{"id":"https://openalex.org/W7224445463","doi":"https://doi.org/10.1183/13993003.congress-2026.pa339","title":"Late Breaking Abstract - A single dose of zumilokibart (APG777) durably suppresses FeNO through 32 weeks in patients with mild-to-moderate asthma","display_name":"Late Breaking Abstract - A single dose of zumilokibart (APG777) durably suppresses FeNO through 32 weeks in patients with mild-to-moderate asthma","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7224445463","doi":"https://doi.org/10.1183/13993003.congress-2026.pa339"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2026.pa339","doi":"https://doi.org/10.1183/13993003.congress-2026.pa339","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2026.pa339","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160113949","display_name":"Mario Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Castro","raw_affiliation_strings":["1University of Kansas School of Medicine, Kansas City, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas School of Medicine, Kansas City, United States","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087200735","display_name":"Jeremy Cole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Cole","raw_affiliation_strings":["2OK Clinical Research, LLC, Edmond, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2OK Clinical Research, LLC, Edmond, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010648860","display_name":"James DeAngelo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James DeAngelo","raw_affiliation_strings":["3Allergy and Clinical Immunology Associates, Pittsburgh, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Allergy and Clinical Immunology Associates, Pittsburgh, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103934431","display_name":"Erica Winter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica Winter","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040547249","display_name":"Abby Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abby Chen","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160083035","display_name":"Xioaye Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xioaye Ma","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023699401","display_name":"Wei Tew","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Tew","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034350503","display_name":"Sai P. Thankamony","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sai Thankamony","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160135612","display_name":"Myreen Tomas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myreen Tomas","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048157968","display_name":"Glenn J. Whelan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Whelan","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075265981","display_name":"Claudia Halaby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Halaby","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112472191","display_name":"Carl L. Dambkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Dambkowski","raw_affiliation_strings":["4Apogee Therapeutics, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Apogee Therapeutics, Waltham, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016828717","display_name":"Amol P. Kamboj","orcid":"https://orcid.org/0000-0003-3611-7326","observed_orcids":["https://orcid.org/0000-0003-3611-7326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amol Kamboj","raw_affiliation_strings":["5Apogee Therapeutics, San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Apogee Therapeutics, San Francisco, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160079310","display_name":"Dave Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210151016","display_name":"Medicines Evaluation Unit","ror":"https://ror.org/05e497m36","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210151016"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dave Singh","raw_affiliation_strings":["6Medicines Evaluation Unit, an IQVIA business, and University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Medicines Evaluation Unit, an IQVIA business, and University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210151016"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA339","last_page":"PA339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-il-13-antibody","display_name":"anti-IL-13 antibody","score":0.949999988079071},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6389999985694885},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9150000214576721},{"id":"https://openalex.org/keywords/type-2-airway-inflammation","display_name":"type 