{"id":"https://openalex.org/W7224259065","doi":"https://doi.org/10.1080/0886022x.2026.2746268","title":"Acute\u2011on\u2011chronic kidney disease (AoCKD): a critical appraisal and call for action to define boundaries and optimize management","display_name":"Acute\u2011on\u2011chronic kidney disease (AoCKD): a critical appraisal and call for action to define boundaries and optimize management","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224259065","doi":"https://doi.org/10.1080/0886022x.2026.2746268","pmid":"https://pubmed.ncbi.nlm.nih.gov/42954720","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13721815"},"language":"en","primary_location":{"id":"doi:10.1080/0886022x.2026.2746268","doi":"https://doi.org/10.1080/0886022x.2026.2746268","is_oa":true,"landing_page_url":"https://doi.org/10.1080/0886022x.2026.2746268","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2026.2746268?needAccess=true","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2026.2746268?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055736015","display_name":"Amin Roshdy Soliman","orcid":"https://orcid.org/0000-0002-5589-1037","observed_orcids":["https://orcid.org/0000-0002-5589-1037"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amin R. Soliman","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0002-5589-1037","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024967639","display_name":"Karim Soliman","orcid":"https://orcid.org/0000-0002-0960-2644","observed_orcids":["https://orcid.org/0000-0002-0960-2644"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karim M. Soliman","raw_affiliation_strings":["Division of Transplant Nephrology, Department of Medicine, Medical University of South Carolina","Medical Services, Ralph H. Johnson VA Medical Centre"],"raw_orcid":"https://orcid.org/0000-0002-0960-2644","affiliations":[{"raw_affiliation_string":"Division of Transplant Nephrology, Department of Medicine, Medical University of South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical Services, Ralph H. Johnson VA Medical Centre","institution_ids":["https://openalex.org/I4210132004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160103554","display_name":"Salwa Ibrahim Mohamed","orcid":"https://orcid.org/0000-0001-9905-6829","observed_orcids":["https://orcid.org/0000-0001-9905-6829"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Salwa Ibrahim Mohamed","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0001-9905-6829","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006021112","display_name":"Mustafa El-Khatib","orcid":"https://orcid.org/0009-0004-8242-8592","observed_orcids":["https://orcid.org/0009-0004-8242-8592"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Mostafa Elkhatib","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0009-0004-8242-8592","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052923542","display_name":"Mohamed Momtaz","orcid":"https://orcid.org/0000-0003-0170-4205","observed_orcids":["https://orcid.org/0000-0003-0170-4205"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed Momtaz","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0003-0170-4205","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083577682","display_name":"Mahmoud M. Elnokeety","orcid":"https://orcid.org/0000-0002-6700-8467","observed_orcids":["https://orcid.org/0000-0002-6700-8467"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mahmoud M. Elnokeety","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0002-6700-8467","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151958814","display_name":"Ahmed Aly","orcid":"https://orcid.org/0009-0006-9695-2656","observed_orcids":["https://orcid.org/0009-0006-9695-2656"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Aly","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0009-0006-9695-2656","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009889971","display_name":"H. Maamoun","orcid":"https://orcid.org/0000-0002-9246-8713","observed_orcids":["https://orcid.org/0000-0002-9246-8713"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hoda Maamoun","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0002-9246-8713","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073026416","display_name":"Tarek Samy Abdelaziz","orcid":"https://orcid.org/0000-0002-1238-1045","observed_orcids":["https://orcid.org/0000-0002-1238-1045"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Tarek S. Abdelaziz","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0002-1238-1045","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073204688","display_name":"Hany Hammad","orcid":"https://orcid.org/0000-0003-0115-0388","observed_orcids":["https://orcid.org/0000-0003-0115-0388"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hany Hammad","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0003-0115-0388","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046092274","display_name":"Mahmoud Maamoun Shaheen","orcid":"https://orcid.org/0000-0002-6144-6044","observed_orcids":["https://orcid.org/0000-0002-6144-6044"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mahmoud M. Shaheen","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0002-6144-6044","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006817605","display_name":"Rasha Ahmed Darwish","orcid":"https://orcid.org/0009-0008-4902-742X","observed_orcids":["https://orcid.org/0009-0008-4902-742X"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rasha Ahmed Darwish","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0009-0008-4902-742X","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078347789","display_name":"Ahmed