{"id":"https://openalex.org/W7224129849","doi":"https://doi.org/10.5281/zenodo.23737653","title":"163\u3001PL-NUT:\u4ece\u8425\u517b\u2014\u4ee3\u8c22\u72b6\u6001\u5230\u808c\u8089\u529f\u80fd\u7ed3\u5c40\u2014\u2014\u5143\u5f8b\u533b\u5b66\u591a\u7ef4\u8ba1\u7b97\u4e0e\u53ef\u8bc1\u4f2a\u9884\u6d4b(PL-NUT: From Nutritional\u2013Metabolic States to Muscle Function Outcomes\u2014Multidimensional Computation and Falsifiable Prediction in Prim-Lex Medicine)","display_name":"163\u3001PL-NUT:\u4ece\u8425\u517b\u2014\u4ee3\u8c22\u72b6\u6001\u5230\u808c\u8089\u529f\u80fd\u7ed3\u5c40\u2014\u2014\u5143\u5f8b\u533b\u5b66\u591a\u7ef4\u8ba1\u7b97\u4e0e\u53ef\u8bc1\u4f2a\u9884\u6d4b(PL-NUT: From Nutritional\u2013Metabolic States to Muscle Function Outcomes\u2014Multidimensional Computation and Falsifiable Prediction in Prim-Lex Medicine)","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224129849","doi":"https://doi.org/10.5281/zenodo.23737653"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23737653","doi":"https://doi.org/10.5281/zenodo.23737653","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23737653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23737653","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160006985","display_name":"Shen Xiaowang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiaowang, Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160006985"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nutritional-assessment","display_name":"nutritional assessment","score":0.7680000066757202},{"id":"https://openalex.org/keywords/muscle-function","display_name":"muscle function","score":0.6919999718666077},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.7080000042915344},{"id":"https://openalex.org/keywords/glim-criteria","display_name":"GLIM criteria","score":0.6919999718666077},{"id":"https://openalex.org/keywords/malnutrition-screening","display_name":"malnutrition screening","score":0.699999988079071},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.6340000033378601},{"id":"https://openalex.org/keywords/lactate-pyruvate-ratio","display_name":"lactate/pyruvate ratio","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mitochondrial-oxygen-consumption","display_name":"mitochondrial oxygen consumption","score":0.6320000290870667},{"id":"https://openalex.org/keywords/siri","display_name":"Siri","score":0.48100000619888306},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.5870000123977661},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.5410000085830688},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9229999780654907},{"id":"https://openalex.org/keywords/testable-predictions","display_name":"falsifiable predictions","score":0.5929999947547913},{"id":"https://openalex.org/keywords/skeletal-muscle-metabolism","display_name":"skeletal muscle metabolism","score":0.6340000033378601},{"id":"https://openalex.org/keywords/community-dwelling-elderly","display_name":"community-dwelling older adults","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hospitalized-older-adults","display_name":"hospitalized older adults","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C197947376","wikidata":"https://www.wikidata.org/wiki/Q5155608","display_name":"Comparability","level":2,"score":0.7368999719619751},{"id":"https://openalex.org/C551997983","wikidata":"https://www.wikidata.org/wiki/Q12167","display_name":"Malnutrition","level":2,"score":0.5235000252723694},{"id":"https://openalex.org/C194051981","wikidata":"https://www.wikidata.org/wiki/Q1337691","display_name":"Economic shortage","level":3,"score":0.46149998903274536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4068000018596649},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.39629998803138733},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34790000319480896},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33730000257492065},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33550000190734863},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.33309999108314514},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C33676613","wikidata":"https://www.wikidata.org/wiki/Q13415176","display_name":"Dimension (graph theory)","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.3230000138282776},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C2780148112","wikidata":"https://www.wikidata.org/wiki/Q1432581","display_name":"Proxy (statistics)","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3098999857902527},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29600000381469727},{"id":"https://openalex.org/C3019971869","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle protein","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C2985213535","wikidata":"https://www.wikidata.org/wiki/Q1626599","display_name":"Reference values","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C2992343062","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle mass","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.25440001487731934}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23737653","doi":"https://doi.org/10.5281/zenodo.23737653","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23737653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23737654","doi":"https://doi.org/10.5281/zenodo.23737654","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23737654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23737653","doi":"https://doi.org/10.5281/zenodo.23737653","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23737653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7224121469","https://openalex.org/W3111307472","https://openalex.org/W4389245360","https://openalex.org/W4417280007","https://openalex.org/W3172494370","https://openalex.org/W4353034921","https://openalex.org/W3000281433","https://openalex.org/W7111850208","https://openalex.org/W3106261613","https://openalex.org/W3100328547"],"abstract_inverted_index":{"The":[0,21,215,287,321,375,528,559,723],"clinical":[1,319,487,500,655,775,810,838,863],"predicament":[2],"in":[3,28,62,131,161,203,229,265,390,431,455,486,814],"nutritional":[4,121,133,247,488],"assessment":[5,134],"is":[6,41,222,377,416,443,497,532,552,563,575,589,633,642,804,836],"not":[7,258,476,534,618,634,692,734,749,764,795,845],"a":[8,13,87,107,137,143,346,367,428,471,492,652,743,807,837],"shortage":[9],"of":[10,15,51,57,72,120,218,245,263,293,339,361,509,561,567,573,579,676,684,695,702,712,737,752,790],"indicators":[11],"but":[12,188,269],"conjunction":[14],"construct":[16],"misalignment":[17],"and":[18,38,46,54,64,69,80,102,159,181,194,211,252,297,301,308,317,342,354,363,394,435,451,516,540,620,624,649,688,706,731,759,779,793,824,842],"integration":[19],"deficit.":[20],"GLIM":[22,298,446,467,480,766],"criteria":[23,667],"demonstrate":[24],"acceptable":[25],"diagnostic":[26],"specificity":[27,33],"hospitalized":[29],"older":[30],"adults":[31],"(pooled":[32],"0.88,":[34],"95%":[35],"CI":[36],"0.81\u20130.93),":[37],"GLIM-defined":[39],"malnutrition":[40],"associated":[42],"with":[43,424,479,671,820],"higher":[44],"in-hospital":[45],"post-discharge":[47],"mortality,":[48],"reduced":[49],"activities":[50],"daily":[52],"living,":[53],"prolonged":[55],"length":[56],"stay;":[58],"however,":[59],"validation":[60,397,594,811],"evidence":[61],"community-dwelling":[63],"nursing-home":[65],"populations":[66],"remains":[67],"insufficient,":[68],"the":[70,118,152,170,175,219,227,235,260,272,325,378,391,396,400,413,432,466,547,555,564,571,576,583,593,608,637,645,696,700,703,709,719],"choice":[71],"first-step":[73],"screening":[74],"tool":[75],"systematically":[76],"alters":[77],"GLIM-based":[78],"sensitivity":[79,439],"agreement.":[81],"Serum":[82],"albumin,":[83],"historically":[84],"treated":[85,784],"as":[86,99,136,151,157,169,345,366,418,427,438,546,591,628,785],"nutrition":[88,