{"id":"https://openalex.org/W7224153389","doi":"https://doi.org/10.1155/anrp/9114246","title":"VAMP5 Mediates Sevoflurane\u2010Induced Immune Modulation in Cervical Cancer: A Clinical Translational Study","display_name":"VAMP5 Mediates Sevoflurane\u2010Induced Immune Modulation in Cervical Cancer: A Clinical Translational Study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7224153389","doi":"https://doi.org/10.1155/anrp/9114246","pmid":"https://pubmed.ncbi.nlm.nih.gov/42959507","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13717480"},"language":"en","primary_location":{"id":"doi:10.1155/anrp/9114246","doi":"https://doi.org/10.1155/anrp/9114246","is_oa":true,"landing_page_url":"https://doi.org/10.1155/anrp/9114246","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/anrp/9114246","source":{"id":"https://openalex.org/S159396029","display_name":"Anesthesiology Research and Practice","issn_l":"1687-6962","issn":["1687-6962","1687-6970"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology Research and Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/anrp/9114246","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034744448","display_name":"Zengzhen Zhang","orcid":"https://orcid.org/0009-0001-7026-0137","observed_orcids":["https://orcid.org/0009-0001-7026-0137"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zengzhen Zhang","raw_affiliation_strings":["Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn"],"raw_orcid":"https://orcid.org/0009-0001-7026-0137","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134729567","display_name":"Xianning Dong","orcid":"https://orcid.org/0000-0001-9479-4574","observed_orcids":["https://orcid.org/0000-0001-9479-4574"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianning Dong","raw_affiliation_strings":["Department of Pathology The Affiliated Hospital of Qingdao University  Qingdao 266061 China  qdu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology The Affiliated Hospital of Qingdao University  Qingdao 266061 China  qdu.edu.cn","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128231287","display_name":"Tingting Yu","orcid":"https://orcid.org/0009-0004-9948-3301","observed_orcids":["https://orcid.org/0009-0004-9948-3301"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Yu","raw_affiliation_strings":["Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160132612","display_name":"Huiqing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiqing Li","raw_affiliation_strings":["Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160126350","display_name":"Xinyu Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Yuan","raw_affiliation_strings":["Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology Shandong Provincial Third Hospital Shandong University  Jinan Shandong 250031 China  sdu.edu.cn","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034744448"],"corresponding_institution_ids":["https://openalex.org/I154099455"],"apc_list":{"value":1100,"currency":"USD","value_usd":1100},"apc_paid":{"value":1100,"currency":"USD","value_usd":1100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76259361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"1","first_page":"9114246","last_page":"9114246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/laparoscopic-radical-hysterectomy","display_name":"laparoscopic radical hysterectomy","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tak1","display_name":"TAK1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/propofol-anesthesia","display_name":"propofol anesthesia","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-immune-infiltration","display_name":"tumor immune infiltration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/anesthetic-choice","display_name":"anesthetic choice","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lymphocyte-subsets","display_name":"lymphocyte subsets","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.8206999897956848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7911999821662903},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7890999913215637},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.7008000016212463},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6305999755859375},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.618399977684021},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.5264000296592712},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4927999973297119},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.4652999937534332},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.44110000133514404},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3930000066757202},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3919000029563904},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.38359999656677246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3684000074863434},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.313400000333786},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C2779494336","wikidata":"https://www.wikidata.org/wiki/Q550675","display_name":"Hysterectomy","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.28790000081062317},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26820001006126404},{"id":"https://openalex.org/C2775961468","wikidata":"https://www.wikidata.org/wiki/Q7487374","display_name":"Sham surgery","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1155/anrp/9114246","doi":"https://doi.org/10.1155/anrp/9114246","is_oa":true,"landing_page_url":"https://doi.org/10.1155/anrp/9114246","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/anrp/9114246","source":{"id":"https://openalex.org/S159396029","display_name":"Anesthesiology Research and Practice","issn_l":"1687-6962","issn":["1687-6962","1687-6970"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology Research and Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13717480","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717480/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717480/pdf/ANRP-2026-9114246.