{"id":"https://openalex.org/W7224136171","doi":"https://doi.org/10.64898/2026.10.25.26366405","title":"VascFlux-GEO: Comparator selection and auditability in vascular transcriptome module prediction","display_name":"VascFlux-GEO: Comparator selection and auditability in vascular transcriptome module prediction","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224136171","doi":"https://doi.org/10.64898/2026.10.25.26366405"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.25.26366405","doi":"https://doi.org/10.64898/2026.10.25.26366405","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.26366405","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/28/2026.10.25.26366405.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/28/2026.10.25.26366405.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113157144","display_name":"Lingsen You","orcid":"https://orcid.org/0000-0003-0794-5907","observed_orcids":["https://orcid.org/0000-0003-0794-5907"]},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingsen You","raw_affiliation_strings":["Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai 200093, China","State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159997226","display_name":"Zisu Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zisu Peng","raw_affiliation_strings":["Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China","NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai 200032, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160033754","display_name":"Yujun Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujun Guo","raw_affiliation_strings":["College of Biomedical Engineering, Fudan University, Shanghai 200438, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Fudan University, Shanghai 200438, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107398981","display_name":"Li Shen","orcid":"https://orcid.org/0009-0001-2157-6880","observed_orcids":["https://orcid.org/0009-0001-2157-6880"]},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai 200093, China","State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111951890","display_name":"Junbo Ge","orcid":"https://orcid.org/0009-0003-3442-4477","observed_orcids":["https://orcid.org/0009-0003-3442-4477","https://orcid.org/0000-0003-1030-7009"]},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junbo Ge","raw_affiliation_strings":["Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai 200093, China","State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Interventional Medicine, Shanghai 200032, China","institution_ids":[]},{"raw_affiliation_string":"Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111951890"],"corresponding_institution_ids":["https://openalex.org/I148128674","https://openalex.org/I24943067","https://openalex.org/I4210127074"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comparator-selection","display_name":"comparator selection","score":0.8029999732971191},{"id":"https://openalex.org/keywords/auditability","display_name":"auditability","score":0.6869999766349792},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.8080000281333923},{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/arterial-stenosis","display_name":"arterial stenosis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cross-validation-error","display_name":"cross-validation error","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5709999799728394},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.4961000084877014},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4171999990940094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3959999978542328},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.39100000262260437},{"id":"https://openalex.org/C3018348675","wikidata":"https://www.wikidata.org/wiki/Q4797557","display_name":"Arterial disease","level":3,"score":0.3578999936580658},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.35670000314712524},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.336899995803833},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.3125},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C19619285","wikidata":"https://www.wikidata.org/wiki/Q196372","display_name":"Observational error","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27079999446868896},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.26330000162124634},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.25.26366405","doi":"https://doi.org/10.64898/2026.10.25.26366405","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.26366405","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/28/2026.10.25.26366405.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.25.26366405","doi":"https://doi.org/10.64898/2026.10.25.26366405","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.26366405","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/28/2026.10.25.26366405.