{"id":"https://openalex.org/W7224322823","doi":"https://doi.org/10.1111/hae.70443","title":"The Correction Factor for Monitoring Efanesoctocog Alfa Is Not Always 2.5","display_name":"The Correction Factor for Monitoring Efanesoctocog Alfa Is Not Always 2.5","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224322823","doi":"https://doi.org/10.1111/hae.70443","pmid":"https://pubmed.ncbi.nlm.nih.gov/42953950"},"language":"en","primary_location":{"id":"doi:10.1111/hae.70443","doi":"https://doi.org/10.1111/hae.70443","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.70443","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70443","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70443","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013543928","display_name":"Sean Platton","orcid":"https://orcid.org/0000-0002-5466-0448","observed_orcids":["https://orcid.org/0000-0002-5466-0448"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sean Platton","raw_affiliation_strings":["Blizard Institute Queen Mary University of London  London UK","The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blizard Institute Queen Mary University of London  London UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119380025","display_name":"Jude Platton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jude Platton","raw_affiliation_strings":["Haemostasis Laboratory, Royal London Hospital Barts Health NHS Trust  London UK","NHS East and South East London Pathology Partnership  London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemostasis Laboratory, Royal London Hospital Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]},{"raw_affiliation_string":"NHS East and South East London Pathology Partnership  London UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157650471","display_name":"Katarzyna Kniola","orcid":"https://orcid.org/0009-0004-4933-9483","observed_orcids":["https://orcid.org/0009-0004-4933-9483"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katarzyna Kniola","raw_affiliation_strings":["Haemostasis Laboratory, Royal London Hospital Barts Health NHS Trust  London UK","NHS East and South East London Pathology Partnership  London UK"],"raw_orcid":"https://orcid.org/0009-0004-4933-9483","affiliations":[{"raw_affiliation_string":"Haemostasis Laboratory, Royal London Hospital Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]},{"raw_affiliation_string":"NHS East and South East London Pathology Partnership  London UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103215744","display_name":"Laurie Aiken","orcid":"https://orcid.org/0000-0001-5678-130X","observed_orcids":["https://orcid.org/0000-0001-5678-130X"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura Aiken","raw_affiliation_strings":["The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0001-5678-130X","affiliations":[{"raw_affiliation_string":"The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087174417","display_name":"Janine Collins","orcid":"https://orcid.org/0000-0002-8716-3261","observed_orcids":["https://orcid.org/0000-0002-8716-3261"]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Janine Collins","raw_affiliation_strings":["The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0002-8716-3261","affiliations":[{"raw_affiliation_string":"The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004024852","display_name":"Suthesh Sivapalaratnam","orcid":"https://orcid.org/0000-0003-0679-7885","observed_orcids":["https://orcid.org/0000-0003-0679-7885","https://orcid.org/0009-0008-0344-7410"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suthesh Sivapalaratnam","raw_affiliation_strings":["Precision Healthcare University Research Institute (PHURI) Queen Mary University London  London UK","The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK"],"raw_orcid":"https://orcid.org/0009-0008-0344-7410","affiliations":[{"raw_affiliation_string":"Precision Healthcare University Research Institute (PHURI) Queen Mary University London  London UK","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073296470","display_name":"Priyanka Raheja","orcid":"https://orcid.org/0000-0001-6365-2899","observed_orcids":["https://orcid.org/0000-0001-6365-2899"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Priyanka Raheja","raw_affiliation_strings":["Precision Healthcare University Research Institute (PHURI) Queen Mary University London  London UK","The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK"],"raw_orcid":"https://orcid.org/0000-0001-6365-2899","affiliations":[{"raw_affiliation_string":"Precision Healthcare University Research Institute (PHURI) Queen Mary University London  London UK","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"The Royal London Hospital Haemophilia Centre Barts Health NHS Trust  London UK","institution_ids":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013543928"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I225661044","https://openalex.org/I2801259928","https://openalex.org/I4405263501"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85602556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/efanesoctocog-alfa","display_name":"efanesoctocog alfa","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.8100000023841858},{"id":"https://openalex.org/keywords/factor-viii-concentrate","display_name":"factor VIII concentrate","score":0.7400000095367432},{"id":"https://openalex.org/keywords/correction-factors","display_name":"correction factors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/one-stage-assay","display_name":"one-stage