{"id":"https://openalex.org/W7224297751","doi":"https://doi.org/10.33925/1683-3759-2026-1229","title":"Effect of ceramic carrier porosity and solubility on antimicrobial drug release in the local treatment of infections caused by periodontal pathogens and fungi","display_name":"Effect of ceramic carrier porosity and solubility on antimicrobial drug release in the local treatment of infections caused by periodontal pathogens and fungi","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224297751","doi":"https://doi.org/10.33925/1683-3759-2026-1229"},"language":"en","primary_location":{"id":"doi:10.33925/1683-3759-2026-1229","doi":"https://doi.org/10.33925/1683-3759-2026-1229","is_oa":true,"landing_page_url":"https://doi.org/10.33925/1683-3759-2026-1229","pdf_url":"https://www.parodont.ru/jour/article/download/1229/700","source":{"id":"https://openalex.org/S4210168575","display_name":"Parodontologiya","issn_l":"1683-3759","issn":["1683-3759","1726-7269"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parodontologiya","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.parodont.ru/jour/article/download/1229/700","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160134202","display_name":"V. S. Zaytsev","orcid":"https://orcid.org/0009-0001-6937-3660","observed_orcids":["https://orcid.org/0009-0001-6937-3660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. S. Zaytsev","raw_affiliation_strings":["Russian University of Medicine"],"raw_orcid":"https://orcid.org/0009-0001-6937-3660","affiliations":[{"raw_affiliation_string":"Russian University of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048737843","display_name":"Grigory A. Volozhin","orcid":"https://orcid.org/0000-0002-0205-2811","observed_orcids":["https://orcid.org/0000-0002-0205-2811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. A. Volozhin","raw_affiliation_strings":["Russian University of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-0205-2811","affiliations":[{"raw_affiliation_string":"Russian University of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047447973","display_name":"\u041f\u043e\u0434\u043f\u043e\u0440\u0438\u043d \u041c\u0438\u0445\u0430\u0438\u043b \u0421\u0435\u0440\u0433\u0435\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-6785-0016","observed_orcids":["https://orcid.org/0000-0001-6785-0016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. S. Podporin","raw_affiliation_strings":["Russian University of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-6785-0016","affiliations":[{"raw_affiliation_string":"Russian University of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056345614","display_name":"Svyatoslav S. Chugunov","orcid":"https://orcid.org/0000-0002-0670-8152","observed_orcids":["https://orcid.org/0000-0002-0670-8152"]},"institutions":[{"id":"https://openalex.org/I125989756","display_name":"Skolkovo Institute of Science and Technology","ror":"https://ror.org/03f9nc143","country_code":"RU","type":"education","lineage":["https://openalex.org/I125989756"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. S. Chugunov","raw_affiliation_strings":["Skolkovo Institute of Science and Technology"],"raw_orcid":"https://orcid.org/0000-0002-0670-8152","affiliations":[{"raw_affiliation_string":"Skolkovo Institute of Science and Technology","institution_ids":["https://openalex.org/I125989756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057733937","display_name":"\u0415\u043b\u0435\u043d\u0430 \u0420\u0443\u0431\u0435\u043d\u043e\u0432\u043d\u0430 \u0421\u0430\u0434\u0447\u0438\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-2039-7108","observed_orcids":["https://orcid.org/0000-0003-2039-7108"]},"institutions":[{"id":"https://openalex.org/I4210110167","display_name":"Institute of Gene Biology","ror":"https://ror.org/01yq9ya27","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110167","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. R. Sadchikova","raw_affiliation_strings":["Institute of Gene Biology of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0003-2039-7108","affiliations":[{"raw_affiliation_string":"Institute of Gene Biology of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210110167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076111929","display_name":"Inna S. Makhneva","orcid":"https://orcid.org/0000-0002-0194-1510","observed_orcids":["https://orcid.org/0000-0002-0194-1510"]},"institutions":[{"id":"https://openalex.org/I4210144395","display_name":"State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan","ror":"https://ror.org/03ad88z33","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210144395"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. S. Makhneva","raw_affiliation_strings":["State Research Center of the Russian Federation \u2013 A.I. Burnazyan Federal Medical Biophysical Center"],"raw_orcid":"https://orcid.org/0000-0002-0194-1510","affiliations":[{"raw_affiliation_string":"State Research Center of the