{"id":"https://openalex.org/W7224165504","doi":"https://doi.org/10.1172/jci201732","title":"Mutant ASXL1 exacerbates CALR-mutant myeloproliferative neoplasms by enhancing a distinct megakaryocyte differentiation program","display_name":"Mutant ASXL1 exacerbates CALR-mutant myeloproliferative neoplasms by enhancing a distinct megakaryocyte differentiation program","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224165504","doi":"https://doi.org/10.1172/jci201732","pmid":"https://pubmed.ncbi.nlm.nih.gov/42955084"},"language":"en","primary_location":{"id":"doi:10.1172/jci201732","doi":"https://doi.org/10.1172/jci201732","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci201732","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1172/jci201732","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024608118","display_name":"F. Kramer","orcid":"https://orcid.org/0000-0002-7615-9291","observed_orcids":["https://orcid.org/0000-0002-7615-9291"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederike Kramer","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115797279","display_name":"Merle Riedemann","orcid":"https://orcid.org/0009-0004-5457-7451","observed_orcids":["https://orcid.org/0009-0004-5457-7451"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merle Riedemann","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065897512","display_name":"Tsega\u2010Ab Abera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsega-Ab Abera","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States of America","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009344303","display_name":"Jessica W. Hem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Hem","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160120026","display_name":"Adela Herce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adela Herce","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010108878","display_name":"Anna E. Marneth","orcid":"https://orcid.org/0000-0001-9065-0581","observed_orcids":["https://orcid.org/0000-0001-9065-0581"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna E. Marneth","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060801158","display_name":"Benjamin Rolles","orcid":"https://orcid.org/0000-0002-7393-861X","observed_orcids":["https://orcid.org/0000-0002-7393-861X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Rolles","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000576503","display_name":"Maximilian Englert","orcid":"https://orcid.org/0000-0002-9066-5801","observed_orcids":["https://orcid.org/0000-0002-9066-5801"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maximilian Englert","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037895248","display_name":"Christian Hackenbroch","orcid":"https://orcid.org/0000-0003-4148-5035","observed_orcids":["https://orcid.org/0000-0003-4148-5035"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Hackenbroch","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103085165","display_name":"Mifra Faiz","orcid":"https://orcid.org/0000-0001-8681-6286","observed_orcids":["https://orcid.org/0000-0001-8681-6286"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mifra Faiz","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010743762","display_name":"Malvina Papanastasiou","orcid":"https://orcid.org/0000-0003-3378-6612","observed_orcids":["https://orcid.org/0000-0003-3378-6612"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malvina Papanastasiou","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, Cambridge, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3378-6612","affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014670331","display_name":"Andrew H. Reiter","orcid":"https://orcid.org/0000-0003-1406-4913","observed_orcids":["https://orcid.org/0000-0003-1406-4913"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew H. Reiter","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, Cambridge, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036255260","display_name":"Steven A. Carr","orcid":"https://orcid.org/0000-0002-7203-4299","observed_orcids":["https://orcid.org/0000-0002-7203-4299"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Carr","raw_affiliation_strings":["The Broad Institute of MIT and Harvard, Cambridge, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7203-4299","affiliations":[{"raw_affiliation_string":"The Broad Institute of MIT and Harvard, Cambridge, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385054","display_name":"Rong Li","orcid":"https://orcid.org/0000-0002-6476-1015","observed_orcids":["https://orcid.org/0000-0002-6476-1015"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Li","raw_affiliation_strings":["Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041427080","display_name":"Xintao Qiu","orcid":"https://orcid.org/0000-0002-8560-7017","observed_orcids":["https://orcid.org/0000-0002-8560-7017"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xintao Qiu","raw_affiliation_strings":["Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8560-7017","affiliations":[{"raw_affiliation_string":"Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160140154","display_name":"Gabriela S. Hobbs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela S. Hobbs","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037028914","display_name":"Raghda Fouda","orcid":"https://orcid.org/0000-0001-6436-6093","observed_orcids":["https://orcid.org/0000-0001-6436-6093"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghda Fouda","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110632576","display_name":"Olga Pozdnyakova","orcid":"https://orcid.org/0000-0003-3529-5622","observed_orcids":["https://orcid.org/0000-0003-3529-5622"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Pozdnyakova","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100904193","display_name":"Masashi Miyauchi","orcid":"https://orcid.org/0000-0002-6301-3429","observed_orcids":["https://orcid.org/0000-0002-6301-3429"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Miyauchi","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103048248","display_name":"Anna S. Nam","orcid":"https://orcid.org/0000-0003-4192-8916","observed_orcids":["https://orcid.org/0000-0003-4192-8916"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna S. Nam","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States of America","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015102296","display_name":"Ann Mullally","orcid":"https://orcid.org/0000-0001-9727-8495","observed_orcids":["https://orcid.org/0000-0001-9727-8495"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Mullally","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, United States of America","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84752361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asxl1-mutation","display_name":"ASXL1 mutation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/calr-mutation","display_name":"CALR mutation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9900000095367432},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mef2c","display_name":"MEF2C","score":0.8610000014305115},{"id":"https://openalex.org/keywords/emperipolesis","display_name":"emperipolesis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/thrombocytosis","display_name":"thrombocytosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.8931000232696533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7376000285148621},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7080000042915344},{"id":"https://openalex.org/C2910274570","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative Disorders","level":2,"score":0.607200026512146},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.604200005531311},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5615000128746033},{"id":"https://openalex.org/C2778193527","wikidata":"https://www.wikidata.org/wiki/Q15320451","display_name":"RUNX1","level":4,"score":0.5109999775886536},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.49230000376701355},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.4643000066280365},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45489999651908875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4480000138282776},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4438000023365021},{"id":"https://openalex.org/C2779310769","wikidata":"https://www.wikidata.org/wiki/Q6553374","display_name":"Lineage markers","level":4,"score":0.4438000023365021},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.42570000886917114},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.3896999955177307},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.38580000400543213},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3785000145435333},{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.3774000108242035},{"id":"https://openalex.org/C2777918643","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocytopoiesis","level":5,"score":0.36880001425743103},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.3483999967575073},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3434000015258789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3400999903678894},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32519999146461487},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.3165000081062317},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.31540000438690186},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2842999994754791},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.2768000066280365},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C12652872","wikidata":"https://www.wikidata.org/wiki/Q18027997","display_name":"IRF4","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.2567000091075897}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1172/jci201732","doi":"https://doi.org/10.1172/jci201732","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci201732","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:42955084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42955084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci201732","doi":"https://doi.org/10.1172/jci201732","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci201732","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970390241","https://openalex.org/W3036358648","https://openalex.org/W4310163247","https://openalex.org/W4406138755","https://openalex.org/W2787661059","https://openalex.org/W4293105207","https://openalex.org/W3205701792","https://openalex.org/W4283379642","https://openalex.org/W3003967832","https://openalex.org/W4293226288"],"abstract_inverted_index":{"ASXL1":[0],"mutations":[1],"confer":[2],"a":[3,50,85],"poor":[4],"prognosis":[5],"in":[6,10,64,125,129,164],"myeloid":[7],"neoplasms,":[8],"including":[9],"CALR-mutated":[11],"myeloproliferative":[12],"neoplasms":[13],"(MPN).":[14],"We":[15],"generated":[16],"Calr-Asxl1":[17,33,65,94,108],"co-mutant":[18,34,66,95,109,127,143],"mice":[19],"and":[20,25,41,149],"found":[21,81],"more":[22,37,62,159],"severe":[23,160],"thrombocytosis":[24],"increased":[26],"splenomegaly,":[27],"compared":[28],"with":[29,48],"Calr":[30],"single-mutant":[31],"animals.":[32],"megakaryocytes":[35,55,96],"displayed":[36,97],"pronounced":[38],"morphological":[39],"abnormalities":[40],"enhanced":[42,99,139],"emperipolesis":[43],"characteristic":[44],"of":[45,83,89,107,113,116,141,153],"inflammation.":[46],"Concordant":[47],"this,":[49],"differentiation":[51,123,148],"trajectory":[52],"directly":[53,75],"to":[54,145],"from":[56],"hematopoietic":[57],"stem":[58],"cells":[59],"(HSC)":[60],"was":[61,111],"prominent":[63],"mice.":[67],"In":[68],"this":[69],"non-canonical":[70],"trajectory,":[71],"where":[72],"megakaryocyte-biased":[73],"HSCs":[74,110,128],"differentiate":[76],"into":[77],"megakaryocyte":[78,90,147],"progenitors,":[79],"we":[80],"upregulation":[82],"Mef2c,":[84],"key":[86],"transcriptional":[87,101,105],"regulator":[88],"lineage":[91],"commitment.":[92],"Mature":[93],"an":[98,120],"proinflammatory":[100],"state,":[102],"whereas":[103],"the":[104,138,154,158],"signature":[106],"indicative":[112],"inflammation-resistance.":[114],"Genotyping":[115],"transcriptomes":[117],"(GoT)":[118],"confirmed":[119],"activated":[121],"megakaryocytic":[122],"program":[124],"CALR-ASXL1":[126,142],"primary":[130],"human":[131],"MPN":[132,144,161],"bone":[133],"marrow.":[134],"These":[135],"findings":[136],"link":[137],"severity":[140],"altered":[146],"help":[150],"explain":[151],"some":[152],"biological":[155],"basis":[156],"for":[157],"phenotype":[162],"observed":[163],"patients.":[165]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}