{"id":"https://openalex.org/W7224410495","doi":"https://doi.org/10.61678/bursamed.2045961","title":"Clinicopathological Factors Associated with Pathological Complete Response After Neoadjuvant Chemotherapy in Breast Cancer: A Single-Center Retrospective Study","display_name":"Clinicopathological Factors Associated with Pathological Complete Response After Neoadjuvant Chemotherapy in Breast Cancer: A Single-Center Retrospective Study","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224410495","doi":"https://doi.org/10.61678/bursamed.2045961"},"language":"en","primary_location":{"id":"doi:10.61678/bursamed.2045961","doi":"https://doi.org/10.61678/bursamed.2045961","is_oa":true,"landing_page_url":"https://doi.org/10.61678/bursamed.2045961","pdf_url":"https://dergipark.org.tr/en/download/article-file/6473916","source":{"id":"https://openalex.org/S5407040307","display_name":"Journal of Bursa Faculty of Medicine","issn_l":"2980-0218","issn":["2980-0218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bursa Faculty of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://dergipark.org.tr/en/download/article-file/6473916","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139298155","display_name":"Mehmet Ali Karatutlu","orcid":"https://orcid.org/0009-0005-6880-3859","observed_orcids":["https://orcid.org/0009-0005-6880-3859"]},"institutions":[{"id":"https://openalex.org/I4210144045","display_name":"Ali Osman Sonmez Oncology Hospital","ror":"https://ror.org/03naspe88","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210144045"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Ali Karatutlu","raw_affiliation_strings":["Department of Internal Medicine , Bursa Ali Osman S\u00f6nmez Oncology Hospital , Bursa , T\u00fcrkiye","Faculty of Medicine"],"raw_orcid":"https://orcid.org/0009-0005-6880-3859","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine , Bursa Ali Osman S\u00f6nmez Oncology Hospital , Bursa , T\u00fcrkiye","institution_ids":["https://openalex.org/I4210144045"]},{"raw_affiliation_string":"Faculty of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027237391","display_name":"Birol Ocak","orcid":"https://orcid.org/0000-0001-7537-1699","observed_orcids":["https://orcid.org/0000-0001-7537-1699"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Birol Ocak","raw_affiliation_strings":["UNIVERSITY OF HEALTH SCIENCES, HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE"],"raw_orcid":"https://orcid.org/0000-0001-7537-1699","affiliations":[{"raw_affiliation_string":"UNIVERSITY OF HEALTH SCIENCES, HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027237391"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80251383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"3","first_page":"63","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":1.0},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.7390000224113464},{"id":"https://openalex.org/keywords/her2-positive","display_name":"HER2-positive","score":0.7490000128746033},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.9700000286102295},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hr-positive-her2-positive-breast-cancer","display_name":"HR-positive HER2-positive breast cancer","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.7419999837875366},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6589999794960022},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8442000150680542},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6934999823570251},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6498000025749207},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6334999799728394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6322000026702881},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5910000205039978},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5723000168800354},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.554099977016449},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5188999772071838},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5153999924659729},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4302000105381012},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C2776085573","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferative index","level":3,"score":0.41280001401901245},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.39570000767707825},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C2777704003","wikidata":"https://www.wikidata.org/wiki/Q4959802","display_name":"Breast surgery","level":4,"score":0.33090001344680786},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3138999938964844},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C2777649267","wikidata":"https://www.wikidata.org/wiki/Q340695","display_name":"Axillary lymph nodes","level":4,"score":0.30239999294281006},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.29499998688697815},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.29179999232292175},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.27090001106262207},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2776608951","wikidata":"https://www.wikidata.org/wiki/Q499","display_name":"Axilla","level":4,"score":0.2605000138282776},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25189998745918274},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.61678/bursamed.2045961","doi":"https://doi.org/10.61678/bursamed.2045961","is_oa":true,"landing_page_url":"https://doi.org/10.61678/bursamed.2045961","pdf_url":"https://dergipark.org.tr/en/download/article-file/6473916","source":{"id":"https://openalex.org/S5407040307","display_name":"Journal