{"id":"https://openalex.org/W7224420806","doi":"https://doi.org/10.1093/hmg/ddag113","title":"Transcriptomic signatures of lipids in blood provide hypotheses of functional mechanisms linked to lipid metabolism and immune-cell regulation","display_name":"Transcriptomic signatures of lipids in blood provide hypotheses of functional mechanisms linked to lipid metabolism and immune-cell regulation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7224420806","doi":"https://doi.org/10.1093/hmg/ddag113","pmid":"https://pubmed.ncbi.nlm.nih.gov/42955849","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13718429"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddag113","doi":"https://doi.org/10.1093/hmg/ddag113","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddag113","pdf_url":"https://academic.oup.com/hmg/article-pdf/35/22/ddag113/72587764/ddag113.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/hmg/article-pdf/35/22/ddag113/72587764/ddag113.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017383315","display_name":"Jessica I. Lundin","orcid":"https://orcid.org/0000-0003-4892-6235","observed_orcids":["https://orcid.org/0000-0003-4892-6235"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jessica I Lundin","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,"],"raw_orcid":"https://orcid.org/0000-0003-4892-6235","affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049372370","display_name":"Mariaelisa Graff","orcid":"https://orcid.org/0000-0001-6380-1735","observed_orcids":["https://orcid.org/0000-0001-6380-1735"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariaelisa Graff","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599 ,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111026806","display_name":"Jeff Haessler","orcid":"https://orcid.org/0000-0002-2756-4370","observed_orcids":["https://orcid.org/0000-0002-2756-4370"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Haessler","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160102411","display_name":"Xinruo Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinruo Zhang","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599 ,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160110400","display_name":"Yanwei Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanwei Cai","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015289714","display_name":"Harriett Fuller","orcid":"https://orcid.org/0000-0001-8381-519X","observed_orcids":["https://orcid.org/0000-0001-8381-519X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harriett Fuller","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057944271","display_name":"Nancy L. Heard\u2010Costa","orcid":"https://orcid.org/0000-0001-9730-0306","observed_orcids":["https://orcid.org/0000-0001-9730-0306"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Heard-Costa","raw_affiliation_strings":["Department of Neurology, Boston University Chobanian & Avedisian School of Medicine , 72 E. Concord St Robinson (B), Boston, MA 02118, United States","Framingham Heart Study, 73 Mt. Wayte Ave, Ste 2, Framingham, Massachusetts , Boston, MA 01702 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Boston University Chobanian & Avedisian School of Medicine , 72 E. Concord St Robinson (B), Boston, MA 02118, United States","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Framingham Heart Study, 73 Mt. Wayte Ave, Ste 2, Framingham, Massachusetts , Boston, MA 01702 ,","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005940300","display_name":"Tianxiao Huan","orcid":"https://orcid.org/0000-0001-5840-9413","observed_orcids":["https://orcid.org/0000-0001-5840-9413"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianxiao Huan","raw_affiliation_strings":["Framingham Heart Study, 73 Mt. Wayte Ave, Ste 2, Framingham, Massachusetts , Boston, MA 01702 ,","Population Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health , Bethesda, MD 20892 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Framingham Heart Study, 73 Mt. Wayte Ave, Ste 2, Framingham, Massachusetts , Boston, MA 01702 ,","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Population Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health , Bethesda, MD 20892 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051097194","display_name":"Roby Joehanes","orcid":"https://orcid.org/0000-0001-5549-9054","observed_orcids":["https://orcid.org/0000-0001-5549-9054"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roby Joehanes","raw_affiliation_strings":["Population Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health , Bethesda, MD 20892 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health , Bethesda, MD 20892 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039527927","display_name":"Joshua M. Landman","orcid":"https://orcid.org/0000-0003-2431-6053","observed_orcids":["https://orcid.org/0000-0003-2431-6053"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua M Landman","raw_affiliation_strings":["Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232,","Vanderbilt Genetics Institute, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232,","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232 ,","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036791650","display_name":"Gina Marie Peloso","orcid":"https://orcid.org/0000-0002-5355-8636","observed_orcids":["https://orcid.org/0000-0002-5355-8636"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina Marie Peloso","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Ave, Boston, MA 02118 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Ave, Boston, MA 02118 ,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160080400","display_name":"Yuxuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxuan Wang","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Ave, Boston, MA 02118 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Ave, Boston, MA 02118 ,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407637","display_name":"Zhe