{"id":"https://openalex.org/W7224376017","doi":"https://doi.org/10.64898/2026.10.24.761522","title":"Rugnux: from diffraction images to structure at synchrotrons and XFELs in one program","display_name":"Rugnux: from diffraction images to structure at synchrotrons and XFELs in one program","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224376017","doi":"https://doi.org/10.64898/2026.10.24.761522"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.24.761522","doi":"https://doi.org/10.64898/2026.10.24.761522","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.24.761522","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.24.761522.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.24.761522.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031557903","display_name":"Filip Leonarski","orcid":"https://orcid.org/0000-0002-2563-7169","observed_orcids":["https://orcid.org/0000-0002-2563-7169"]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]},{"id":"https://openalex.org/I4387155338","display_name":"Swiss Light Source","ror":"https://ror.org/04xrb7c55","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908","https://openalex.org/I4387155338"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Filip Leonarski","raw_affiliation_strings":["Swiss Light Source, Center for Photon Science, Paul Scherrer Institute, Villigen PSI, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2563-7169","affiliations":[{"raw_affiliation_string":"Swiss Light Source, Center for Photon Science, Paul Scherrer Institute, Villigen PSI, Switzerland","institution_ids":["https://openalex.org/I2802229908","https://openalex.org/I4387155338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048297384","display_name":"Meitian Wang","orcid":"https://orcid.org/0000-0002-5340-3036","observed_orcids":["https://orcid.org/0000-0002-5340-3036"]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]},{"id":"https://openalex.org/I4387155338","display_name":"Swiss Light Source","ror":"https://ror.org/04xrb7c55","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908","https://openalex.org/I4387155338"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Meitian Wang","raw_affiliation_strings":["Swiss Light Source, Center for Photon Science, Paul Scherrer Institute, Villigen PSI, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5340-3036","affiliations":[{"raw_affiliation_string":"Swiss Light Source, Center for Photon Science, Paul Scherrer Institute, Villigen PSI, Switzerland","institution_ids":["https://openalex.org/I2802229908","https://openalex.org/I4387155338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031557903"],"corresponding_institution_ids":["https://openalex.org/I2802229908","https://openalex.org/I4387155338"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11183","display_name":"Advanced X-ray Imaging Techniques","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macromolecular-crystallography","display_name":"macromolecular crystallography","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gpu-accelerated-image-processing","display_name":"GPU-accelerated image processing","score":0.7409999966621399},{"id":"https://openalex.org/keywords/serial-femtosecond-crystallography","display_name":"serial femtosecond crystallography","score":0.8309999704360962},{"id":"https://openalex.org/keywords/data-merging","display_name":"data merging","score":0.625}],"concepts":[{"id":"https://openalex.org/C207114421","wikidata":"https://www.wikidata.org/wiki/Q133900","display_name":"Diffraction","level":2,"score":0.7146999835968018},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5570999979972839},{"id":"https://openalex.org/C74050887","wikidata":"https://www.wikidata.org/wiki/Q848368","display_name":"Rotation (mathematics)","level":2,"score":0.48500001430511475},{"id":"https://openalex.org/C50515024","wikidata":"https://www.wikidata.org/wiki/Q826582","display_name":"X-ray crystallography","level":3,"score":0.4406000077724457},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.39969998598098755},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3650999963283539},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3257000148296356},{"id":"https://openalex.org/C133462117","wikidata":"https://www.wikidata.org/wiki/Q4929239","display_name":"Data collection","level":2,"score":0.31540000438690186},{"id":"https://openalex.org/C163985040","wikidata":"https://www.wikidata.org/wiki/Q1172399","display_name":"Data acquisition","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C175309249","wikidata":"https://www.wikidata.org/wiki/Q725864","display_name":"Pipeline transport","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.259799987077713}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.24.761522","doi":"https://doi.org/10.64898/2026.10.24.761522","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.24.761522","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.24.761522.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.24.761522","doi":"https://doi.org/10.64898/2026.10.24.761522","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.24.761522","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.24.761522.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224376017.pdf","grobid_xml":"https://content.openalex.org/works/W7224376017.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1966180432","https://openalex.org/W1987587134","https://openalex.org/W2000843938","https://openalex.org/W2006922696","https://openalex.org/W2047214756","https://openalex.org/W2050195612","https://openalex.org/W2055197082","https://openalex.org/W2096064309","https://openalex.org/W2102182691","https://openalex.org/W2108959691","https://openalex.org/W2122109248","https://openalex.org/W2122994276","https://openalex.org/W2130479394","https://openalex.org/W2142355662","https://openalex.org/W2143660875","https://openalex.org/W2152448366","https://openalex.org/W2159211495","https://openalex.org/W2163341755","https://openalex.org/W2292767755","https://openalex.org/W2338161063","https://openalex.org/W2545727401","https://openalex.org/W2793311671","https://openalex.org/W2894469531","https://openalex.org/W2946672706","https://openalex.org/W3008344486","https://openalex.org/W3177828909","https://openalex.org/W3211795435","https://openalex.org/W4229042017","https://openalex.org/W4248872320","https://openalex.org/W4307407928","https://openalex.org/W4313545377","https://openalex.org/W4378952892","https://openalex.org/W4381549880","https://openalex.org/W4407640964","https://openalex.org/W4414976722","https://openalex.org/W6945393950","https://openalex.org/W7215051345"],"related_works":["https://openalex.org/W2323230945","https://openalex.org/W3198683175","https://openalex.org/W1996909670","https://openalex.org/W7221119977","https://openalex.org/W2162608849","https://openalex.org/W4299973563","https://openalex.org/W7098381843","https://openalex.org/W2566700808","https://openalex.org/W2090032180","https://openalex.org/W1990689358"],"abstract_inverted_index":{"Abstract":[0],"Rising":[1],"data":[2,27,61],"rates":[3],"in":[4],"macromolecular":[5],"crystallography":[6],"outpace":[7],"multi-program":[8],"pipelines":[9],"on":[10,41],"computing":[11],"clusters.":[12],"Rugnux,":[13],"a":[14,51],"single":[15],"GPU-accelerated":[16],"program,":[17],"turns":[18],"rotation":[19],"or":[20],"serial":[21],"still":[22],"diffraction":[23],"images":[24],"into":[25],"merged":[26],"and":[28],"an":[29],"initial":[30],"structure.":[31],"At":[32],"synchrotrons,":[33],"results":[34],"arrive":[35],"seconds":[36],"after":[37],"the":[38,66],"last":[39],"image;":[40],"one":[42],"workstation,":[43],"207":[44],"public":[45],"datasets":[46],"from":[47],"36":[48],"sources":[49],"took":[50],"median":[52],"of":[53],"15":[54],"s":[55],"each,":[56],"with":[57],"deposition-quality.":[58],"Serial":[59],"XFEL":[60],"were":[62],"processed":[63],"faster":[64],"than":[65],"collection":[67],"rate,":[68],"enabling":[69],"real-time":[70],"structure":[71],"determination.":[72]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}