{"id":"https://openalex.org/W7224522711","doi":"https://doi.org/10.1002/cns3.70094","title":"Rethinking Delivery Timing in Prenatally Diagnosed Spinal Muscular Atrophy: A Case Report With 2\u2010Year Follow\u2010Up","display_name":"Rethinking Delivery Timing in Prenatally Diagnosed Spinal Muscular Atrophy: A Case Report With 2\u2010Year Follow\u2010Up","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224522711","doi":"https://doi.org/10.1002/cns3.70094"},"language":"en","primary_location":{"id":"doi:10.1002/cns3.70094","doi":"https://doi.org/10.1002/cns3.70094","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cns3.70094","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns3.70094","source":{"id":"https://openalex.org/S4387285655","display_name":"Annals of the Child Neurology Society","issn_l":"2831-3267","issn":["2831-3267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Child Neurology Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns3.70094","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010464377","display_name":"\u00c9milie Groulx\u2010Boivin","orcid":"https://orcid.org/0000-0001-6459-271X","observed_orcids":["https://orcid.org/0000-0001-6459-271X"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Emilie Groulx\u2010Boivin","raw_affiliation_strings":["Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","Department of Pediatrics McGill University Montreal Quebec Canada","McGill University Health Centre Research Institute Montreal Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0001-6459-271X","affiliations":[{"raw_affiliation_string":"Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Pediatrics McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"McGill University Health Centre Research Institute Montreal Quebec Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061746847","display_name":"Olivier Fortin","orcid":"https://orcid.org/0000-0002-9349-0592","observed_orcids":["https://orcid.org/0000-0002-9349-0592","https://orcid.org/0000-0001-5268-6727"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Olivier Fortin","raw_affiliation_strings":["Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","Department of Pediatrics McGill University Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Pediatrics McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033202429","display_name":"Simon Thebault","orcid":"https://orcid.org/0000-0003-0395-3395","observed_orcids":["https://orcid.org/0000-0003-0395-3395"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Simon Thebault","raw_affiliation_strings":["Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0003-0395-3395","affiliations":[{"raw_affiliation_string":"Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160085088","display_name":"Unain Ansari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Unain Ansari","raw_affiliation_strings":["Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160140005","display_name":"Victoria Nixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Victoria Nixon","raw_affiliation_strings":["McGill University Health Centre Research Institute Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University Health Centre Research Institute Montreal Quebec Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119846754","display_name":"Ariane Belzile","orcid":"https://orcid.org/0009-0000-3891-1254","observed_orcids":["https://orcid.org/0009-0000-3891-1254"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ariane Belzile","raw_affiliation_strings":["McGill University Health Centre Research Institute Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University Health Centre Research Institute Montreal Quebec Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085077606","display_name":"Richard Nicolas Brown","orcid":"https://orcid.org/0000-0002-5476-2698","observed_orcids":["https://orcid.org/0000-0002-5476-2698"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Richard Brown","raw_affiliation_strings":["Department of Obstetrics &amp; Gynecology McGill University Health Center, McGill University Montreal Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0002-5476-2698","affiliations":[{"raw_affiliation_string":"Department of Obstetrics &amp; Gynecology McGill University Health Center, McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079112883","display_name":"Jarred Garfinkle","orcid":"https://orcid.org/0000-0002-4604-1081","observed_orcids":["https://orcid.org/0000-0002-4604-1081"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jarred Garfinkle","raw_affiliation_strings":["Department of Pediatrics McGill University Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040407437","display_name":"Maryam Oskoui","orcid":"https://orcid.org/0000-0003-1042-0108","observed_orcids":["https://orcid.org/0000-0003-1042-0108"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Maryam Oskoui","raw_affiliation_strings":["Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","Department of Pediatrics McGill University Montreal Quebec Canada","McGill University Health Centre Research Institute Montreal Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0003-1042-0108","affiliations":[{"raw_affiliation_string":"Department of Neurology &amp; Neurosurgery McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Pediatrics McGill University Montreal Quebec Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"McGill University Health Centre Research Institute Montreal Quebec Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040407437"],"corresponding_institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86522872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-muscular-atrophy","display_name":"spinal muscular atrophy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/delivery-timing","display_name":"delivery timing","score":0.8539999723434448},{"id":"https://openalex.org/keywords/late-preterm-birth","display_name":"late preterm birth","score":0.7279999852180481},{"id":"https://openalex.org/keywords/nusinersen","display_name":"nusinersen","score":0.8130000233650208},{"id":"https://openalex.org/keywords/smn1-deletion","display_name":"SMN1 deletion","score":0.8370000123977661},{"id":"https://openalex.org/keywords/smn2","display_name":"SMN2","score":0.7260000109672546},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neonatal-management","display_name":"neonatal management","score":0.7739999890327454},{"id":"https://openalex.org/keywords/motor-outcome","display_name":"motor outcome","score":0.574999988079071},{"id":"https://openalex.org/keywords/developmental-delay","display_name":"developmental