{"id":"https://openalex.org/W7224390237","doi":"https://doi.org/10.1080/02699052.2026.2747020","title":"Sertraline reverses depressive-like behaviors in males and females following early life hypoxic brain injury","display_name":"Sertraline reverses depressive-like behaviors in males and females following early life hypoxic brain injury","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224390237","doi":"https://doi.org/10.1080/02699052.2026.2747020","pmid":"https://pubmed.ncbi.nlm.nih.gov/42954228"},"language":"en","primary_location":{"id":"doi:10.1080/02699052.2026.2747020","doi":"https://doi.org/10.1080/02699052.2026.2747020","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02699052.2026.2747020","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047745213","display_name":"Sondos Kassem-Moussa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160368002","display_name":"Lebanese University","ror":"https://ror.org/05x6qnc69","country_code":"LB","type":"education","lineage":["https://openalex.org/I160368002"]},{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Sondos Kassem-Moussa","raw_affiliation_strings":["American University of Beirut","Lebanese University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American University of Beirut","institution_ids":["https://openalex.org/I98635879"]},{"raw_affiliation_string":"Lebanese University","institution_ids":["https://openalex.org/I160368002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039718142","display_name":"Marawan A. Elbaset","orcid":"https://orcid.org/0000-0002-0861-6251","observed_orcids":["https://orcid.org/0000-0002-0861-6251"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marawan A. Elbaset","raw_affiliation_strings":["Indiana University School of Medicine","Indiana University School of Medicine, Riley Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana University School of Medicine, Riley Hospital for Children","institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117647236","display_name":"Aidan Looney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aidan Looney","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114389955","display_name":"Mariah Ozkir","orcid":"https://orcid.org/0009-0006-0864-4419","observed_orcids":["https://orcid.org/0009-0006-0864-4419"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariah Ozkir","raw_affiliation_strings":["Indiana University School of Medicine, Riley Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Riley Hospital for Children","institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073376549","display_name":"Hussein Fayyad\u2010Kazan","orcid":"https://orcid.org/0000-0002-3465-4630","observed_orcids":["https://orcid.org/0000-0002-3465-4630"]},"institutions":[{"id":"https://openalex.org/I160368002","display_name":"Lebanese University","ror":"https://ror.org/05x6qnc69","country_code":"LB","type":"education","lineage":["https://openalex.org/I160368002"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Hussein Fayyad-Kazan","raw_affiliation_strings":["Lebanese University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lebanese University","institution_ids":["https://openalex.org/I160368002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076222076","display_name":"Fletcher A. White","orcid":"https://orcid.org/0000-0002-8408-9262","observed_orcids":["https://orcid.org/0000-0002-8408-9262"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fletcher A. White","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013944105","display_name":"Eva Hamade","orcid":"https://orcid.org/0000-0001-5152-913X","observed_orcids":["https://orcid.org/0000-0001-5152-913X"]},"institutions":[{"id":"https://openalex.org/I160368002","display_name":"Lebanese University","ror":"https://ror.org/05x6qnc69","country_code":"LB","type":"education","lineage":["https://openalex.org/I160368002"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Eva Hamade","raw_affiliation_strings":["Lebanese University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lebanese University","institution_ids":["https://openalex.org/I160368002"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030257565","display_name":"Makram Obeid","orcid":"https://orcid.org/0000-0003-4349-674X","observed_orcids":["https://orcid.org/0000-0003-4349-674X","https://orcid.org/0000-0002-6422-1860"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB","US"],"is_corresponding":true,"raw_author_name":"Makram Obeid","raw_affiliation_strings":["American University of Beirut","Indiana University School of Medicine","Indiana University School of Medicine, Riley Hospital for Children"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American University of Beirut","institution_ids":["https://openalex.org/I98635879"]},{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana University School of Medicine, Riley Hospital for Children","institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030257565"],"corresponding_institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4394709130","https://openalex.org/I98635879"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88486705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":1.0},{"id":"https://openalex.org/keywords/neonatal-hypoxia","display_name":"neonatal hypoxia","score":0.859000027179718},{"id":"https://openalex.org/keywords/hypoxic-seizures","display_name":"hypoxic seizures","score":0.8790000081062317},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.8980000019073486},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6620000004768372},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chronic-antidepressant-treatment","display_name":"chronic antidepressant