of Bursa Faculty of Medicine","issn_l":"2980-0218","issn":["2980-0218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bursa Faculty of Medicine","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/2045961","doi":null,"is_oa":false,"landing_page_url":"https://izlik.org/JA67XE75JC","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bursa Faculty of Medicine, Vol. 4 No. 3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.61678/bursamed.2045961","doi":"https://doi.org/10.61678/bursamed.2045961","is_oa":true,"landing_page_url":"https://doi.org/10.61678/bursamed.2045961","pdf_url":"https://dergipark.org.tr/en/download/article-file/6473916","source":{"id":"https://openalex.org/S5407040307","display_name":"Journal of Bursa Faculty of Medicine","issn_l":"2980-0218","issn":["2980-0218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bursa Faculty of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224410495.pdf","grobid_xml":"https://content.openalex.org/works/W7224410495.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2050761481","https://openalex.org/W2053074390","https://openalex.org/W2057084727","https://openalex.org/W2075894019","https://openalex.org/W2094718541","https://openalex.org/W2095861620","https://openalex.org/W2123591186","https://openalex.org/W2147415463","https://openalex.org/W2158501247","https://openalex.org/W2573152477","https://openalex.org/W2588219859","https://openalex.org/W2622451842","https://openalex.org/W2791139688","https://openalex.org/W2806209829","https://openalex.org/W2883371940","https://openalex.org/W2972922660","https://openalex.org/W2999400187","https://openalex.org/W3006930853","https://openalex.org/W3036334626","https://openalex.org/W3122861570","https://openalex.org/W3205023169","https://openalex.org/W4321459395","https://openalex.org/W4380288730","https://openalex.org/W4389681263","https://openalex.org/W4401786450","https://openalex.org/W4402356295","https://openalex.org/W4402551965","https://openalex.org/W4406782885","https://openalex.org/W4408657857","https://openalex.org/W7118527112","https://openalex.org/W7138292671"],"related_works":["https://openalex.org/W3033674033","https://openalex.org/W4393342433","https://openalex.org/W3130697901","https://openalex.org/W4212917378","https://openalex.org/W4322758246","https://openalex.org/W4402356295","https://openalex.org/W4288178725","https://openalex.org/W4388040713","https://openalex.org/W7033421853","https://openalex.org/W4396598708"],"abstract_inverted_index":{"Objective:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,235],"determine":[5],"the":[6,84,91,222],"pathological":[7,233],"complete":[8],"response":[9,234],"(pCR)":[10],"rate":[11],"and":[12,31,51,74,93,109,153,209,227],"evaluate":[13],"clinicopathological":[14],"factors":[15],"associated":[16,102,167,188,214],"with":[17,21,103,168,189,192,215],"pCR":[18,80,104,125,135,172,190,216],"in":[19,90,128,143,147,151,156,231,239],"patients":[20,132],"breast":[22,92,158],"cancer":[23],"who":[24,38],"underwent":[25],"surgery":[26,43],"after":[27,98,217],"neoadjuvant":[28,99,236],"chemotherapy":[29],"(NAC).Materials":[30],"Methods:":[32],"We":[33],"retrospectively":[34],"reviewed":[35],"53":[36,131],"women":[37],"received":[39],"NAC":[40],"followed":[41],"by":[42,137],"at":[44,118],"a":[45],"single":[46],"center":[47],"between":[48],"January":[49],"2019":[50],"August":[52],"2024.":[53],"Demographic":[54],"characteristics,":[55],"clinical":[56],"stage,":[57],"histological":[58,207,226],"grade,":[59],"estrogen":[60],"receptor":[61,64,70],"(ER),":[62],"progesterone":[63],"(PR),":[65],"human":[66],"epidermal":[67],"growth":[68],"factor":[69],"2":[71],"(HER2)":[72],"status,":[73],"Ki-67":[75],"proliferation":[76],"index":[77],"were":[78,105,140,166,212],"evaluated.":[79],"was":[81,120,126,185],"defined":[82],"as":[83],"absence":[85],"of":[86,130,171,225],"residual":[87],"invasive":[88],"tumor":[89,229],"sampled":[94],"axillary":[95],"lymph":[96],"nodes":[97],"treatment.":[100,237],"Factors":[101],"assessed":[106],"using":[107],"univariable":[108],"multivariable":[110,161],"binary":[111],"logistic":[112],"regression":[113],"analyses.Results:":[114],"The":[115,134],"mean":[116],"age":[117],"diagnosis":[119],"51.09":[121],"\u00b1":[122],"10.07":[123],"years.":[124],"achieved":[127],"19":[129],"(35.8%).":[133],"rates":[136],"molecular":[138],"subgroup":[139],"9.1%":[141],"(2/22)":[142],"HR-positive/HER2-negative,":[144],"45.0%":[145],"(9/20)":[146],"HR-positive/HER2-positive,":[148],"100%":[149],"(3/3)":[150],"HR-negative/HER2-positive,":[152],"62.5%":[154],"(5/8)":[155],"triple-negative":[157],"cancer.":[159],"In":[160,201],"analysis,":[162],"grade":[163,174,208],"III":[164],"tumors":[165,176],"higher":[169],"odds":[170],"than":[173],"II":[175],"(OR":[177,195],"92.07;":[178],"95%":[179,197],"CI":[180,198],"9.17\u2013924.63;":[181],"p<0.001).":[182],"HER2":[183,193,210],"positivity":[184,211],"also":[186],"independently":[187,213],"compared":[191],"negativity":[194],"9.71;":[196],"1.04\u201390.48;":[199],"p=0.046).Conclusion:":[200],"this":[202],"single-center":[203],"retrospective":[204],"study,":[205],"high":[206],"NAC.":[218],"These":[219],"findings":[220],"support":[221],"potential":[223],"importance":[224],"biological":[228],"characteristics":[230],"predicting":[232],"Validation":[238],"larger":[240],"prospective":[241],"cohorts":[242],"is":[243],"warranted.":[244]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}