{"id":"https://openalex.org/W7224320294","doi":"https://doi.org/10.1096/fj.202604338rr","title":"Genetic Prioritization of BTN3A2 Reveals an Interferon\u2010Responsive T\u2010Cell Program in Dermatomyositis Through Single\u2010Cell Mendelian Randomization and Multi\u2010Omics Integration","display_name":"Genetic Prioritization of BTN3A2 Reveals an Interferon\u2010Responsive T\u2010Cell Program in Dermatomyositis Through Single\u2010Cell Mendelian Randomization and Multi\u2010Omics Integration","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224320294","doi":"https://doi.org/10.1096/fj.202604338rr","pmid":"https://pubmed.ncbi.nlm.nih.gov/42954955"},"language":"en","primary_location":{"id":"doi:10.1096/fj.202604338rr","doi":"https://doi.org/10.1096/fj.202604338rr","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202604338rr","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106165517","display_name":"Jin Jiajia","orcid":"https://orcid.org/0009-0003-4490-0158","observed_orcids":["https://orcid.org/0009-0003-4490-0158"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Jin","raw_affiliation_strings":["Department of Rheumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":"https://orcid.org/0009-0003-4490-0158","affiliations":[{"raw_affiliation_string":"Department of Rheumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160118332","display_name":"Yifan Di","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Di","raw_affiliation_strings":["Department of Rehabilitation, RenJi Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, RenJi Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157901907","display_name":"Xueliang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueliang Zhang","raw_affiliation_strings":["Department of Rheumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160145005","display_name":"Shuhui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhui Sun","raw_affiliation_strings":["Rheumatology, RenJi Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, RenJi Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138473456","display_name":"Minkai Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minkai Chen","raw_affiliation_strings":["Department of Orthopedics Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160112454","display_name":"Zichen Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zichen Guo","raw_affiliation_strings":["Department of Orthopedics Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160125172","display_name":"Huijing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huijing Wang","raw_affiliation_strings":["Rheumatology, RenJi Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, RenJi Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160090437","display_name":"Shengming Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shengming Dai","raw_affiliation_strings":["Department of Rheumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5160090437","https://openalex.org/A5160125172"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210144482"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83580228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/btn3a2","display_name":"BTN3A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-drb1","display_name":"HLA-DRB1","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hla-c","display_name":"HLA-C","score":0.9940000176429749},{"id":"https://openalex.org/keywords/single-cell-eqtl","display_name":"single-cell eQTL","score":0.6930000185966492},{"id":"https://openalex.org/keywords/two-sample-mendelian-randomization","display_name":"two-sample Mendelian randomization","score":0.8230000138282776},{"id":"https://openalex.org/keywords/bayesian-colocalization","display_name":"Bayesian colocalization","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7039999961853027},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/antiviral-pathways","display_name":"antiviral pathways","score":0.9359999895095825},{"id":"https://openalex.org/keywords/autoimmune-disease-genetics","display_name":"autoimmune disease genetics","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6154000163078308},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6050999760627747},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.5587000250816345},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.5432999730110168},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5138000249862671},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5027999877929688},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4959000051021576},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.48030000925064087},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.46050000190734863},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41179999709129333},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.40230000019073486},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.38670000433921814},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.3808000087738037},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.37400001287460327},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.37070000171661377},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.36000001430511475},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35190001130104065},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3472999930381775},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3463999927043915},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.33340001106262207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.29249998927116394},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.29030001163482666},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.28679999709129333},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.259799987077713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25940001010