Wang","orcid":"https://orcid.org/0000-0002-8046-4969","observed_orcids":["https://orcid.org/0000-0002-8046-4969"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe Wang","raw_affiliation_strings":["Department of Epidemiology, University of Alabama at Birmingham , 1665 University Boulevard, Birmingham, AL 35233 ,","The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , 1468 Madison Ave, New York, NY 10029,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Alabama at Birmingham , 1665 University Boulevard, Birmingham, AL 35233 ,","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai , 1468 Madison Ave, New York, NY 10029,","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028714205","display_name":"Jennifer Elizabeth Below","orcid":"https://orcid.org/0000-0002-1346-1872","observed_orcids":["https://orcid.org/0000-0002-1346-1872","https://orcid.org/0000-0002-6372-6402"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E Below","raw_affiliation_strings":["Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232,","Vanderbilt Genetics Institute, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232,","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute, Vanderbilt University Medical Center , 2215 Garland Ave, 507 Light Hall, Nashville, TN 37232 ,","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074117194","display_name":"Daniel A Levy","orcid":"https://orcid.org/0000-0003-1843-8724","observed_orcids":["https://orcid.org/0000-0003-1843-8724"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Levy","raw_affiliation_strings":["Framingham Heart Study, 73 Mt. Wayte Ave, Ste 2, Framingham, Massachusetts , Boston, MA 01702 ,","Population Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health , Bethesda, MD 20892 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Framingham Heart Study, 73 Mt. Wayte Ave, Ste 2, Framingham, Massachusetts , Boston, MA 01702 ,","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Population Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health , Bethesda, MD 20892 ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062296084","display_name":"Kari E. North","orcid":"https://orcid.org/0000-0002-8903-0366","observed_orcids":["https://orcid.org/0000-0002-8903-0366","https://orcid.org/0000-0002-0581-149X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari E North","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599 ,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079207212","display_name":"Alex P. Reiner","orcid":"https://orcid.org/0000-0002-1427-4470","observed_orcids":["https://orcid.org/0000-0002-1427-4470","https://orcid.org/0000-0002-0607-6714","https://orcid.org/0000-0001-8866-6672"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex P Reiner","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, University of Washington , Box #351619, Seattle, WA 98195 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, University of Washington , Box #351619, Seattle, WA 98195 ,","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160075424","display_name":"Ryan Zukowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Zukowski","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Ave, Boston, MA 02118 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health , 801 Massachusetts Ave, Boston, MA 02118 ,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053681099","display_name":"Ulrike Peters","orcid":"https://orcid.org/0000-0001-5666-9318","observed_orcids":["https://orcid.org/0000-0001-5666-9318"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrike Peters","raw_affiliation_strings":["Department of Epidemiology, School of Public Health, University of Washington , Box #351619, Seattle, WA 98195 ,","Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,"],"raw_orcid":"https://orcid.org/0000-0001-5666-9318","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, University of Washington , Box #351619, Seattle, WA 98195 ,","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003856334","display_name":"Charles L Kooperberg","orcid":"https://orcid.org/0000-0002-7986-8560","observed_orcids":["https://orcid.org/0000-0002-7986-8560"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles Kooperberg","raw_affiliation_strings":["Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,"],"raw_orcid":"https://orcid.org/0000-0002-7986-8560","affiliations":[{"raw_affiliation_string":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , 1100 Fairview Avenue N, Seattle, WA 98109 ,","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5003856334","https://openalex.org/A5017383315"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76696457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.47530001401901245,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.188400000333786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7279999852180481},{"id":"https://openalex.org/keywords/blood-transcriptome","display_name":"blood transcriptome","score":0.656000018119812},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.4699999988079071},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7720000147819519},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.46700000762939453},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.9599999785423279},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.6769999861717224},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.7250000238418579},{"id":"https://openalex.org/keywords/npc2","display_name":"NPC2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/squalene-epoxidase","display_name":"squalene