{"id":"https://openalex.org/W7224254434","doi":"https://doi.org/10.63375/icrs.26.007","title":"Recurrent keratoconjunctivitis in X-linked agammaglobulinemia: a microbiome analysis: a case report","display_name":"Recurrent keratoconjunctivitis in X-linked agammaglobulinemia: a microbiome analysis: a case report","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224254434","doi":"https://doi.org/10.63375/icrs.26.007"},"language":"en","primary_location":{"id":"doi:10.63375/icrs.26.007","doi":"https://doi.org/10.63375/icrs.26.007","is_oa":true,"landing_page_url":"https://doi.org/10.63375/icrs.26.007","pdf_url":null,"source":{"id":"https://openalex.org/S5407047657","display_name":"Insights in Cataract and Refractive Surgery","issn_l":"3059-1503","issn":["3059-1503","3059-1511"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insights in Cataract and Refractive Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.63375/icrs.26.007","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137477611","display_name":"Bo Ree Kim","orcid":"https://orcid.org/0009-0000-4270-8312","observed_orcids":["https://orcid.org/0009-0000-4270-8312"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]},{"id":"https://openalex.org/I4405258598","display_name":"Ewha Womans University Mokdong Hospital","ror":"https://ror.org/00ypk0v12","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I138925566","https://openalex.org/I4210132203","https://openalex.org/I4405258598"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bo Ree Kim","raw_affiliation_strings":["Department of Ophthalmology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0009-0000-4270-8312","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I138925566","https://openalex.org/I4405258598"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016070679","display_name":"Kyung Eun Han","orcid":"https://orcid.org/0000-0001-8484-6086","observed_orcids":["https://orcid.org/0000-0001-8484-6086"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kyung Eun Han","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8484-6086","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016070679"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88970525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"3","first_page":"111","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-linked-agammaglobulinemia","display_name":"X-linked agammaglobulinemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":0.9829999804496765},{"id":"https://openalex.org/keywords/staphylococcus-epidermidis","display_name":"Staphylococcus epidermidis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.7440000176429749},{"id":"https://openalex.org/keywords/corneal-neovascularization","display_name":"corneal neovascularization","score":0.921999990940094},{"id":"https://openalex.org/keywords/conjunctival-infection","display_name":"conjunctival infection","score":0.6169999837875366},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7918999791145325},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.614300012588501},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5109000205993652},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.46320000290870667},{"id":"https://openalex.org/C2781403741","wikidata":"https://www.wikidata.org/wiki/Q1638140","display_name":"Hypopyon","level":3,"score":0.4368000030517578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41909998655319214},{"id":"https://openalex.org/C2776469317","wikidata":"https://www.wikidata.org/wiki/Q3686833","display_name":"Vernal keratoconjunctivitis","level":2,"score":0.4172999858856201},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.41019999980926514},{"id":"https://openalex.org/C2778064476","wikidata":"https://www.wikidata.org/wiki/Q1623006","display_name":"Keratoconjunctivitis","level":2,"score":0.38359999656677246},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.3743000030517578},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.349700003862381},{"id":"https://openalex.org/C189539697","wikidata":"https://www.wikidata.org/wiki/Q1125312","display_name":"Microbiological culture","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.305400013923645},{"id":"https://openalex.org/C2778836808","wikidata":"https://www.wikidata.org/wiki/Q424940","display_name":"Moxifloxacin","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C2779190853","wikidata":"https://www.wikidata.org/wiki/Q526920","display_name":"Nasolacrimal