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiol Res Pract","raw_type":"Text"},{"id":"pmid:42959507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42959507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology research and practice","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1155/anrp/9114246","doi":"https://doi.org/10.1155/anrp/9114246","is_oa":true,"landing_page_url":"https://doi.org/10.1155/anrp/9114246","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/anrp/9114246","source":{"id":"https://openalex.org/S159396029","display_name":"Anesthesiology Research and Practice","issn_l":"1687-6962","issn":["1687-6962","1687-6970"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320330403","display_name":"Medical and Health Science and Technology Development Project of Shandong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224153389.pdf","grobid_xml":"https://content.openalex.org/works/W7224153389.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W3130707976","https://openalex.org/W3196334591","https://openalex.org/W3199339713","https://openalex.org/W4205344268","https://openalex.org/W4286515291","https://openalex.org/W4309364270","https://openalex.org/W4313649247","https://openalex.org/W4386705865","https://openalex.org/W4388000623","https://openalex.org/W4389345543","https://openalex.org/W4389348389","https://openalex.org/W4389794914","https://openalex.org/W4391175978","https://openalex.org/W4392299443","https://openalex.org/W4405330830","https://openalex.org/W4409999786","https://openalex.org/W4412070932"],"related_works":["https://openalex.org/W2560406934","https://openalex.org/W3197413956","https://openalex.org/W2885961364","https://openalex.org/W4294990754","https://openalex.org/W4291000566","https://openalex.org/W7119694875","https://openalex.org/W7164035594","https://openalex.org/W2884655205","https://openalex.org/W2408799953","https://openalex.org/W3203721638"],"abstract_inverted_index":{"Background":[0],"Sevoflurane,":[1],"a":[2,63,72,230],"commonly":[3],"used":[4],"inhaled":[5],"anesthetic,":[6],"has":[7],"been":[8],"implicated":[9],"in":[10,37,71,180],"modulating":[11],"tumor":[12,148,174],"biology":[13],"and":[14,46,92,125,147,153,176,188,209,237],"perioperative":[15,105,245],"immune":[16,149,177,238,246],"responses,":[17],"yet":[18],"the":[19,49,166],"underlying":[20],"molecular":[21,232],"mechanisms":[22],"remain":[23],"poorly":[24],"understood.":[25],"This":[26,225],"study":[27,226],"aims":[28],"to":[29,47,67,141,165,258],"investigate":[30],"whether":[31],"sevoflurane":[32,90,242],"regulates":[33],"key":[34],"immune\u2010related":[35],"genes":[36,70,113,146],"cervical":[38,79,181],"cancer":[39,80],"patients":[40,81],"undergoing":[41,82],"laparoscopic":[42],"radical":[43],"hysterectomy":[44],"(LRH)":[45],"explore":[48],"clinical":[50,73],"relevance":[51],"of":[52,77,111,202],"such":[53,216],"regulation.":[54],"Methods":[55],"Based":[56],"on":[57],"prior":[58],"RNA\u2010seq":[59],"screening,":[60],"we":[61],"established":[62],"two\u2010step":[64],"validation":[65],"framework":[66],"identify":[68,227],"sevoflurane\u2010regulated":[69],"cohort.":[74],"A":[75],"total":[76],"116":[78],"LRH":[83],"were":[84,101,114,120,136,155],"enrolled,":[85],"including":[86],"70":[87],"who":[88,94],"received":[89,95],"anesthesia":[91,256],"46":[93],"propofol":[96,167],"anesthesia.":[97],"Peripheral":[98],"blood":[99],"samples":[100],"collected":[102],"at":[103,207],"five":[104],"time":[106],"points.":[107],"mRNA":[108],"expression":[109,128,170,197],"levels":[110],"candidate":[112,145],"measured":[115],"by":[116,122,131],"qRT\u2010PCR,":[117],"lymphocyte":[118,222],"subsets":[119],"analyzed":[121],"flow":[123],"cytometry,":[124],"VAMP5":[126,154,169,196,228],"protein":[127],"was":[129,218],"assessed":[130],"intracellular":[132],"staining.":[133],"Bioinformatics":[134],"analyses":[135],"performed":[137],"using":[138],"TCGA":[139],"data":[140],"evaluate":[142],"associations":[143],"between":[144,234],"infiltration.":[150],"Results":[151],"MAP3K7":[152],"validated":[156],"as":[157,229],"sevoflurane\u2010downregulated":[158],"targets,":[159],"showing":[160],"sustained":[161],"suppression":[162],"postoperatively":[163],"compared":[164],"group.":[168],"correlated":[171],"significantly":[172],"with":[173,194,251],"progression":[175],"cell":[178],"infiltration":[179],"cancer,":[182],"particularly":[183],"CD8":[184,203],"+":[185,204],"T\u2010cells,":[186],"B\u2010cells,":[187],"macrophages.":[189],"Among":[190],"sevoflurane\u2010treated":[191],"patients,":[192],"those":[193],"lower":[195],"exhibited":[198],"delayed":[199],"postoperative":[200],"recovery":[201,247],"T\u2010cell":[205],"counts":[206],"48":[208],"72":[210],"h":[211],"after":[212],"surgery,":[213],"whereas":[214],"no":[215],"difference":[217],"observed":[219],"for":[220,254],"other":[221],"subsets.":[223],"Conclusions":[224],"novel":[231],"link":[233],"anesthetic":[235],"choice":[236],"modulation,":[239],"suggesting":[240],"that":[241],"may":[243],"influence":[244],"through":[248],"vesicle\u2010associated":[249],"mechanisms,":[250],"potential":[252],"implications":[253],"optimizing":[255],"strategies":[257],"improve":[259],"oncologic":[260],"outcomes.":[261]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-30T00:00:00"}