{"id":"https://openalex.org/W7224129247","doi":"https://doi.org/10.3390/jcm15218377","title":"Early Body-Composition Trajectory During Tirzepatide Treatment for Obesity: A Real-World Bioimpedance Cohort Study","display_name":"Early Body-Composition Trajectory During Tirzepatide Treatment for Obesity: A Real-World Bioimpedance Cohort Study","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224129247","doi":"https://doi.org/10.3390/jcm15218377"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15218377","doi":"https://doi.org/10.3390/jcm15218377","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15218377","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jcm15218377","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092164841","display_name":"Enes ZAFER","orcid":"https://orcid.org/0009-0001-4547-0255","observed_orcids":["https://orcid.org/0009-0001-4547-0255"]},"institutions":[{"id":"https://openalex.org/I103703290","display_name":"Sakarya University","ror":"https://ror.org/04ttnw109","country_code":"TR","type":"education","lineage":["https://openalex.org/I103703290"]},{"id":"https://openalex.org/I4210116985","display_name":"Sakarya E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02h67ht97","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I103703290","https://openalex.org/I4210116985"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Enes Zafer","raw_affiliation_strings":["Department of Internal Medicine, Sakarya University Training and Research Hospital, 54100 Sakarya, Turkey"],"raw_orcid":"https://orcid.org/0009-0001-4547-0255","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sakarya University Training and Research Hospital, 54100 Sakarya, Turkey","institution_ids":["https://openalex.org/I103703290","https://openalex.org/I4210116985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026206428","display_name":"Deniz \u00c7eki\u00e7","orcid":"https://orcid.org/0000-0002-7114-9334","observed_orcids":["https://orcid.org/0000-0002-7114-9334"]},"institutions":[{"id":"https://openalex.org/I103703290","display_name":"Sakarya University","ror":"https://ror.org/04ttnw109","country_code":"TR","type":"education","lineage":["https://openalex.org/I103703290"]},{"id":"https://openalex.org/I4210116985","display_name":"Sakarya E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02h67ht97","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I103703290","https://openalex.org/I4210116985"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Deniz \u00c7eki\u00e7","raw_affiliation_strings":["Department of Internal Medicine, Sakarya University Training and Research Hospital, 54100 Sakarya, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-7114-9334","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sakarya University Training and Research Hospital, 54100 Sakarya, Turkey","institution_ids":["https://openalex.org/I103703290","https://openalex.org/I4210116985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101999654","display_name":"Ahmed Bilal Gen\u00e7","orcid":"https://orcid.org/0000-0002-1607-6355","observed_orcids":["https://orcid.org/0000-0002-1607-6355"]},"institutions":[{"id":"https://openalex.org/I103703290","display_name":"Sakarya University","ror":"https://ror.org/04ttnw109","country_code":"TR","type":"education","lineage":["https://openalex.org/I103703290"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmed Bilal Gen\u00e7","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1607-6355","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey","institution_ids":["https://openalex.org/I103703290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032429263","display_name":"Sel\u00e7uk Yaylac\u0131","orcid":"https://orcid.org/0000-0002-6768-7973","observed_orcids":["https://orcid.org/0000-0002-6768-7973"]},"institutions":[{"id":"https://openalex.org/I103703290","display_name":"Sakarya University","ror":"https://ror.org/04ttnw109","country_code":"TR","type":"education","lineage":["https://openalex.org/I103703290"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Sel\u00e7uk Yaylac\u0131","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-6768-7973","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Sakarya University, 54100 Sakarya, Turkey","institution_ids":["https://openalex.org/I103703290"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032429263"],"corresponding_institution_ids":["https://openalex.org/I103703290"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83582144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"8377","last_page":"8377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirzepatide","display_name":"tirzepatide","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9639999866485596},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.878000020980835},{"id":"https://openalex.org/keywords/fat-free-mass","display_name":"fat-free