{"id":"https://openalex.org/W7224465235","doi":"https://doi.org/10.3390/ph19111703","title":"Pharmacokinetics and Single-Time-Point Organ Distribution of the SGLT2 Inhibitor Dapagliflozin After Cardiac Irradiation in Rats: An Exploratory Study","display_name":"Pharmacokinetics and Single-Time-Point Organ Distribution of the SGLT2 Inhibitor Dapagliflozin After Cardiac Irradiation in Rats: An Exploratory Study","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224465235","doi":"https://doi.org/10.3390/ph19111703"},"language":"en","primary_location":{"id":"doi:10.3390/ph19111703","doi":"https://doi.org/10.3390/ph19111703","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph19111703","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ph19111703","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033799711","display_name":"Chen-Hsi Hsieh","orcid":"https://orcid.org/0000-0003-0279-4695","observed_orcids":["https://orcid.org/0000-0003-0279-4695"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I4210102996","display_name":"Far Eastern Memorial Hospital","ror":"https://ror.org/019tq3436","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210102996"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chen-Hsi Hsieh","raw_affiliation_strings":["Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan","School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan","institution_ids":["https://openalex.org/I4210102996"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024511117","display_name":"Hui\u2010Ju Tien","orcid":"https://orcid.org/0000-0002-5908-5278","observed_orcids":["https://orcid.org/0000-0002-5908-5278"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I4210102996","display_name":"Far Eastern Memorial Hospital","ror":"https://ror.org/019tq3436","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210102996"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Ju Tien","raw_affiliation_strings":["Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-5908-5278","affiliations":[{"raw_affiliation_string":"Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan","institution_ids":["https://openalex.org/I4210102996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405014","display_name":"Liying Wang","orcid":"https://orcid.org/0000-0003-3075-6872","observed_orcids":["https://orcid.org/0000-0003-3075-6872"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Ying Wang","raw_affiliation_strings":["Physical Therapy Center, National Taiwan University Hospital, Taipei 100, Taiwan","School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-3075-6872","affiliations":[{"raw_affiliation_string":"Physical Therapy Center, National Taiwan University Hospital, Taipei 100, Taiwan","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100731675","display_name":"Yu-Jen Chen","orcid":"https://orcid.org/0000-0001-9794-8938","observed_orcids":["https://orcid.org/0000-0001-9794-8938","https://orcid.org/0000-0002-1953-4614"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Jen Chen","raw_affiliation_strings":["Departments of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan","Institute of Traditional Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-9794-8938","affiliations":[{"raw_affiliation_string":"Departments of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Institute of Traditional Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081021734","display_name":"Shan-Hui Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102996","display_name":"Far Eastern Memorial Hospital","ror":"https://ror.org/019tq3436","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210102996"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shan-Hui Huang","raw_affiliation_strings":["Division of Cardiology, Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan","institution_ids":["https://openalex.org/I4210102996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033799711"],"corresponding_institution_ids":["https://openalex.org/I148366613","https://openalex.org/I4210102996"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86669768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"11","first_page":"1703","last_page":"1703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.14650000631809235,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.06440000236034393,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cardiac-irradiation","display_name":"cardiac irradiation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9269999861717224},{"id":"https://openalex.org/keywords/organ-distribution","display_name":"organ distribution","score":0.7839999794960022},{"id":"https://openalex.org/keywords/radiation-dose-response","display_name":"radiation dose-response","score":0.33899998664855957},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3700000047683716},{"id":"https://openalex.org/keywords/non-compartmental-analysis","display_name":"non-compartmental analysis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tmax","display_name":"Tmax","score":0.8550000190734863},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8126999735832214},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.7591000199317932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7016000151634216},{"id":"https://openalex.org/C2993469949","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Cardiac dysfunction","level":3,"score":0.6018000245094299},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5188000202178955},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5030999779701233},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5023999810218811},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.46059998869895935},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.46050000190734863},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.4300999939441681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42399999499320984},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.42089998722076416},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.41819998621940613},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.40639999508857727},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.3538999855518341},{"id":"https://openalex.org/C190729725","wikidata":"https://www.wikidata.org/wiki/Q5012817","display_name":"CLs