{"id":"https://openalex.org/W7224410203","doi":"https://doi.org/10.17691/stm2026.18.5.03","title":"Development of Liposomes Based on a Pyrrolo[3,2-L]Acridinone Derivative and Assessment of Their Antitumor Activity in Leukosis","display_name":"Development of Liposomes Based on a Pyrrolo[3,2-L]Acridinone Derivative and Assessment of Their Antitumor Activity in Leukosis","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224410203","doi":"https://doi.org/10.17691/stm2026.18.5.03"},"language":"en","primary_location":{"id":"doi:10.17691/stm2026.18.5.03","doi":"https://doi.org/10.17691/stm2026.18.5.03","is_oa":true,"landing_page_url":"https://doi.org/10.17691/stm2026.18.5.03","pdf_url":"https://www.stm-journal.ru/upload/iblock/361/1k3mzlvdn2sxuxmkyisoxm96391urlgj.pdf","source":{"id":"https://openalex.org/S4306540259","display_name":"\u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0435","issn_l":"2076-4243","issn":["2076-4243","2309-995X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sovremennye tehnologii v medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.stm-journal.ru/upload/iblock/361/1k3mzlvdn2sxuxmkyisoxm96391urlgj.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160111563","display_name":"L.L. Nikolaeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.L. Nikolaeva","raw_affiliation_strings":["Research Institute of Experimental Oncology and Carcinogenesis 1 ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Experimental Oncology and Carcinogenesis 1 ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160105489","display_name":"R.A. Bandin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R.A. Bandin","raw_affiliation_strings":["I.M. Sechenov First Moscow State Medical University (Sechenov University) , 8/2 Trubetskaya St. , Moscow , 119048 , Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.M. Sechenov First Moscow State Medical University (Sechenov University) , 8/2 Trubetskaya St. , Moscow , 119048 , Russia;","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100878746","display_name":"Ya. V. Kuznetsova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ya.V. Kuznetsova","raw_affiliation_strings":["I.M. Sechenov First Moscow State Medical University (Sechenov University) , 8/2 Trubetskaya St. , Moscow , 119048 , Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.M. Sechenov First Moscow State Medical University (Sechenov University) , 8/2 Trubetskaya St. , Moscow , 119048 , Russia;","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046134372","display_name":"\u0414. \u0410. \u041a\u043e\u0437\u0438\u043d","orcid":"https://orcid.org/0000-0003-1125-1932","observed_orcids":["https://orcid.org/0000-0003-1125-1932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.A. Kozin","raw_affiliation_strings":["Research Institute of Experimental Oncology and Carcinogenesis 1 ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Experimental Oncology and Carcinogenesis 1 ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018557350","display_name":"\u0410\u043d\u043d\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430 \u041b\u0430\u043d\u0446\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-0650-2023","observed_orcids":["https://orcid.org/0000-0002-0650-2023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.V. Lantsova","raw_affiliation_strings":["Research Institute of Experimental Oncology and Carcinogenesis 1 ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Experimental Oncology and Carcinogenesis 1 ;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074882160","display_name":"\u0415\u043a\u0430\u0442\u0435\u0440\u0438\u043d\u0430 \u0412\u0438\u043a\u0442\u043e\u0440\u043e\u0432\u043d\u0430 \u0421\u0430\u043d\u0430\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-5592-5137","observed_orcids":["https://orcid.org/0000-0002-5592-5137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.V. Sanarova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109127658","display_name":"Yu. V. Shklyaev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu.V. Shklyaev","raw_affiliation_strings":["Research Institute of Experimental Oncology and Carcinogenesis 1 ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Experimental Oncology and Carcinogenesis 1 ;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045455473","display_name":"\u0417\u043e\u044f \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u043d\u0430 \u0428\u043f\u0440\u0430\u0445","orcid":"https://orcid.org/0000-0003-3034-750X","observed_orcids":["https://orcid.org/0000-0003-3034-750X"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Z.S. Shprakh","raw_affiliation_strings":["; Associate Professor, Pharmacy Department 2 ;","N.N. Blokhin National Medical Research Center of Oncology , Ministry of Health of the Russian Federation , 24 Kashirskoye Shosse , Moscow , 115522 , Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"; Associate Professor, Pharmacy Department 2 ;","institution_ids":[]},{"raw_affiliation_string":"N.N. Blokhin National Medical Research Center of Oncology , Ministry of Health of the Russian Federation , 24 Kashirskoye Shosse , Moscow , 115522 , Russia;","institution_ids":["https://openalex.org/I4210090957","https://openalex.org/I4210117042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68291934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"5","first_page":"30","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/acridine-derivatives","display_name":"acridine derivatives","score":0.9649999737739563},{"id":"https://openalex.org/keywords/leukosis","display_name":"leukosis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/liposome-stability","display_name":"liposome stability","score":0.5960000157356262},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.9139999747276306},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.8837000131607056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7860999703407288},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5162000060081482},{"id":"https://openalex.org/C2776924795","wikidata":"https://www.wikidata.org/wiki/Q342713","display_name":"Acridine","level":2,"score":0.44940000772476196},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.4223000109195709},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.4043999910354614},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36970001459121704},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.36169999837875366},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C2910410043","wikidata":"https://www.wikidata.org/wiki/Q342713","display_name":"Acridine derivatives","level":2,"score":0.35670000314712524},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2962999939918518},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.2896000146865845},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2689000070095062},{"id":"https://openalex.org/C68528507","wikidata":"https://www.wikidata.org/wiki/Q692267","display_name":"Cryoprotectant","level":4,"score":0.2678000032901764},{"id":"https://openalex.org/C155887181","wikidata":"https://www.wikidata.org/wiki/Q5053552","display_name":"Cationic liposome","level":4,"score":0.26019999384880066}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.17691/stm2026.18.5.03","doi":"https://doi.org/10.17691/stm2026.18.5.03","is_oa":true,"landing_page_url":"https://doi.org/10.17691/stm2026.18.5.03","pdf_url":"https://www.stm-journal.ru/upload/iblock/361/1k3mzlvdn2sxuxmkyisoxm96391urlgj.pdf","source":{"id":"https://openalex.org/S4306540259","display_name":"\u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0435","issn_l":"2076-4243","issn":["2076-4243","2309-995X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sovremennye tehnologii v medicine","raw_type":"journal-article"},{"id":"pmh:https://cyberleninka.ru/article/n/development-of-liposomes-based-on-a-pyrrolo-3-2-l-acridinone-derivative-and-assessment-of-their-antitumor-activity-in-leukosis","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/development-of-liposomes-based-on-a-pyrrolo-3-2-l-acridinone-derivative-and-assessment-of-their-antitumor-activity-in-leukosis","pdf_url":"https://cyberleninka.ru/article/n/development-of-liposomes-based-on-a-pyrrolo-3-2-l-acridinone-derivative-and-assessment-of-their-antitumor-activity-in-leukosis/pdf","source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:https://cyberleninka.ru/article/n/razrabotka-liposom-na-osnove-proizvodnogo-pirrolo-3-2-l-akridinona-i-otsenka-ih-protivoopuholevoy-aktivnosti-pri-leykoze","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/razrabotka-liposom-na-osnove-proizvodnogo-pirrolo-3-2-l-akridinona-i-otsenka-ih-protivoopuholevoy-aktivnosti-pri-leykoze","pdf_url":"https://cyberleninka.ru/article/n/razrabotka-liposom-na-osnove-proizvodnogo-pirrolo-3-2-l-akridinona-i-otsenka-ih-protivoopuholevoy-aktivnosti-pri-leykoze/pdf","source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.17691/stm2026.18.5.03","doi":"https://doi.org/10.17691/stm2026.18.5.03","is_oa":true,"landing_page_url":"https://doi.org/10.17691/stm2026.18.5.03","pdf_url":"https://www.stm-journal.ru/upload/iblock/361/1k3mzlvdn2sxuxmkyisoxm96391urlgj.pdf","source":{"id":"https://openalex.org/S4306540259","display_name":"\u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0435","issn_l":"2076-4243","issn":["2076-4243","2309-995X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sovremennye tehnologii v medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224410203.pdf","grobid_xml":"https://content.openalex.org/works/W7224410203.