{"id":"https://openalex.org/W7224130665","doi":"https://doi.org/10.21037/jgo-2026-0669","title":"Self-expandable metal stent (SEMS) with iodine-125 intraluminal brachytherapy versus SEMS alone for unresectable malignant distal biliary obstruction: survival and patency analysis","display_name":"Self-expandable metal stent (SEMS) with iodine-125 intraluminal brachytherapy versus SEMS alone for unresectable malignant distal biliary obstruction: survival and patency analysis","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224130665","doi":"https://doi.org/10.21037/jgo-2026-0669","pmid":"https://pubmed.ncbi.nlm.nih.gov/42996843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740521"},"language":"en","primary_location":{"id":"doi:10.21037/jgo-2026-0669","doi":"https://doi.org/10.21037/jgo-2026-0669","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0669","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/jgo-2026-0669","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101290059","display_name":"Lijie Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijie Qiu","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154405819","display_name":"Zhenkang Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenkang Qiu","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156084264","display_name":"Xiaobo Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Fu","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114186529","display_name":"Yuzhe Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhe Cao","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086904892","display_name":"Zixiong Chen","orcid":"https://orcid.org/0000-0001-7151-8024","observed_orcids":["https://orcid.org/0000-0001-7151-8024"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixiong Chen","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056610632","display_name":"Maoyuan Mu","orcid":"https://orcid.org/0000-0001-5632-0167","observed_orcids":["https://orcid.org/0000-0001-5632-0167"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maoyuan Mu","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160004168","display_name":"Chen Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Liu","raw_affiliation_strings":["Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051075615","display_name":"Fei Gao","orcid":"https://orcid.org/0000-0002-4086-2575","observed_orcids":["https://orcid.org/0000-0002-4086-2575"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Gao","raw_affiliation_strings":["Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive & Interventional Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051075615"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711","https://openalex.org/I4391768007"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"307","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12634","display_name":"Ureteral procedures and complications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-expanding-metal-stents","display_name":"self-expanding metal stents","score":0.9480000138282776},{"id":"https://openalex.org/keywords/iodine-125-seed-implantation","display_name":"iodine-125 seed implantation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/malignant-biliary-obstruction","display_name":"malignant biliary obstruction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/distal-biliary-obstruction","display_name":"distal biliary obstruction","score":0.8730000257492065},{"id":"https://openalex.org/keywords/stent-patency","display_name":"stent patency","score":0.8009999990463257},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9850000143051147},{"id":"https://openalex.org/keywords/locoregional-therapy","display_name":"locoregional therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/biliary-drainage","display_name":"biliary drainage","score":0.5839999914169312},{"id":"https://openalex.org/keywords/extrahepatic-bile-ducts","display_name":"extrahepatic bile ducts","score":0.6359999775886536},{"id":"https://openalex.org/keywords/unresectable-biliary-cancer","display_name":"unresectable biliary cancer","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9685999751091003},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.8271999955177307},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6456999778747559},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.5878999829292297},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5580999851226807},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4860999882221222},{"id":"https://openalex.org/C2775982439","wikidata":"https://www.wikidata.org/wiki/Q3562150","display_name":"Biliary tract","level":2,"score":0.40869998931884766},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39419999718666077},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.36410000920295715},{"id":"https://openalex.org/C2780813298","wikidata":"https://www.wikidata.org/wiki/Q2071287","display_name":"Percutaneous","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.3082999885082245},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C3018651493","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Biliary drainage","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C2781464078","wikidata":"https://www.wikidata.org/wiki/Q7685898","display_name":"Target lesion","level":4,"score":0.25200000405311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/jgo-2026-0669","doi":"https://doi.org/10.21037/jgo-2026-0669","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0669","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740521","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740521/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740521/pdf/jgo-17-5-307.