{"id":"https://openalex.org/W7224155263","doi":"https://doi.org/10.1111/jdi.70481","title":"The clock\u2010output gene DBP regulates muscle insulin sensitivity and its fluctuations","display_name":"The clock\u2010output gene DBP regulates muscle insulin sensitivity and its fluctuations","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224155263","doi":"https://doi.org/10.1111/jdi.70481","pmid":"https://pubmed.ncbi.nlm.nih.gov/42952331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13717317"},"language":"en","primary_location":{"id":"doi:10.1111/jdi.70481","doi":"https://doi.org/10.1111/jdi.70481","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdi.70481","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.70481","source":{"id":"https://openalex.org/S107365432","display_name":"Journal of Diabetes Investigation","issn_l":"2040-1116","issn":["2040-1116","2040-1124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310322041","host_organization_name":"Asian Association for the Study of Diabetes","host_organization_lineage":["https://openalex.org/P4310322041"],"host_organization_lineage_names":["Asian Association for the Study of Diabetes"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.70481","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093220300","display_name":"Chika Yodokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chika Yodokawa","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027513518","display_name":"Yasuko Kajimura","orcid":"https://orcid.org/0000-0002-0819-6904","observed_orcids":["https://orcid.org/0000-0002-0819-6904"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuko Kajimura","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063056494","display_name":"Akihiko Taguchi","orcid":"https://orcid.org/0000-0001-8544-5698","observed_orcids":["https://orcid.org/0000-0001-8544-5698"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Taguchi","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":"https://orcid.org/0000-0001-8544-5698","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054252428","display_name":"Syunsuke Hiroshige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Syunsuke Hiroshige","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063252374","display_name":"Yuko Nagao","orcid":"https://orcid.org/0009-0000-8771-2243","observed_orcids":["https://orcid.org/0009-0000-8771-2243"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Nagao","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100905428","display_name":"Masaru Akiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Akiyama","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115888748","display_name":"Takuma Yodokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuma Yodokawa","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086553284","display_name":"Konosuke Masuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Konosuke Masuda","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160093074","display_name":"Hajime Mikami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Mikami","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014105657","display_name":"Yukio Tanizawa","orcid":"https://orcid.org/0000-0002-4742-8245","observed_orcids":["https://orcid.org/0000-0002-4742-8245"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Tanizawa","raw_affiliation_strings":["Yamaguchi University  Yamaguchi City Japan"],"raw_orcid":"https://orcid.org/0000-0002-4742-8245","affiliations":[{"raw_affiliation_string":"Yamaguchi University  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102947863","display_name":"Yasuharu Ohta","orcid":"https://orcid.org/0000-0002-9117-6874","observed_orcids":["https://orcid.org/0000-0002-9117-6874"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuharu Ohta","raw_affiliation_strings":["Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan"],"raw_orcid":"https://orcid.org/0000-0002-9117-6874","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio\u2010Signal Analysis Yamaguchi University, Graduate School of Medicine  Yamaguchi City Japan","institution_ids":["https://openalex.org/I173915773"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102947863"],"corresponding_institution_ids":["https://openalex.org/I173915773"],"apc_list":{"value":3850,"currency":"USD","value_usd":3850},"apc_paid":{"value":3850,"currency":"USD","value_usd":3850},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78897168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dbp","display_name":"DBP","score":0.7559999823570251},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9520000219345093},{"id":"https://openalex.org/keywords/skeletal-muscle-insulin-sensitivity","display_name":"skeletal muscle insulin sensitivity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/insulin-tolerance","display_name":"insulin tolerance","score":0.527999997138977},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6340000033378601},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hepatic-insulin-sensitivity","display_name":"hepatic insulin sensitivity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/circadian-oscillations","display_name":"circadian oscillations","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8909000158309937},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8758999705314636},{"id":"https://openalex.org/C21786239","wikidata":"https://www.wikidata.org/wiki/Q185962","display_name":"Zeitgeber","level":4,"score":0.7696999907493591},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6247000098228455},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5932999849319458},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5608000159263611},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4943999946117401},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4839000105857849},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.46869999170303345},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4571000039577484},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4323999881744385},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4251999855041504},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.3946000039577484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.357699990272522},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.3395000100135803},{"id":"https://openalex.org/C2779772378","wikidata":"https://www.wikidata.org/wiki/Q6953452","display_name":"NEFA","level":3,"score":0.3312999904155731},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.33070001006126404},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3212999999523163},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.31769999861717224},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.30160000920295715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2980000078678131},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.27390000224113464},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C144855686","wikidata":"https://www.wikidata.org/wiki/Q6042245","display_name":"Insulin