{"id":"https://openalex.org/W7224129012","doi":"https://doi.org/10.1093/rap/rkag133","title":"A LRRC37A2 single nucleotide variant is associated with emphysema in Japanese patients with rheumatoid arthritis","display_name":"A LRRC37A2 single nucleotide variant is associated with emphysema in Japanese patients with rheumatoid arthritis","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W7224129012","doi":"https://doi.org/10.1093/rap/rkag133"},"language":"en","primary_location":{"id":"doi:10.1093/rap/rkag133","doi":"https://doi.org/10.1093/rap/rkag133","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rap/rkag133","pdf_url":"https://academic.oup.com/rheumap/advance-article-pdf/doi/10.1093/rap/rkag133/72556272/rkag133.pdf","source":{"id":"https://openalex.org/S2735938563","display_name":"Rheumatology Advances in Practice","issn_l":"2514-1775","issn":["2514-1775"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology Advances in Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/rheumap/advance-article-pdf/doi/10.1093/rap/rkag133/72556272/rkag133.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025137772","display_name":"Takashi Higuchi","orcid":"https://orcid.org/0000-0002-7489-1657","observed_orcids":["https://orcid.org/0000-0002-7489-1657"]},"institutions":[{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Higuchi","raw_affiliation_strings":["NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110932934","display_name":"Shomi Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shomi Oka","raw_affiliation_strings":["NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","institution_ids":["https://openalex.org/I4210115833"]},{"raw_affiliation_string":"NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031587921","display_name":"Kota Shimada","orcid":"https://orcid.org/0000-0002-2860-4266","observed_orcids":["https://orcid.org/0000-0002-2860-4266"]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210151172","display_name":"Tokyo Metropolitan Tama Medical Center","ror":"https://ror.org/04c3ebg91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151172"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Shimada","raw_affiliation_strings":["NHO Sagamihara National Hospital Department of Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","Tokyo Metropolitan Tama Medical Center Department of Rheumatic Diseases, , 2-8-29 Musashi-dai, Fuchu, 183-8524,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Sagamihara National Hospital Department of Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","institution_ids":["https://openalex.org/I4210115833"]},{"raw_affiliation_string":"Tokyo Metropolitan Tama Medical Center Department of Rheumatic Diseases, , 2-8-29 Musashi-dai, Fuchu, 183-8524,","institution_ids":["https://openalex.org/I4210151172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017597381","display_name":"Shinichiro Tsunoda","orcid":"https://orcid.org/0000-0003-3647-7604","observed_orcids":["https://orcid.org/0000-0003-3647-7604"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I4210117281","display_name":"Sumitomo Hospital","ror":"https://ror.org/02m9ewz37","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210117281"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Tsunoda","raw_affiliation_strings":["Hyogo College of Medicine Division of Rheumatology, Department of Internal Medicine, , 1-1 Mukogawa-cho, Nishinomiya, 663-8501,","Sumitomo Hospital Department of Nephrology, , 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hyogo College of Medicine Division of Rheumatology, Department of Internal Medicine, , 1-1 Mukogawa-cho, Nishinomiya, 663-8501,","institution_ids":["https://openalex.org/I137459256"]},{"raw_affiliation_string":"Sumitomo Hospital Department of Nephrology, , 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005,","institution_ids":["https://openalex.org/I4210117281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160050495","display_name":"Satoshi Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255650","display_name":"Niigata Rheumatic Center","ror":"https://ror.org/038hap456","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255650"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Ito","raw_affiliation_strings":["Niigata Rheumatic Center Department of Rheumatology, , 1-2-8 Hon-cho, Shibata, 957-0054,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Niigata Rheumatic Center Department of Rheumatology, , 1-2-8 Hon-cho, Shibata, 957-0054,","institution_ids":["https://openalex.org/I4405255650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104199002","display_name":"Misuzu Fujimori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127032","display_name":"Himeji Medical Center","ror":"https://ror.org/037767x92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210127032","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misuzu Fujimori","raw_affiliation_strings":["NHO Himeji Medical Center Department of Rheumatology, , 68 Hon-machi, Himeji, 670-8520,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Himeji Medical Center Department of Rheumatology, , 68 Hon-machi, Himeji, 