{"id":"https://openalex.org/W7224320678","doi":"https://doi.org/10.3390/ijms27219683","title":"Association Between Alterations in Penicillin-Binding Proteins and \u03b2-Lactam Resistance in Ligilactobacillus salivarius","display_name":"Association Between Alterations in Penicillin-Binding Proteins and \u03b2-Lactam Resistance in Ligilactobacillus salivarius","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224320678","doi":"https://doi.org/10.3390/ijms27219683"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27219683","doi":"https://doi.org/10.3390/ijms27219683","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219683","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27219683","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007001721","display_name":"Marta Dec","orcid":"https://orcid.org/0000-0002-5456-9652","observed_orcids":["https://orcid.org/0000-0002-5456-9652"]},"institutions":[{"id":"https://openalex.org/I158552681","display_name":"University of Life Sciences in Lublin","ror":"https://ror.org/03hq67y94","country_code":"PL","type":"education","lineage":["https://openalex.org/I158552681"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Marta Dec","raw_affiliation_strings":["Department of Veterinary Prevention and Avian Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30 Street, 20-612 Lublin, Poland"],"raw_orcid":"https://orcid.org/0000-0002-5456-9652","affiliations":[{"raw_affiliation_string":"Department of Veterinary Prevention and Avian Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30 Street, 20-612 Lublin, Poland","institution_ids":["https://openalex.org/I158552681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017090687","display_name":"Tomasz Hauschild","orcid":"https://orcid.org/0000-0002-1262-5548","observed_orcids":["https://orcid.org/0000-0002-1262-5548"]},"institutions":[{"id":"https://openalex.org/I245364917","display_name":"University of Bia\u0142ystok","ror":"https://ror.org/01qaqcf60","country_code":"PL","type":"education","lineage":["https://openalex.org/I245364917"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Hauschild","raw_affiliation_strings":["Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, Cio\u0142kowskiego Street 1J, 15-245 Bialystok, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, Cio\u0142kowskiego Street 1J, 15-245 Bialystok, Poland","institution_ids":["https://openalex.org/I245364917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052265178","display_name":"Renata Urban\u2010Chmiel","orcid":"https://orcid.org/0000-0001-8245-1646","observed_orcids":["https://orcid.org/0000-0001-8245-1646"]},"institutions":[{"id":"https://openalex.org/I158552681","display_name":"University of Life Sciences in Lublin","ror":"https://ror.org/03hq67y94","country_code":"PL","type":"education","lineage":["https://openalex.org/I158552681"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Renata Urban-Chmiel","raw_affiliation_strings":["Department of Veterinary Prevention and Avian Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30 Street, 20-612 Lublin, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8245-1646","affiliations":[{"raw_affiliation_string":"Department of Veterinary Prevention and Avian Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30 Street, 20-612 Lublin, Poland","institution_ids":["https://openalex.org/I158552681"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007001721"],"corresponding_institution_ids":["https://openalex.org/I158552681"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77874771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"21","first_page":"9683","last_page":"9683"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligilactobacillus-salivarius","display_name":"Lactobacillus salivarius","score":0.9890000224113464},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.9309999942779541},{"id":"https://openalex.org/keywords/penicillin-binding-proteins","display_name":"penicillin-binding proteins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ftsi","display_name":"FtsI","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pbp1a","display_name":"PBP1a","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ampicillin-resistance","display_name":"ampicillin resistance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cephalosporin-resistance","display_name":"cephalosporin resistance","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7433000206947327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5814999938011169},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5214999914169312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5149999856948853},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.5105999708175659},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.47189998626708984},{"id":"https://openalex.org/C183641309","wikidata":"https://www.wikidata.org/wiki/Q306264","display_name":"Amp resistance","level":4,"score":0.3720000088214874},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.34929999709129333},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.34540000557899475},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3366999924182892},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3285999894142151},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.32499998807907104},{"id":"https://openalex.org/C77434933","wikidata":"https://www.wikidata.org/wiki/Q4043440","display_name":"Multilocus