{"id":"https://openalex.org/W7224193380","doi":"https://doi.org/10.1136/bcr-2026-274132","title":"Amivantamab-associated capillary leak syndrome presenting with severe anasarca and profound hypoalbuminaemia in metastatic non-small cell lung cancer","display_name":"Amivantamab-associated capillary leak syndrome presenting with severe anasarca and profound hypoalbuminaemia in metastatic non-small cell lung cancer","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224193380","doi":"https://doi.org/10.1136/bcr-2026-274132","pmid":"https://pubmed.ncbi.nlm.nih.gov/42957346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723746"},"language":"en","primary_location":{"id":"doi:10.1136/bcr-2026-274132","doi":"https://doi.org/10.1136/bcr-2026-274132","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bcr-2026-274132","pdf_url":"https://casereports.bmj.com/content/bmjcr/19/10/e274132.full.pdf","source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://casereports.bmj.com/content/bmjcr/19/10/e274132.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012656609","display_name":"Carmi Bartal","orcid":"https://orcid.org/0000-0003-0894-5466","observed_orcids":["https://orcid.org/0000-0003-0894-5466"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Carmi Bartal","raw_affiliation_strings":["Internal Medicine Daycare, Ben-Gurion University of the Negev, Be\u2019er Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Daycare, Ben-Gurion University of the Negev, Be\u2019er Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081012352","display_name":"Julia Dudnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Julia Dudnik","raw_affiliation_strings":["Ben-Gurion University of the Negev, Be\u2019er Sheva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben-Gurion University of the Negev, Be\u2019er Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084479162","display_name":"Aya Biderman","orcid":"https://orcid.org/0000-0003-2186-6973","observed_orcids":["https://orcid.org/0000-0003-2186-6973"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aya Biderman","raw_affiliation_strings":["Family Medicine, Ben-Gurion University of the Negev, Be\u2019er Sheva, Israel"],"raw_orcid":"https://orcid.org/0000-0003-2186-6973","affiliations":[{"raw_affiliation_string":"Family Medicine, Ben-Gurion University of the Negev, Be\u2019er Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012656609"],"corresponding_institution_ids":["https://openalex.org/I124227911"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84513244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"10","first_page":"e274132","last_page":"e274132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amivantamab","display_name":"amivantamab","score":1.0},{"id":"https://openalex.org/keywords/capillary-leak","display_name":"capillary leak syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anasarca","display_name":"anasarca","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypoalbuminemia","display_name":"hypoalbuminemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/met-inhibition","display_name":"MET inhibition","score":0.3869999945163727},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9300000071525574},{"id":"https://openalex.org/keywords/intravenous-albumin","display_name":"intravenous albumin","score":0.7850000262260437},{"id":"https://openalex.org/keywords/loop-diuretics","display_name":"loop diuretics","score":0.9229999780654907},{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":0.9449999928474426},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2776548574","wikidata":"https://www.wikidata.org/wiki/Q486485","display_name":"Anasarca","level":2,"score":0.9156000018119812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8765000104904175},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4648999869823456},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.41819998621940613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39320001006126404},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3783999979496002},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.352400004863739},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C2780378346","wikidata":"https://www.wikidata.org/wiki/Q1349983","display_name":"Leak","level":2,"score":0.3422999978065491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3395000100135803},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.3391000032424927},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3151000142097473},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2948000133037567},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2615000009536743},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1136/bcr-2026-274132","doi":"https://doi.org/10.1136/bcr-2026-274132","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bcr-2026-274132","pdf_url":"https://casereports.bmj.com/content/bmjcr/19/10/e274132.full.pdf","source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723746","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723746/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723746/pdf/bcr-19-10.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Rep","raw_type":"Text"},{"id":"pmid:42957346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42957346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ case reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/bcr-2026-274132","doi":"https://doi.org/10.1136/bcr-2026-274132","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bcr-2026-274132","pdf_url":"https://casereports.bmj.com/content/bmjcr/19/10/e274132.full.pdf","source":{"id":"https://openalex.org/S141953298","display_name":"BMJ Case Reports","issn_l":"1757-790X","issn":["1757-790X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224193380.pdf","grobid_xml":"https://content.openalex.org/works/W7224193380.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1958537456","https://openalex.org/W2013720729","https://openalex.org/W2069421644","https://openalex.org/W2082825524","https://openalex.org/W2146240758","https://openalex.org/W2170278848","https://openalex.org/W2255518001","https://openalex.org/W2258611395","https://openalex.org/W2564926618","https://openalex.org/W2595489634","https://openalex.org/W2755030794","https://openalex.org/W2900042512","https://openalex.org/W2913429974","https://openalex.org/W2916784537","https://openalex.org/W2940782615","https://openalex.org/W2950686883","https://openalex.org/W3089450989","https://openalex.org/W3174421288","https://openalex.org/W4363651546"],"related_works":["https://openalex.org/W7224655215","https://openalex.org/W4414889198","https://openalex.org/W3018209496","https://openalex.org/W4402134627","https://openalex.org/W2751020214","https://openalex.org/W3162579173","https://openalex.org/W4413790187","https://openalex.org/W4226169170","https://openalex.org/W4387521749","https://openalex.org/W1981198111"],"abstract_inverted_index":{"Amivantamab,":[0],"a":[1,37,115,127],"bispecific":[2],"EGFR\u2013MET":[3],"(Epidermal":[4],"Growth":[5],"Factor-Mesenchymal-Epithelial":[6],"Transition":[7],"Factor)":[8],"antibody,":[9],"is":[10,21],"increasingly":[11],"used":[12],"in":[13,39,99],"advanced":[14],"non-small":[15],"cell":[16,80],"lung":[17],"cancer":[18],"(NSCLC)":[19],"and":[20,30,55,82,88,102,122],"associated":[22],"with":[23,43,90,95],"MET-related":[24],"adverse":[25],"events,":[26],"including":[27],"peripheral":[28],"oedema":[29],"hypoalbuminamia.":[31],"We":[32],"report":[33],"the":[34,60,124],"case":[35,113],"of":[36,63,86,118,126],"woman":[38],"her":[40],"early":[41],"70s":[42],"metastatic":[44],"EGFR-positive":[45],"NSCLC":[46],"who":[47],"developed":[48],"rapidly":[49],"progressive":[50],"anasarca,":[51],"acute":[52],"kidney":[53],"injury":[54],"profound":[56],"hypoalbuminaemia":[57],"immediately":[58],"after":[59],"first":[61],"dose":[62],"amivantamab.":[64],"Extensive":[65],"evaluation":[66],"excluded":[67],"cardiac":[68],"failure,":[69],"nephrotic":[70],"syndrome,":[71],"hepatic":[72],"disease,":[73,78],"protein-losing":[74],"enteropathy,":[75],"infection,":[76],"autoimmune":[77],"plasma":[79],"dyscrasia":[81],"tumour":[83],"progression.":[84],"Discontinuation":[85],"amivantamab":[87],"treatment":[89],"scheduled":[91],"intravenous":[92],"albumin":[93],"combined":[94],"loop":[96],"diuretics":[97],"resulted":[98],"complete":[100],"clinical":[101],"biochemical":[103],"recovery,":[104],"sustained":[105],"at":[106],"6-month":[107],"follow-up":[108],"while":[109],"continuing":[110],"osimertinib.":[111],"This":[112],"represents":[114],"severe":[116],"manifestation":[117],"amivantamab-associated":[119],"fluid":[120],"retention":[121],"supports":[123],"recognition":[125],"drug-induced":[128],"capillary":[129],"leak":[130],"phenotype.":[131]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-30T00:00:00"}