Russian Federation \u2013 A.I. Burnazyan Federal Medical Biophysical Center","institution_ids":["https://openalex.org/I4210144395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001874084","display_name":"Victor N. Tsarev","orcid":"https://orcid.org/0000-0002-3311-0367","observed_orcids":["https://orcid.org/0000-0002-3311-0367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. N. Tsarev","raw_affiliation_strings":["Russian University of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-3311-0367","affiliations":[{"raw_affiliation_string":"Russian University of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160133910","display_name":"A. M. Sarkisyan","orcid":"https://orcid.org/0009-0005-6051-0517","observed_orcids":["https://orcid.org/0009-0005-6051-0517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. M. Sarkisyan","raw_affiliation_strings":["Russian University of Medicine"],"raw_orcid":"https://orcid.org/0009-0005-6051-0517","affiliations":[{"raw_affiliation_string":"Russian University of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87026989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.7070000171661377},{"id":"https://openalex.org/keywords/calcium-phosphate-ceramics","display_name":"calcium phosphate ceramics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tricalcium-phosphate","display_name":"tricalcium phosphate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.5590000152587891},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.996999979019165},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.847000002861023},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.902999997138977},{"id":"https://openalex.org/keywords/prevotella-intermedia","display_name":"Prevotella intermedia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chronic-periodontitis","display_name":"chronic periodontitis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/peri-implantitis","display_name":"peri-implantitis","score":0.972000002861023},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5486999750137329},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.5450000166893005},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.541700005531311},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4821999967098236},{"id":"https://openalex.org/C2778660310","wikidata":"https://www.wikidata.org/wiki/Q177998","display_name":"Agar","level":3,"score":0.4749999940395355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46810001134872437},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.4343000054359436},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4226999878883362},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C11636898","wikidata":"https://www.wikidata.org/wiki/Q390585","display_name":"Agar diffusion test","level":4,"score":0.4124000072479248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4050999879837036},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4000999927520752},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3619999885559082},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.34860000014305115},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.3109000027179718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30979999899864197},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.30489999055862427},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25380000472068787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33925/1683-3759-2026-1229","doi":"https://doi.org/10.33925/1683-3759-2026-1229","is_oa":true,"landing_page_url":"https://doi.org/10.33925/1683-3759-2026-1229","pdf_url":"https://www.parodont.ru/jour/article/download/1229/700","source":{"id":"https://openalex.org/S4210168575","display_name":"Parodontologiya","issn_l":"1683-3759","issn":["1683-3759","1726-7269"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parodontologiya","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33925/1683-3759-2026-1229","doi":"https://doi.org/10.33925/1683-3759-2026-1229","is_oa":true,"landing_page_url":"https://doi.org/10.33925/1683-3759-2026-1229","pdf_url":"https://www.parodont.ru/jour/article/download/1229/700","source":{"id":"https://openalex.org/S4210168575","display_name":"Parodontologiya","issn_l":"1683-3759","issn":["1683-3759","1726-7269"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parodontologiya","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224297751.pdf","grobid_xml":"https://content.openalex.org/works/W7224297751.