{"id":"https://openalex.org/W7224399568","doi":"https://doi.org/10.1080/14786419.2026.2753099","title":"Flavonoid-enriched extract from Forsythia suspensa leaf tea (FSLT-FE) attenuates cigarette smoke/lipopolysaccharide-induced COPD-like lung injury in mice: UPLC-MS profiling and network pharmacology analysis","display_name":"Flavonoid-enriched extract from Forsythia suspensa leaf tea (FSLT-FE) attenuates cigarette smoke/lipopolysaccharide-induced COPD-like lung injury in mice: UPLC-MS profiling and network pharmacology analysis","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224399568","doi":"https://doi.org/10.1080/14786419.2026.2753099","pmid":"https://pubmed.ncbi.nlm.nih.gov/42956290"},"language":"en","primary_location":{"id":"doi:10.1080/14786419.2026.2753099","doi":"https://doi.org/10.1080/14786419.2026.2753099","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2026.2753099","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071996898","display_name":"Xuli Zuo","orcid":"https://orcid.org/0000-0001-5149-8484","observed_orcids":["https://orcid.org/0000-0001-5149-8484"]},"institutions":[{"id":"https://openalex.org/I4210111546","display_name":"Xian Mental Health Center","ror":"https://ror.org/020299x40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111546"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuli Zuo","raw_affiliation_strings":["Xi\u2019an Mental Health Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Mental Health Center","institution_ids":["https://openalex.org/I4210111546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102701333","display_name":"Zongshuo Li","orcid":"https://orcid.org/0009-0009-7347-7284","observed_orcids":["https://orcid.org/0009-0009-7347-7284"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongshuo Li","raw_affiliation_strings":["School of Life Sciences, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037889520","display_name":"\u674e\u4f1f\u4e1c","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Li","raw_affiliation_strings":["School of Chinese Materia Medica, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117619750","display_name":"Qing Shao","orcid":"https://orcid.org/0000-0002-1048-1325","observed_orcids":["https://orcid.org/0000-0002-1048-1325","https://orcid.org/0009-0001-4052-5317"]},"institutions":[{"id":"https://openalex.org/I4210111546","display_name":"Xian Mental Health Center","ror":"https://ror.org/020299x40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111546"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Shao","raw_affiliation_strings":["Xi\u2019an Mental Health Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Mental Health Center","institution_ids":["https://openalex.org/I4210111546"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5117619750"],"corresponding_institution_ids":["https://openalex.org/I4210111546"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81395746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.4578000009059906,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.4578000009059906,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.09640000015497208,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/forsythia-suspensa","display_name":"Forsythia suspensa","score":0.9710000157356262},{"id":"https://openalex.org/keywords/leaf-tea","display_name":"leaf tea","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.39399999380111694},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.9359999895095825},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5837000012397766},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5426999926567078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48420000076293945},{"id":"https://openalex.org/C2776409889","wikidata":"https://www.wikidata.org/wiki/Q672980","display_name":"Forsythia","level":5,"score":0.4684999883174896},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.37459999322891235},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.36000001430511475},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.3206999897956848},{"id":"https://openalex.org/C2993711000","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell injury","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C2779526882","wikidata":"https://www.wikidata.org/wiki/Q7404463","display_name":"Salidroside","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2838999927043915},{"id":"https://openalex.org/C2776190711","wikidata":"https://www.wikidata.org/wiki/Q7398663","display_name":"Safety