{"id":"https://openalex.org/W7224230705","doi":"https://doi.org/10.64898/2026.10.28.762556","title":"Limited cross strain CMV protection by a bivalent (gB/pp65) vaccine is based on an impaired gB antibody response and evasion of pp65 cell mediated immunity","display_name":"Limited cross strain CMV protection by a bivalent (gB/pp65) vaccine is based on an impaired gB antibody response and evasion of pp65 cell mediated immunity","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224230705","doi":"https://doi.org/10.64898/2026.10.28.762556"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.28.762556","doi":"https://doi.org/10.64898/2026.10.28.762556","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762556","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762556.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762556.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160099481","display_name":"K.Yeon Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Yeon Choi","raw_affiliation_strings":["Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039797255","display_name":"Yushu Qin","orcid":"https://orcid.org/0000-0002-5198-4818","observed_orcids":["https://orcid.org/0000-0002-5198-4818"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yushu Qin","raw_affiliation_strings":["Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039258899","display_name":"Nadia S. El\u2010Hamdi","orcid":"https://orcid.org/0000-0001-9664-0763","observed_orcids":["https://orcid.org/0000-0001-9664-0763"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia El-Hamdi","raw_affiliation_strings":["Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090234467","display_name":"Alistair McGregor","orcid":"https://orcid.org/0000-0002-5994-516X","observed_orcids":["https://orcid.org/0000-0002-5994-516X"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alistair McGregor","raw_affiliation_strings":["Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5994-516X","affiliations":[{"raw_affiliation_string":"Department of Microbial Pathogenesis & Immunology, Texas A&M University, Health Science Center, College of Medicine, Bryan, Texas, United States of America","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090234467"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-cytomegalovirus-infection","display_name":"congenital cytomegalovirus infection","score":0.953000009059906},{"id":"https://openalex.org/keywords/guinea-pig-cytomegalovirus","display_name":"guinea pig cytomegalovirus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cmv-vaccine","display_name":"CMV vaccine","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cross-strain-protection","display_name":"cross-strain protection","score":0.9240000247955322},{"id":"https://openalex.org/keywords/gb-glycoprotein","display_name":"gB glycoprotein","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bivalent-vaccine","display_name":"bivalent vaccine","score":0.7490000128746033},{"id":"https://openalex.org/keywords/adenovirus-vectored-vaccine","display_name":"adenovirus vector vaccine","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.765999972820282},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.6579999923706055},{"id":"https://openalex.org/keywords/viremia","display_name":"viremia","score":0.6240000128746033},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.7329999804496765},{"id":"https://openalex.org/keywords/antigen-conservation","display_name":"antigen conservation","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8414999842643738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5753999948501587},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5471000075340271},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5145000219345093},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5080999732017517},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.4781999886035919},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.44179999828338623},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.43479999899864197},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4041000008583069},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.39910000562667847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37459999322891235},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.36010000109672546},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.35100001096725464},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.32100000977516174},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.2612000107765198},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.2587999999523163}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.28.762556","doi":"https://doi.org/10.64898/2026.10.28.762556","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762556","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762556.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.28.762556","doi":"https://doi.org/10.64898/2026.10.28.762556","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.28.762556","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/29/2026.10.28.762556.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224230705.pdf","grobid_xml":"https://content.openalex.org/works/W7224230705.