670-8520,","institution_ids":["https://openalex.org/I4210127032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160013592","display_name":"Tadashi Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254286","display_name":"Sakurajyuji Hospital","ror":"https://ror.org/01mq28k31","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254286"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Nakamura","raw_affiliation_strings":["Sakurajyuji Hospital Department of Rheumatology, , 1-1-1 Miyukikibe, Minami-ku, Kumamoto, 861-4173,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sakurajyuji Hospital Department of Rheumatology, , 1-1-1 Miyukikibe, Minami-ku, Kumamoto, 861-4173,","institution_ids":["https://openalex.org/I4405254286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113323991","display_name":"Michita Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152596","display_name":"Nagoya Medical Center","ror":"https://ror.org/04ftw3n55","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210152596"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michita Suzuki","raw_affiliation_strings":["NHO Nagoya Medical Center Department of Internal Medicine, , 4-1-1 Sannomaru, Naka-ku, Nagoya, 460-0001,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Nagoya Medical Center Department of Internal Medicine, , 4-1-1 Sannomaru, Naka-ku, Nagoya, 460-0001,","institution_ids":["https://openalex.org/I4210152596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110575131","display_name":"Koichiro Saisho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285685","display_name":"National Hospital Organization Miyakonojo Medical Center","ror":"https://ror.org/05xvbs762","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405285685"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Saisho","raw_affiliation_strings":["NHO Miyakonojo Medical Center Department of Orthopedics/Rheumatology, , 5033-1 Iwayoshi-cho, Miyakonojo, 885-0014,","Tanimura Hospital , 10-2 Kitakoji, Nobeoka, 882-0041,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Miyakonojo Medical Center Department of Orthopedics/Rheumatology, , 5033-1 Iwayoshi-cho, Miyakonojo, 885-0014,","institution_ids":["https://openalex.org/I4405285685"]},{"raw_affiliation_string":"Tanimura Hospital , 10-2 Kitakoji, Nobeoka, 882-0041,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028568416","display_name":"S Shinohara","orcid":"https://orcid.org/0000-0001-8850-0859","observed_orcids":["https://orcid.org/0000-0001-8850-0859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Shinohara","raw_affiliation_strings":["Tochigi Rheumatology Clinic , 1-1-9 Ekimaedori, Utsunomiya, 321-0964,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tochigi Rheumatology Clinic , 1-1-9 Ekimaedori, Utsunomiya, 321-0964,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001329573","display_name":"Toshihiro Matsui","orcid":"https://orcid.org/0000-0001-9324-1089","observed_orcids":["https://orcid.org/0000-0001-9324-1089"]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Matsui","raw_affiliation_strings":["NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","NHO Sagamihara National Hospital Department of Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","institution_ids":["https://openalex.org/I4210115833"]},{"raw_affiliation_string":"NHO Sagamihara National Hospital Department of Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","institution_ids":["https://openalex.org/I4210115833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057574490","display_name":"Kiyoshi Migita","orcid":"https://orcid.org/0000-0003-1339-5622","observed_orcids":["https://orcid.org/0000-0003-1339-5622"]},"institutions":[{"id":"https://openalex.org/I130830085","display_name":"Fukushima Medical University","ror":"https://ror.org/012eh0r35","country_code":"JP","type":"education","lineage":["https://openalex.org/I130830085"]},{"id":"https://openalex.org/I4210118695","display_name":"Nagasaki Medical Center","ror":"https://ror.org/02qv90y91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118695","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Migita","raw_affiliation_strings":["Fukushima Medical University School of Medicine Department of Gastroenterology and Rheumatology, , 1 Hikarigaoka, Fukushima, 960-1295,","NHO Nagasaki Medical Center Clinical Research Center, , 2-1001-1 Kubara, Omura, 856-8562,","St. Francis Hospital Department of Internal Medicine, , 9-20 Komine-machi, Nagasaki, 852-8125,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fukushima Medical University School of Medicine Department of Gastroenterology and Rheumatology, , 1 Hikarigaoka, Fukushima, 960-1295,","institution_ids":["https://openalex.org/I130830085"]},{"raw_affiliation_string":"NHO Nagasaki Medical Center Clinical Research Center, , 2-1001-1 Kubara, Omura, 856-8562,","institution_ids":["https://openalex.org/I4210118695"]},{"raw_affiliation_string":"St. Francis Hospital Department of Internal Medicine, , 9-20 Komine-machi, Nagasaki, 852-8125,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112910079","display_name":"Shouhei Nagaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090395","display_name":"Yokohama Minami Kyosai