mass","score":0.925000011920929},{"id":"https://openalex.org/keywords/fat-loss","display_name":"fat loss","score":0.925000011920929},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6000000238418579},{"id":"https://openalex.org/keywords/bioelectrical-impedance-analysis","display_name":"bioelectrical impedance analysis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/total-body-water","display_name":"total body water","score":0.9459999799728394},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.7369999885559082},{"id":"https://openalex.org/keywords/lean-tissue-loss","display_name":"lean tissue loss","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9365000128746033},{"id":"https://openalex.org/C33872192","wikidata":"https://www.wikidata.org/wiki/Q864287","display_name":"Bioelectrical impedance analysis","level":3,"score":0.8614000082015991},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6571999788284302},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6018000245094299},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.5956000089645386},{"id":"https://openalex.org/C166504685","wikidata":"https://www.wikidata.org/wiki/Q843905","display_name":"Circumference","level":2,"score":0.4952999949455261},{"id":"https://openalex.org/C2993503589","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Fat mass","level":3,"score":0.4828000068664551},{"id":"https://openalex.org/C84029825","wikidata":"https://www.wikidata.org/wiki/Q4936981","display_name":"Body water","level":3,"score":0.45190000534057617},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44670000672340393},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.44609999656677246},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4244000017642975},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32989999651908875},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3285999894142151},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32760000228881836},{"id":"https://openalex.org/C2780005051","wikidata":"https://www.wikidata.org/wiki/Q797258","display_name":"Body fat percentage","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C162151065","wikidata":"https://www.wikidata.org/wiki/Q3798215","display_name":"Body adiposity index","level":5,"score":0.28769999742507935},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.2745000123977661},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2732999920845032},{"id":"https://openalex.org/C3018577593","wikidata":"https://www.wikidata.org/wiki/Q470749","display_name":"Limits of agreement","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C2777501473","wikidata":"https://www.wikidata.org/wiki/Q1796666","display_name":"Body surface area","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2779543058","wikidata":"https://www.wikidata.org/wiki/Q4200712","display_name":"Mass index","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C105054674","wikidata":"https://www.wikidata.org/wiki/Q3707381","display_name":"Mean difference","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C41826966","wikidata":"https://www.wikidata.org/wiki/Q2540769","display_name":"Waist-to-height ratio","level":4,"score":0.2549999952316284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/jcm15218377","doi":"https://doi.org/10.3390/jcm15218377","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15218377","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/jcm15218377","doi":"https://doi.org/10.3390/jcm15218377","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15218377","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1920410436","https://openalex.org/W2004177180","https://openalex.org/W2034361573","https://openalex.org/W2037049254","https://openalex.org/W2075960917","https://openalex.org/W2090202818","https://openalex.org/W2101713668","https://openalex.org/W2138012664","https://openalex.org/W2155965977","https://openalex.org/W2160234571","https://openalex.org/W2163278718","https://openalex.org/W2170120842","https://openalex.org/W2171704781","https://openalex.org/W2275737843","https://openalex.org/W2323434259","https://openalex.org/W2783583147","https://openalex.org/W2955327798","https://openalex.org/W2964443996","https://openalex.org/W2981414419","https://openalex.org/W3127371223","https://openalex.org/W4210945502","https://openalex.org/W4220745397","https://openalex.org/W4224295659","https://openalex.org/W4225632118","https://openalex.org/W4281934192","https://openalex.org/W4284698204","https://openalex.org/W4297537478","https://openalex.org/W4313880066","