pharmacology","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.26759999990463257},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2531000077724457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/14786419.2026.2753099","doi":"https://doi.org/10.1080/14786419.2026.2753099","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2026.2753099","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:42956290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42956290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322935","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2153095652","https://openalex.org/W2384066807","https://openalex.org/W2462500506","https://openalex.org/W2546365773","https://openalex.org/W2552567545","https://openalex.org/W2606513998","https://openalex.org/W2756462278","https://openalex.org/W2905311179","https://openalex.org/W2911027211","https://openalex.org/W2917075888","https://openalex.org/W2984506896","https://openalex.org/W3008160342","https://openalex.org/W3013726226","https://openalex.org/W3047163368","https://openalex.org/W3094182880","https://openalex.org/W3095600581","https://openalex.org/W3118309040","https://openalex.org/W3121747711","https://openalex.org/W3156431662","https://openalex.org/W3184251573","https://openalex.org/W3193934323","https://openalex.org/W4205407124","https://openalex.org/W4210344722","https://openalex.org/W4214871602","https://openalex.org/W4220761888","https://openalex.org/W4229024305","https://openalex.org/W4229060185","https://openalex.org/W4283706895","https://openalex.org/W4296680285","https://openalex.org/W4310460141","https://openalex.org/W4319771788","https://openalex.org/W4380482075","https://openalex.org/W4384154735","https://openalex.org/W4385212762","https://openalex.org/W4385397256","https://openalex.org/W4389452727","https://openalex.org/W4390272265","https://openalex.org/W4392377137","https://openalex.org/W4408834880","https://openalex.org/W4409701372","https://openalex.org/W4415986329"],"related_works":["https://openalex.org/W4392843149","https://openalex.org/W4406184190","https://openalex.org/W2967429643","https://openalex.org/W3204576469","https://openalex.org/W4281757635","https://openalex.org/W2035931526","https://openalex.org/W951110982","https://openalex.org/W2376857626","https://openalex.org/W4211063362","https://openalex.org/W2409147853"],"abstract_inverted_index":{"Flavonoids":[0],"from":[1,29],"Forsythia":[2],"suspensa":[3,31],"leaves":[4],"may":[5],"benefit":[6],"Chronic":[7],"obstructive":[8],"pulmonary":[9],"disease":[10],"(COPD)":[11],"through":[12,142],"anti-inflammatory":[13],"and":[14,41,68,75,90,93,97,114,126,138],"antioxidant":[15],"mechanisms,":[16],"but":[17],"the":[18],"underlying":[19],"pathways":[20,141],"remain":[21],"poorly":[22],"defined.":[23],"We":[24],"profiled":[25],"a":[26,46,149],"flavonoid-enriched":[27],"extract":[28],"F.":[30],"leaf":[32],"tea":[33],"(FSLT-FE)":[34],"by":[35,53],"ultra-performance":[36],"liquid":[37],"chromatography\u2013mass":[38],"spectrometry":[39],"(UPLC-MS)":[40],"evaluated":[42],"its":[43,146],"efficacy":[44],"in":[45,122],"cigarette":[47],"smoke/LPS-induced":[48],"COPD":[49],"mouse":[50],"model,":[51],"complemented":[52],"network":[54],"pharmacology.":[55],"UPLC-MS":[56],"identified":[57,102],"62":[58],"constituents,":[59],"including":[60,110],"rutin,":[61],"quercetin,":[62],"hesperidin,":[63],"caffeic":[64],"acid,":[65],"forsythoside":[66],"A,":[67],"phillygenin.":[69],"FSLT-FE":[70,134],"dose-dependently":[71],"attenuated":[72],"lung":[73,154],"inflammation":[74],"structural":[76],"damage,":[77],"reduced":[78],"IL-6,":[79],"TNF-\u03b1,":[80],"CXCL1/KC":[81],"(the":[82],"murine":[83],"functional":[84],"homologue":[85],"of":[86],"human":[87],"IL-8),":[88],"IL-1\u03b2,":[89],"malondialdehyde":[91],"levels,":[92],"increased":[94],"superoxide":[95],"dismutase":[96],"catalase":[98],"activities.":[99],"Network":[100],"pharmacology":[101],"23":[103],"active":[104],"ingredients":[105],"targeting":[106],"98":[107],"COPD-associated":[108],"proteins,":[109],"AKT1,":[111],"MAPK1,":[112],"MMP2,":[113],"epidermal":[115],"growth":[116],"factor":[117],"receptor":[118],"(EGFR),":[119],"with":[120],"enrichment":[121],"NF-\u03baB,":[123],"PI3K-Akt,":[124],"MAPK,":[125],"IL-17":[127],"signalling":[128],"pathways.":[129],"These":[130],"results":[131],"indicate":[132],"that":[133],"acts":[135],"on":[136],"inflammatory":[137],"oxidative":[139],"stress":[140],"multiple":[143],"components,":[144],"supporting":[145],"potential":[147],"as":[148],"protective":[150],"agent":[151],"against":[152],"COPD-like":[153],"injury.":[155]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}