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1431736806","https://openalex.org/W1551678721","https://openalex.org/W1980936615","https://openalex.org/W2063526980","https://openalex.org/W2155720898","https://openalex.org/W2497176862","https://openalex.org/W2891074395","https://openalex.org/W3107141941","https://openalex.org/W4200208115","https://openalex.org/W4213417829","https://openalex.org/W4306391415","https://openalex.org/W4306765465","https://openalex.org/W4313244883","https://openalex.org/W4313467029","https://openalex.org/W4318473113","https://openalex.org/W4318826660","https://openalex.org/W4386023174","https://openalex.org/W4392895301","https://openalex.org/W4400765490","https://openalex.org/W4403045981","https://openalex.org/W4403275510","https://openalex.org/W4404408349","https://openalex.org/W4409885436","https://openalex.org/W4410487718","https://openalex.org/W4412438228","https://openalex.org/W4413406788","https://openalex.org/W4416229619","https://openalex.org/W4417262645","https://openalex.org/W7124323225","https://openalex.org/W7124677411"],"related_works":["https://openalex.org/W4403275510","https://openalex.org/W2409934678","https://openalex.org/W2411271904","https://openalex.org/W1765972731","https://openalex.org/W7120371745","https://openalex.org/W2800117875","https://openalex.org/W2290258382","https://openalex.org/W3034928388","https://openalex.org/W2396051665","https://openalex.org/W2085016383"],"abstract_inverted_index":{"The":[0,17,65,232],"chemical":[1,15],"structure":[2],"of":[3,23,30,35,45,52,67,131,135,225,240,266],"acridine":[4,24],"contains":[5],"ring-shaped":[6],"nitrogen":[7],"atoms,":[8],"which":[9,53],"determine":[10],"its":[11,26],"numerous":[12],"biological":[13],"and":[14,25,43,63,81,89,104,120,128,145,163,174,199,213],"properties.":[16],"scientific":[18],"community":[19],"considers":[20],"the":[21,41,68,73,109,126,132,136,158,164,167,176,183,205,214,238],"effects":[22],"derivatives":[27],"on":[28,76,151],"tumors":[29],"various":[31],"origins":[32],"to":[33,57,71,114,124,210,218,229],"be":[34,58],"particular":[36],"interest.":[37],"Numerous":[38],"publications":[39],"report":[40],"synthesis":[42],"study":[44,69,82],"new":[46],"compounds":[47],"in":[48,108,155,188,204,237,258],"this":[49],"group,":[50],"some":[51],"have":[54],"been":[55],"shown":[56],"more":[59],"effective":[60],"than":[61],"5-fluorouracil":[62],"cisplatin.":[64],"aim":[66],"was":[70,138,149,201,227,245],"develop":[72],"liposomes":[74,92,165,181],"based":[75],"pyrrolo[3,2-l]acridinone":[77],"derivative":[78],"Mob-155":[79,160,179,195,267],"S":[80,161,180,196],"their":[83],"antitumor":[84],"activity":[85,148],"regarding":[86],"leukosis.":[87],"Materials":[88],"Methods.":[90],"Acridinone":[91],"were":[93,106,122],"prepared":[94],"using":[95],"a":[96,152,255],"thin-film":[97],"method":[98],"followed":[99],"by":[100],"lyophilization.":[101,115],"Lactose,":[102],"mannose,":[103],"sucrose":[105],"dissolved":[107],"dispersion":[110],"as":[111],"cryoprotectants":[112],"prior":[113],"Spectrophotometry,":[116],"dynamic":[117],"light":[118],"scattering,":[119],"electrophoresis":[121],"used":[123],"obtain":[125],"qualitative":[127],"quantitative":[129],"characteristics":[130],"liposomes.":[133],"Stability":[134],"samples":[137],"monitored":[139],"at":[140,193,262],"two":[141],"temperature":[142],"conditions":[143],"(6\u20138\u00b0C":[144],"21\u201323\u00b0C).":[146],"Cytotoxic":[147],"determined":[150],"Jurkat":[153],"line":[154],"comparison":[156],"with":[157,222],"native":[159],"substance":[162],"without":[166],"active":[168],"compound.":[169],"Results.":[170],"Immediately":[171],"after":[172],"production":[173],"during":[175],"short-term":[177],"storage,":[178],"had":[182],"particles":[184],"about":[185],"200":[186],"nm":[187],"size.":[189],"After":[190],"40-day":[191],"storage":[192],"21\u201323\u00b0C,":[194],"concentration":[197],"decreased,":[198],"there":[200],"an":[202],"increase":[203],"mean":[206],"particle":[207],"size":[208],"up":[209,217],"300\u2013320":[211],"nm,":[212],"polydispersity":[215],"index":[216],"0.45\u20130.55.":[219],"Experimental":[220],"lyophilization":[221],"three":[223],"types":[224],"saccharides":[226],"performed":[228],"improve":[230],"stabilization.":[231],"marked":[233],"protective":[234],"effect":[235],"manifested":[236],"preservation":[239],"key":[241],"quality":[242],"liposome":[243],"parameters":[244],"observed":[246],"only":[247],"under":[248],"10%":[249],"mannose.":[250],"In":[251],"vitro":[252],"studies":[253],"demonstrated":[254],"significant":[256],"reduction":[257],"tumor":[259],"cell":[260],"viability":[261],"relatively":[263],"low":[264],"concentrations":[265],"S.":[268]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}