{"id":"https://openalex.org/W7224414865","doi":"https://doi.org/10.1183/13993003.congress-2026.pa1476","title":"A \u03b3-carboxyglutamate polymer detaches airway mucus and restores functional airway patency in a murine model of muco-obstructive lung disease","display_name":"A \u03b3-carboxyglutamate polymer detaches airway mucus and restores functional airway patency in a murine model of muco-obstructive lung disease","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7224414865","doi":"https://doi.org/10.1183/13993003.congress-2026.pa1476"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2026.pa1476","doi":"https://doi.org/10.1183/13993003.congress-2026.pa1476","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2026.pa1476","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003741282","display_name":"Anna Ermund","orcid":"https://orcid.org/0000-0002-3233-043X","observed_orcids":["https://orcid.org/0000-0002-3233-043X"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Ermund","raw_affiliation_strings":["1Univ. Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160091814","display_name":"Christian Recktenwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christian Recktenwald","raw_affiliation_strings":["1Univ. Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087497191","display_name":"Sergio Trillo\u2010Muyo","orcid":"https://orcid.org/0000-0002-3135-9134","observed_orcids":["https://orcid.org/0000-0002-3135-9134"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sergio Trillo-Muyo","raw_affiliation_strings":["1Univ. Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041929121","display_name":"Thaher Pelaseyed","orcid":"https://orcid.org/0000-0002-6434-3913","observed_orcids":["https://orcid.org/0000-0002-6434-3913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thaher Pelaseyed","raw_affiliation_strings":["2MucoLife Therapeutics AB, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MucoLife Therapeutics AB, Gothenburg, Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036876226","display_name":"Gunnar C. Hansson","orcid":"https://orcid.org/0000-0002-1900-1869","observed_orcids":["https://orcid.org/0000-0002-1900-1869"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunnar C. Hansson","raw_affiliation_strings":["3Univ. Gothenburg, MucoLife, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Univ. Gothenburg, MucoLife, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1476","last_page":"PA1476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-mucus","display_name":"airway mucus","score":0.699999988079071},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.8560000061988831},{"id":"https://openalex.org/keywords/muco-obstructive-lung-disease","display_name":"muco-obstructive lung disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mucus-plugs","display_name":"mucus plugs","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":1.0},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nebulized-drug-delivery","display_name":"nebulized drug delivery","score":0.7599999904632568},{"id":"https://openalex.org/keywords/systemic-toxicity","display_name":"systemic toxicity","score":0.6150000095367432},{"id":"https://openalex.org/keywords/lung-epithelium","display_name":"lung epithelium","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.9539999961853027},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.7609000205993652},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7541999816894531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7264000177383423},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.6593999862670898},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5824000239372253},{"id":"https://openalex.org/C2776385078","wikidata":"https://www.wikidata.org/wiki/Q7631714","display_name":"Submucosal glands","level":3,"score":0.4449999928474426},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.421999990940094},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.4203000068664551},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39010000228881836},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.38909998536109924},{"id":"https://openalex.org/C114682108","wikidata":"https://www.wikidata.org/wiki/Q1952044","display_name":"Mucociliary clearance","level":3,"score":0.36329999566078186},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3544999957084656},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.35100001096725464},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3240000009536743},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25859999656677246},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2026.pa1476","doi":"https://doi.org/10.1183/13993003.congress-2026.pa1476","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2026.pa1476","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Airway pharmacology and treatment","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2344306556","https://openalex.org/W4366520356","https://openalex.org/W4378176077","https://openalex.org/W4225299255","https://openalex.org/W4388189223","https://openalex.org/W7203482084","https://openalex.org/W2090511042","https://openalex.org/W4289012754","https://openalex.org/W4210391483","https://openalex.org/W2575941171"],"abstract_inverted_index":{"Introduction":[0],"COPD,":[1,233],"cystic":[2,234],"fibrosis,":[3],"and":[4,15,47,58,90,101,108,115,135,199,223,236],"asthma":[5],"are":[6],"characterised":[7],"by":[8,80,96,203],"an":[9],"attached,":[10],"laminated":[11],"mucus":[12,44,56,73,92,137,148,165,204,230],"that":[13,41],"covers":[14],"obstructs":[16],"the":[17],"airways":[18],"(Fernandez-Blanco":[19],"et":[20,208],"al":[21],"J":[22,211],"Clin":[23],"Invest":[24],"Insights":[25],"2018;3:e120994).":[26],"Current":[27],"muco-active":[28],"therapies":[29],"show":[30],"limited":[31],"efficacy.":[32],"We":[33],"developed":[34],"MLT-001,":[35],"a":[36,64,190,220],"synthetic":[37],"polymer":[38],"of":[39,67,99,225],"\u03b3-carboxyglutamate":[40],"disrupts":[42],"pathological":[43,55],"attachment.":[45],"Aims":[46],"objectives":[48],"To":[49],"investigate":[50],"whether":[51],"MLT-001":[52,83,123,159],"can":[53],"disrupt":[54],"attachment":[57],"thereby":[59],"reduces":[60],"airway":[61,116,133,182,201],"obstruction":[62,89,134,154,202],"in":[63,77,144,232],"murine":[65],"model":[66],"muco-obstructive":[68],"lung":[69,104],"disease.":[70],"Methods":[71],"Airway":[72,88],"accumulation":[74],"was":[75,84,150],"induced":[76],"C57BL/6":[78],"mice":[79],"intranasal":[81],"interleukin-13.":[82],"administered":[85],"via":[86],"nebulisation.":[87],"epithelial":[91,136,183],"coverage":[93],"were":[94,110],"quantified":[95],"morphometric":[97],"analysis":[98],"Carnoy-fixed":[100],"Alcian":[102],"blue/PAS-stained":[103],"sections.":[105],"Dose-response":[106],"relationships":[107],"safety":[109],"assessed,":[111],"including":[112],"systemic":[113],"toxicity":[114,180],"effects":[117],"at":[118,167,174],"supratherapeutic":[119],"doses.":[120,171],"Results":[121],"Nebulised":[122],"(1":[124],"mM,":[125],"two":[126,129],"doses":[127,176],"over":[128],"days)":[130],"significantly":[131],"reduced":[132,153],"coverage,":[138],"restoring":[139],"levels":[140],"to":[141],"those":[142],"observed":[143],"na\u00efve":[145],"mice.":[146],"Sustained":[147],"detachment":[149],"observed,":[151],"with":[152,163],"persisting":[155],"days":[156],"after":[157],"treatment.":[158],"demonstrated":[160],"high":[161,175],"potency,":[162],"effective":[164],"clearance":[166],"estimated":[168],"picomole-range":[169],"lung-delivered":[170],"Systemic":[172],"administration":[173],"revealed":[177],"no":[178],"detectable":[179],"or":[181],"injury.":[184],"Conclusion":[185],"Given":[186],"recent":[187],"data":[188],"demonstrating":[189],"strong":[191],"correlation":[192],"between":[193],"functional":[194],"parameters":[195],"such":[196],"as":[197],"FEV1":[198],"mechanistic":[200],"plugs":[205,231],"(Dunican":[206],"E.M.,":[207],"al.":[209],"Am":[210],"Respir":[212],"Crit":[213],"Care":[214],"Med":[215],"2021:15;203),":[216],"this":[217],"study":[218],"supports":[219],"novel":[221],"strategy":[222],"mechanism":[224],"action":[226],"for":[227],"eliminating":[228],"persistent":[229],"fibrosis":[235],"asthma.":[237]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}