2 airway inflammation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/single-dose-pharmacokinetics","display_name":"single-dose pharmacokinetics","score":0.7590000033378601},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.5299999713897705},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5709999799728394},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8661999702453613},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7037000060081482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4018000066280365},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.31790000200271606},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2655999958515167},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.24879999458789825},{"id":"https://openalex.org/C3018209156","wikidata":"https://www.wikidata.org/wiki/Q287961","display_name":"\u03b22 adrenergic receptor","level":4,"score":0.24220000207424164},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.23520000278949738}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2026.pa339","doi":"https://doi.org/10.1183/13993003.congress-2026.pa339","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2026.pa339","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165518039","https://openalex.org/W7224401294","https://openalex.org/W7224183220","https://openalex.org/W7224538997","https://openalex.org/W2341287298","https://openalex.org/W7224246273","https://openalex.org/W4396516188","https://openalex.org/W3080821177","https://openalex.org/W4416636154","https://openalex.org/W2314739501"],"abstract_inverted_index":{"Introduction:":[0],"IL-13":[1,201],"is":[2,30],"a":[3,31,59,83],"key":[4],"driver":[5],"of":[6,55,62,86,143,199,213,245],"type":[7,206,238],"2":[8,139,207,239],"airway":[9],"inflammation":[10],"and":[11,22,50,53,94,152,168,202,216,252],"fractional":[12],"exhaled":[13],"nitric":[14],"oxide":[15],"(FeNO),":[16],"both":[17],"associated":[18],"with":[19,40,66,74,136,150,157,163,178,223,231,257],"exacerbation":[20],"risk":[21],"impaired":[23],"lung":[24],"function":[25],"in":[26,64,204,229,237,255],"asthma.":[27,259],"Zumilokibart":[28,132,194],"(APG777)":[29],"half-life-extended":[32],"anti-IL-13":[33],"antibody":[34],"that":[35],"achieves":[36],"early":[37],"peak":[38],"exposures":[39],"sustained":[41,172,224],"activity.":[42],"Aim:":[43],"This":[44,101],"phase":[45],"1b":[46],"study":[47],"evaluates":[48],"safety":[49],"the":[51],"magnitude":[52],"durability":[54],"FeNO":[56,75,159,188,219],"suppression":[57,160,198,225],"following":[58],"single":[60,84,211],"dose":[61,85,212],"zumilokibart":[63,87,214],"adults":[65,105],"mild-to-moderate":[67],"asthma":[68],"(":[69],"NCT06920901":[70],").":[71],"Methods:":[72],"Participants":[73],"\u226525":[76],"ppb":[77,145,149,167],"were":[78,97,122],"randomized":[79],"3:1":[80],"to":[81,184,196],"receive":[82],"720":[88],"mg":[89],"or":[90,128],"placebo.":[91],"Safety,":[92],"FeNO,":[93,135],"pharmacodynamic":[95],"biomarkers":[96],"assessed":[98],"longitudinally.":[99],"Results:":[100],"analysis":[102],"included":[103],"19":[104],"(N=14,":[106],"zumilokibart;":[107],"N=5,":[108],"placebo;":[109],"mean":[110,164],"age":[111],"44.5":[112],"years;":[113],"42.1%":[114],"female).":[115],"Through":[116],"Week":[117,138,174,185,192],"32,":[118],"adverse":[119],"events":[120],"(AEs)":[121],"predominantly":[123],"mild;":[124],"no":[125],"\u2265grade":[126],"3":[127],"serious":[129],"AEs":[130],"occurred.":[131],"rapidly":[133,215],"suppressed":[134,190,218],"maximal":[137],"reductions":[140,165,203,236],"from":[141,170],"baseline":[142,171],"45.1\u00b115.7":[144],"(mean\u00b1SE":[146],"vs":[147,155],"10.6\u00b17.5":[148],"placebo)":[151],"-60.2\u00b14.3%":[153],"(%\u00b1SE":[154],"-10.2\u00b18.7%":[156],"placebo).":[158],"was":[161],"durable,":[162],">40":[166],">50%":[169],"at":[173],"32.":[175],"Among":[176],"participants":[177,230],"extended":[179,246],"follow-up":[180],"[Week":[181],"36":[182],"(N=11)":[183],"48":[186,227],"(N=2)],":[187],"remained":[189],"through":[191,220,226],"48.":[193],"led":[195],"near-complete":[197],"serum":[200],"other":[205],"biomarkers.":[208,240],"Conclusions:":[209],"A":[210],"durably":[217],"32":[221],"weeks,":[222],"weeks":[228],"available":[232],"follow-up,":[233],"accompanied":[234],"by":[235],"These":[241],"findings":[242],"support":[243],"evaluation":[244],"dosing":[247],"intervals,":[248],"including":[249],"12-,":[250],"24-,":[251],"48-week":[253],"dosing,":[254],"patients":[256],"moderate-to-severe":[258]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-30T00:00:00"}
