{"id":"https://openalex.org/W7224288685","doi":"https://doi.org/10.1183/13993003.congress-2026.oa1187","title":"Gene expression signatures of usual interstitial pneumonia radiologic features in idiopathic pulmonary fibrosis lung tissue","display_name":"Gene expression signatures of usual interstitial pneumonia radiologic features in idiopathic pulmonary fibrosis lung tissue","publication_year":2026,"publication_date":"2026-09-05","ids":{"openalex":"https://openalex.org/W7224288685","doi":"https://doi.org/10.1183/13993003.congress-2026.oa1187"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2026.oa1187","doi":"https://doi.org/10.1183/13993003.congress-2026.oa1187","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2026.oa1187","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093212928","display_name":"Samin Abbasidezfouli","orcid":"https://orcid.org/0000-0002-0213-071X","observed_orcids":["https://orcid.org/0000-0002-0213-071X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Samin Abbasidezfouli","raw_affiliation_strings":["1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160150060","display_name":"Chen Xi Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chen Xi Yang","raw_affiliation_strings":["1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086241666","display_name":"Stacey Ledoux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stacey Ledoux","raw_affiliation_strings":["1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104086011","display_name":"Joel David Cooper","orcid":"https://orcid.org/0000-0003-2434-6738","observed_orcids":["https://orcid.org/0000-0003-2434-6738"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel D. Cooper","raw_affiliation_strings":["2Department of Thoracic Surgery, University of Pennsylvania, Philadelphia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Thoracic Surgery, University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160073153","display_name":"James C. Hogg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James C. Hogg","raw_affiliation_strings":["1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064883167","display_name":"Drago\u015f M. Vasilescu","orcid":"https://orcid.org/0000-0003-3936-4365","observed_orcids":["https://orcid.org/0000-0003-3936-4365"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dragos M. Vasilescu","raw_affiliation_strings":["1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081815232","display_name":"G.C. Goobie","orcid":"https://orcid.org/0000-0001-7982-5635","observed_orcids":["https://orcid.org/0000-0001-7982-5635"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gillian C. Goobie","raw_affiliation_strings":["3Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057548689","display_name":"Tillie\u2010Louise Hackett","orcid":"https://orcid.org/0000-0001-7134-3287","observed_orcids":["https://orcid.org/0000-0001-7134-3287"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tillie-Louise Hackett","raw_affiliation_strings":["1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA1187","last_page":"OA1187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/usual-interstitial-pneumonia","display_name":"usual interstitial pneumonia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8339999914169312},{"id":"https://openalex.org/keywords/honeycombing","display_name":"honeycombing","score":0.949999988079071},{"id":"https://openalex.org/keywords/reticulation","display_name":"reticulation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ground-glass-opacities","display_name":"ground-glass opacities","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.47999998927116394},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.9399999976158142},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7839999794960022},{"id":"https://openalex.org/keywords/t-cell-dysregulation","display_name":"T cell dysregulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/metabolic-suppression","display_name":"metabolic suppression","score":0.574999988079071},{"id":"https://openalex.org/keywords/lung-tissue","display_name":"lung tissue","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.7928000092506409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7738999724388123},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6940000057220459},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5799000263214111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5228999853134155},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5113999843597412},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49160000681877136},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.3955000042915344},{"id":"https://openalex.org/C2777405647","wikidata":"https://www.wikidata.org/wiki/Q17147306","display_name":"Usual