epoxidase","score":0.972000002861023},{"id":"https://openalex.org/keywords/ddah2","display_name":"DDAH2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fcgrt","display_name":"FCGRT","score":0.996999979019165},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6349999904632568},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.746999979019165},{"id":"https://openalex.org/keywords/colocalization","display_name":"colocalization","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8812000155448914},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7087000012397766},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.635200023651123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5920000076293945},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.571399986743927},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.5368000268936157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4537999927997589},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4242999851703644},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.39160001277923584},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.37940001487731934},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.361299991607666},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3172999918460846},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.3158999979496002},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2761000096797943},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.25940001010894775},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2540000081062317},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/hmg/ddag113","doi":"https://doi.org/10.1093/hmg/ddag113","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddag113","pdf_url":"https://academic.oup.com/hmg/article-pdf/35/22/ddag113/72587764/ddag113.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13718429","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13718429/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13718429/pdf/ddag113.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Mol Genet","raw_type":"Text"},{"id":"pmid:42955849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42955849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/hmg/ddag113","doi":"https://doi.org/10.1093/hmg/ddag113","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddag113","pdf_url":"https://academic.oup.com/hmg/article-pdf/35/22/ddag113/72587764/ddag113.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1052645489","display_name":null,"funder_award_id":"117626","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1129490614","display_name":null,"funder_award_id":"HHSN268201500014C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1131636781","display_name":null,"funder_award_id":"S10OD028685","funder_id":"https://openalex.org/F4320308793","funder_display_name":"Fred Hutchinson Cancer Research Center"},{"id":"https://openalex.org/G122915289","display_name":null,"funder_award_id":"UL1TR000371","funder_id":"https://openalex.org/F4320333360","funder_display_name":"Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston"},{"id":"https://openalex.org/G1233095484","display_name":"Using genetic variation to study biology of blood lipids & coronary heart disease","funder_award_id":"R01HL127564","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1490530680","display_name":null,"funder_award_id":"HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1620252213","display_name":"Center for Clinical and Translational Sciences (CCTS)","funder_award_id":"UL1TR000371","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1757295093","display_name":null,"funder_award_id":"75N92021D00002","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G1830252914","display_name":null,"funder_award_id":"R01-HL142711","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1851406594","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G205646552","display_name":null,"funder_award_id":"75N92021D00001","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G205733141","display_name":null,"funder_award_id":"R01HL-120393","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2096685756","display_name":null,"funder_award_id":"HHSN268201800002I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G232264632","display_name":null,"funder_award_id":"R01-HL120393","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2544448910","display_name":null,"funder_award_id":"HHSN268201800002I","funder_id":"https://openalex.org/F4320316384","funder_display_name":"New York Genome Center"},{"id":"https://openalex.org/G2574430291","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320338421","funder_display_name":"NHLBI Division of Intramural Research"},{"id":"https://openalex.org/G2615153583","display_name":null,"funder_award_id":"75N92021D00003","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G264675175","display_name":null,"funder_award_id":"HHSN268201600034I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2777343687","display_name":null,"funder_award_id":"75N92021D00001","funder_id":"https://openalex.org/F4320308793","funder_display_name":"Fred Hutchinson Cancer Research Center"},{"id":"https://openalex.org/G278200998","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2786316047","display_name":null,"funder_award_id":"R01-HL151152","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2833631237","display_name":null,"funder_award_id":"3R01HL-117626-02S1","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3078883119","display_name":null,"funder_award_id":"HHSN268201800001I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3161388866","display_name":null,"funder_award_id":"R01-HL127564","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3190602077","display_name":null,"funder_award_id":"R01DK122503","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3194560040","display_name":null,"funder_award_id":"HHSN268201600032I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3722109428","display_name":"Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical Care","funder_award_id":"R01HL151152","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3769459334","display_name":null,"funder_award_id":"HHSN268201600034I","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3819938352","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3827278403","display_name":null,"funder_award_id":"75N92021D00004","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3904784472","display_name":null,"funder_award_id":"HHSN268201800001I","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4030405119","display_name":null,"funder_award_id":"HHSN268201600034I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4040422891","display_name":null,"funder_award_id":"75N92021D00004","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G4110967700","display_name":"Rare variants and NHLBI traits in deeply phenotyped cohorts","funder_award_id":"U01HL120393","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4134796104","display_name":"PAGE III: Population Architecture using Genomics and Epidemiology","funder_award_id":"R01HG010297","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G447592127","display_name":null,"funder_award_id":"3U54HG003067-12S2","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4499735890","display_name":null,"funder_award_id":"75N92021D00003","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4514711904","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320316183","funder_display_name":"Evans Medical Foundation"},{"id":"https://openalex.org/G472208673","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320309647","funder_display_name":"School of Medicine, Boston University"},{"id":"https://openalex.org/G4826951158","display_name":null,"funder_award_id":"NO1-HC-25195","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4949958486","display_name":null,"funder_award_id":"HHSN268201600032I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4976486911","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5163278296","display_name":null,"funder_award_id":"HHSN268201800002I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G53375319","display_name":null,"funder_award_id":"3R01HL117004-02S3","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5519421502","display_name":null,"funder_award_id":"U01HL-120393","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G554960330","display_name":null,"funder_award_id":"75N92021D00002","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5631728042","display_name":null,"funder_award_id":"phs000921","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5717342023","display_name":null,"funder_award_id":"HHSN268201800002I","funder_id":"https://openalex.org/F4320338421","funder_display_name":"NHLBI Division of Intramural Research"},{"id":"https://openalex.org/G5805320778","display_name":null,"funder_award_id":"NO1\u2010HC\u201025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6151559349","display_name":"Framingham: Inflammation, Genes & Cardiovascular Disease","funder_award_id":"R01HL076784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G631129105","display_name":null,"funder_award_id":"R01 HL","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6374953548","display_name":null,"funder_award_id":"75N92021D00004","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6615318374","display_name":null,"funder_award_id":"HHSN268201800001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6668578234","display_name":null,"funder_award_id":"R01HL092577","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6894818919","display_name":null,"funder_award_id":"75N92021D00002","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7159829730","display_name":null,"funder_award_id":"75N92021D00001","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7270333588","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G738282736","display_name":null,"funder_award_id":"HHSN268201800001I","funder_id":"https://openalex.org/F4320316384","funder_display_name":"New York Genome Center"},{"id":"https://openalex.org/G7821233859","display_name":null,"funder_award_id":"75N92021D00001","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7851177580","display_name":null,"funder_award_id":"S10-OD-028685","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7865763634","display_name":null,"funder_award_id":"phs000920","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7945866738","display_name":null,"funder_award_id":"NO1-HC-25195","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8323569422","display_name":null,"funder_award_id":"HHSN268201800002I","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8343607012","display_name":"Studies of Rare Genetic Variation in the Isolated Population of Sardinia","funder_award_id":"R01HL117626","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8566225511","display_name":null,"funder_award_id":"75N92021D00003","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8683204365","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000135092","display_name":null,"funder_award_id":"NO1-HC-25195","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000867580","display_name":"Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias","funder_award_id":"R01HL142711","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000887157","display_name":"IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL","funder_award_id":"R01HL092577","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000892667","display_name":"Genotypic and phenotypic approaches to subtype individuals with coronary heart disease","funder_award_id":"K01HL171839","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308793","display_name":"Fred Hutchinson Cancer Research Center","ror":"https://ror.org/007ps6h72"},{"id":"https://openalex.org/F4320309647","display_name":"School of Medicine, Boston University","ror":"https://ror.org/05qwgg493"},{"id":"https://openalex.org/F4320316183","display_name":"Evans Medical Foundation","ror":"https://ror.org/00mv13746"},{"id":"https://openalex.org/F4320316384","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333360","display_name":"Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224420806.pdf","grobid_xml":"https://content.openalex.org/works/W7224420806.