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastrointest Oncol","raw_type":"Text"},{"id":"pmid:42996843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42996843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jgo-2026-0669","doi":"https://doi.org/10.21037/jgo-2026-0669","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0669","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224130665.pdf","grobid_xml":"https://content.openalex.org/works/W7224130665.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2048858268","https://openalex.org/W2056251299","https://openalex.org/W2087489678","https://openalex.org/W2112347626","https://openalex.org/W2113237839","https://openalex.org/W2125775716","https://openalex.org/W2126052700","https://openalex.org/W2129063500","https://openalex.org/W2134023012","https://openalex.org/W2135886487","https://openalex.org/W2140790678","https://openalex.org/W2141078344","https://openalex.org/W2148620480","https://openalex.org/W2766143211","https://openalex.org/W2784269006","https://openalex.org/W2796702195","https://openalex.org/W2886135411","https://openalex.org/W2965475925","https://openalex.org/W2991749634","https://openalex.org/W3036377090","https://openalex.org/W3067935524","https://openalex.org/W3096902339","https://openalex.org/W3165477400","https://openalex.org/W3189259032","https://openalex.org/W3209852184","https://openalex.org/W4210501456","https://openalex.org/W4296465903","https://openalex.org/W4311020860","https://openalex.org/W4386003132","https://openalex.org/W4386442590","https://openalex.org/W4411768522"],"related_works":["https://openalex.org/W2714310985","https://openalex.org/W4362555422","https://openalex.org/W3030144032","https://openalex.org/W4253262206","https://openalex.org/W3005278030","https://openalex.org/W2784269006","https://openalex.org/W2949098682","https://openalex.org/W2997169303","https://openalex.org/W3161843035","https://openalex.org/W4323046222"],"abstract_inverted_index":{"Background:":[0],"In":[1],"patients":[2,111],"with":[3,10,31,83,114,314],"unresectable":[4,90,115],"malignant":[5,91],"biliary":[6,48,93],"obstruction,":[7],"brachytherapy":[8,29,85,130,211,241,266,285,306],"combined":[9,30,82],"self-expandable":[11],"metal":[12],"stents":[13],"(SEMS)":[14],"has":[15],"demonstrated":[16],"extended":[17],"stent":[18,178,207,274,290,296,321],"patency":[19,179,184,208,275],"and":[20,35,60,126,167,177,185,194,223,253,267,277,298,320],"survival.":[21],"However,":[22],"researches":[23],"rarely":[24],"evaluate":[25],"the":[26,42,55,78,87,140,191,195,201,210,219,240,249,263],"outcomes":[27],"of":[28,57,72,80,89,102,183,265],"subsequent":[32,168,268,309],"systemic":[33,269,310],"therapy,":[34],"most":[36],"obstruction":[37,94],"sites":[38],"are":[39],"located":[40],"in":[41,86,209,218,239,248,293,300,317],"hilar":[43],"bile":[44],"ducts.":[45],"The":[46,70,129,171,181,206,236],"extrahepatic":[47],"tract":[49],"lacks":[50],"intrinsic":[51],"structural":[52],"support,":[53],"limiting":[54],"application":[56],"locoregional":[58,100],"therapies":[59],"predisposing":[61],"to":[62,76,98,282,295],"rapid":[63],"clinical":[64],"deterioration":[65],"if":[66],"drainage":[67],"is":[68,75,312],"delayed.":[69],"purpose":[71],"this":[73,103,301],"study":[74,107,172],"investigate":[77],"utility":[79],"SEMS":[81,118,145],"125I":[84,284,305],"treatment":[88,119],"distal":[92],"(MDBO),":[95],"providing":[96],"evidence":[97],"guide":[99],"management":[101],"patient":[104,318],"population.Methods:":[105],"This":[106],"retrospectively":[108],"enrolled":[109],"187":[110],"first":[112],"diagnosed":[113],"MDBO":[116,302],"undergoing":[117],"at":[120],"our":[121],"center":[122],"between":[123],"August":[124],"2020":[125],"July":[127],"2024.":[128],"group":[131,142,212,221,242,251],"simultaneously":[132],"received":[133,143],"iodine-125":[134],"seed":[135],"implantation":[136],"(53":[137],"patients),":[138],"while":[139],"control":[141,220,250],"only":[144],"placement":[146,291],"(134":[147],"patients).":[148],"We":[149],"collected":[150],"comprehensive":[151],"clinicopathological":[152],"data,":[153],"including":[154],"demographics,":[155],"tumor":[156],"characteristics,":[157],"hepatic":[158],"function,":[159],"Eastern":[160],"Cooperative":[161],"Oncology":[162],"Group":[163],"(ECOG)":[164],"performance":[165],"status,":[166],"anticancer":[169],"therapies.":[170],"endpoints":[173],"included":[174],"overall":[175,186,237,278],"survival":[176,187,238,279,299,319],"time.":[180],"duration":[182],"was":[188,213,243],"calculated":[189],"using":[190,200],"Kaplan-Meier":[192],"method,":[193],"risk":[196],"factors":[197],"were":[198],"assessed":[199],"Cox":[202],"proportional":[203],"hazards":[204],"models.Results:":[205],"significantly":[214,244,271],"longer":[215,245],"than":[216,246,289],"that":[217,247],"[275":[222],"168":[224],"days,":[225,255],"hazard":[226],"ratio":[227],"(HR)":[228],"=0.50,":[229],"95%":[230,258],"confidence":[231],"interval":[232],"(CI):":[233],"0.29\u20130.88,":[234],"P=0.01].":[235],"(208":[252],"152":[254],"HR":[256],"=0.60,":[257],"CI:":[259],"0.39\u20130.93,":[260],"P=0.02).":[261],"Furthermore,":[262],"combination":[264],"therapy":[270,311],"improved":[272],"both":[273],"(P=0.02)":[276],"(P=0.001)":[280],"compared":[281],"monotherapy.Conclusions:":[283],"appears":[286],"more":[287],"effective":[288],"alone":[292],"regard":[294],"dysfunction":[297],"cohort.":[303],"Moreover,":[304],"followed":[307],"by":[308],"associated":[313],"further":[315],"extensions":[316],"patency.":[322]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-29T00:00:00"}