Fayed","orcid":"https://orcid.org/0000-0002-6041-4016","observed_orcids":["https://orcid.org/0000-0002-6041-4016","https://orcid.org/0009-0004-3453-2731"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Fayed","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0002-6041-4016","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038066381","display_name":"Dina A. Abdellatif","orcid":"https://orcid.org/0000-0001-5398-3387","observed_orcids":["https://orcid.org/0000-0001-5398-3387"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Dina A. Abdellatif","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0001-5398-3387","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122226032","display_name":"Nouran Hatem Samir","orcid":"https://orcid.org/0000-0003-1007-943X","observed_orcids":["https://orcid.org/0000-0003-1007-943X","https://orcid.org/0009-0009-0840-5284"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nouran Hatem Samir","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0003-1007-943X","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029314174","display_name":"Ahmed S. Hegazy","orcid":"https://orcid.org/0009-0002-3620-1480","observed_orcids":["https://orcid.org/0009-0002-3620-1480"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed S. Hegazy","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0009-0002-3620-1480","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050089753","display_name":"S. Khashab","orcid":"https://orcid.org/0000-0001-6857-4076","observed_orcids":["https://orcid.org/0000-0001-6857-4076"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210164576","display_name":"Cairo University hospitals","ror":"https://ror.org/058djb788","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210164576"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahier El-Khashab","raw_affiliation_strings":["Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University"],"raw_orcid":"https://orcid.org/0000-0001-6857-4076","affiliations":[{"raw_affiliation_string":"Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160128417","display_name":"Kasr Alainy Nephrology group (KANG)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kasr Alainy Nephrology group (KANG)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073026416"],"corresponding_institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210164576"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63588667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"1","first_page":"2746268","last_page":"2746268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-on-chronic-kidney-disease","display_name":"acute-on-chronic kidney disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7979999780654907},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8700000047683716},{"id":"https://openalex.org/keywords/kdigo-criteria","display_name":"KDIGO criteria","score":0.6069999933242798},{"id":"https://openalex.org/keywords/nice-guidance","display_name":"NICE guidelines","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.765999972820282},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5619999766349792},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5899999737739563},{"id":"https://openalex.org/keywords/imaging-recommendations","display_name":"imaging recommendations","score":0.4230000078678131},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9164999723434448},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7802000045776367},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7003999948501587},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.6474999785423279},{"id":"https://openalex.org/C152541439","wikidata":"https://www.wikidata.org/wiki/Q5186693","display_name":"Critical appraisal","level":3,"score":0.6111999750137329},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5996999740600586},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.599399983882904},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5108000040054321},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4846999943256378},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.45890000462532043},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44929999113082886},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4449999928474426},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.35030001401901245},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2779962950","wikidata":"https://www.wikidata.org/wiki/Q5659376","display_name":"Harmonization","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2578999996185303},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2526000142097473},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/0886022x.2026.2746268","doi":"https://doi.org/10.1080/0886022x.2026.2746268","is_oa":true,"landing_page_url":"https://doi.org/10.1080/0886022x.2026.2746268","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2026.2746268?needAccess=true","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13721815","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13721815/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13721815/pdf/IRNF_48_2746268.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ren Fail","raw_type":"Text"},{"id":"pmid:42954720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42954720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal failure","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:783b0d88571a4355a9d6f92cc9832f91","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/783b0d88571a4355a9d6f92cc9832f91","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Renal Failure, Vol 48, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/0886022x.2026.2746268","doi":"https://doi.org/10.1080/0886022x.2026.2746268","is_oa":true,"landing_page_url":"https://doi.org/10.1080/0886022x.2026.2746268","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2026.2746268?needAccess=true","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321148","display_name":"Cairo University","ror":"https://ror.org/03q21mh05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224259065.pdf","grobid_xml":"https://content.openalex.org/works/W7224259065.