assay","score":0.746999979019165},{"id":"https://openalex.org/keywords/pharmacokinetic-monitoring","display_name":"pharmacokinetic monitoring","score":0.6140000224113464},{"id":"https://openalex.org/keywords/recombinant-factor-viii","display_name":"recombinant factor VIII","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8978000283241272},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.48989999294281006},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4259999990463257},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.42410001158714294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4115999937057495},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.38109999895095825},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C2777232031","wikidata":"https://www.wikidata.org/wiki/Q2092064","display_name":"Haemophilia A","level":3,"score":0.35100001096725464},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.349700003862381},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31369999051094055},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3093999922275543},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3059999942779541},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2816999852657318},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C105054674","wikidata":"https://www.wikidata.org/wiki/Q3707381","display_name":"Mean difference","level":3,"score":0.2628999948501587}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/hae.70443","doi":"https://doi.org/10.1111/hae.70443","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.70443","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70443","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:42953950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/hae.70443","doi":"https://doi.org/10.1111/hae.70443","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.70443","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70443","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224322823.pdf","grobid_xml":"https://content.openalex.org/works/W7224322823.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2425394528","https://openalex.org/W2995549906","https://openalex.org/W3007050672","https://openalex.org/W3034754042","https://openalex.org/W3084060684","https://openalex.org/W3213466971","https://openalex.org/W4224312731","https://openalex.org/W4388014839","https://openalex.org/W4400723327","https://openalex.org/W4406199937","https://openalex.org/W4412508948","https://openalex.org/W4413087305","https://openalex.org/W4416008926","https://openalex.org/W7154909286"],"related_works":["https://openalex.org/W7129590091","https://openalex.org/W4388014839","https://openalex.org/W7124889638","https://openalex.org/W7129660821","https://openalex.org/W7215123216","https://openalex.org/W4416008926","https://openalex.org/W7154909286","https://openalex.org/W7164802708","https://openalex.org/W7221792302","https://openalex.org/W2993763077"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Efanesoctocog":[1],"alfa":[2],"(Altuvoct)":[3],"is":[4,27,183,204],"a":[5,93,107,141,147,177],"recombinant":[6],"super-extended":[7],"half-life":[8],"factor":[9],"(F)VIII":[10],"concentrate":[11],"licensed":[12],"in":[13,82,206],"the":[14,47,83,104,200],"United":[15],"Kingdom":[16],"for":[17,45,79,189,221],"patients":[18,120],"with":[19,70,92,153],"severe":[20],"and":[21,40,131,134,137,157,168,203],"moderate":[22],"haemophilia":[23],"A.":[24],"Concentrate":[25],"potency":[26],"assigned":[28],"by":[29,57],"one-stage":[30],"assays":[31,38,191,220],"(OSA)":[32],"using":[33,66,127,166,171,223],"Actin":[34,132],"FSL.":[35],"Chromogenic":[36],"FVIII:C":[37,163,197],"(CA)":[39],"some":[41],"OSA":[42,75,128,172],"are":[43,90,228],"inaccurate":[44],"Altuvoct;":[46],"product":[48],"information":[49],"sheet":[50],"suggests":[51],"results":[52,89],"of":[53,85,106],"these":[54],"be":[55,77],"divided":[56],"2.5":[58],"to":[59,122,194],"approximate":[60],"FVIII:C.":[61],"UK":[62],"experts":[63],"recommend":[64],"against":[65,146],"correction":[67],"factors":[68],"(CF),":[69],"guidance":[71],"that":[72,87,176,181,226],"only":[73],"validated":[74],"should":[76,217],"used":[78],"Altuvoct,":[80],"or,":[81],"presence":[84],"FVIII-mimetics,":[86],"CA":[88,135,167],"reported":[91],"caveat":[94],"about":[95],"assay":[96],"inaccuracy.":[97],"METHODS:":[98],"Over":[99],"four":[100],"months,":[101],"we":[102],"assessed":[103],"impact":[105],"fixed":[108],"CF":[109,160,179,188,227],"on":[110,140],"FVIII:C,":[111],"testing":[112],"70":[113],"samples":[114,152],"collected":[115],"during":[116],"pharmacokinetic":[117],"assessment":[118],"when":[119,165,170],"switched":[121],"Altuvoct.":[123],"All":[124],"were":[125],"tested":[126],"(Actin":[129,173],"FSL":[130],"FS)":[133],"(BIOPHEN":[136],"Siemens":[138],"FVIII:C)":[139],"Sysmex":[142],"CN-6500":[143],"analyser,":[144],"calibrated":[145],"plasma":[148],"standard.":[149],"RESULTS:":[150],"For":[151],"Altuvoct":[154,190,222],"between":[155],"10":[156],"269":[158],"IU/dL,":[159],"increased":[161,164],"as":[162],"decreased":[169],"FS),":[174],"suggesting":[175],"single":[178],"across":[180,199],"range":[182],"inappropriate.":[184],"CONCLUSIONS:":[185],"A":[186],"universal":[187],"may":[192],"lead":[193],"clinically":[195],"significant":[196],"underestimation":[198],"measurement":[201],"range,":[202],"inappropriate":[205],"most":[207],"cases.":[208],"Should":[209],"product-specific":[210],"calibrators":[211],"(and":[212],"controls)":[213],"become":[214],"available,":[215],"laboratories":[216],"verify":[218],"their":[219],"them":[224],"so":[225],"not":[229],"required.":[230]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}