oscillation","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1111/jdi.70481","doi":"https://doi.org/10.1111/jdi.70481","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdi.70481","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.70481","source":{"id":"https://openalex.org/S107365432","display_name":"Journal of Diabetes Investigation","issn_l":"2040-1116","issn":["2040-1116","2040-1124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310322041","host_organization_name":"Asian Association for the Study of Diabetes","host_organization_lineage":["https://openalex.org/P4310322041"],"host_organization_lineage_names":["Asian Association for the Study of Diabetes"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13717317","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717317/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717317/pdf/JDI-9999-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Diabetes Investig","raw_type":"Text"},{"id":"pmid:42952331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42952331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of diabetes investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jdi.70481","doi":"https://doi.org/10.1111/jdi.70481","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdi.70481","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.70481","source":{"id":"https://openalex.org/S107365432","display_name":"Journal of Diabetes Investigation","issn_l":"2040-1116","issn":["2040-1116","2040-1124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310322041","host_organization_name":"Asian Association for the Study of Diabetes","host_organization_lineage":["https://openalex.org/P4310322041"],"host_organization_lineage_names":["Asian Association for the Study of Diabetes"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6607151010","display_name":"Regulation of glucose and lipid metabolism by the clock gene DBP via muscle insulin sensitivity","funder_award_id":"22K08626","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320325269","display_name":"Japan Diabetes Society","ror":"https://ror.org/05mhc7495"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224155263.pdf","grobid_xml":"https://content.openalex.org/works/W7224155263.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1964634897","https://openalex.org/W1973794425","https://openalex.org/W2009415249","https://openalex.org/W2011593647","https://openalex.org/W2056229820","https://openalex.org/W2091912666","https://openalex.org/W2108235045","https://openalex.org/W2113336371","https://openalex.org/W2135531598","https://openalex.org/W2147712103","https://openalex.org/W2157481078","https://openalex.org/W2161635288","https://openalex.org/W2162650381","https://openalex.org/W2165273254","https://openalex.org/W2171313404","https://openalex.org/W2319744098","https://openalex.org/W2333878333","https://openalex.org/W2530200176","https://openalex.org/W2598409364","https://openalex.org/W2613605621","https://openalex.org/W2742557263","https://openalex.org/W2793581639","https://openalex.org/W2889056797","https://openalex.org/W2969433956","https://openalex.org/W2986664957","https://openalex.org/W3017111020","https://openalex.org/W3109303974","https://openalex.org/W3120209268","https://openalex.org/W3205987381","https://openalex.org/W4224053800","https://openalex.org/W4323914102","https://openalex.org/W4376598348","https://openalex.org/W4379054460","https://openalex.org/W4396574390","https://openalex.org/W4403142046","https://openalex.org/W7073787924"],"related_works":["https://openalex.org/W4411292020","https://openalex.org/W4417315892","https://openalex.org/W1964634897","https://openalex.org/W2319744098","https://openalex.org/W2889056797","https://openalex.org/W837855123","https://openalex.org/W2333878333","https://openalex.org/W2895746148","https://openalex.org/W2268957452","https://openalex.org/W1986930741"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Circadian":[1],"rhythm":[2],"disruption":[3],"is":[4,24],"associated":[5],"with":[6,210],"metabolic":[7],"disorders,":[8],"yet":[9],"the":[10,31,98,129,153,171,186,214],"role":[11,44,240],"of":[12,226,244],"clock":[13,26],"genes":[14],"in":[15,45,63,106,117,131,138,147,157,174,241],"glucose":[16,46,142],"metabolism":[17],"remains":[18],"unclear.":[19],"D-box":[20],"binding":[21],"protein":[22],"(DBP)":[23],"a":[25,211,239],"output":[27],"gene":[28],"that":[29,122,220],"activates":[30],"D-box,":[32],"and":[33,72,78,87,144,182,196,234],"we":[34,82],"used":[35],"systemic":[36,124],"Dbp":[37],"knockout":[38],"(KO)":[39],"mice":[40,66,159],"to":[41,111],"investigate":[42],"DBP's":[43],"metabolism.":[47],"METHODS:":[48],"We":[49],"generated":[50],"two":[51],"independent":[52],"KO":[53,99,139,158,175],"mouse":[54],"lines.":[55],"Intraperitoneal":[56],"insulin":[57,80,102,125,207,228,246],"tolerance":[58],"tests":[59],"(IPITTs)":[60],"were":[61,155,168],"performed":[62],"13-week-old":[64],"male":[65],"at":[67,160],"zeitgeber":[68],"time":[69],"(ZT)":[70],"1":[71],"ZT":[73],"13.":[74],"To":[75],"assess":[76],"hepatic":[77],"muscle":[79,149,227,245],"sensitivity,":[81,229],"examined":[83],"2-deoxy-D-glucose":[84],"(2DG)":[85],"content":[86],"AKT":[88,145],"phosphorylation":[89,146],"followed":[90],"by":[91],"transcriptome":[92,178],"analysis":[93,179],"using":[94],"muscle.":[95],"RESULTS:":[96],"In":[97],"mice,":[100,114,133],"enhanced":[101],"sensitivity":[103,126,208],"was":[104],"observed":[105,156],"ZT1":[107],"following":[108],"IPITT":[109],"compared":[110],"wild-type":[112],"(WT)":[113],"but":[115,151],"not":[116,136,152],"ZT13.":[118],"These":[119],"findings":[120],"indicate":[121],"while":[123],"fluctuates":[127],"throughout":[128],"day":[130],"WT":[132],"it":[134],"does":[135],"fluctuate":[137],"mice.":[140,176],"Increased":[141],"uptake":[143],"gastrocnemius":[148],"(GM),":[150],"liver,":[154],"ZT1.":[161],"Plasma":[162],"nonesterified":[163],"fatty":[164],"acid":[165],"(NEFA)":[166],"levels":[167],"reduced":[169],"during":[170,213],"inactive":[172,215],"phase":[173],"Muscle":[177,206],"identified":[180],"chemokine":[181,192,200],"cytokine-related":[183],"pathways":[184],"as":[185],"most":[187],"enriched,":[188],"including":[189],"C-C":[190,199],"motif":[191],"ligand":[193],"5":[194,203],"(CCL5)":[195],"its":[197],"receptor":[198,201],"type":[202],"(CCR5).":[204],"CONCLUSION:":[205],"oscillates,":[209],"reduction":[212],"phase.":[216],"This":[217],"study":[218],"demonstrates":[219],"DBP":[221,237],"deficiency":[222],"suppresses":[223],"circadian":[224,242],"fluctuations":[225],"likely":[230],"via":[231],"plasma":[232],"NEFA":[233],"CCL5-CCR5":[235],"signaling.":[236],"plays":[238],"regulation":[243],"sensitivity.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-30T00:00:00"}