upper limits","level":2,"score":0.3479999899864197},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3237999975681305},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C2908939727","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Hepatic dysfunction","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.2892000079154968},{"id":"https://openalex.org/C2983668108","wikidata":"https://www.wikidata.org/wiki/Q280453","display_name":"Spectral analysis","level":3,"score":0.28630000352859497},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.2797999978065491},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2711000144481659},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2567000091075897},{"id":"https://openalex.org/C3941253","wikidata":"https://www.wikidata.org/wiki/Q47270","display_name":"Half-life","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C2987828669","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical study","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ph19111703","doi":"https://doi.org/10.3390/ph19111703","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph19111703","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ph19111703","doi":"https://doi.org/10.3390/ph19111703","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph19111703","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323468","display_name":"Far Eastern Memorial Hospital","ror":"https://ror.org/019tq3436"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1989031443","https://openalex.org/W1995530184","https://openalex.org/W2058488701","https://openalex.org/W2071424589","https://openalex.org/W2075044961","https://openalex.org/W2126910534","https://openalex.org/W2140231263","https://openalex.org/W2345572214","https://openalex.org/W2460646680","https://openalex.org/W2519709378","https://openalex.org/W2592609832","https://openalex.org/W2771630528","https://openalex.org/W2772835527","https://openalex.org/W2899649250","https://openalex.org/W2900413769","https://openalex.org/W2911865361","https://openalex.org/W2945881782","https://openalex.org/W2974260792","https://openalex.org/W2978703489","https://openalex.org/W2999431040","https://openalex.org/W3007620216","https://openalex.org/W3035502881","https://openalex.org/W3082724415","https://openalex.org/W3147955627","https://openalex.org/W3199730338","https://openalex.org/W3215795069","https://openalex.org/W4236357753","https://openalex.org/W4308419880","https://openalex.org/W4321105489","https://openalex.org/W4405732086","https://openalex.org/W4406318174"],"related_works":["https://openalex.org/W4408301495","https://openalex.org/W4410621808","https://openalex.org/W1606827863","https://openalex.org/W4378211371","https://openalex.org/W4387996379","https://openalex.org/W4408445107","https://openalex.org/W4225143919","https://openalex.org/W1995615699","https://openalex.org/W4306291500","https://openalex.org/W4367315651"],"abstract_inverted_index":{"Background:":[0],"Cardiac":[1],"stereotactic":[2],"body":[3],"radiation":[4],"therapy":[5],"(SBRT)":[6],"and":[7,81,197,252],"dapagliflozin":[8],"(DAPA)":[9],"act":[10],"on":[11],"overlapping":[12],"electrophysiological":[13],"pathways,":[14],"but":[15,143],"whether":[16,259],"cardiac":[17,44,220,233,264],"irradiation":[18,36,234],"alters":[19],"DAPA":[20,49,65,176,199,244,260],"disposition":[21],"is":[22],"unknown.":[23],"Methods:":[24],"Male":[25],"Sprague-Dawley":[26],"rats":[27],"received":[28],"sham":[29],"irradiation,":[30,33],"2-Gy":[31,130,204],"whole-heart":[32],"or":[34,57],"12-Gy":[35,181],"of":[37,165],"a":[38,238],"central":[39],"1.0":[40,42],"\u00d7":[41],"cm":[43],"field,":[45],"followed":[46],"by":[47,68,97],"oral":[48],"(3":[50],"mg/kg)":[51],"2":[52,131],"h":[53,55,59,61,88,132,183,206],"(2":[54],"post-RT)":[56,62],"24":[58,137,182,205],"(24":[60],"later.":[63],"Plasma":[64],"was":[66,125,147,167,177,200],"measured":[67,85],"HPLC-UV":[69],"over":[70],"240":[71],"min":[72],"for":[73,104],"non-compartmental":[74],"analysis":[75],"(n":[76,91],"=":[77,92,117,151,218],"6/group);":[78],"heart,":[79],"liver,":[80],"kidney":[82],"concentrations":[83,221],"were":[84,95,122,159],"once,":[86],"4":[87,173],"after":[89],"dosing":[90],"5/group).":[93],"Groups":[94],"compared":[96],"Welch":[98],"ANOVA":[99],"with":[100],"Games\u2013Howell":[101],"tests":[102],"(Kruskal\u2013Wallis":[103],"Tmax).":[105],"Results:":[106],"AUC0\u2013240":[107],"did":[108,222,235],"not":[109,148,223,236,254],"differ":[110,224],"significantly":[111,225],"among":[112],"groups":[113],"(247\u2013305":[114],"min\u00b7\u00b5g/mL;":[115],"p":[116,194,217],"0.66),":[118],"although":[119],"confidence":[120],"intervals":[121],"wide.":[123],"Tmax":[124],"numerically":[126],"longer":[127],"in":[128,179,202,241],"the":[129,144,180,203],"post-RT":[133,184,207],"group":[134,185,208],"(190":[135],"\u00b1":[136,140,187,191,210,214],"vs.":[138,189,212],"100":[139],"31":[141],"min),":[142],"Kruskal\u2013Wallis":[145],"test":[146],"significant":[149],"(p":[150],"0.090).":[152],"Terminal-phase":[153],"parameters":[154],"(t1/2,":[155],"MRT,":[156],"CL/F,":[157],"Vss/F)":[158],"treated":[160],"as":[161],"exploratory":[162,231],"because":[163],"40\u201363%":[164],"AUC0\u2013\u221e":[166],"extrapolated;":[168],"none":[169],"differed":[170],"significantly.":[171],"At":[172],"h,":[174],"renal":[175],"lower":[178],"(23.52":[186],"2.40":[188],"56.09":[190],"2.45":[192],"\u00b5g/g;":[193,216],"<":[195],"0.001),":[196],"hepatic":[198],"higher":[201],"(17.32":[209],"3.17":[211],"6.67":[213],"1.58":[215],"0.003);":[219],"from":[226],"control.":[227],"Conclusions:":[228],"In":[229],"this":[230],"study,":[232],"produce":[237],"detectable":[239],"change":[240],"early":[242],"systemic":[243],"exposure.":[245],"The":[246],"single-time-point":[247],"organ":[248],"differences":[249],"are":[250],"hypothesis-generating":[251],"do":[253],"establish":[255],"altered":[256],"tissue":[257],"exposure;":[258],"timing":[261],"relative":[262],"to":[263],"SBRT":[265],"matters":[266],"clinically":[267],"requires":[268],"dedicated":[269],"study.":[270]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-30T00:00:00"}