{"id":"https://openalex.org/W7224137189","doi":"https://doi.org/10.3389/fbioe.2026.1882780","title":"Ultrasound-activated phase-change nanodroplets for root canal biofilm eradication: mechanistic Investigation and experimental validation","display_name":"Ultrasound-activated phase-change nanodroplets for root canal biofilm eradication: mechanistic Investigation and experimental validation","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224137189","doi":"https://doi.org/10.3389/fbioe.2026.1882780"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2026.1882780","doi":"https://doi.org/10.3389/fbioe.2026.1882780","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1882780","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1882780/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1882780/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029911611","display_name":"Xiaoyu Qian","orcid":"https://orcid.org/0000-0003-2224-3882","observed_orcids":["https://orcid.org/0000-0003-2224-3882"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Qian","raw_affiliation_strings":["Academy for Advanced Interdisciplinary Studies, Peking University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy for Advanced Interdisciplinary Studies, Peking University","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013424469","display_name":"Jie Dang","orcid":"https://orcid.org/0000-0003-3235-3591","observed_orcids":["https://orcid.org/0000-0003-3235-3591"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Dang","raw_affiliation_strings":["Academy for Advanced Interdisciplinary Studies, Peking University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy for Advanced Interdisciplinary Studies, Peking University","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136971317","display_name":"Ziqi Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqi Shi","raw_affiliation_strings":["School of Mechanics and Engineering Science, Peking University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanics and Engineering Science, Peking University","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100752546","display_name":"Jue Zhang","orcid":"https://orcid.org/0000-0001-7983-470X","observed_orcids":["https://orcid.org/0000-0001-7983-470X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jue Zhang","raw_affiliation_strings":["Academy for Advanced Interdisciplinary Studies, Peking University","School of Mechanics and Engineering Science, Peking University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy for Advanced Interdisciplinary Studies, Peking University","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Mechanics and Engineering Science, Peking University","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100752546"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74720597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.11630000174045563,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cavitation","display_name":"cavitation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/phase-transitions","display_name":"phase transitions","score":0.6110000014305115},{"id":"https://openalex.org/keywords/thermal-safety","display_name":"thermal safety","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9307000041007996},{"id":"https://openalex.org/C2779747767","wikidata":"https://www.wikidata.org/wiki/Q848390","display_name":"Root canal","level":2,"score":0.8823999762535095},{"id":"https://openalex.org/C207057113","wikidata":"https://www.wikidata.org/wiki/Q201666","display_name":"Cavitation","level":2,"score":0.7330999970436096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5069000124931335},{"id":"https://openalex.org/C81288441","wikidata":"https://www.wikidata.org/wiki/Q20736125","display_name":"Ultrasonic sensor","level":2,"score":0.4975000023841858},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4494999945163727},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4341999888420105},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41110000014305115},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4027999937534332},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25699999928474426},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.2565999925136566}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fbioe.2026.1882780","doi":"https://doi.org/10.3389/fbioe.2026.1882780","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1882780","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1882780/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:22e65e6fece249d9b0d9f11962fda9dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/22e65e6fece249d9b0d9f11962fda9dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2026.1882780","doi":"https://doi.org/10.3389/fbioe.2026.1882780","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1882780","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1882780/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224137189.pdf","grobid_xml":"https://content.openalex.org/works/W7224137189.