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W642687531","https://openalex.org/W1636327287","https://openalex.org/W1956835743","https://openalex.org/W1978929392","https://openalex.org/W2037282757","https://openalex.org/W2120833963","https://openalex.org/W2133520037","https://openalex.org/W2146256166","https://openalex.org/W2150782426","https://openalex.org/W2151451331","https://openalex.org/W2153118028","https://openalex.org/W2161527180","https://openalex.org/W2169353806","https://openalex.org/W2202954603","https://openalex.org/W2209106767","https://openalex.org/W2513047692","https://openalex.org/W2528302205","https://openalex.org/W2577928265","https://openalex.org/W2580897959","https://openalex.org/W2586588530","https://openalex.org/W2589014554","https://openalex.org/W2596258020","https://openalex.org/W2767038995","https://openalex.org/W2805983714","https://openalex.org/W2900102282","https://openalex.org/W2911294343","https://openalex.org/W2918502052","https://openalex.org/W2924348116","https://openalex.org/W2963404097","https://openalex.org/W2969316478","https://openalex.org/W2969533952","https://openalex.org/W2985219249","https://openalex.org/W2991550215","https://openalex.org/W3036672623","https://openalex.org/W3039945792","https://openalex.org/W3042936392","https://openalex.org/W3043543310","https://openalex.org/W3113356730","https://openalex.org/W3114796419","https://openalex.org/W3121239749","https://openalex.org/W3200355203","https://openalex.org/W3200602313","https://openalex.org/W3201399830","https://openalex.org/W3205422331","https://openalex.org/W3205644245","https://openalex.org/W4210436487","https://openalex.org/W4223473226","https://openalex.org/W4224299153","https://openalex.org/W4238813742","https://openalex.org/W4285490843","https://openalex.org/W4293692670","https://openalex.org/W4302283931","https://openalex.org/W4318817498","https://openalex.org/W4391533010","https://openalex.org/W4392500048","https://openalex.org/W4393070680","https://openalex.org/W4406778273","https://openalex.org/W4407824443","https://openalex.org/W4408150050","https://openalex.org/W4408254597","https://openalex.org/W4408422252","https://openalex.org/W4409391344","https://openalex.org/W4411011653","https://openalex.org/W4411515402","https://openalex.org/W4412372209","https://openalex.org/W4413506647","https://openalex.org/W4414777584"],"related_works":["https://openalex.org/W4318817498","https://openalex.org/W2467067181","https://openalex.org/W1516667337","https://openalex.org/W4392830139","https://openalex.org/W7151757053","https://openalex.org/W2153118028","https://openalex.org/W4405828632","https://openalex.org/W7117326614","https://openalex.org/W2416849719","https://openalex.org/W2757528416"],"abstract_inverted_index":{"Blood":[0],"lipids":[1],"are":[2],"well-established":[3],"risk":[4],"factors":[5],"for":[6,70,113,125,168,251],"cardiovascular":[7,201],"and":[8,41,58,86,103,116,123,127,135,139,155,194,203,206,243],"other":[9],"chronic":[10],"diseases,":[11],"yet":[12],"the":[13,160],"underlying":[14],"functional":[15],"mechanisms":[16,246],"remain":[17],"unclear.":[18],"We":[19,53,185],"conducted":[20],"a":[21],"large-scale,":[22],"genome-wide":[23],"transcriptome":[24],"analysis":[25,108],"of":[26,38,162,197,208,227,234],"serum":[27],"lipid":[28,110,169,236,252],"levels":[29,193],"using":[30],"whole":[31],"blood":[32],"RNA-sequencing":[33],"data":[34],"from":[35],"6898":[36],"individuals":[37],"diverse":[39],"races":[40],"ethnicities":[42],"(17%":[43],"Black":[44],"or":[45],"African":[46],"American,":[47],"15%":[48],"Hispanic":[49],"Latino/a,":[50],"68%":[51],"White).":[52],"utilized":[54],"mixed-effects":[55],"linear":[56],"regression":[57],"meta-analyzed":[59],"four":[60],"discovery":[61],"datasets":[62,94],"(n":[63,95],"=":[64,96],"4398":[65],"participants),":[66],"identifying":[67],"significant":[68],"associations":[69,242],"27":[71],"genes":[72,132,164,221],"with":[73,78,83,88,175,182,191,200,211],"low-density":[74],"lipoproteins":[75,80],"(LDL),":[76],"974":[77],"high-density":[79],"(HDL),":[81],"1229":[82],"triglycerides":[84],"(TRIG),":[85],"276":[87],"total":[89],"cholesterol":[90,177],"(TCHO).":[91],"Two":[92],"replication":[93],"2500":[97],"participants)":[98],"confirmed":[99],"3,":[100],"55,":[101],"380,":[102],"31":[104],"genes,":[105,119],"respectively.":[106],"Enrichment":[107],"revealed":[109],"metabolic":[111],"processes":[112],"LDL,":[114],"HDL,":[115],"TCHO":[117],"associated":[118,131,199,220],"including":[120],"LDLR,":[121],"NPC2,":[122],"SQLE":[124],"LDL":[126,192],"TCHO,":[128],"while":[129],"TRIG":[130,183,204,219],"highlighted":[133],"immune":[134],"allergic":[136],"response,":[137],"cancer,":[138],"molecular":[140],"signaling":[141],"gene":[142,195],"enrichment":[143,216],"pathways.":[144],"To":[145],"infer":[146],"causality,":[147],"we":[148],"performed":[149],"bidirectional":[150],"two-sample":[151],"Mendelian":[152],"randomization":[153],"(MR)":[154],"colocalization":[156],"analyses.":[157],"MR":[158],"identified":[159,187],"expression":[161,196,207],"8":[163],"as":[165,247],"possibly":[166],"causal":[167],"levels;":[170],"notable":[171],"EEPD1":[172],"expression,":[173],"linked":[174,181,210],"cellular":[176],"homeostasis,":[178],"was":[179],"inversely":[180],"levels.":[184,237],"also":[186],"novel":[188,241],"variants":[189],"shared":[190],"DDAH2,":[198],"disease,":[202],"level":[205],"FCGRT,":[209],"maintaining":[212],"triglyceride":[213],"homeostasis.":[214],"Phenome-wide":[215],"analyses":[217],"reported":[218],"were":[222],"enriched":[223],"in":[224],"secondary":[225],"malignancy":[226],"bone":[228],"suggesting":[229],"broader":[230],"systemic":[231],"health":[232],"implications":[233],"modified":[235],"These":[238],"findings":[239],"highlight":[240],"genetic":[244],"regulatory":[245],"potential":[248],"therapeutic":[249],"targets":[250],"dysregulation.":[253]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-30T00:00:00"}