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2964385526","display_name":null,"funder_award_id":"FudanX24AI003","funder_id":"https://openalex.org/F4320321851","funder_display_name":"Fudan University"},{"id":"https://openalex.org/G6632806875","display_name":null,"funder_award_id":"yg2023-01","funder_id":"https://openalex.org/F4320321851","funder_display_name":"Fudan University"},{"id":"https://openalex.org/G8495842136","display_name":null,"funder_award_id":"82170342","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224136171.pdf","grobid_xml":"https://content.openalex.org/works/W7224136171.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W274441265","https://openalex.org/W1767470961","https://openalex.org/W2008985174","https://openalex.org/W2020541351","https://openalex.org/W2061623382","https://openalex.org/W2107665951","https://openalex.org/W2112337773","https://openalex.org/W2130410032","https://openalex.org/W2137499573","https://openalex.org/W2141007997","https://openalex.org/W2159707944","https://openalex.org/W2161167193","https://openalex.org/W2170989872","https://openalex.org/W2302501749","https://openalex.org/W2341128841","https://openalex.org/W2414283705","https://openalex.org/W2544068456","https://openalex.org/W2736722877","https://openalex.org/W2787894218","https://openalex.org/W3080434086","https://openalex.org/W3106889297","https://openalex.org/W4234698323","https://openalex.org/W4415016954","https://openalex.org/W7204271950"],"related_works":["https://openalex.org/W4366542224","https://openalex.org/W2530428398","https://openalex.org/W3001202832","https://openalex.org/W2080290965","https://openalex.org/W4239423838","https://openalex.org/W2993040505","https://openalex.org/W3014064419","https://openalex.org/W2150271670","https://openalex.org/W4311026451","https://openalex.org/W7214621014"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Mathematical":[2],"coupling":[3],"and":[4,29,32,63,86,92,166,197,231,237],"comparator":[5,164],"selection":[6],"are":[7,37],"established":[8,220],"concerns":[9],"when":[10],"a":[11],"transcriptome":[12,43],"response":[13],"is":[14],"defined":[15],"as":[16],"follow-up":[17,101,163,175],"minus":[18],"baseline.":[19],"We":[20],"assessed":[21],"whether":[22,33],"apparent":[23],"within-cohort":[24,211],"improvement":[25],"survives":[26],"matched":[27],"constant-follow-up":[28,214],"scalar-shrinkage":[30],"controls,":[31],"specified":[34],"evaluation":[35],"faults":[36],"detectable":[38],"in":[39,216],"an":[40,93,198],"auditable":[41],"vascular":[42],"benchmark.":[44],"Results":[45],"Using":[46],"eight":[47],"frozen":[48],"modules,":[49],"72":[50],"rosuvastatin":[51],"pairs,":[52,57],"14":[53],"peripheral":[54,149],"artery":[55,96,150],"disease":[56],"20":[58],"repeated":[59],"subject-held-out":[60],"five-fold":[61],"partitions,":[62],"5,000":[64],"subject":[65],"bootstrap":[66],"draws":[67],"of":[68],"fixed":[69],"losses,":[70],"we":[71],"compared":[72],"15":[73],"explicit":[74],"specifications.":[75],"Supporting":[76],"post":[77],"hoc":[78],"analyses":[79],"included":[80],"800":[81],"known-truth":[82],"training/test":[83],"simulations,":[84],"annotation":[85],"input-ablation":[87],"sensitivities,":[88],"complete-tuning":[89],"integrity":[90],"checks,":[91],"independent-source":[94],"cross-sectional":[95],"description.":[97],"In":[98,148],"GSE86216,":[99],"nested":[100,152],"ridge":[102,153],"had":[103,127,155],"lower":[104,128,209],"observed":[105,129,158,210],"repeated-CV":[106],"mean":[107,111,174,178],"absolute":[108],"error":[109,130,212],"than":[110,160,213],"follow-up,":[112],"0.3280":[113],"versus":[114],"0.3405":[115],"(difference":[116],"0.0126;":[117],"descriptive":[118],"central":[119],"95%":[120],"percentile":[121],"range":[122],"0.0033\u20130.0224),":[123],"while":[124,183],"scalar":[125],"shrinkage":[126],"(0.3256).":[131],"These":[132,203],"ranges":[133],"have":[134],"no":[135,167],"validated":[136],"coverage":[137],"guarantee.":[138],"No":[139],"full-matrix":[140,221],"advantage":[141,168],"was":[142,145,169],"established;":[143],"equivalence":[144],"not":[146,225],"tested.":[147],"disease,":[151],"(0.3449)":[154],"slightly":[156],"higher":[157],"MAE":[159],"the":[161,184],"median":[162],"(0.3409),":[165],"established.":[170],"Simulations":[171],"illustrated":[172],"how":[173],"can":[176],"outperform":[177],"change":[179],"without":[180,219],"temporal":[181],"signal,":[182],"GSE281841":[185],"histological":[186],"stenosis-grade":[187],"description":[188],"remained":[189],"limited":[190],"by":[191],"anatomical":[192],"imbalance,":[193],"unconfirmed":[194],"participant":[195],"identity":[196],"unresolved":[199],"sample-count":[200],"discrepancy.":[201],"Conclusions":[202],"retrospective,":[204],"nonconfirmatory":[205],"comparisons":[206],"show":[207],"modestly":[208],"controls":[215],"one":[217],"cohort,":[218],"advantage.":[222],"They":[223],"do":[224],"partition":[226],"prediction":[227],"into":[228],"mathematical,":[229],"technical":[230],"biological":[232],"components.":[233],"Independent":[234],"longitudinal":[235],"validation":[236],"clinical":[238],"utility":[239],"remain":[240],"unestablished.":[241]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}