894775},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.2549999952316284},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000071797","descriptor_name":"Butyrophilins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071797","descriptor_name":"Butyrophilins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003882","descriptor_name":"Dermatomyositis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003882","descriptor_name":"Dermatomyositis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003882","descriptor_name":"Dermatomyositis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.202604338rr","doi":"https://doi.org/10.1096/fj.202604338rr","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202604338rr","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:42954955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42954955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1549199866","https://openalex.org/W1905058580","https://openalex.org/W1973094248","https://openalex.org/W2012034410","https://openalex.org/W2035618305","https://openalex.org/W2069089843","https://openalex.org/W2073836327","https://openalex.org/W2094318390","https://openalex.org/W2112203259","https://openalex.org/W2128736149","https://openalex.org/W2130410032","https://openalex.org/W2159985097","https://openalex.org/W2161967080","https://openalex.org/W2214074259","https://openalex.org/W2400303083","https://openalex.org/W2766822525","https://openalex.org/W2792190570","https://openalex.org/W2794544412","https://openalex.org/W2805983714","https://openalex.org/W2966350772","https://openalex.org/W2982438975","https://openalex.org/W3095316811","https://openalex.org/W3175752499","https://openalex.org/W4223893712","https://openalex.org/W4225426244","https://openalex.org/W4281570422","https://openalex.org/W4283581540","https://openalex.org/W4307106797","https://openalex.org/W4308834893","https://openalex.org/W4313279535","https://openalex.org/W4387052604","https://openalex.org/W4402247989","https://openalex.org/W4405422444","https://openalex.org/W4414919334"],"related_works":["https://openalex.org/W7159626212","https://openalex.org/W2983030905","https://openalex.org/W4281615312","https://openalex.org/W2694965183","https://openalex.org/W2511960824","https://openalex.org/W6925087459","https://openalex.org/W3120340437","https://openalex.org/W4367299468","https://openalex.org/W4317105081","https://openalex.org/W4200184993"],"abstract_inverted_index":{"ABSTRACT":[0],"Dermatomyositis":[1],"(DM)":[2],"is":[3],"a":[4,231],"complex":[5],"autoimmune":[6],"disorder":[7],"characterized":[8],"by":[9,83,154],"genetic":[10,20,222],"susceptibility":[11],"and":[12,22,41,81,99,112,126,135,145,150,167,169,176,188,197,217,238],"dysregulated":[13],"immune":[14,24,120,226],"activation.":[15],"However,":[16],"the":[17,56],"relationship":[18],"between":[19],"variation":[21],"specific":[23],"cell":[25],"states":[26],"remains":[27],"poorly":[28],"understood.":[29],"We":[30,46,117],"aimed":[31],"to":[32],"identify":[33],"genetically":[34,232],"supported":[35,153,233],"immune\u2010cell\u2010specific":[36,48],"molecular":[37],"programs":[38],"underlying":[39],"DM":[40,60,125,164,237],"investigate":[42],"their":[43],"biological":[44],"relevance.":[45],"integrated":[47],"single\u2010cell":[49,101],"expression":[50,105,203],"quantitative":[51],"trait":[52],"loci":[53],"(sc\u2010eQTLs)":[54],"from":[55],"OneK1K":[57],"cohort":[58],"with":[59,124,207,224,236],"genome\u2010wide":[61],"association":[62],"study":[63],"(GWAS)":[64],"summary":[65],"statistics":[66],"using":[67,76,90],"two\u2010sample":[68],"Mendelian":[69],"randomization":[70],"(MR).":[71],"Candidate":[72],"genes":[73],"were":[74,192],"replicated":[75],"an":[77,239],"independent":[78],"sc\u2010eQTL":[79],"dataset":[80],"prioritized":[82,127],"Bayesian":[84],"colocalization.":[85],"Multi\u2010tissue":[86],"validation":[87],"was":[88,151,159,170,204],"performed":[89],"skeletal":[91],"muscle":[92,155,165],"transcriptomics,":[93],"peripheral":[94],"blood":[95],"mononuclear":[96],"cells":[97,182],"(PBMC),":[98],"skin":[100,199],"RNA":[102],"sequencing,":[103],"protein":[104],"data,":[106],"clinical":[107],"phenotypes,":[108],"virtual":[109],"knockout":[110,213],"analysis,":[111],"gain\u2010of\u2010function":[113],"analyses":[114],"of":[115],"BTN3A2.":[116,136],"identified":[118,228],"204":[119],"cell\u2010specific":[121],"eGenes":[122],"associated":[123,235],"four":[128],"high\u2010confidence":[129],"genes,":[130],"including":[131],"HLA\u2010DRB1,":[132],"HLA\u2010C,":[133],"Lnc\u2010HLA\u2010B\u20102,":[134],"BTN3A2":[137,158,179,202,229],"showed":[138],"robust":[139],"colocalization":[140],"across":[141,173],"multiple":[142],"CD4":[143],"+":[144,147,180],"CD8":[146],"T\u2010cell":[148,241],"subsets":[149],"further":[152],"transcriptomic":[156],"data.":[157],"consistently":[160],"upregulated":[161],"in":[162,194,211],"both":[163],"tissues":[166],"PBMCs":[168,196],"broadly":[171],"expressed":[172],"T\u2010cell,":[174],"NK\u2010cell,":[175],"B\u2010cell":[177],"populations.":[178],"T":[181,200],"exhibited":[183],"enhanced":[184],"cytotoxic,":[185],"activation,":[186],"antigen\u2010presentation,":[187],"interferon\u2010responsive":[189,240],"programs,":[190],"which":[191],"reproduced":[193],"circulating":[195],"lesional":[198],"cells.":[201],"negatively":[205],"correlated":[206],"MMT8":[208],"scores,":[209],"while":[210],"silico":[212],"analysis":[214],"implicated":[215],"interferon\u2010stimulated":[216],"antiviral":[218],"pathways.":[219],"Integrating":[220],"cell\u2010type\u2010specific":[221],"evidence":[223],"multi\u2010tissue":[225],"profiling":[227],"as":[230],"candidate":[234],"state,":[242],"providing":[243],"novel":[244],"insights":[245],"for":[246],"future":[247],"mechanistic":[248],"investigation.":[249]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-30T00:00:00"}