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W750660743","https://openalex.org/W1539104055","https://openalex.org/W1785628209","https://openalex.org/W1879654670","https://openalex.org/W1889142680","https://openalex.org/W1973708619","https://openalex.org/W1974646273","https://openalex.org/W1984034888","https://openalex.org/W1996472983","https://openalex.org/W2014133189","https://openalex.org/W2020851142","https://openalex.org/W2026570165","https://openalex.org/W2033782922","https://openalex.org/W2041799491","https://openalex.org/W2045944192","https://openalex.org/W2074360461","https://openalex.org/W2082222365","https://openalex.org/W2091978710","https://openalex.org/W2092890929","https://openalex.org/W2096728165","https://openalex.org/W2103589467","https://openalex.org/W2108640614","https://openalex.org/W2138452771","https://openalex.org/W2142161841","https://openalex.org/W2156763025","https://openalex.org/W2159305020","https://openalex.org/W2159518657","https://openalex.org/W2164350818","https://openalex.org/W2166789299","https://openalex.org/W2168744744","https://openalex.org/W2262975933","https://openalex.org/W2295928395","https://openalex.org/W2320610464","https://openalex.org/W2434854000","https://openalex.org/W2463416845","https://openalex.org/W2471390345","https://openalex.org/W2519957152","https://openalex.org/W2539968206","https://openalex.org/W2616662114","https://openalex.org/W2666621883","https://openalex.org/W2787003107","https://openalex.org/W2802722509","https://openalex.org/W2904685881","https://openalex.org/W2971202011","https://openalex.org/W2975865261","https://openalex.org/W3002953431","https://openalex.org/W3003945836","https://openalex.org/W3010448212","https://openalex.org/W3044914269","https://openalex.org/W3071612139","https://openalex.org/W3113332877","https://openalex.org/W3133935348","https://openalex.org/W3136794850","https://openalex.org/W3137600830","https://openalex.org/W3174633785","https://openalex.org/W3183579907","https://openalex.org/W4224326384","https://openalex.org/W4280519877","https://openalex.org/W4282929837","https://openalex.org/W4293212219","https://openalex.org/W4320892455","https://openalex.org/W4383682505","https://openalex.org/W4391136077","https://openalex.org/W4391592984","https://openalex.org/W4399138394","https://openalex.org/W4402217464","https://openalex.org/W4402626990","https://openalex.org/W4410108917","https://openalex.org/W4415418985","https://openalex.org/W7134885137"],"related_works":["https://openalex.org/W4415418985","https://openalex.org/W3137600830","https://openalex.org/W3183579907","https://openalex.org/W3071612139","https://openalex.org/W4402626990","https://openalex.org/W4224326384","https://openalex.org/W3003945836","https://openalex.org/W4321607523","https://openalex.org/W3133935348","https://openalex.org/W2133080844"],"abstract_inverted_index":{"2.":[0],"Abstract":[1],"Congenital":[2],"CMV":[3,78],"(cCMV)":[4],"is":[5,20,33,66,95,110],"a":[6,18,21,73,77,89,111,141,169,211,248,276],"leading":[7],"cause":[8],"of":[9,76,92,264,286,298],"hearing":[10],"loss":[11],"and":[12,17,51,71,105,116,130,161,296],"cognitive":[13],"impairment":[14],"in":[15,184,196],"newborns":[16],"vaccine":[19,43,58,125,157,173,187,192,233,278],"high":[22],"priority.":[23],"The":[24,60],"guinea":[25,29],"pig":[26,30],"with":[27],"species-specific":[28],"cytomegalovirus":[31],"(GPCMV)":[32],"the":[34,155,185,232,245],"only":[35],"small":[36],"animal":[37],"model":[38],"for":[39,118,135],"cCMV.":[40],"Prior":[41],"GPCMV":[42,93,106,128,207,222,293],"studies":[44],"have":[45],"focused":[46],"on":[47],"prototype":[48,269],"strain":[49,91,223],"22122":[50,270],"not":[52],"evaluated":[53,134],"cross-strain":[54,101,136,281],"protection,":[55],"an":[56,67],"important":[57,117],"benchmark.":[59],"essential":[61],"viral":[62],"entry":[63],"gB":[64,81,99,129,163,172,290],"glycoprotein":[65],"immunodominant":[68],"antibody":[69,86,100,176],"target":[70,242],"considered":[72],"corner":[74],"stone":[75],"vaccine.":[79],"Trimeric":[80],"antigen":[82,115],"induces":[83],"potent":[84],"neutralizing":[85,198],"titers":[87,164],"but":[88],"clinical":[90,220],"(TAMYC)":[94],"highly":[96],"cell-associated":[97],"limiting":[98],"protection.":[102,137],"In":[103,210],"HCMV":[104],"tegument":[107],"protein":[108],"pp65":[109,131,149,259,265,288],"major":[112],"T":[113,255],"cell":[114,256],"convalescent":[119,206],"immunity.":[120],"A":[121],"defective":[122],"adenovirus":[123],"(Ad)":[124],"strategy":[126],"encoding":[127],"(AdgB+AdGP83)":[132],"was":[133,182],"Vaccinated":[138],"animals":[139,215],"induced":[140],"cell-mediated":[142],"response":[143,177,257],"via":[144],"IFN\u03b3":[145],"ELISPOT":[146],"assay":[147],"against":[148,219,258,292],"peptides":[150],"conserved":[151],"between":[152,300],"strains.":[153,301],"Additionally,":[154],"combined":[156,186],"produced":[158],"similar":[159,203],"anti-gB":[160],"prefusion":[162],"to":[165,178,189,204,227,235,241,268],"historical":[166,190],"sera":[167,193],"from":[168],"standalone":[170],"trimeric":[171],"(AdgB).":[174],"However,":[175,231],"gB(AD-1)":[179],"oligomerization":[180],"domain":[181],"impaired":[183],"compared":[188,226,267],"AdgB":[191],"which":[194],"resulted":[195],"reduced":[197],"titer":[199],"that":[200,275],"were":[201],"more":[202],"naturally":[205],"infected":[208],"animals.":[209],"pathogenicity":[212],"study,":[213],"vaccinated":[214],"had":[216],"partial":[217],"protection":[218,282],"TAMYC":[221,252],"challenge":[224],"(SQ)":[225],"non-vaccinated":[228],"control":[229],"group.":[230],"failed":[234],"prevent":[236],"viremia":[237],"or":[238,289],"virus":[239,253],"dissemination":[240],"organs,":[243],"including":[244],"salivary":[246],"glands,":[247],"notable":[249],"limitation.":[250],"Potentially,":[251],"evades":[254],"by":[260],"dramatically":[261],"reducing":[262],"levels":[263],"expression":[266],"strain.":[271],"Overall,":[272],"results":[273],"indicate":[274],"combination":[277],"offers":[279],"limited":[280],"despite":[283],"prior":[284],"success":[285],"separate":[287],"vaccines":[291],"(22122":[294],"strain)":[295],"conservation":[297],"antigens":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}