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1970935015","https://openalex.org/W1982020003","https://openalex.org/W1987204096","https://openalex.org/W1989183074","https://openalex.org/W1995873025","https://openalex.org/W2002838713","https://openalex.org/W2008105065","https://openalex.org/W2016899444","https://openalex.org/W2018785348","https://openalex.org/W2052485385","https://openalex.org/W2061450850","https://openalex.org/W2108786601","https://openalex.org/W2120189687","https://openalex.org/W2134803287","https://openalex.org/W2152088778","https://openalex.org/W2168731722","https://openalex.org/W2190268594","https://openalex.org/W2317138703","https://openalex.org/W2335546580","https://openalex.org/W2480010979","https://openalex.org/W2532100587","https://openalex.org/W2758396470","https://openalex.org/W2767093529","https://openalex.org/W2786496311","https://openalex.org/W2961844027","https://openalex.org/W2984875688","https://openalex.org/W3000004257","https://openalex.org/W3034471736","https://openalex.org/W3093809186","https://openalex.org/W3160544972","https://openalex.org/W4200591426","https://openalex.org/W4210476954","https://openalex.org/W4220710925","https://openalex.org/W4281719011","https://openalex.org/W4318716688","https://openalex.org/W4362657410","https://openalex.org/W4377089120","https://openalex.org/W4390338505","https://openalex.org/W4400658309","https://openalex.org/W4400792516"],"related_works":["https://openalex.org/W4225096953","https://openalex.org/W3096013293","https://openalex.org/W7140129595","https://openalex.org/W4319214796","https://openalex.org/W2299125128","https://openalex.org/W4220798867","https://openalex.org/W4323653128","https://openalex.org/W3022576762","https://openalex.org/W2141347203","https://openalex.org/W2770196271"],"abstract_inverted_index":{"Refractory":[0],"root":[1,20,146,170],"canal":[2,21,147,171],"infections":[3],"pose":[4],"a":[5,26,154,162],"major":[6],"clinical":[7],"challenge,":[8],"as":[9],"conventional":[10],"treatments":[11],"fail":[12],"to":[13,52],"eradicate":[14],"biofilms":[15,71,77],"in":[16],"the":[17,54,103,116,138,150],"complex":[18],"narrow":[19],"structure.":[22],"This":[23,135],"study":[24],"proposed":[25],"novel":[27,163],"strategy":[28],"of":[29,60,95,142],"ultrasound-activated":[30,143],"phase-change":[31],"nanodroplets":[32],"(PCNDs)":[33],"for":[34,145,157,167],"biofilm":[35,132,148],"elimination":[36,133],"and":[37,41,120,123,140],"elucidated":[38],"its":[39],"physicochemical":[40],"biomechanical":[42],"mechanisms.":[43],"A":[44],"coupled":[45],"Yang\u2013Church\u2013Pitt":[46],"(YCP)":[47],"dynamic":[48],"model":[49,113,152],"was":[50,127],"established":[51],"simulate":[53],"complete":[55],"phase":[56],"transition-cavitation-energy":[57],"release":[58],"process":[59],"PCNDs":[61,74,144],"under":[62],"ultrasonic":[63,86,159],"irradiation.":[64],"Ex":[65],"vivo":[66],"experiments":[67],"on":[68],"E.":[69],"faecalis":[70],"confirmed":[72],"that":[73],"efficiently":[75],"disrupted":[76],"via":[78],"cavitation":[79,118,125],"effects,":[80],"with":[81,85,130],"efficacy":[82,141],"positively":[83],"correlated":[84,129],"intensity":[87],"but":[88],"no":[89],"significant":[90],"frequency":[91],"influence.":[92],"Minimal":[93],"temperature":[94],"approximately":[96],"2":[97],"\u00b0C":[98],"rises":[99],"during":[100],"treatment":[101],"verified":[102],"strategy\u2019s":[104],"biosafety,":[105],"preventing":[106],"dental":[107],"hard":[108],"tissue":[109],"damage.":[110],"The":[111],"YCP":[112,151],"accurately":[114],"predicted":[115],"system\u2019s":[117],"characteristics":[119],"thermal":[121],"dynamics,":[122],"simulated":[124],"energy":[126],"strongly":[128],"experimental":[131],"efficiency.":[134],"work":[136],"validated":[137],"safety":[139],"removal;":[149],"provided":[153],"theoretical":[155],"framework":[156],"optimizing":[158],"parameters,":[160],"offering":[161],"mechanistically":[164],"informed":[165],"approach":[166],"managing":[168],"refractory":[169],"infections.":[172]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}
