{"id":"https://openalex.org/W7224438312","doi":"https://doi.org/10.21873/invivo.14531","title":"Long-term Disease Control After Probable Endobronchial Small-cell Transformation During Osimertinib Therapy for EGFR -mutant Lung Adenocarcinoma","display_name":"Long-term Disease Control After Probable Endobronchial Small-cell Transformation During Osimertinib Therapy for EGFR -mutant Lung Adenocarcinoma","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224438312","doi":"https://doi.org/10.21873/invivo.14531","pmid":"https://pubmed.ncbi.nlm.nih.gov/42957218","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13724012"},"language":"en","primary_location":{"id":"doi:10.21873/invivo.14531","doi":"https://doi.org/10.21873/invivo.14531","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.14531","pdf_url":null,"source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21873/invivo.14531","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001253230","display_name":"Nozomu Murayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143192","display_name":"Toyama University Hospital","ror":"https://ror.org/04a2npp96","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210143192"]},{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NOZOMU MURAYAMA","raw_affiliation_strings":["First Department of Internal Medicine, Toyama University Hospital, Toyama, Japan; nozomum@med.u-toyama.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Toyama University Hospital, Toyama, Japan; nozomum@med.u-toyama.ac.jp","institution_ids":["https://openalex.org/I4210143192","https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070801389","display_name":"Minehiko Inomata","orcid":"https://orcid.org/0000-0002-6846-187X","observed_orcids":["https://orcid.org/0000-0002-6846-187X"]},"institutions":[{"id":"https://openalex.org/I4210143192","display_name":"Toyama University Hospital","ror":"https://ror.org/04a2npp96","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210143192"]},{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MINEHIKO INOMATA","raw_affiliation_strings":["First Department of Internal Medicine, Toyama University Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Toyama University Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4210143192","https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160096985","display_name":"MASAHIRO MATSUMOTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143192","display_name":"Toyama University Hospital","ror":"https://ror.org/04a2npp96","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210143192"]},{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAHIRO MATSUMOTO","raw_affiliation_strings":["First Department of Internal Medicine, Toyama University Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Toyama University Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4210143192","https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074844785","display_name":"\u5927\u8f14 \u53e4\u5ddd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285283","display_name":"Toyama Red Cross Hospital","ror":"https://ror.org/0546xef16","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405285283"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"DAISUKE FURUKAWA","raw_affiliation_strings":["Department of Respiratory and Allergy Medicine, Toyama Red Cross Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Allergy Medicine, Toyama Red Cross Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4405285283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160092294","display_name":"TOMOMI ICHIKAWA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285283","display_name":"Toyama Red Cross Hospital","ror":"https://ror.org/0546xef16","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405285283"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOMOMI ICHIKAWA","raw_affiliation_strings":["Department of Respiratory and Allergy Medicine, Toyama Red Cross Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Allergy Medicine, Toyama Red Cross Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4405285283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025889209","display_name":"Yoshinobu Maeda","orcid":"https://orcid.org/0000-0003-1634-5487","observed_orcids":["https://orcid.org/0000-0003-1634-5487"]},"institutions":[{"id":"https://openalex.org/I4405285283","display_name":"Toyama Red Cross Hospital","ror":"https://ror.org/0546xef16","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405285283"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHINOBU MAEDA","raw_affiliation_strings":["Department of Diagnostic Pathology, Toyama Red Cross Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Toyama Red Cross Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4405285283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089390438","display_name":"Hideki Shinno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087637","display_name":"Toyama Prefectural Central Hospital","ror":"https://ror.org/004cah429","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIDEKI SHINNO","raw_affiliation_strings":["Department of Thoracic Surgery, Toyama Prefectural Central Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Toyama Prefectural Central Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4210087637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042125699","display_name":"Yuko Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087637","display_name":"Toyama Prefectural Central Hospital","ror":"https://ror.org/004cah429","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUKO NAKANISHI","raw_affiliation_strings":["Department of Diagnostic Pathology, Toyama Prefectural