818],"marker,":[89],"has":[90,238,601,849],"been":[91,833],"explicitly":[92,725],"characterized":[93],"by":[94,554,708,799],"an":[95,100,336,358],"ASPEN":[96],"position":[97],"paper":[98],"inflammation-":[101],"disease-severity-related":[103],"indicator":[104],"rather":[105,224],"than":[106,165,225,605],"valid":[108,713],"proxy":[109,349,370],"for":[110,350,371,587,644,668],"total":[111],"body":[112],"protein":[113],"or":[114,739,755,774,817],"muscle":[115,267,461],"mass.":[116],"Meanwhile,":[117],"dimension":[119],"status":[122],"most":[123,556],"directly":[124],"linked":[125],"to":[126,207,278,448,464,615,636,717,781],"functional":[127,149,472,489],"outcomes\u2014muscle":[128],"function\u2014typically":[129],"appears":[130],"routine":[132,294],"only":[135,650],"coarse":[138],"\u201csarcopenia":[139],"yes/no\u201d":[140],"classification,":[141],"lacking":[142],"predictive":[144,243,613,852],"structure":[145,327,381],"that":[146,474,600,727,742,760,847,858],"takes":[147],"continuous":[148,638,669],"change":[150,436],"outcome,":[153],"routinely":[154,249],"available":[155,250],"variables":[156],"inputs,":[158],"improvement":[160],"prediction":[162,603,839],"error":[163,604,683],"(rather":[164],"statistical":[166],"significance":[167],"alone)":[168],"criterion.":[171],"Prim-Lex":[172],"Medicine":[173],"posits":[174],"Animal-Life":[176],"Prim-Fire\u2014the":[177],"NADH/NAD\u207a":[178,264,738],"redox":[179],"couple":[180],"glycolysis\u2013oxidative":[182],"phosphorylation":[183],"coupling\u2014as":[184],"its":[185,189],"theoretical":[186],"anchor,":[187],"direct":[190,735],"measurements":[191],"(NAD(P)H":[192],"FLIM":[193],",":[195,335,357,364,423,525,606,678,681],"lactate/pyruvate":[196],"ratio,":[197],"mitochondrial":[198],"oxygen":[199],"consumption)":[200],"are":[201,388,733,783],"inaccessible":[202],"general":[204,230],"hospitals":[205],"due":[206],"equipment,":[208],"reagent":[209],"standardization,":[210],"cross-centre":[212],"comparability":[213],"barriers.":[214],"methodological":[216,407],"shift":[217,256],"PL-NUT":[220,761,848],"framework":[221,724],"explicit:":[223],"\u201cmeasuring":[226],"Prim-Fire\u201d":[228],"hospitals,":[231],"it":[232,270,843,856],"tests":[233],"whether":[234],"Prim-Fire":[236,740],"level":[237],"left":[239],"reproducible":[240],"week-12":[241,419,714],"handgrip-strength":[242],"traces\u2014independent":[244],"conventional":[246],"variables\u2014in":[248],"metabolic":[251],"inflammatory":[253,373],"variables.":[254],"This":[255],"does":[257,475,748,844,855],"deny":[259],"fundamental":[261],"role":[262],"skeletal":[266],"metabolism,":[268],"refuses":[271],"untested":[273],"leap":[274],"from":[275,312],"\u201cmechanistic":[276],"importance\u201d":[277],"\u201croutine":[279],"proxies":[280],"must":[281,544,763,794],"carry":[282],"clinically":[283],"detectable":[284],"incremental":[285,851],"information\u201d.":[286],"detection":[288],"layer":[289,323],"comprises":[290],"six":[291],"groups":[292],"information:":[295],"MNA-SF":[296],"components,":[299],"anthropometry":[300],"handgrip":[302,420,426,469,715],"strength,":[303],"fasting":[304],"plasma":[305],"glucose":[306],"(FPG)":[307],"HbA1c,":[309,343,524,729],"SIRI":[310],"derived":[311],"complete":[313],"blood":[314],"count,":[315],"hs-CRP,":[316],"standard":[318,686],"data.":[320],"computation":[322],"compresses":[324],"Five-Element":[326,753],"into":[328],"two":[329],"fixed":[330],"equal-weight":[331,337,359,568],"modules:":[332],"Fire":[333],"()":[334,356,535],"aggregation":[338,360,569],"standardized":[340,362,520],"FPG":[341],"positioned":[344,365],"joint":[347,368],"candidate":[348,369,530,673],"host":[351],"glucose-metabolic":[352],"burden;":[353],"Wood":[355],"systemic":[372],"burden.":[374],"interaction":[376,580,747],"sole":[379],"coupling":[380],"entering":[382],"formal":[383],"testing.":[384],"All":[385],"standardization":[386],"parameters":[387,402],"estimated":[389],"training":[392],