{"id":"https://openalex.org/W7224137370","doi":"https://doi.org/10.1021/acsabm.6c01464","title":"pH-Responsive Dopamine-Grafted Polysaccharide Hydrogel with Enhanced Antibacterial and Hemostatic Properties","display_name":"pH-Responsive Dopamine-Grafted Polysaccharide Hydrogel with Enhanced Antibacterial and Hemostatic Properties","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224137370","doi":"https://doi.org/10.1021/acsabm.6c01464","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949054"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.6c01464","doi":"https://doi.org/10.1021/acsabm.6c01464","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.6c01464","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132991990","display_name":"Zhiyuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyuan Zhang","raw_affiliation_strings":["Qingdao University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University , , , ,","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160041679","display_name":"Jia Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Liu","raw_affiliation_strings":["Qingdao University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University , , , ,","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027339637","display_name":"Xiuling Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuling Hou","raw_affiliation_strings":["Qingdao University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University , , , ,","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160010466","display_name":"Haotian Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haotian Ma","raw_affiliation_strings":["Qingdao University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University , , , ,","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160027929","display_name":"Shaojuan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I44468530","display_name":"Qingdao University of Technology","ror":"https://ror.org/01qzc0f54","country_code":"CN","type":"education","lineage":["https://openalex.org/I44468530"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaojuan Chen","raw_affiliation_strings":["Qingdao University , , , ,","Qingdao University of Technology , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao University , , , ,","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"Qingdao University of Technology , , ,","institution_ids":["https://openalex.org/I44468530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025498731","display_name":"Fang Qun Zhou","orcid":"https://orcid.org/0000-0002-0924-5173","observed_orcids":["https://orcid.org/0000-0002-0924-5173"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fang Zhou","raw_affiliation_strings":["Qingdao University , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-0924-5173","affiliations":[{"raw_affiliation_string":"Qingdao University , , , ,","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025498731","https://openalex.org/A5160027929"],"corresponding_institution_ids":["https://openalex.org/I108688024","https://openalex.org/I44468530"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66678233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensitive-hydrogels","display_name":"pH-responsive hydrogels","score":0.9120000004768372},{"id":"https://openalex.org/keywords/carboxymethyl-chitosan","display_name":"carboxymethyl chitosan","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxidized-hyaluronic-acid","display_name":"oxidized hyaluronic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/schiff-base-cross-linking","display_name":"Schiff base crosslinking","score":0.996999979019165},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antibacterial-hydrogel","display_name":"antibacterial hydrogel","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tissue-adhesion","display_name":"tissue adhesion","score":0.6840000152587891},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-release","display_name":"stimuli-responsive drug release","score":0.796999990940094},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.621999979019165},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9129999876022339},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9240000247955322},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8208000063896179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7059000134468079},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.638700008392334},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.6169999837875366},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5929999947547913},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.49470001459121704},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.4878000020980835},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.47609999775886536},{"id":"https://openalex.org/C2910835652","wikidata":"https://www.wikidata.org/wiki/Q1642182","display_name":"Hemostatic