sequence typing","level":4,"score":0.32429999113082886},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3190000057220459},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C2780795924","wikidata":"https://www.wikidata.org/wiki/Q3825336","display_name":"Lactobacillus salivarius","level":4,"score":0.3003999888896942},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.26840001344680786},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.25999999046325684}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms27219683","doi":"https://doi.org/10.3390/ijms27219683","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219683","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms27219683","doi":"https://doi.org/10.3390/ijms27219683","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219683","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W132492715","https://openalex.org/W1945145639","https://openalex.org/W1968002257","https://openalex.org/W1978440583","https://openalex.org/W2097991427","https://openalex.org/W2105999876","https://openalex.org/W2111804766","https://openalex.org/W2114151609","https://openalex.org/W2117520981","https://openalex.org/W2122784613","https://openalex.org/W2130359204","https://openalex.org/W2136222303","https://openalex.org/W2159982881","https://openalex.org/W2167222281","https://openalex.org/W2172024836","https://openalex.org/W2339775922","https://openalex.org/W2537821265","https://openalex.org/W2587021829","https://openalex.org/W2754528796","https://openalex.org/W2788228074","https://openalex.org/W2898614328","https://openalex.org/W2898810625","https://openalex.org/W2952034688","https://openalex.org/W2975831761","https://openalex.org/W3003569286","https://openalex.org/W3047889964","https://openalex.org/W3048398081","https://openalex.org/W3109735703","https://openalex.org/W3146609163","https://openalex.org/W3192395443","https://openalex.org/W4251751280","https://openalex.org/W4286434257","https://openalex.org/W4323851647","https://openalex.org/W4389508507","https://openalex.org/W4390788626","https://openalex.org/W4392856681","https://openalex.org/W4415847519","https://openalex.org/W4417461836","https://openalex.org/W7130433290"],"related_works":["https://openalex.org/W2069344672","https://openalex.org/W2086209375","https://openalex.org/W2059432035","https://openalex.org/W4315786250","https://openalex.org/W1545926652","https://openalex.org/W4240837659","https://openalex.org/W2788055109","https://openalex.org/W3007746341","https://openalex.org/W2029644435","https://openalex.org/W2082424882"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,11,79,128,135,194,210],"this":[3],"study":[4],"was":[5,44],"to":[6,42,62,100,106,206],"elucidate":[7],"the":[8,47,132,192,208,215],"molecular":[9],"basis":[10],"\u03b2-lactam":[12,175],"resistance":[13,64,163,176,217],"in":[14,22,67,120,131,177,182,191,214],"Ligilactobacillus":[15],"salivarius,":[16],"with":[17,143,162,171],"a":[18],"focus":[19],"on":[20],"mutations":[21],"genes":[23,117],"encoding":[24],"penicillin-binding":[25],"proteins":[26],"(PBPs).":[27],"Twelve":[28],"L.":[29,178],"salivarius":[30,179],"strains":[31,34,88,97,124,142],"(2":[32],"reference":[33],"and":[35,55,72,109,137,158,180,188],"10":[36],"turkey-derived":[37],"isolates)":[38],"were":[39,60,74,89,98,118],"analyzed.":[40],"Susceptibility":[41],"\u03b2-lactams":[43],"determined":[45],"by":[46,76],"broth":[48],"microdilution":[49],"method.":[50],"Whole-genome":[51],"sequencing":[52],"(WGS)":[53],"analyses":[54],"polymerase":[56],"chain":[57],"reaction":[58],"(PCR)":[59],"used":[61],"detect":[63],"genes.":[65],"Alterations":[66],"3":[68],"PBPs":[69],"(FtsI,":[70],"PBP2x-like,":[71],"PBP1A)":[73],"identified":[75],"comparative":[77],"analysis":[78],"presumptive":[80],"amino":[81],"acid":[82],"(aa)":[83],"sequences.":[84],"Phylogenetic":[85],"relationships":[86],"between":[87,174],"assessed":[90],"using":[91],"multilocus":[92],"sequence":[93],"typing":[94],"(MLST).":[95],"Six":[96],"resistant":[99],"ampicillin":[101,145],"(MIC":[102],"ranging":[103],"from":[104],"32":[105],"\u2265128":[107],"mg/L)":[108,148],"showed":[110,149],"elevated":[111,144],"MICs":[112,146],"for":[113],"cephalosporins.":[114],"No":[115],"\u03b2-lactamase":[116,196],"detected":[119],"any":[121],"strain.":[122],"Resistant":[123],"exhibited":[125],"distinct":[126],"patterns":[127],"aa":[129],"alterations":[130,181,213],"transpeptidase":[133],"domains":[134],"FtsI":[136,187],"PBP2x-like":[138,189],"proteins,":[139,190],"whereas":[140],"susceptible":[141],"(2\u20134":[147],"only":[150],"partial":[151],"alteration":[152],"profiles.":[153],"PBP1A":[154],"displayed":[155],"limited":[156],"variation":[157],"no":[159],"clear":[160],"association":[161,173],"phenotype.":[164,218],"Taken":[165],"together,":[166],"these":[167,211],"findings":[168],"are":[169,204],"consistent":[170],"an":[172],"high-molecular-weight":[183],"(HMW)":[184],"PBPs,":[185],"particularly":[186],"absence":[193],"detectable":[195],"production.":[197],"However,":[198],"further":[199],"studies,":[200],"including":[201],"functional":[202],"analyses,":[203],"needed":[205],"clarify":[207],"role":[209],"PBP":[212],"observed":[216]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-30T00:00:00"}