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W2005120007","https://openalex.org/W2021690806","https://openalex.org/W2072796929","https://openalex.org/W2141559993","https://openalex.org/W2143262001","https://openalex.org/W2148152947","https://openalex.org/W2150433066","https://openalex.org/W2164819474","https://openalex.org/W2167156043","https://openalex.org/W2582718620","https://openalex.org/W2591419591","https://openalex.org/W2889446840","https://openalex.org/W2897635562","https://openalex.org/W2900460035","https://openalex.org/W2905044425","https://openalex.org/W3001996811","https://openalex.org/W3019784005","https://openalex.org/W3028971041","https://openalex.org/W3092029213","https://openalex.org/W3123055175","https://openalex.org/W3135075847","https://openalex.org/W3177086065","https://openalex.org/W3179081715","https://openalex.org/W3191280566","https://openalex.org/W3197252695","https://openalex.org/W3197715777","https://openalex.org/W4220713807","https://openalex.org/W4223586104","https://openalex.org/W4306780054","https://openalex.org/W4311240531","https://openalex.org/W4311857683","https://openalex.org/W4318274761","https://openalex.org/W4318933605","https://openalex.org/W4365452229","https://openalex.org/W4379508762","https://openalex.org/W4381194480","https://openalex.org/W4385716470","https://openalex.org/W4391880483","https://openalex.org/W4392710752","https://openalex.org/W4392980187","https://openalex.org/W4393381378","https://openalex.org/W4404403276","https://openalex.org/W4404532249","https://openalex.org/W4404567081","https://openalex.org/W4405264816","https://openalex.org/W4406167322","https://openalex.org/W4406392207","https://openalex.org/W4408694011","https://openalex.org/W4410765724","https://openalex.org/W4410765785","https://openalex.org/W4411919858","https://openalex.org/W4412638339","https://openalex.org/W4413107695","https://openalex.org/W4415098222","https://openalex.org/W4415303190","https://openalex.org/W4415422961","https://openalex.org/W4415423786","https://openalex.org/W4416013920"],"related_works":["https://openalex.org/W2218584580","https://openalex.org/W3029597062","https://openalex.org/W2591419591","https://openalex.org/W3179081715","https://openalex.org/W4385716470","https://openalex.org/W1986489636","https://openalex.org/W2970167054","https://openalex.org/W4213331168","https://openalex.org/W3019784005","https://openalex.org/W2065737867"],"abstract_inverted_index":{"Acute\u2011on\u2011chronic":[0],"kidney":[1,139,214],"disease":[2,215],"(AoCKD)":[3],"refers":[4],"to":[5,44,58,61,83,150],"an":[6,174],"acute":[7,94,128,137],"decline":[8],"in":[9,13,96,119,125,130,159,192],"renal":[10],"function":[11],"occurring":[12],"individuals":[14],"with":[15,132],"established":[16],"CKD.":[17,97],"Despite":[18],"its":[19],"major":[20,35],"clinical":[21,68],"impact-including":[22],"increased":[23,190],"mortality,":[24],"accelerated":[25],"CKD":[26,160],"progression,":[27],"and":[28,54,60,67,79,90,108,114,141,170,183,226],"higher":[29],"cardiovascular":[30],"risk-AoCKD":[31],"remains":[32],"underrepresented":[33],"within":[34,212],"guideline":[36,48],"frameworks":[37,116],"(KDIGO,":[38],"ADQI,":[39,113],"NICE).":[40],"Our":[41],"review":[42],"aims":[43],"critically":[45],"appraise":[46],"existing":[47],"frameworks,":[49],"definitions,":[50,218],"biomarkers,":[51],"imaging":[52,106,224],"recommendations,":[53],"research":[55],"gaps":[56],"related":[57],"AoCKD,":[59,135],"highlight":[62],"priorities":[63],"for":[64,168],"future":[65],"harmonization":[66],"integration.":[69],"We":[70,121,172],"conducted":[71],"a":[72,205],"targeted":[73],"literature":[74],"search":[75],"of":[76,177,220,228],"PubMed,":[77],"Embase,":[78],"the":[80,189,198,213],"Cochrane":[81],"Library,":[82],"identify":[84],"guidelines,":[85],"consensus":[86],"reports,":[87],"observational":[88],"studies,":[89],"systematic":[91],"reviews":[92],"describing":[93,127],"deterioration":[95,129],"Extracted":[98],"data":[99],"included":[100],"definitional":[101],"criteria,":[102],"epidemiology,":[103],"biomarker":[104],"performance,":[105],"guidance,":[107],"prognostic":[109,157],"outcomes.":[110],"Current":[111],"KDIGO,":[112],"NICE":[115],"were":[117],"evaluated":[118],"parallel.":[120],"report":[122],"marked":[123],"heterogeneity":[124],"definitions":[126,154],"CKD,":[131],"terms":[133],"including":[134],"AKI\u2011on\u2011CKD,":[136],"pre\u2011existing":[138],"dysfunction,":[140],"cROCK\u2011based":[142],"definitions.":[143],"Reported":[144],"incidence":[145],"varies":[146],"widely":[147],"(1-33%)":[148],"due":[149],"inconsistent":[151],"criteria.":[152,185],"Creatinine\u2011based":[153],"show":[155],"reduced":[156],"accuracy":[158],"populations,":[161],"whereas":[162],"cystatin\u2011C-based":[163,221],"eGFR":[164],"demonstrates":[165],"superior":[166],"discrimination":[167],"mortality":[169,191],"progression.":[171],"propose":[173],"operational":[175],"definition":[176,187],"AoCKD":[178,203],"that":[179],"includes":[180],"functional":[181],"criteria":[182],"biomarker-based":[184],"The":[186],"reflects":[188],"this":[193],"phenotype":[194],"even":[195],"before":[196],"reaching":[197],"KDIGO-AKI":[199],"threshold.":[200],"In":[201],"conclusion,":[202],"is":[204],"clinically":[206],"significant":[207],"but":[208],"poorly":[209],"defined":[210],"state":[211],"continuum.":[216],"Harmonized":[217],"incorporation":[219],"markers,":[222],"structured":[223],"pathways,":[225],"integration":[227],"early":[229],"biomarkers":[230],"are":[231],"urgently":[232],"needed.":[233]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-30T00:00:00"}