duct","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26260000467300415},{"id":"https://openalex.org/C2779617845","wikidata":"https://www.wikidata.org/wiki/Q1563808","display_name":"Superinfection","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C2778847519","wikidata":"https://www.wikidata.org/wiki/Q7133233","display_name":"Papulopustular","level":4,"score":0.25949999690055847},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.2578999996185303},{"id":"https://openalex.org/C2781302119","wikidata":"https://www.wikidata.org/wiki/Q48228","display_name":"Eyelid","level":2,"score":0.2533000111579895},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C2778663903","wikidata":"https://www.wikidata.org/wiki/Q140018","display_name":"Streptococcaceae","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.63375/icrs.26.007","doi":"https://doi.org/10.63375/icrs.26.007","is_oa":true,"landing_page_url":"https://doi.org/10.63375/icrs.26.007","pdf_url":null,"source":{"id":"https://openalex.org/S5407047657","display_name":"Insights in Cataract and Refractive Surgery","issn_l":"3059-1503","issn":["3059-1503","3059-1511"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insights in Cataract and Refractive Surgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.63375/icrs.26.007","doi":"https://doi.org/10.63375/icrs.26.007","is_oa":true,"landing_page_url":"https://doi.org/10.63375/icrs.26.007","pdf_url":null,"source":{"id":"https://openalex.org/S5407047657","display_name":"Insights in Cataract and Refractive Surgery","issn_l":"3059-1503","issn":["3059-1503","3059-1511"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insights in Cataract and Refractive Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2038413203","https://openalex.org/W2051540789","https://openalex.org/W2056397946","https://openalex.org/W2071980849","https://openalex.org/W2111271972","https://openalex.org/W2143890508","https://openalex.org/W2170486072","https://openalex.org/W2583905438","https://openalex.org/W3035723578","https://openalex.org/W3178944058","https://openalex.org/W3196208401","https://openalex.org/W4223525860","https://openalex.org/W4379197134"],"related_works":["https://openalex.org/W4223525860","https://openalex.org/W7212428194","https://openalex.org/W2071557999","https://openalex.org/W4312129826","https://openalex.org/W2063820963","https://openalex.org/W4413412589","https://openalex.org/W3049554143","https://openalex.org/W7222793512","https://openalex.org/W156794421","https://openalex.org/W3084833450"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"describe":[2],"recurrent":[3,139],"keratoconjunctivitis":[4],"in":[5,33,45,53,92,138],"a":[6,103],"patient":[7,129],"with":[8,23,26,49,61,130,145],"X-linked":[9],"agammaglobulinemia":[10],"(XLA)":[11],"and":[12,30,43,64,88,117,124],"report":[13],"the":[14,34,46,54,93,146],"findings":[15],"of":[16,97],"microbiome":[17,112,156],"analysis.Case":[18],"summary:":[19],"A":[20],"15-year-old":[21],"male":[22],"XLA":[24],"presented":[25],"photophobia,":[27],"epiphora,":[28],"redness,":[29],"reduced":[31],"vision":[32],"right":[35,47,104],"eye.":[36,95],"Examination":[37],"revealed":[38],"corneal":[39,57,84],"infiltration,":[40],"neovascularization":[41],"(NV),":[42],"thinning":[44,89],"eye,":[48],"multiple":[50],"subepithelial":[51],"opacities":[52],"left.":[55],"The":[56],"lesions":[58],"improved":[59],"transiently":[60],"topical":[62,132],"corticosteroids":[63],"antibiotics":[65],"but":[66],"repeatedly":[67],"worsened":[68],"approximately":[69],"1":[70],"week":[71],"before":[72,150],"each":[73,151],"scheduled":[74,152],"monthly":[75],"intravenous":[76],"immunoglobulin":[77],"(IVIG)":[78],"infusion.":[79,154],"Approximately":[80],"23":[81],"months":[82],"later,":[83],"NV,":[85],"central":[86],"opacity,":[87],"also":[90,107],"developed":[91],"left":[94],"Cultures":[96],"both":[98],"conjunctivae":[99],"yielded":[100,108],"Haemophilus":[101],"influenzae;":[102],"eyelid":[105],"culture":[106],"Staphylococcus":[109,125],"epidermidis.":[110],"Conjunctival":[111,155],"analysis":[113,157],"confirmed":[114],"H.":[115],"influenzae":[116],"detected":[118,158],"additional":[119,159],"organisms\u2014Mycoplasma":[120],"amphoriforme,":[121],"Streptococcus":[122],"pneumoniae,":[123],"aureus.Conclusion:":[126],"In":[127],"this":[128],"XLA,":[131],"therapy":[133],"provided":[134],"only":[135],"transient":[136],"improvement":[137],"keratoconjunctivitis.":[140],"Exacerbations":[141],"were":[142],"temporally":[143],"associated":[144],"presumed":[147],"trough":[148],"period":[149],"IVIG":[153],"organisms":[160],"not":[161],"identified":[162],"by":[163],"bacterial":[164],"culture.":[165]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}
