{"id":"https://openalex.org/W7224376564","doi":"https://doi.org/10.5281/zenodo.23754589","title":"FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF DOMPERIDONE LOADED NANOSTRUCTURED LIPID CARRIERS BY QbD","display_name":"FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF DOMPERIDONE LOADED NANOSTRUCTURED LIPID CARRIERS BY QbD","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224376564","doi":"https://doi.org/10.5281/zenodo.23754589"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23754589","doi":"https://doi.org/10.5281/zenodo.23754589","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23754589","pdf_url":null,"source":{"id":"https://openalex.org/S76264521","display_name":"Degr\u00e9s","issn_l":"0376-8163","issn":["0376-8163"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5281/zenodo.23754589","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160113092","display_name":"Nalla Divya Sri, Balusu Haarika, Raghavarapu Prasanthi and Chekkilla Bhargavi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nalla Divya Sri, Balusu Haarika, Raghavarapu Prasanthi and Chekkilla Bhargavi","raw_affiliation_strings":["Sarojini Naidu Vanita Pharmacy maha Vidyalaya, Tarnaka, Secunderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarojini Naidu Vanita Pharmacy maha Vidyalaya, Tarnaka, Secunderabad, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160113092"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81054898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/domperidone","display_name":"domperidone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":0.9160000085830688},{"id":"https://openalex.org/keywords/high-pressure-homogenization","display_name":"high-pressure homogenization","score":0.953000009059906},{"id":"https://openalex.org/keywords/stearic-acid","display_name":"stearic acid","score":0.8100000023841858},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8880000114440918},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.9660000205039978},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.9470000267028809},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stabilizer-concentration","display_name":"stabilizer concentration","score":0.847000002861023},{"id":"https://openalex.org/keywords/prokinetic-agents","display_name":"prokinetic agents","score":0.5289999842643738},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.7204999923706055},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.6582000255584717},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.6115000247955322},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5875999927520752},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5698999762535095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5266000032424927},{"id":"https://openalex.org/C2779516699","wikidata":"https://www.wikidata.org/wiki/Q209685","display_name":"Stearic acid","level":2,"score":0.48809999227523804},{"id":"https://openalex.org/C2775995038","wikidata":"https://www.wikidata.org/wiki/Q424238","display_name":"Domperidone","level":3,"score":0.47040000557899475},{"id":"https://openalex.org/C92397422","wikidata":"https://www.wikidata.org/wiki/Q5062082","display_name":"Central composite design","level":3,"score":0.4699000120162964},{"id":"https://openalex.org/C3019981671","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Immediate release","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41440001130104065},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.391400009393692},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.38100001215934753},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3504999876022339},{"id":"https://openalex.org/C18168003","wikidata":"https://www.wikidata.org/wiki/Q628595","display_name":"Eutectic system","level":3,"score":0.3476000130176544},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.3434000015258789},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.34049999713897705},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C3020385749","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Extended release","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2903999984264374},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C2777247143","wikidata":"https://www.wikidata.org/wiki/Q1429522","display_name":"Prokinetic agent","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2612999975681305},{"id":"https://openalex.org/C192797455","wikidata":"https://www.wikidata.org/wiki/Q4116863","display_name":"Homogenizer","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23754589","doi":"https://doi.org/10.5281/zenodo.23754589","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23754589","pdf_url":null,"source":{"id":"https://openalex.org/S76264521","display_name":"Degr\u00e9s","issn_l":"0376-8163","issn":["0376-8163"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23754590","doi":"https://doi.org/10.5281/zenodo.23754590","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23754590","pdf_url":null,"source":{"id":"https://openalex.org/S76264521","display_name":"Degr\u00e9s","issn_l":"0376-8163","issn":["0376-8163"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23754589","doi":"https://doi.org/10.5281/zenodo.23754589","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23754589","pdf_url":null,"source":{"id":"https://openalex.org/S76264521","display_name":"Degr\u00e9s","issn_l":"0376-8163","issn":["0376-8163"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","jufo-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107760138","https://openalex.org/W4417255298","https://openalex.org/W4302140531","https://openalex.org/W4387296703","https://openalex.org/W2609080138","https://openalex.org/W4226182751","https://openalex.org/W2791532428","https://openalex.org/W2596576361","https://openalex.org/W2964748180","https://openalex.org/W2134365263"],"abstract_inverted_index":{"ABSTRACTDomperidone":[0],"is":[1,8,117],"a":[2,9,78,191],"prokinetic":[3],"and":[4,21,28,100,159,169,187,197,202],"antiemetic":[5],"medication.":[6],"It":[7,53],"member":[10],"of":[11,14,125,151],"the":[12,51,57,83,112,118,121,126,130,149,184],"class":[13],"medicationsknown":[15],"as":[16,26],"dopamine":[17,139],"antagonists.":[18],"Stearic":[19],"acid":[20,23],"oleic":[22],"were":[24,95,163],"utilized":[25],"liquid":[27],"solid":[29],"lipids":[30],"inthe":[31],"high-pressure":[32],"homogenization":[33],"method":[34],"to":[35,49,63,190],"produce":[36],"dopamine-loaded":[37],"nanostructured":[38,143],"lipid":[39,144],"carriers(NLCs).":[40],"Fourier":[41],"transform":[42],"infrared":[43],"spectroscopy,":[44],"or":[45],"FTIR,":[46],"was":[47,54,72,102],"used":[48],"characterize":[50],"generatedNLCs.":[52],"discovered":[55],"that":[56,105,138,182],"encapsulation":[58],"efficiency":[59],"ranged":[60],"from":[61,108],"64":[62],"86%.":[64],"According":[65],"toNLC's":[66],"in-vitro":[67,160],"release":[68,76,85,107,123],"profile,":[69],"every":[70],"batch":[71],"evident.":[73],"continuous":[74],"medication":[75,84],"for":[77,133],"fulltwelve":[79],"hours.":[80],"Based":[81,128],"on":[82,129],"characteristics":[86],"in":[87,193,205],"vitro":[88],"The":[89],"NLCs'":[90],"spherical":[91],"shape":[92],"andsmooth":[93],"surface":[94],"demonstrated":[96],"by":[97,142],"visualization":[98],"experiments,":[99],"it":[101,136],"also":[103],"observed":[104],"thedrug":[106],"NLCs":[109],"rose":[110],"with":[111,120,176],"solid-lipid":[113],"ratio.":[114],"Among":[115],"F9":[116],"formulation":[119],"highestdrug":[122],"out":[124],"nine.":[127],"data":[131,180],"collected":[132],"this":[134],"study,":[135],"appears":[137],"maybe":[140],"delivered":[141],"carriers,":[145],"which":[146],"may":[147],"decrease":[148,192],"frequency":[150],"doses.":[152],"Dependentvariables,":[153],"including":[154],"zeta":[155,194],"potential,":[156],"particle":[157,198],"size,":[158],"drug":[161,206],"release,":[162],"measured":[164],"usingDesign":[165],"Export":[166],"13":[167],"software":[168],"32":[170],"factorial":[171],"design":[172,175],"Central":[173],"composite":[174],"Response":[177],"surfaceapproach.":[178],"Preliminary":[179],"showed":[181],"increasing":[183],"stabilizer":[185],"concentration":[186],"sonication":[188],"cyclesled":[189],"potential":[195],"(-14.0)":[196],"size":[199],"(243":[200],"nm)":[201],"an":[203],"increase":[204],"release(96.33\u00b10.02).":[207]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-30T00:00:00"}