{"id":"https://openalex.org/W7224310075","doi":"https://doi.org/10.1038/s41401-026-01944-0","title":"Transcription factor EB as a novel target for dimethyl fumarate to restore endothelial function in diabetes","display_name":"Transcription factor EB as a novel target for dimethyl fumarate to restore endothelial function in diabetes","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224310075","doi":"https://doi.org/10.1038/s41401-026-01944-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42957749"},"language":"en","primary_location":{"id":"doi:10.1038/s41401-026-01944-0","doi":"https://doi.org/10.1038/s41401-026-01944-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41401-026-01944-0","pdf_url":"https://www.nature.com/articles/s41401-026-01944-0.pdf","source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41401-026-01944-0.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028831855","display_name":"Lei He","orcid":"https://orcid.org/0000-0002-8287-1197","observed_orcids":["https://orcid.org/0000-0002-8287-1197"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Lei He","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111157300","display_name":"Ri Min Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ri Min Tan","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160110577","display_name":"Leyi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Leyi Wu","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160075504","display_name":"Qinghua Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Qinghua Chen","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160081872","display_name":"Jinzhao Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jinzhao Yang","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160081579","display_name":"Ziyu Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ziyu Han","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160129884","display_name":"Yang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160090596","display_name":"Gang Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210094699","display_name":"Shenzhen Sixth People's Hospital","ror":"https://ror.org/00qftst12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Fan","raw_affiliation_strings":["Medical Research Center, Pan-Vascular Research Group, Shenzhen University Affiliated Sixth Hospital, Shenzhen, 518000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Pan-Vascular Research Group, Shenzhen University Affiliated Sixth Hospital, Shenzhen, 518000, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210094699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101231578","display_name":"Yu Huang","orcid":"https://orcid.org/0009-0006-6304-9057","observed_orcids":["https://orcid.org/0009-0006-6304-9057"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Yu Huang","raw_affiliation_strings":["Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China. yu.huang@cityu.edu.hk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China. yu.huang@cityu.edu.hk","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159712236","display_name":"Cheng-lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng-Lin Zhang","raw_affiliation_strings":["Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, 518060, China. zhangchenglin07@sina.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, 518060, China. zhangchenglin07@sina.cn","institution_ids":["https://openalex.org/I180726961"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101231578","https://openalex.org/A5159712236"],"corresponding_institution_ids":["https://openalex.org/I168719708","https://openalex.org/I180726961"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84218333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4927000105381012,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4927000105381012,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tfeb","display_name":"TFEB","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dimethyl-fumarate","display_name":"dimethyl fumarate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9739999771118164},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8619999885559082},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.5879999995231628},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2776819417","wikidata":"https://www.wikidata.org/wiki/Q418123","display_name":"Dimethyl fumarate","level":3,"score":0.8956999778747559},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5960000157356262},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5522000193595886},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5468999743461609},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5117999911308289},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40799999237060547},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.385699987411499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36390000581741333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3628000020980835},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.35030001401901245},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3474999964237213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3199000060558319},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31850001215934753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3156999945640564},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29030001163482666},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2648000121116638