delay","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8357999920845032},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.6392999887466431},{"id":"https://openalex.org/C2778558090","wikidata":"https://www.wikidata.org/wiki/Q580290","display_name":"Spinal muscular atrophy","level":3,"score":0.6166999936103821},{"id":"https://openalex.org/C2778045022","wikidata":"https://www.wikidata.org/wiki/Q18031604","display_name":"SMN1","level":4,"score":0.5688999891281128},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4878000020980835},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.454800009727478},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.41999998688697815},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.39089998602867126},{"id":"https://openalex.org/C161921814","wikidata":"https://www.wikidata.org/wiki/Q493743","display_name":"SMA*","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.35659998655319214},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3292999863624573},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.32440000772476196},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2779421357","wikidata":"https://www.wikidata.org/wiki/Q210427","display_name":"Cerebral palsy","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C103728769","wikidata":"https://www.wikidata.org/wiki/Q812554","display_name":"Bayley Scales of Infant Development","level":4,"score":0.29179999232292175},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2903999984264374},{"id":"https://openalex.org/C2775887326","wikidata":"https://www.wikidata.org/wiki/Q3308829","display_name":"Prenatal care","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C2988438704","wikidata":"https://www.wikidata.org/wiki/Q2996165","display_name":"Motor function","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2558000087738037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/cns3.70094","doi":"https://doi.org/10.1002/cns3.70094","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cns3.70094","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns3.70094","source":{"id":"https://openalex.org/S4387285655","display_name":"Annals of the Child Neurology Society","issn_l":"2831-3267","issn":["2831-3267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Child Neurology Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/cns3.70094","doi":"https://doi.org/10.1002/cns3.70094","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cns3.70094","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns3.70094","source":{"id":"https://openalex.org/S4387285655","display_name":"Annals of the Child Neurology Society","issn_l":"2831-3267","issn":["2831-3267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Child Neurology Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224522711.pdf","grobid_xml":"https://content.openalex.org/works/W7224522711.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2021723263","https://openalex.org/W3159239056","https://openalex.org/W3198859173","https://openalex.org/W4382599512","https://openalex.org/W4386723723","https://openalex.org/W4391225338","https://openalex.org/W4400037749","https://openalex.org/W4402935682","https://openalex.org/W4402951392","https://openalex.org/W4407732842","https://openalex.org/W4407802609","https://openalex.org/W4409229149","https://openalex.org/W4411718857","https://openalex.org/W7124852347"],"related_works":["https://openalex.org/W7124852347","https://openalex.org/W4283575844","https://openalex.org/W4414824520","https://openalex.org/W4386723723","https://openalex.org/W4304182639","https://openalex.org/W7124972106","https://openalex.org/W4411718857","https://openalex.org/W4402935682","https://openalex.org/W3159239056","https://openalex.org/W7005262910"],"abstract_inverted_index":{"ABSTRACT":[0],"Objective":[1],"We":[2],"describe":[3],"the":[4,170,192],"clinical":[5],"course":[6],"and":[7,24,30,60,90,145,180,187],"outcome":[8],"of":[9,41,183,196],"a":[10,38],"prenatally":[11,197],"diagnosed":[12,198],"infant":[13,36],"with":[14,52],"spinal":[15],"muscular":[16],"atrophy":[17],"(SMA)":[18],"treated":[19],"immediately":[20],"after":[21],"early\u2010term":[22],"birth":[23],"highlight":[25],"considerations":[26],"regarding":[27],"delivery":[28,61,186],"timing":[29],"neonatal":[31,194],"management.":[32],"Methods":[33],"This":[34,150],"male":[35],"had":[37],"family":[39],"history":[40],"SMA":[42],"type":[43],"1A.":[44],"Chorionic":[45],"villus":[46],"sampling":[47],"confirmed":[48],"homozygous":[49],"SMN1":[50],"deletion":[51],"two":[53],"SMN2":[54],"copies.":[55],"Serial":[56],"ultrasounds":[57],"were":[58],"reassuring,":[59],"was":[62,70,102,129],"induced":[63],"at":[64,72,79,131,138],"37":[65],"+":[66],"0":[67],"weeks.":[68],"Nusinersen":[69],"initiated":[71],"24":[73],"h,":[74],"followed":[75],"by":[76,178],"onasemnogene":[77],"abeparvovec\u2010xioi":[78],"9":[80],"days.":[81],"Results":[82],"At":[83],"birth,":[84],"he":[85],"exhibited":[86],"respiratory":[87],"distress,":[88],"hypotonia,":[89],"reduced":[91],"spontaneous":[92],"movements.":[93],"Cerebrospinal":[94],"fluid":[95],"neurofilament":[96],"light":[97],"chain":[98],"on":[99],"day":[100],"1":[101],"markedly":[103],"elevated":[104],"(12":[105],"273":[106],"pg/ml),":[107],"indicating":[108],"substantial":[109],"prenatal":[110],"neuronal":[111],"injury.":[112],"Motor":[113],"function":[114],"improved:":[115],"CHOP\u2010INTEND":[116],"scores":[117],"increased":[118],"from":[119],"26/64":[120],"(day":[121],"8)":[122],"to":[123],"64/64":[124],"(16":[125],"months).":[126],"Independent":[127],"ambulation":[128],"achieved":[130],"18":[132],"months.":[133],"However,":[134],"standardized":[135,188],"developmental":[136],"testing":[137],"25":[139],"months":[140],"demonstrated":[141],"persistent":[142],"gross":[143],"motor":[144,156],"expressive":[146],"language":[147],"delay.":[148],"Interpretation":[149],"patient":[151],"illustrates":[152],"that":[153,169],"clinically":[154],"significant":[155],"neuron":[157],"injury":[158],"may":[159,174],"occur":[160],"in":[161],"utero":[162],"despite":[163],"reassuring":[164],"fetal":[165],"surveillance.":[166],"It":[167],"suggests":[168],"optimal":[171],"treatment":[172],"window":[173],"already":[175],"be":[176],"closing":[177],"term":[179],"supports":[181],"consideration":[182],"elective":[184],"late\u2010preterm":[185],"institutional":[189],"protocols":[190],"for":[191],"early":[193],"management":[195],"SMA.":[199]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}