Agent","level":3,"score":0.45989999175071716},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.3873000144958496},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.3727000057697296},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.34929999709129333},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.3422999978065491},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3224000036716461},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.31709998846054077},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.29919999837875366},{"id":"https://openalex.org/C2909810335","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostatics","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.2581000030040741}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsabm.6c01464","doi":"https://doi.org/10.1021/acsabm.6c01464","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.6c01464","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:42949054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2022850833","https://openalex.org/W2521337837","https://openalex.org/W2916903224","https://openalex.org/W2940007259","https://openalex.org/W2950151274","https://openalex.org/W2955661759","https://openalex.org/W3013068665","https://openalex.org/W3049094321","https://openalex.org/W4206321479","https://openalex.org/W4221118584","https://openalex.org/W4283016507","https://openalex.org/W4306167676","https://openalex.org/W4319316798","https://openalex.org/W4324335398","https://openalex.org/W4360953632","https://openalex.org/W4385281019","https://openalex.org/W4389914516","https://openalex.org/W4390274924","https://openalex.org/W4391939571","https://openalex.org/W4392936848","https://openalex.org/W4401155263","https://openalex.org/W4402572868","https://openalex.org/W4402749875","https://openalex.org/W4406867309","https://openalex.org/W4409054440","https://openalex.org/W4412555221","https://openalex.org/W4413186907","https://openalex.org/W4414167311","https://openalex.org/W4414660525","https://openalex.org/W4415534941","https://openalex.org/W4415773064","https://openalex.org/W4416676008","https://openalex.org/W4417530597","https://openalex.org/W7116873252","https://openalex.org/W7125147730","https://openalex.org/W7131404749","https://openalex.org/W7149907024","https://openalex.org/W7211908723"],"related_works":["https://openalex.org/W7214317637","https://openalex.org/W2962071930","https://openalex.org/W4417465709","https://openalex.org/W4390233816","https://openalex.org/W7163901577","https://openalex.org/W4407186659","https://openalex.org/W7212154317","https://openalex.org/W2984253304","https://openalex.org/W4387662548","https://openalex.org/W2468224966"],"abstract_inverted_index":{"Polysaccharide":[0],"hydrogels":[1,129],"crosslinked":[2,53],"via":[3],"Schiff":[4,60],"base":[5,61],"linkages":[6],"demonstrate":[7],"significant":[8,39],"potential":[9,193],"in":[10,117,175],"drug":[11,106,110],"delivery":[12],"and":[13,22,42,45,63,77,104,124,136,158,161,188],"tissue":[14,132,196],"engineering.":[15],"In":[16],"this":[17],"study,":[18],"carboxymethyl":[19],"chitosan":[20],"(CMC)":[21],"dopamine-grafted":[23,182],"oxidized":[24],"hyaluronic":[25],"acid":[26],"(DA-OHA)":[27],"were":[28,83],"employed":[29],"as":[30,194],"active":[31],"components":[32],"to":[33,168],"fabricate":[34],"a":[35,51,94,195],"composite":[36],"hydrogel":[37,49,82,91,141,184],"with":[38,93,119,130],"pH":[40,115,122],"responsiveness":[41],"excellent":[43],"antibacterial":[44,134,151,187],"hemostatic":[46,78,137,189],"capacities.":[47],"The":[48,67,139,179],"formed":[50],"reversibly":[52],"network":[54],"through":[55],"the":[56,81,89,172,176],"synergistic":[57],"combination":[58],"of":[59,80,98,146,171],"reactions":[62],"multiple":[64],"hydrogen":[65],"bonds.":[66],"porous":[68],"morphology,":[69],"swelling":[70,103],"behavior,":[71,74],"stimuli-responsive":[72],"release":[73,107,111],"adhesive,":[75],"antibacterial,":[76],"performances":[79],"comprehensively":[84],"evaluated.":[85],"Results":[86],"demonstrated":[87],"that":[88,120],"optimal":[90],"fabricated":[92],"CMC-to-DA-OHA":[95],"mass":[96],"ratio":[97],"3:1":[99],"possessed":[100],"favorable":[101],"pH-dependent":[102],"tunable":[105],"profiles,":[108],"wherein":[109],"was":[112],"enhanced":[113,186],"at":[114,121],"6.0":[116],"comparison":[118],"7.2":[123],"8.0.":[125],"Dopamine":[126],"modification":[127],"endows":[128],"improved":[131],"adhesion,":[133],"capacity,":[135],"performance.":[138],"optimized":[140],"achieves":[142],"an":[143],"adhesion":[144],"strength":[145],"approximately":[147],"11.8":[148],"kPa,":[149],"exhibits":[150,191],"rates":[152],"above":[153],"97%":[154],"against":[155],"Staphylococcus":[156],"aureus":[157],"Escherichia":[159],"coli,":[160],"reduces":[162],"blood":[163,173],"loss":[164,174],"by":[165],"93.3%,":[166],"corresponding":[167],"only":[169],"6.7%":[170],"control":[177],"group.":[178],"as-prepared":[180],"pH-responsive":[181],"polysaccharide":[183],"possessing":[185],"functionalities":[190],"great":[192],"engineering":[197],"scaffold":[198],"for":[199],"wound":[200],"healing.":[201]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-29T00:00:00"}