}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41401-026-01944-0","doi":"https://doi.org/10.1038/s41401-026-01944-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41401-026-01944-0","pdf_url":"https://www.nature.com/articles/s41401-026-01944-0.pdf","source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},{"id":"pmid:42957749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42957749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41401-026-01944-0","doi":"https://doi.org/10.1038/s41401-026-01944-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41401-026-01944-0","pdf_url":"https://www.nature.com/articles/s41401-026-01944-0.pdf","source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3551335491","display_name":null,"funder_award_id":"82370259","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309893","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320333998","display_name":"Shenzhen Research Institute, City University of Hong Kong","ror":"https://ror.org/00xc0ma20"},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224310075.pdf","grobid_xml":"https://content.openalex.org/works/W7224310075.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2071198822","https://openalex.org/W2078184757","https://openalex.org/W2583400730","https://openalex.org/W2793142753","https://openalex.org/W2887157296","https://openalex.org/W2889111495","https://openalex.org/W2915324695","https://openalex.org/W2960061163","https://openalex.org/W2981358051","https://openalex.org/W3112571447","https://openalex.org/W3119359641","https://openalex.org/W3125424605","https://openalex.org/W3153100958","https://openalex.org/W3155415663","https://openalex.org/W4213016250","https://openalex.org/W4393265844","https://openalex.org/W4396936199","https://openalex.org/W4402313775","https://openalex.org/W4408684170","https://openalex.org/W4411793562","https://openalex.org/W4417454710"],"related_works":["https://openalex.org/W7001094919","https://openalex.org/W4240547753","https://openalex.org/W1998820529","https://openalex.org/W4412334964","https://openalex.org/W2793729777","https://openalex.org/W2986255901","https://openalex.org/W1991777583","https://openalex.org/W822944951","https://openalex.org/W3014484503","https://openalex.org/W3043286996"],"abstract_inverted_index":{"Diabetes":[0],"mellitus-associated":[1],"endothelial":[2,41,92,96,141,233],"dysfunction":[3,42,234],"represents":[4,248],"a":[5,208,218,249,260],"pivotal":[6],"early":[7],"event":[8],"in":[9,78,114,117,126,133,170,194,197,222,235],"diabetic":[10,40,51,268],"vasculopathy,":[11],"linking":[12],"metabolic":[13],"derangements":[14],"to":[15,108],"vascular":[16,76,269],"injury.":[17],"Dimethyl":[18],"fumarate":[19],"(DMF),":[20],"an":[21],"FDA-approved":[22],"drug":[23],"for":[24,72,253,264],"multiple":[25],"sclerosis":[26],"and":[27,32,43,54,75,80,95,116,130,146,156,167,172,213,227,241,259],"psoriasis,":[28],"exhibits":[29],"potent":[30],"anti-inflammatory":[31],"antioxidant":[33],"properties,":[34],"yet":[35],"whether":[36],"it":[37],"protects":[38],"against":[39],"the":[44,55,110,121,148,254,265],"underlying":[45],"molecular":[46],"mechanisms":[47],"remain":[48],"unclear.":[49],"Here,":[50],"db/db":[52,127],"mice":[53,105],"non-diabetic":[56],"db/m":[57],"+":[58],"littermates":[59],"were":[60,106,178,188],"treated":[61],"with":[62],"DMF":[63,113,119,181,187,231,258],"(100":[64],"mg\u00b7kg":[65],"-1":[66,68],"\u00b7d":[67],")":[69,104],"or":[70,196],"vehicle":[71],"4":[73],"weeks,":[74],"function":[77],"aortic":[79,140],"mesenteric":[81,134],"artery":[82],"rings":[83],"was":[84],"assessed":[85],"by":[86,180,191,237],"wire":[87],"myography.":[88],"Human":[89],"umbilical":[90],"vein":[91],"cells":[93],"(HUVECs)":[94],"cell":[97],"(EC)-specific":[98],"Tfeb":[99,102,200],"knockout":[100],"(":[101],"ECKO":[103,201],"employed":[107],"investigate":[109],"target":[111,263],"of":[112,150,159,162,176,186,199,220,225,257,267],"vitro":[115],"vivo.":[118],"restored":[120],"impaired":[122],"endothelium-dependent":[123],"relaxations":[124,132],"(EDRs)":[125],"mouse":[128,173],"aortas":[129,198],"insulin-induced":[131],"arteries,":[135],"improved":[136],"glucose":[137],"tolerance,":[138],"reduced":[139],"mitochondrial":[142],"ROS":[143],"(mito-ROS)":[144],"accumulation,":[145],"lowered":[147],"expression":[149],"inflammatory":[151,168,226],"markers.":[152],"IL-1\u03b2":[153],"induced":[154],"phosphorylation":[155,240],"cytoplasmic":[157],"retention":[158],"TFEB":[160,163,192,221,239,243,247],"(indicative":[161],"inhibition),":[164],"mito-ROS":[165],"production,":[166],"responses":[169],"HUVECs":[171,195],"aortas,":[174],"all":[175],"which":[177],"reversed":[179,190],"pretreatment.":[182],"These":[183],"protective":[184],"effects":[185,256],"largely":[189],"knockdown":[193],"mice.":[202],"RNA":[203],"sequencing":[204],"data":[205],"analysis":[206],"revealed":[207],"substantial":[209],"overlap":[210],"between":[211],"DMF-regulated":[212],"TFEB-overexpression":[214],"transcriptional":[215],"profiles,":[216],"implicating":[217],"role":[219],"DMF-induced":[223],"suppression":[224],"oxidative":[228],"pathways.":[229],"Together,":[230],"ameliorates":[232],"diabetes":[236],"inhibiting":[238],"restoring":[242],"nuclear":[244],"activity.":[245],"Endothelial":[246],"critical":[250],"mediator":[251],"responsible":[252],"vaso-protective":[255],"promising":[261],"therapeutic":[262],"treatment":[266],"complications.":[270]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}