayd\u0131n University , Istanbul , TUR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Urology , Istanbul Ayd\u0131n University , Istanbul , TUR","institution_ids":["https://openalex.org/I179948855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.1876000016927719,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9599999785423279},{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":1.0},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7789999842643738},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.828000009059906},{"id":"https://openalex.org/keywords/long-term-drug-therapy","display_name":"long-term drug therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.40299999713897705},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.5849999785423279},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9491000175476074},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.7052000164985657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6935999989509583},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.684499979019165},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5526999831199646},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5077999830245972},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4390000104904175},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.392300009727478},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.37709999084472656},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.3425000011920929},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C206179267","wikidata":"https://www.wikidata.org/wiki/Q188952","display_name":"Medical history","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7759/cureus.118763","doi":"https://doi.org/10.7759/cureus.118763","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.118763","pdf_url":"https://www.cureus.com/articles/539016-long-term-phosphodiesterase-type-5-pde5-inhibitor-therapy-and-serum-uric-acid-levels-in-men-with-erectile-dysfunction-a-retrospective-analysis.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7759/cureus.118763","doi":"https://doi.org/10.7759/cureus.118763","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.118763","pdf_url":"https://www.cureus.com/articles/539016-long-term-phosphodiesterase-type-5-pde5-inhibitor-therapy-and-serum-uric-acid-levels-in-men-with-erectile-dysfunction-a-retrospective-analysis.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224533932.pdf","grobid_xml":"https://content.openalex.org/works/W7224533932.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1487665790","https://openalex.org/W1810057733","https://openalex.org/W2010468497","https://openalex.org/W2062676246","https://openalex.org/W2087037896","https://openalex.org/W2103154123","https://openalex.org/W2110856610","https://openalex.org/W2162309758","https://openalex.org/W2559229196","https://openalex.org/W2613616661","https://openalex.org/W4401670288","https://openalex.org/W4410506300","https://openalex.org/W4412632082"],"related_works":["https://openalex.org/W2613616661","https://openalex.org/W3130942635","https://openalex.org/W1487665790","https://openalex.org/W4200158136","https://openalex.org/W3212376188","https://openalex.org/W7156154946","https://openalex.org/W2784281132","https://openalex.org/W4409315242","https://openalex.org/W4210947279"],"abstract_inverted_index":{"Background:":[0],"Serum":[1],"uric":[2],"acid":[3],"(UA)":[4],"is":[5],"linked":[6],"to":[7,169,177,248],"metabolic":[8,244,251,279],"dysfunction":[9,21],"and":[10,55,105,118,128,133,140,151,184,205,243,252],"endothelial":[11],"impairment,":[12],"both":[13],"of":[14,68,91,181,189,234,277,284],"which":[15],"play":[16],"a":[17,76,178,185,257,269],"role":[18],"in":[19,43,47,225,260],"erectile":[20],"(ED).Phosphodiesterase":[22],"type":[23],"5":[24],"inhibitors":[25],"(PDE5is)":[26],"are":[27],"first-line":[28],"therapy":[29,54,74,217],"for":[30],"ED;":[31],"however,":[32],"their":[33],"effect":[34],"on":[35],"UA":[36,45,85,124,132,160,192,223,246],"metabolism":[37],"remains":[38],"unclear.This":[39],"study":[40],"evaluated":[41],"changes":[42],"serum":[44,109,159,222],"levels":[46,96,224],"men":[48,69,226,261],"with":[49,60,70,80,195,227],"ED":[50,71,286],"receiving":[51,72,262],"long-term":[52],"PDE5i":[53,73,216],"explored":[56],"clinical":[57,134],"factors":[58,281],"associated":[59],"UA.Methods:":[61],"We":[62],"retrospectively":[63],"reviewed":[64],"the":[65,231,237,275],"medical":[66],"records":[67],"at":[75],"tertiary":[77],"care":[78],"center.Patients":[79],"endocrine":[81],"disorders,":[82],"conditions":[83],"affecting":[84],"metabolism,":[86],"recent":[87],"infections,":[88],"or":[89],"use":[90],"medications":[92],"influencing":[93],"sex":[94],"steroid":[95],"were":[97,126,136],"excluded.Demographic":[98],"characteristics,":[99],"body":[100],"mass":[101],"index":[102],"(BMI),":[103],"comorbidities,":[104],"laboratory":[106],"parameters":[107],"-including":[108],"UA,":[110,235],"lipid":[111],"profile,":[112],"fasting":[113],"glucose,":[114],"HbA1c,":[115],"vitamin":[116],"D,":[117],"total":[119],"testosterone":[120],"-were":[121],"collected.Pre-and":[122],"post-treatment":[123],"measurements":[125],"summarized,":[127],"associations":[129],"between":[130,240],"baseline":[131],"variables":[135],"assessed":[137],"using":[138],"Pearson":[139],"Spearman":[141,201,211],"correlation":[142],"coefficients.Results:":[143],"Mean":[144],"age":[145,206],"was":[146,154],"59.4":[147],"\u00b1":[148,156,164,171],"9.4":[149],"years,":[150],"mean":[152,179],"BMI":[153,196],"30.1":[155],"5.0":[157],"kg/m\u00b2.Mean":[158],"decreased":[161],"from":[162],"360.8":[163],"79.3":[165],"\u00b5mol/L":[166,173,183],"before":[167],"treatment":[168],"352.8":[170],"77.7":[172],"after":[174],"treatment,":[175],"corresponding":[176],"change":[180,188],"-8.1":[182],"median":[186],"paired":[187],"-1.0":[190],"\u00b5mol/L.Baseline":[191],"correlated":[193],"positively":[194],"(Pearson":[197,207],"r":[198,208],"=":[199,203,209,213],"0.253;":[200],"\u03c1":[202,212],"0.293)":[204],"0.335;":[210],"0.346).Conclusions:":[214],"Long-term":[215],"does":[218],"not":[219,267],"significantly":[220],"affect":[221],"ED.BMI":[228],"emerged":[229],"as":[230,282],"primary":[232],"determinant":[233],"highlighting":[236],"close":[238],"relationship":[239,271],"obesity,":[241],"hyperuricemia,":[242],"dysfunction.Serum":[245],"appears":[247],"reflect":[249],"systemic":[250],"vascular":[253],"health":[254],"rather":[255],"than":[256],"treatment-responsive":[258],"marker":[259],"PDE5":[263],"inhibitors.These":[264],"findings":[265],"do":[266],"denote":[268],"causal":[270],"but":[272],"instead":[273],"underscore":[274],"importance":[276],"addressing":[278],"risk":[280],"part":[283],"comprehensive":[285],"management.":[287]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-10-30T00:00:00"}