treatment","score":0.6850000023841858},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.9186999797821045},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.6391000151634216},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.5705000162124634},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.5212000012397766},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5116000175476074},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5044999718666077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4794999957084656},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.47589999437332153},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4747999906539917},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4422999918460846},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.44029998779296875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41200000047683716},{"id":"https://openalex.org/C128188215","wikidata":"https://www.wikidata.org/wiki/Q3026765","display_name":"Neuropharmacology","level":2,"score":0.4097999930381775},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3862000107765198},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3610999882221222},{"id":"https://openalex.org/C2777975874","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head injury","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.27129998803138733},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25459998846054077},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.2531999945640564}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/02699052.2026.2747020","doi":"https://doi.org/10.1080/02699052.2026.2747020","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02699052.2026.2747020","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},{"id":"pmid:42954228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42954228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain injury","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309999","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21"},{"id":"https://openalex.org/F4320332961","display_name":"School of Medicine, Indiana University","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1481377459","https://openalex.org/W1595266116","https://openalex.org/W1984683671","https://openalex.org/W1985546825","https://openalex.org/W1989963542","https://openalex.org/W2012622060","https://openalex.org/W2018981935","https://openalex.org/W2025113055","https://openalex.org/W2026437014","https://openalex.org/W2035998652","https://openalex.org/W2068385565","https://openalex.org/W2070968783","https://openalex.org/W2086957009","https://openalex.org/W2097212923","https://openalex.org/W2133295820","https://openalex.org/W2135632106","https://openalex.org/W2141588371","https://openalex.org/W2145818012","https://openalex.org/W2162332184","https://openalex.org/W2171218472","https://openalex.org/W2520685154","https://openalex.org/W2593214036","https://openalex.org/W2606020647","https://openalex.org/W2890639359","https://openalex.org/W2913613226","https://openalex.org/W2954300307","https://openalex.org/W2954945707","https://openalex.org/W3032930677","https://openalex.org/W3109692647","https://openalex.org/W3124173062","https://openalex.org/W3170430616","https://openalex.org/W3213883948","https://openalex.org/W4210347126","https://openalex.org/W4220665505","https://openalex.org/W4224271993","https://openalex.org/W4313588617","https://openalex.org/W4316668828","https://openalex.org/W4384157333","https://openalex.org/W4392468734","https://openalex.org/W4399528001","https://openalex.org/W4403934163","https://openalex.org/W4408040569","https://openalex.org/W4414522639","https://openalex.org/W7125708074"],"related_works":["https://openalex.org/W4414522639","https://openalex.org/W2740034206","https://openalex.org/W2913613226","https://openalex.org/W2620294685","https://openalex.org/W2083029100","https://openalex.org/W2939452672","https://openalex.org/W1997368488","https://openalex.org/W1865242748","https://openalex.org/W2167041343","https://openalex.org/W2801439079"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Later-life":[1],"behavioral":[2],"deficits":[3],"associated":[4,174],"with":[5,175],"neonatal":[6],"hypoxic":[7,39,138,177],"brain":[8,139,178],"injury":[9,179],"remain":[10],"without":[11,146],"definitive":[12],"treatment":[13,184],"options.":[14],"We":[15],"have":[16],"previously":[17],"shown":[18],"that":[19,166,181],"a":[20,34,45,51,130],"one-week":[21],"course":[22,49],"of":[23,37,59],"sertraline":[24,48,183],"prevents":[25],"depressive-like":[26,141],"behaviors":[27,58,142],"but":[28,128],"worsens":[29],"anxiety":[30],"in":[31,64,113,119,122,125,133,143,159,187],"males":[32,61],"using":[33],"rat":[35,77],"model":[36],"early-life":[38,176],"seizures.":[40],"Here,":[41],"we":[42],"examined":[43],"whether":[44],"more":[46,52,170],"extended":[47],"has":[50],"favorable":[53],"effect":[54],"on":[55],"later-life":[56],"emotional":[57],"both":[60,126,144,188],"and":[62,75,89,98,180],"females":[63,168],"this":[65],"model.":[66],"METHOD:":[67],"Postnatal":[68],"day":[69],"10":[70],"(P10)":[71],"Sprague":[72],"Dawley":[73],"male":[74],"female":[76],"pups":[78],"were":[79,94,111],"subjected":[80],"to":[81,106,129,172,195],"global":[82],"hypoxia.":[83],"The":[84],"open":[85],"field":[86],"test":[87,92],"(OFT)":[88],"forced":[90],"swim":[91],"(FST)":[93],"performed":[95],"at":[96,152],"P50-52":[97],"P53-54,":[99],"respectively.":[100],"Sertraline":[101,135],"was":[102],"administered":[103],"from":[104],"P22":[105],"P55.":[107],"RESULTS:":[108],"All":[109],"groups":[110],"comparable":[112,155],"the":[114,123],"OFT.":[115],"Hypoxic":[116],"seizures":[117],"resulted":[118],"increased":[120],"immobility":[121],"FST":[124],"genders,":[127],"greater":[131],"extent":[132],"females.":[134],"mitigated":[136],"these":[137],"injury-induced":[140],"genders":[145],"anxiogenic":[147],"side":[148],"effects.":[149],"Histological":[150],"analyses":[151],"P55":[153],"revealed":[154],"hippocampal":[156],"neuronal":[157],"densities":[158],"all":[160],"groups.":[161],"CONCLUSIONS:":[162],"These":[163],"findings":[164],"suggest":[165],"adolescent":[167],"are":[169,193],"susceptible":[171],"depression":[173],"chronic":[182],"is":[185],"beneficial":[186],"genders.":[189],"Further":[190],"mechanistic":[191],"studies":[192],"warranted":[194],"elucidate":[196],"underlying":[197],"pathways.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}