"set":[393,398,595],"frozen;":[395],"applies":[399],"training-set":[401],"without":[403],"re-estimation.":[404],"Four":[405],"core":[406],"choices":[408],"define":[409],"this":[410,835],"protocol.":[411],"First,":[412],"primary":[414,565,577,584,639],"outcome":[415,473,648,689,791],"frozen":[417,590],"strength":[421,442],"(kg)":[422],"baseline":[425,433,502],"mandatory":[429],"covariate":[430],"model":[434,494,531,541,610],"score":[437],"analysis.":[440],"Handgrip":[441],"chosen":[444],"over":[445],"diagnosis":[447],"avoid":[449],"circularity":[450],"information":[452],"leakage":[453],"inherent":[454],"using":[456],"GLIM\u2019s":[457],"own":[458],"components":[459],"(weight,":[460],"mass,":[462],"inflammation)":[463],"predict":[465],"label;":[468],"provides":[470],"fully":[477],"overlap":[478],"rules":[481],"yet":[482,832],"holds":[483],"independent":[484],"standing":[485],"assessment.":[490],"Second,":[491],"four-tier":[493],"comparison":[495,560,572,585],"hierarchy":[496],"established:":[498],"(conventional":[499],"baseline:":[501],"handgrip,":[503],"age,":[504],"sex,":[505],"MNA-SF;":[506],"slope":[507,625,674],"degrees":[508,675],"freedom":[510,677],"),":[511,513,515],"(;":[512,514],"(baseline":[517],"+":[518],"four":[519,666,704],"raw":[521],"variables:":[522],"FPG,":[523,728],";":[526,536],").":[527],"maximum":[529,672,701],"(),":[533],"sample":[537,659],"size":[538,660],"planning":[539],"complexity":[542],"auditing":[543],"use":[545],"benchmark,":[548],"because":[549],"overfitting":[550],"risk":[551,769],"driven":[553],"parameterized":[557],"model.":[558],"versus":[562,574],"test":[566,578],"parsimony;":[570],"increment.":[581],"Third,":[582],"quantity":[586],"H1":[588],"on":[592],"(a":[596],"positive":[597],"value":[598],"indicates":[599],"lower":[602],"i.e.,":[607],"extended":[609],"improves).":[611],"MAE,":[612],"(allowed":[614],"be":[616,796],"negative,":[617],"truncated),":[619],"continuous-outcome":[621],"calibration":[622],"(intercept":[623],")":[626],"serve":[627],"supporting":[629],"evidence.":[630,864],"Probability-scale":[631],"DCA":[632,641],"applied":[635],"outcome;":[640],"reserved":[643],"binary":[646],"secondary":[647],"under":[651],"pre-specified,":[653],"guideline-concordant":[654],"decision":[656],"scenario.":[657],"Fourth,":[658],"follows":[661],"Riley":[662],"et":[663],"al.":[664],"(2019)":[665],"outcomes,":[670],"target":[679],"shrinkage":[680],"estimation":[682],"residual":[685],"deviation":[687],"mean":[690],"each":[691],"exceeding":[693],"10%":[694],"true":[697],"value,":[698,853],"taking":[699],"criteria,":[705],"dividing":[707],"expected":[710],"proportion":[711],"data":[716,823,830],"obtain":[718],"planned":[720],"recruitment":[721],"number.":[722],"states":[726],"SIRI,":[730],"hs-CRP":[732],"measures":[736],"coherence;":[741],"statistically":[744],"significant":[745],"Fire\u2013Wood":[746],"constitute":[750],"proof":[751],"generative":[754],"restrictive":[756],"biological":[757],"mechanisms;":[758],"scores":[762],"replace":[765],"diagnosis,":[767],"refeeding-syndrome":[768],"screening,":[770],"nutrition-support":[771],"indication":[772],"judgment,":[773],"decision-making.":[776],"Death,":[777],"disability,":[778],"loss":[780],"follow-up":[782],"three":[786],"mechanistically":[787],"distinct":[788],"forms":[789],"unavailability":[792],"uniformly":[797],"imputed":[798],"MICE.":[800],"Its":[801],"anticipated":[802],"contribution":[803],"strictly":[805],"limited:":[806],"minimum":[808],"viable":[809],"protocol":[812],"executable":[813],"geriatric,":[815],"rehabilitation,":[816],"clinics,":[819],"actually":[821],"collectable":[822],"honestly":[825],"falsifiable":[826],"hypotheses.":[827],"No":[828],"patient":[829],"have":[831],"obtained;":[834],"research":[840],"protocol,":[841],"claim":[846,857],"established":[850],"nor":[854],"any":[859],"simulation":[860],"output":[861],"constitutes":[862]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}