https://openalex.org/W4360620261","https://openalex.org/W4382050932","https://openalex.org/W4388695162","https://openalex.org/W4389082549","https://openalex.org/W4389555309","https://openalex.org/W4393195787","https://openalex.org/W4395005471","https://openalex.org/W4396515179","https://openalex.org/W4400137596","https://openalex.org/W4402399279","https://openalex.org/W4402651091","https://openalex.org/W4402834318","https://openalex.org/W4402992155","https://openalex.org/W4403382203","https://openalex.org/W4404310616","https://openalex.org/W4405676027","https://openalex.org/W4406352787","https://openalex.org/W4406800510","https://openalex.org/W4407945207","https://openalex.org/W4410277932","https://openalex.org/W4410325205","https://openalex.org/W4412203922","https://openalex.org/W4412952595","https://openalex.org/W4414636304","https://openalex.org/W4415043957","https://openalex.org/W4415946518","https://openalex.org/W4416103071","https://openalex.org/W4417497606","https://openalex.org/W7123352158","https://openalex.org/W7127655935","https://openalex.org/W7142505035","https://openalex.org/W7154695117","https://openalex.org/W7155186935","https://openalex.org/W7155366197","https://openalex.org/W7155550467","https://openalex.org/W7163149303"],"related_works":["https://openalex.org/W7161287544","https://openalex.org/W4399689888","https://openalex.org/W7222268289","https://openalex.org/W4407945207","https://openalex.org/W7155366197","https://openalex.org/W4413889595","https://openalex.org/W4411297266","https://openalex.org/W7214309535","https://openalex.org/W4402283038","https://openalex.org/W4411659179"],"abstract_inverted_index":{"Background/Objectives:":[0],"Whether":[1],"the":[2,12,22,28,33,37,166,216,238],"loss":[3,159,168,222,274],"of":[4,25,41,51,189,215,251,279],"fat-free":[5],"mass":[6,138,206],"(FFM)":[7],"during":[8,223],"tirzepatide":[9,56,224],"treatment":[10,26,42,225],"exceeds":[11],"proportion":[13],"expected":[14],"in":[15,43,160],"negative":[16],"energy":[17],"balance":[18],"is":[19,264],"debated,":[20],"and":[21,67,81,86,89,121,143,184,199,263],"earliest":[23],"weeks":[24,40,152,201],"are":[27,98],"least":[29,182,187],"characterized.":[30],"We":[31],"described":[32],"body-composition":[34],"trajectory":[35],"over":[36],"first":[38],"12":[39,87,126,151,176,200],"routine":[44],"care.":[45],"Methods:":[46],"In":[47,192],"this":[48],"retrospective":[49],"cohort":[50],"adults":[52],"with":[53,92,194,230],"obesity":[54],"starting":[55],"monotherapy,":[57],"body":[58,64,130,190],"weight,":[59],"fat":[60,137,205,228],"mass,":[61,229],"FFM,":[62],"total":[63],"water":[65,259],"(TBW),":[66],"waist":[68],"circumference":[69],"were":[70,90,123],"measured":[71,124,174],"by":[72,133,139,146,247],"single-frequency,":[73],"foot-to-foot":[74],"bioelectrical":[75],"impedance":[76],"analysis":[77],"(BIA)":[78],"at":[79,82,125,150,175,181,186,197,253],"baseline":[80,198],"approximately":[83],"4,":[84],"8,":[85],"weeks,":[88,177],"analyzed":[91],"linear":[93],"mixed-effects":[94],"models;":[95],"follow-up":[96,119],"values":[97],"available-data,":[99],"on-treatment":[100],"estimates.":[101],"Results:":[102],"Of":[103,172],"476":[104],"patients":[105,161,173,193],"(mean":[106],"age":[107],"40":[108],"years,":[109],"66%":[110],"female,":[111],"mean":[112,167],"body-mass":[113],"index":[114],"38.7":[115],"kg/m2),":[116],"268":[117],"had":[118,179],"data":[120,196],"111":[122],"weeks.":[127],"Estimated":[128],"marginal":[129],"weight":[131,217,221],"fell":[132],"11.22":[134],"kg":[135,141,148],"(10.4%),":[136],"7.90":[140],"(16.8%),":[142],"BIA-derived":[144,232],"FFM":[145,233],"3.35":[147],"(5.4%)":[149],"(all":[153],"p":[154],"<":[155],"0.001);":[156],"assuming":[157],"5-kg-less":[158],"without":[162],"a":[163,231,248,277],"12-week":[164],"measurement,":[165],"remained":[169],"7.4":[170],"kg.":[171],"89.2%":[178],"lost":[180],"5%":[183],"57.7%":[185],"10%":[188],"weight.":[191],"complete":[195],"(n":[202],"=":[203],"85),":[204],"accounted":[207],"for":[208],"68.3%":[209],"(95%":[210],"CI":[211],"56.1":[212],"to":[213,237],"80.8)":[214],"lost.":[218],"Conclusions:":[219],"Early":[220],"was":[226],"predominantly":[227],"fraction":[234],"numerically":[235],"close":[236],"commonly":[239],"cited":[240],"one-fourth.":[241],"Because":[242],"device-FFM":[243],"equaled":[244],"TBW":[245],"divided":[246],"fixed":[249],"coefficient":[250],"0.731":[252],"every":[254],"visit,":[255],"it":[256],"cannot":[257],"separate":[258],"from":[260],"lean":[261,272],"tissue":[262,273],"best":[265],"read":[266],"as":[267],"an":[268],"upper":[269],"bound":[270],"on":[271],"rather":[275],"than":[276],"measure":[278],"muscle.":[280]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