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2045264957","https://openalex.org/W2109833361","https://openalex.org/W2140616239","https://openalex.org/W2141563676","https://openalex.org/W2144440398","https://openalex.org/W2155008443","https://openalex.org/W2786339835","https://openalex.org/W2975693463","https://openalex.org/W2998695366","https://openalex.org/W3024616968","https://openalex.org/W3046837090","https://openalex.org/W3048614345","https://openalex.org/W3091577200","https://openalex.org/W3098102754","https://openalex.org/W4246992273","https://openalex.org/W4285416990","https://openalex.org/W4327731605","https://openalex.org/W4396791459","https://openalex.org/W4404718442","https://openalex.org/W4407462981","https://openalex.org/W4413786651"],"related_works":["https://openalex.org/W2984096263","https://openalex.org/W4383217969","https://openalex.org/W2401469261","https://openalex.org/W1980304115","https://openalex.org/W3150940858","https://openalex.org/W7140738553","https://openalex.org/W2802396386","https://openalex.org/W4360962214","https://openalex.org/W2054293906","https://openalex.org/W7223337697"],"abstract_inverted_index":{"Relevance":[0],".":[1,84,130,225,311],"Dysbiosis":[2],"of":[3,10,24,30,46,76,80,90,101,104,133,147,171,189,214,217,221,287,293,314,347],"the":[4,22,31,44,65,70,77,88,97,212,218,291,294,344,348],"oral":[5],"microbiome,":[6],"with":[7,145,168,192,238],"a":[8,18,207,270],"predominance":[9],"anaerobic":[11],"periodontal":[12],"pathogens":[13],"and":[14,28,43,93,99,113,117,128,140,154,174,197,228,265,290,316,337,350],"Candida":[15,175],"species,":[16],"plays":[17],"key":[19],"role":[20],"in":[21,343],"pathogenesis":[23],"chronic":[25],"periodontitis,":[26],"peri-implantitis,":[27],"osteomyelitis":[29],"jaws.":[32],"Systemic":[33],"antibiotic":[34,49],"therapy":[35],"is":[36,318,327],"limited":[37],"by":[38,321],"poor":[39],"penetration":[40],"into":[41],"bone":[42],"risk":[45],"selecting":[47,69],"for":[48,124,252,260,329],"resistance.":[50],"Local":[51],"drug":[52,62,81],"delivery":[53],"using":[54,163],"calcium":[55,107,288],"phosphate":[56,108,115],"carriers":[57,349],"can":[58],"achieve":[59],"exceptionally":[60],"high":[61],"concentrations":[63],"at":[64,205,211],"infection":[66],"site;":[67],"however,":[68],"optimal":[71],"carrier":[72,239,325],"requires":[73],"an":[74,164,234],"understanding":[75],"physicochemical":[78],"mechanisms":[79],"release.":[82],"Objective":[83],"To":[85],"determine":[86],"how":[87],"release":[89,159,313],"metronidazole,":[91],"ciprofloxacin,":[92],"fluconazole":[94,155,317],"depends":[95],"on":[96,356],"porosity":[98],"solubility":[100,292,326],"three":[102],"types":[103],"ceramics:":[105],"biogenic":[106],"ceramics":[109],"(BCPC),":[110],"hydroxyapatite":[111],"(HA),":[112],"tricalcium":[114],"(TCP),":[116],"to":[118,285],"identify":[119],"biologically":[120],"appropriate":[121],"drug\u2013carrier":[122],"combinations":[123,333],"microbiota":[125],"modulation.":[126],"Materials":[127],"methods":[129],"Disks":[131],"made":[132],"BCPC":[134,241,277],"(porosity,":[135],"33.7%),":[136],"synthetic":[137],"HA":[138,245,275],"(24.5%),":[139],"TCP":[141,243,273],"(26.0%)":[142],"were":[143,203,299],"impregnated":[144],"solutions":[146],"ciprofloxacin":[148],"(2":[149,156],"mg/mL),":[150,153],"metronidazole":[151,227,315],"(5":[152],"mg/mL).":[157],"Drug":[158],"was":[160],"assessed":[161],"indirectly":[162],"agar":[165],"diffusion":[166],"assay":[167],"test":[169],"strains":[170],"Prevotella":[172],"intermedia":[173],"albicans":[176],"ATCC":[177],"90028":[178],"(n":[179],"=":[180,263,308],"24":[181],"per":[182],"combination).":[183],"Statistical":[184],"analysis":[185,188],"included":[186],"one-way":[187],"variance":[190],"(ANOVA)":[191],"Tukey":[193],"post":[194],"hoc":[195],"comparisons":[196],"Pearson":[198],"correlation":[199],"analysis.":[200],"The":[201,312,331],"experiments":[202],"conducted":[204],"Transgenbank,":[206],"unique":[208],"research":[209],"facility":[210],"Institute":[213],"Gene":[215],"Biology":[216],"Russian":[219],"Academy":[220],"Sciences,":[222],"Russia.":[223],"Results":[224],"For":[226],"fluconazole,":[229],"inhibition":[230],"zone":[231],"diameters":[232],"showed":[233,269],"almost":[235],"linear":[236],"relationship":[237],"porosity:":[240],">":[242,244,247,249,255,257,274,276,279,281],"(30.40":[246],"25.16":[248],"24.14":[250],"mm":[251,259],"metronidazole;":[253],"22.16":[254],"19.08":[256],"17.98":[258],"fluconazole;":[261],"r":[262],"0.997":[264],"0.990,":[266],"respectively).":[267],"Ciprofloxacin":[268],"different":[271],"ranking:":[272],"(25.59":[278],"22.64":[280],"17.91":[282],"mm),":[283],"owing":[284],"chelation":[286],"ions":[289],"matrix.":[295],"All":[296],"between-group":[297],"differences":[298,342],"statistically":[300],"significant":[301],"(":[302],"p":[303],"<":[304],"0.001;":[305],"\u03b7":[306],"2":[307],"0.899\u20130.947).":[309],"Conclusion":[310],"determined":[319],"exclusively":[320],"pore":[322],"volume,":[323],"whereas":[324],"critical":[328],"ciprofloxacin.":[330],"recommended":[332],"are":[334],"metronidazole\u2013BCPC,":[335],"ciprofloxacin\u2013TCP,":[336],"fluconazole\u2013BCPC.":[338],"These":[339],"patterns":[340],"explain":[341],"clinical":[345],"effectiveness":[346],"enable":[351],"individualized":[352],"local":[353],"treatment":[354],"based":[355],"microbiome":[357],"composition.":[358]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-10-30T00:00:00"}