{"id":"https://openalex.org/W7224508320","doi":"https://doi.org/10.6065/apem.2550394.197","title":"Triptorelin-stimulated gonadotropin concentrations for precocious puberty","display_name":"Triptorelin-stimulated gonadotropin concentrations for precocious puberty","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224508320","doi":"https://doi.org/10.6065/apem.2550394.197"},"language":"en","primary_location":{"id":"doi:10.6065/apem.2550394.197","doi":"https://doi.org/10.6065/apem.2550394.197","is_oa":true,"landing_page_url":"https://doi.org/10.6065/apem.2550394.197","pdf_url":"https://e-apem.org/upload/pdf/apem-2550394-197.pdf","source":{"id":"https://openalex.org/S2764536087","display_name":"Annals of Pediatric Endocrinology & Metabolism","issn_l":"2287-1012","issn":["2287-1012","2287-1292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319470","host_organization_name":"Korean Society of Pediatric Endocrinology","host_organization_lineage":["https://openalex.org/P4310319470"],"host_organization_lineage_names":["Korean Society of Pediatric Endocrinology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pediatric Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://e-apem.org/upload/pdf/apem-2550394-197.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084112119","display_name":"Eunjung Koh","orcid":"https://orcid.org/0000-0002-7110-8583","observed_orcids":["https://orcid.org/0000-0002-7110-8583"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4405260804","display_name":"Chonnam National University Children's Hospital","ror":"https://ror.org/049weex04","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4405260804"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunjung Koh","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Medical School and Children\u2019s Hospital, Gwangju, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7110-8583","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Medical School and Children\u2019s Hospital, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4405260804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074434351","display_name":"Chan Jong Kim","orcid":"https://orcid.org/0000-0001-6519-2427","observed_orcids":["https://orcid.org/0000-0001-6519-2427"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4405260804","display_name":"Chonnam National University Children's Hospital","ror":"https://ror.org/049weex04","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4405260804"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chan Jong Kim","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Medical School and Children\u2019s Hospital, Gwangju, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6519-2427","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Medical School and Children\u2019s Hospital, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4405260804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.860509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"5","first_page":"319","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-precocious-puberty","display_name":"central precocious puberty","score":0.902999997138977},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8149999976158142},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.8880000114440918},{"id":"https://openalex.org/keywords/premature-thelarche","display_name":"premature thelarche","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sampling-time","display_name":"sampling time","score":0.6449999809265137},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9496999979019165},{"id":"https://openalex.org/C2779448150","wikidata":"https://www.wikidata.org/wiki/Q1992452","display_name":"Triptorelin","level":5,"score":0.9049000144004822},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6241000294685364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5960000157356262},{"id":"https://openalex.org/C2908531242","wikidata":"https://www.wikidata.org/wiki/Q224513","display_name":"Central precocious puberty","level":4,"score":0.5669000148773193},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5418000221252441},{"id":"https://openalex.org/C2779093440","wikidata":"https://www.wikidata.org/wiki/Q907160","display_name":"Leuprorelin","level":5,"score":0.5407999753952026},{"id":"https://openalex.org/C2776880931","wikidata":"https://www.wikidata.org/wiki/Q6745783","display_name":"Breast development","level":3,"score":0.5069000124931335},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5002999901771545},{"id":"https://openalex.org/C2778367240","wikidata":"https://www.wikidata.org/wiki/Q224513","display_name":"Precocious puberty","level":3,"score":0.487199991941452},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4812999963760376},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.47029998898506165},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.44510000944137573},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3434999883174896},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C2778058571","wikidata":"https://www.wikidata.org/wiki/Q334655","display_name":"Amenorrhea","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C2987691683","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling