{"id":"https://openalex.org/W7224376008","doi":"https://doi.org/10.1002/cmdc.70529","title":"Utilization of Unusual Nonproteinogenic Amino Acids: A New Paradigm for Natural Products Drug Discovery","display_name":"Utilization of Unusual Nonproteinogenic Amino Acids: A New Paradigm for Natural Products Drug Discovery","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224376008","doi":"https://doi.org/10.1002/cmdc.70529","pmid":"https://pubmed.ncbi.nlm.nih.gov/42956362"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.70529","doi":"https://doi.org/10.1002/cmdc.70529","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.70529","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061757867","display_name":"Rohit Man Singh","orcid":"https://orcid.org/0000-0001-8542-6534","observed_orcids":["https://orcid.org/0000-0001-8542-6534"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]},{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rohit Singh","raw_affiliation_strings":["Department of Pharmaceutical Chemistry College of Pharmacy JSS University  Noida Uttar Pradesh India","Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"],"raw_orcid":"https://orcid.org/0000-0001-8542-6534","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry College of Pharmacy JSS University  Noida Uttar Pradesh India","institution_ids":["https://openalex.org/I126824641"]},{"raw_affiliation_string":"Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111004952","display_name":"Vikrant Nawal Vikram","orcid":"https://orcid.org/0009-0000-8290-8810","observed_orcids":["https://orcid.org/0009-0000-8290-8810"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikrant Nawal Vikram","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India","Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"],"raw_orcid":"https://orcid.org/0009-0000-8290-8810","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075946768","display_name":"Tadigoppula Narender","orcid":"https://orcid.org/0009-0009-1616-2008","observed_orcids":["https://orcid.org/0009-0009-1616-2008"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narender Tadigoppula","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India","Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India"],"raw_orcid":"https://orcid.org/0009-0009-1616-2008","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Medicinal and Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh India","institution_ids":["https://openalex.org/I185249246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075946768"],"corresponding_institution_ids":["https://openalex.org/I185249246","https://openalex.org/I99364266"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61566618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/unusual-amino-acids","display_name":"unusual amino acids","score":0.8489999771118164},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.7940000295639038},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.8949999809265137},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7419999837875366},{"id":"https://openalex.org/keywords/amino-acid-incorporation","display_name":"amino acid incorporation","score":0.4620000123977661},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.6340000033378601},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9620000123977661},{"id":"https://openalex.org/keywords/therapeutic-use","display_name":"therapeutic applications","score":0.6179999709129333},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/nutritional-benefits","display_name":"nutritional benefits","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6462000012397766},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5903000235557556},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5440999865531921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4381999969482422},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3928000032901764},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.35429999232292175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33730000257492065},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28349998593330383},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25780001282691956},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cmdc.70529","doi":"https://doi.org/10.1002/cmdc.70529","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.70529","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:42956362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42956362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W17903931","https://openalex.org/W1143747296","https://openalex.org/W1519800783","https://openalex.org/W1521339763","https://openalex.org/W1573392996","https://openalex.org/W1573501789","https://openalex.org/W1598906599","https://openalex.org/W1876579582","https://openalex.org/W1967328395","https://openalex.org/W1969655820","https://openalex.org/W1972951200","https://openalex.org/W1974132142","https://openalex.org/W1974683523","https://openalex.org/W1974935871","https://openalex.org/W1977656062","https://openalex.org/W1979095213","https://openalex.org/W1979827269","https://openalex.org/W1980447245","https://openalex.org/W1981782157","https://openalex.org/W1983065399","https://openalex.org/W1989971736","https://openalex.org/W1993849862","https://openalex.org/W1996465350","https://openalex.org/W1996833979","https://openalex.org/W1998331753","https://openalex.org/W1998971393","https://openalex.org/W1999123168","https://openalex.org/W2001950508","https://openalex.org/W2004017387","https://openalex.org/W2010394107","https://openalex.org/W2011248836","https://openalex.org/W2011726623","https://openalex.org/W2011842740","https://openalex.org/W2012251902","https://openalex.org/W2012405841","https://openalex.org/W2013686836","https://openalex.org/W2013803267","https://openalex.org/W2014104775","https://openalex.org/W2015595808","https://openalex.org/W2016316202","https://openalex.org/W2016652676","https://openalex.org/W2016707378","https://openalex.org/W2017358079","https://openalex.org/W2019859558","https://openalex.org/W2020320704","https://openalex.org/W2022686121","https://openalex.org/W2024052292","https://openalex.org/W2024421510","https://openalex.org/W2028508635","https://openalex.org/W2029402191","https://openalex.org/W2031031116","https://openalex.org/W2034613428","https://openalex.org/W2035030718","https://openalex.org/W2041136792","https://openalex.org/W2041639041","https://openalex.org/W2043014039","https://openalex.org/W2044511894","https://openalex.org/W2045320365","https://openalex.org/W2046283367","https://openalex.org/W2046701361","https://openalex.org/W2050183208","https://openalex.org/W2052446181","https://openalex.org/W2055868545","https://openalex.org/W2055919299","https://openalex.org/W2059687919","https://openalex.org/W2062985225","https://openalex.org/W2064785231","https://openalex.org/W2065269605","https://openalex.org/W2065945557","https://openalex.org/W2067871615","https://openalex.org/W2069942553","https://openalex.org/W2071147072","https://openalex.org/W2076240559","https://openalex.org/W2077900711","https://openalex.org/W2079212779","https://openalex.org/W2079357657","https://openalex.org/W2079937579","https://openalex.org/W2080828509","https://openalex.org/W2081850628","https://openalex.org/W2086601987","https://openalex.org/W2087624008","https://openalex.org/W2088699042","https://openalex.org/W2091178457","https://openalex.org/W2092903306","https://openalex.org/W2095333886","https://openalex.org/W2097956065","https://openalex.org/W2105085689","https://openalex.org/W2105932465","https://openalex.org/W2107972568","https://openalex.org/W2109967743","https://openalex.org/W2113782837","https://openalex.org/W2122944457","https://openalex.org/W2124599706","https://openalex.org/W2126245949","https://openalex.org/W2127738643","https://openalex.org/W2128503184","https://openalex.org/W2130426440","https://openalex.org/W2131642993","https://openalex.org/W2133472683","https://openalex.org/W2134963477","https://openalex.org/W2138028417","https://openalex.org/W2146918483","https://openalex.org/W2156635671","https://openalex.org/W2164440816","https://openalex.org/W2167652732","https://openalex.org/W2302132150","https://openalex.org/W2319107209","https://openalex.org/W2324156582","https://openalex.org/W2325402248","https://openalex.org/W2400594308","https://openalex.org/W2460826691","https://openalex.org/W2472478882","https://openalex.org/W2494601529","https://openalex.org/W2503600929","https://openalex.org/W2516283850","https://openalex.org/W2517054293","https://openalex.org/W2517876396","https://openalex.org/W2528498725","https://openalex.org/W2551055644","https://openalex.org/W2555654491","https://openalex.org/W2563427432","https://openalex.org/W2587574299","https://openalex.org/W2594854790","https://openalex.org/W2605454618","https://openalex.org/W2748532629","https://openalex.org/W2762803319","https://openalex.org/W2789559817","https://openalex.org/W2795999113","https://openalex.org/W2796690810","https://openalex.org/W2809218586","https://openalex.org/W2880685757","https://openalex.org/W2895405444","https://openalex.org/W2901554904","https://openalex.org/W2909553885","https://openalex.org/W2910007475","https://openalex.org/W2913565730","https://openalex.org/W2920839646","https://openalex.org/W2922279652","https://openalex.org/W2965017801","https://openalex.org/W3004230874","https://openalex.org/W3013108948","https://openalex.org/W3131468492","https://openalex.org/W3155522177","https://openalex.org/W4220896368","https://openalex.org/W4240991955","https://openalex.org/W4244717134","https://openalex.org/W4247471409","https://openalex.org/W4254394762"],"related_works":["https://openalex.org/W3087613416","https://openalex.org/W7159669468","https://openalex.org/W2352698391","https://openalex.org/W7124443682","https://openalex.org/W4205385055","https://openalex.org/W2480653744","https://openalex.org/W4283169097","https://openalex.org/W2947168009","https://openalex.org/W4405196058","https://openalex.org/W4404240157"],"abstract_inverted_index":{"Nonproteinogenic":[0],"amino":[1,39,50],"acids":[2],"(NPAAs)":[3],"have":[4,19],"become":[5],"essential":[6],"in":[7,125],"developing":[8],"small":[9],"molecules,":[10],"peptides,":[11],"and":[12,17,25,62,78,96],"proteins":[13],"as":[14,116,118],"modern-day":[15],"chemistry":[16],"biology":[18],"progressed.":[20],"The":[21,52,69],"distribution,":[22],"pharmacological":[23],"functions,":[24,95],"metabolism":[26],"of":[27,54,64,72,114],"naturally":[28,84],"occurring":[29,85],"NPAAs":[30,43,55],"are":[31],"primarily":[32],"unknown":[33],"compared":[34],"to":[35,76,104],"the":[36,46,59,80,111],"better-studied":[37],"proteinogenic":[38,49],"acids;":[40],"however,":[41],"natural":[42],"vastly":[44],"outnumber":[45],"well-known":[47],"22":[48],"acids.":[51],"incorporation":[53],"can":[56],"significantly":[57],"affect":[58],"stability,":[60],"potency,":[61],"bioavailability":[63],"drugs":[65],"or":[66],"drugs-like":[67],"candidates.":[68],"primary":[70],"goal":[71],"this":[73],"review":[74],"is":[75,103],"compile":[77],"summarize":[79],"current":[81],"knowledge":[82],"on":[83,91],"NPAAs,":[86,115],"with":[87],"a":[88],"particular":[89],"focus":[90],"their":[92],"sources,":[93],"biological":[94],"potential":[97],"therapeutic":[98,126],"applications.":[99],"A":[100],"secondary":[101],"objective":[102],"demonstrate":[105],"how":[106,119],"little":[107],"we":[108],"know":[109],"about":[110],"nutritional":[112],"benefits":[113],"well":[117],"documented":[120],"toxicity":[121],"could":[122],"be":[123],"used":[124],"development.":[127]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}