Central Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Toyama Prefectural Central Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4210087637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160145798","display_name":"SHIN ISHIZAWA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087637","display_name":"Toyama Prefectural Central Hospital","ror":"https://ror.org/004cah429","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHIN ISHIZAWA","raw_affiliation_strings":["Department of Diagnostic Pathology, Toyama Prefectural Central Hospital, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology, Toyama Prefectural Central Hospital, Toyama, Japan","institution_ids":["https://openalex.org/I4210087637"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85118958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"6","first_page":"3940","last_page":"3946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":0.9419999718666077},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/long-term-disease-control","display_name":"long-term disease control","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.894599974155426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7935000061988831},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6758999824523926},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6240000128746033},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.5648000240325928},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5109000205993652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5054000020027161},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4401000142097473},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4147000014781952},{"id":"https://openalex.org/C2779563347","wikidata":"https://www.wikidata.org/wiki/Q843799","display_name":"Adenocarcinoma of the lung","level":4,"score":0.39800000190734863},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3465999960899353},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.2685000002384186}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.21873/invivo.14531","doi":"https://doi.org/10.21873/invivo.14531","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.14531","pdf_url":null,"source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13724012","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724012/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724012/pdf/in_vivo-40-3940.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"Text"},{"id":"pmid:42957218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42957218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/invivo.14531","doi":"https://doi.org/10.21873/invivo.14531","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.14531","pdf_url":null,"source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224438312.pdf","grobid_xml":"https://content.openalex.org/works/W7224438312.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385306421","https://openalex.org/W4366831111","https://openalex.org/W2593459221","https://openalex.org/W2766090936","https://openalex.org/W7007789659","https://openalex.org/W7221766414","https://openalex.org/W3198586649","https://openalex.org/W4394690298","https://openalex.org/W3097152074","https://openalex.org/W2600318014"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"-mutant":[1],"non-small-cell":[2],"lung":[3,15,46],"cancer":[4,16],"(NSCLC),":[5],"but":[6],"acquired":[7],"resistance":[8,21],"is":[9,18,171],"inevitable.":[10],"Histologic":[11],"transformation":[12],"to":[13,118,173],"small-cell":[14],"(SCLC)":[17],"a":[19,30,62,107],"recognized":[20],"mechanism,":[22],"typically":[23],"presenting":[24],"with":[25],"widespread":[26],"metastatic":[27],"disease":[28,51,134,158],"and":[29,74,86,93,101,126,152],"poor":[31],"prognosis.":[32],"Optimal":[33],"post-transformation":[34],"treatment":[35,176],"strategies":[36],"have":[37],"not":[38],"been":[39],"established.":[40],"CASE":[41],"REPORT:":[42],"exon":[43],"19":[44],"deletion-positive":[45],"adenocarcinoma":[47,92],"who":[48],"achieved":[49],"prolonged":[50,157],"control":[52,135,159],"on":[53],"osimertinib":[54,153,166],"for":[55],"mediastinal":[56],"lymph":[57],"node":[58],"recurrence":[59],"before":[60],"developing":[61],"new":[63],"endobronchial":[64,95],"lesion":[65,96],"in":[66,132,160],"the":[67,79,90,94,127],"left":[68],"main":[69],"bronchus.":[70],"Rigid":[71],"bronchoscopic":[72,146],"resection":[73],"temporary":[75,148],"airway":[76,149],"stenting":[77],"relieved":[78],"critical":[80],"obstruction.":[81],"Pathologic":[82],"examination":[83],"confirmed":[84],"SCLC,":[85],"immunohistochemistry":[87],"of":[88,103,110,129],"both":[89],"initial":[91],"demonstrated":[97],"concordant":[98],"p53":[99],"over-expression":[100],"loss":[102],"Rb":[104],"expression,":[105],"supporting":[106],"clinical":[108],"diagnosis":[109],"probable":[111],"histologic":[112],"transformation.":[113],"The":[114],"patient":[115],"was":[116],"bridged":[117],"sequential":[119],"chemoradiotherapy,":[120,151],"followed":[121],"by":[122],"successful":[123],"stent":[124],"removal":[125],"resumption":[128,154],"osimertinib,":[130],"resulting":[131],"long-term":[133],"exceeding":[136],"four":[137],"years.":[138],"CONCLUSION:":[139],"An":[140],"individualized,":[141],"multidisciplinary":[142],"approach":[143],"comprising":[144],"rigid":[145],"resection,":[147],"stenting,":[150],"may":[155],"achieve":[156],"locoregionally":[161],"confined":[162],"SCLC":[163],"arising":[164],"during":[165],"therapy.":[167],"Further":[168],"case":[169],"accumulation":[170],"warranted":[172],"establish":[174],"optimal":[175],"strategies.":[177]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}