interstitial pneumonia","level":4,"score":0.37059998512268066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36169999837875366},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.3296000063419342},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C2778873089","wikidata":"https://www.wikidata.org/wiki/Q3281418","display_name":"Collagen VI","level":3,"score":0.3028999865055084},{"id":"https://openalex.org/C2779412668","wikidata":"https://www.wikidata.org/wiki/Q5893790","display_name":"Honeycombing","level":4,"score":0.29580000042915344},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2939999997615814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C2777001051","wikidata":"https://www.wikidata.org/wiki/Q3150728","display_name":"Ground-glass opacity","level":4,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2026.oa1187","doi":"https://doi.org/10.1183/13993003.congress-2026.oa1187","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2026.oa1187","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4318815856","https://openalex.org/W7224570826","https://openalex.org/W4220974589","https://openalex.org/W4410273780","https://openalex.org/W4280512799","https://openalex.org/W7096111357","https://openalex.org/W2014973313","https://openalex.org/W1980798450","https://openalex.org/W2886616492","https://openalex.org/W2968769612"],"abstract_inverted_index":{"Background:":[0],"Idiopathic":[1],"pulmonary":[2],"fibrosis":[3],"(IPF)":[4],"is":[5,36],"diagnosed":[6],"by":[7,198],"the":[8,22,27,30],"identification":[9],"of":[10,32,48,91,99,174],"honeycombing":[11,259],"(HC)":[12],"and":[13,55,66,78,110,126,143,156,164,178,184,189,209,217,247,254,260],"reticulation":[14,261],"(RT)":[15],"on":[16],"computed":[17],"tomography":[18],"(CT)":[19],"imaging,":[20],"but":[21],"molecular":[23,235],"signatures":[24,43],"that":[25],"drive":[26],"pathology":[28],"within":[29,57],"tissue":[31,97,139,214,220,249],"these":[33],"radiological":[34],"features":[35],"unknown.":[37],"Aim:":[38],"To":[39],"characterize":[40],"gene":[41,119,131],"expression":[42,120],"associated":[44],"with":[45,117,172,182,224],"CT-defined":[46],"regions":[47,160],"normal":[49,103,225,246],"lung,":[50],"ground-glass":[51],"opacity":[52],"(GGO),":[53],"RT,":[54],"HC":[56,111,185],"IPF":[58,64,104,137,226,238],"lungs.":[59],"Methods:":[60],"Lungs":[61],"from":[62,241],"10":[63,67,74],"patients":[65],"donor":[68],"control":[69,100,149,170,195],"lungs":[70,93],"were":[71,84],"inflated":[72],"to":[73,86,94,148,169,194,250],"cm":[75],"H\u2082O":[76],"pressure":[77],"frozen.":[79],"In":[80,212],"vivo":[81,88],"CT":[82,89],"scans":[83,90],"registered":[85],"ex":[87],"explanted":[92],"enable":[95],"targeted":[96],"sampling":[98],"lung":[101,105,138,150,239],"(n=61),":[102],"(n=56),":[106],"GGO":[107,159,213,248],"(n=23),":[108],"RT":[109,183],"(n=37).":[112],"RNA":[113],"sequencing":[114],"was":[115],"performed,":[116],"differential":[118],"analyzed":[121],"using":[122,130],"linear":[123],"mixed-effects":[124],"models":[125],"pathway":[127],"analysis":[128],"conducted":[129],"set":[132],"enrichment":[133,173],"analysis.":[134],"Results:":[135],"Normal":[136],"expressed":[140],"1087":[141],"up-":[142,163,188],"242":[144],"downregulated":[145,166,191],"genes":[146,167,216,222],"compared":[147,168,193],"tissue,":[151,171,196,240],"reflecting":[152],"extracellular":[153,175,201],"matrix":[154,176,202],"deposition":[155],"metabolic":[157,204],"suppression.":[158],"had":[161,186],"894":[162],"302":[165],"pathways":[177],"mesenchyme":[179],"activation.":[180],"Tissue":[181],"1688":[187],"672":[190],"genes,":[192],"marked":[197],"cilium":[199],"movement,":[200],"activation,":[203],"repression,":[205],"impaired":[206,251],"wound":[207,252],"healing,":[208],"T-cell":[210],"dysregulation.":[211],"998":[215],"in":[218,237,245,257],"RT/HC":[219],"65":[221],"overlapped":[223],"tissue.":[227],"Conclusions:":[228],"Our":[229],"findings":[230],"show":[231],"a":[232],"spatial,":[233],"stepwise":[234],"progression":[236],"early":[242],"fibrotic":[243],"activation":[244],"healing":[253],"immune":[255],"suppression":[256],"advanced":[258],"regions.":[262]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-30T00:00:00"}