time","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.6065/apem.2550394.197","doi":"https://doi.org/10.6065/apem.2550394.197","is_oa":true,"landing_page_url":"https://doi.org/10.6065/apem.2550394.197","pdf_url":"https://e-apem.org/upload/pdf/apem-2550394-197.pdf","source":{"id":"https://openalex.org/S2764536087","display_name":"Annals of Pediatric Endocrinology & Metabolism","issn_l":"2287-1012","issn":["2287-1012","2287-1292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319470","host_organization_name":"Korean Society of Pediatric Endocrinology","host_organization_lineage":["https://openalex.org/P4310319470"],"host_organization_lineage_names":["Korean Society of Pediatric Endocrinology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pediatric Endocrinology &amp; Metabolism","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.6065/apem.2550394.197","doi":"https://doi.org/10.6065/apem.2550394.197","is_oa":true,"landing_page_url":"https://doi.org/10.6065/apem.2550394.197","pdf_url":"https://e-apem.org/upload/pdf/apem-2550394-197.pdf","source":{"id":"https://openalex.org/S2764536087","display_name":"Annals of Pediatric Endocrinology & Metabolism","issn_l":"2287-1012","issn":["2287-1012","2287-1292"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319470","host_organization_name":"Korean Society of Pediatric Endocrinology","host_organization_lineage":["https://openalex.org/P4310319470"],"host_organization_lineage_names":["Korean Society of Pediatric Endocrinology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pediatric Endocrinology &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224508320.pdf","grobid_xml":"https://content.openalex.org/works/W7224508320.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2030187192","https://openalex.org/W2032548769","https://openalex.org/W2037483573","https://openalex.org/W2056107078","https://openalex.org/W2092419142","https://openalex.org/W2116664513","https://openalex.org/W2133546239","https://openalex.org/W2135502436","https://openalex.org/W2153589742","https://openalex.org/W2170468182","https://openalex.org/W2171944504","https://openalex.org/W2387362699","https://openalex.org/W2416153234","https://openalex.org/W3045641415","https://openalex.org/W3112039794","https://openalex.org/W3216216359","https://openalex.org/W4388824337","https://openalex.org/W4403249465"],"related_works":["https://openalex.org/W4388824337","https://openalex.org/W3216216359","https://openalex.org/W4416911433","https://openalex.org/W4385237528","https://openalex.org/W7152645943","https://openalex.org/W2056107078","https://openalex.org/W4403249465","https://openalex.org/W4396226092","https://openalex.org/W2070876155","https://openalex.org/W4396534718"],"abstract_inverted_index":{"Purpose:":[0],"Subcutaneous":[1],"triptorelin":[2,48],"stimulation":[3],"testing":[4,49],"is":[5,18],"used":[6],"to":[7,214],"evaluate":[8],"girls":[9,35,118],"with":[10,42,52],"early":[11],"breast":[12,43],"development":[13,44],"when":[14],"intravenous":[15],"gonadotropin-releasing":[16],"hormone":[17,55,59],"unavailable,":[19],"but":[20],"the":[21,121,154,170,184],"optimal":[22],"sampling":[23,208],"times":[24],"and":[25,45,57,66,103,106,136,165,187,217],"minimum":[26],"test":[27],"duration":[28],"remain":[29],"uncertain.Methods:":[30],"We":[31,90],"retrospectively":[32],"analyzed":[33],"186":[34],"younger":[36],"than":[37],"8":[38],"years":[39],"who":[40],"presented":[41],"underwent":[46],"subcutaneous":[47],"(0.1":[50],"mg),":[51],"serum":[53],"luteinizing":[54],"(LH)":[56],"follicle-stimulating":[58],"measured":[60],"at":[61,99,150,158,162,166,178,203],"0,":[62],"30,":[63,100],"60,":[64,101],"90,":[65,102],"120":[67,104,140,167,210],"minutes.":[68,141],"Central":[69],"precocious":[70],"puberty":[71],"(CPP)":[72],"was":[73,114,176,212],"defined":[74],"as":[75,86],"peak":[76,223],"LH":[77,98,108,147,188,199,224],"\u22655.0":[78],"IU/L;":[79],"those":[80],"below":[81],"this":[82],"threshold":[83,225],"were":[84],"classified":[85],"premature":[87],"thelarche":[88],"(PT).":[89],"performed":[91],"receiver":[92],"operating":[93],"characteristic":[94],"analyses":[95],"for":[96],"stimulated":[97,198],"minutes":[105,152,168,211],"compared":[107],"trajectories":[109,189],"using":[110,221],"mixed-effects":[111],"modeling.Results:":[112],"CPP":[113,155],"identified":[115],"in":[116,153,169],"88":[117],"(47.3%).":[119],"Using":[120],"5.0":[122,227],"IU/L":[123],"threshold,":[124],"cumulative":[125],"detection":[126],"reached":[127],"90.9%":[128],"by":[129,133,139],"60":[130,159],"minutes,":[131,135],"95.5%":[132],"90":[134],"100%":[137],"only":[138],"Peak":[142],"timing":[143],"differed":[144,190],"between":[145,192],"groups:":[146],"peaked":[148],"mainly":[149],"30\u201360":[151],"group":[156,172],"(33.0%":[157],"minutes;":[160],"29.5%":[161],"30":[163],"minutes)":[164],"PT":[171],"(51.0%).":[173],"Diagnostic":[174],"discrimination":[175,202],"excellent":[177,201],"all":[179],"time":[180,206],"points":[181],"(area":[182],"under":[183],"curve,":[185],"0.993\u20130.999),":[186],"significantly":[191],"groups":[193],"(group-by-time":[194],"interaction,":[195],"P<0.001).Conclusion:":[196],"Although":[197],"showed":[200],"each":[204],"sampled":[205],"point,":[207],"through":[209],"required":[213],"maximize":[215],"sensitivity":[216],"minimize":[218],"false-negative":[219],"classification":[220],"a":[222],"of":[226],"IU/L.":[228]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}