Hospital","ror":"https://ror.org/00d0rvy84","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090395"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shouhei Nagaoka","raw_affiliation_strings":["Yokohama Minami Kyosai Hospital Department of Rheumatology, , 1-21-1 Rokuura-higashi, Kanazawa-ku, Yokohama, 236-0037,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yokohama Minami Kyosai Hospital Department of Rheumatology, , 1-21-1 Rokuura-higashi, Kanazawa-ku, Yokohama, 236-0037,","institution_ids":["https://openalex.org/I4210090395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019331714","display_name":"Shigeto Tohma","orcid":"https://orcid.org/0000-0003-4945-7629","observed_orcids":["https://orcid.org/0000-0003-4945-7629"]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Tohma","raw_affiliation_strings":["NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","institution_ids":["https://openalex.org/I4210115833"]},{"raw_affiliation_string":"NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103184166","display_name":"Kenji Itoh","orcid":"https://orcid.org/0000-0002-4122-2983","observed_orcids":["https://orcid.org/0000-0002-4122-2983"]},"institutions":[{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Itoh","raw_affiliation_strings":["NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101789417","display_name":"Hiroshi Furukawa","orcid":"https://orcid.org/0000-0002-4022-0767","observed_orcids":["https://orcid.org/0000-0002-4022-0767"]},"institutions":[{"id":"https://openalex.org/I4210115833","display_name":"National Sagamihara Hospital","ror":"https://ror.org/01gvfxs59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115833","https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Furukawa","raw_affiliation_strings":["NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHO Sagamihara National Hospital Clinical Research Center for Allergy and Rheumatology, , 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392,","institution_ids":["https://openalex.org/I4210115833"]},{"raw_affiliation_string":"NHO Tokyo National Hospital Department of Clinical Research, , 3-1-1 Takeoka, Kiyose, 204-8585,","institution_ids":["https://openalex.org/I4210156366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5101789417"],"corresponding_institution_ids":["https://openalex.org/I4210115833","https://openalex.org/I4210156366"],"apc_list":{"value":2255,"currency":"GBP","value_usd":2974},"apc_paid":{"value":2255,"currency":"GBP","value_usd":2974},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87285671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-nucleotide-variants","display_name":"single nucleotide variants","score":0.968999981880188},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7170000076293945},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.8830000162124634},{"id":"https://openalex.org/keywords/extra-articular-manifestations","display_name":"extra-articular manifestations","score":0.8840000033378601},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.7950000166893005},{"id":"https://openalex.org/keywords/steinbrocker-classification","display_name":"Steinbrocker classification","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9103000164031982},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7268000245094299},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6129999756813049},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.6032000184059143},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.5705000162124634},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5497000217437744},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5396999716758728},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5188000202178955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4715999960899353},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.3921000063419342},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37770000100135803},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.3702000081539154},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35929998755455017},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.32170000672340393},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C2781301800","wikidata":"https://www.wikidata.org/wiki/Q193894","display_name":"Sarcoidosis","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.28619998693466187},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.27489998936653137},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.26829999685287476},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/rap/rkag133","doi":"https://doi.org/10.1093/rap/rkag133","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rap/rkag133","pdf_url":"https://academic.oup.com/rheumap/advance-article-pdf/doi/10.1093/rap/rkag133/72556272/rkag133.pdf","source":{"id":"https://openalex.org/S2735938563","display_name":"Rheumatology Advances in Practice","issn_l":"2514-1775","issn":["2514-1775"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology Advances in Practice","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/rap/rkag133","doi":"https://doi.org/10.1093/rap/rkag133","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rap/rkag133","pdf_url":"https://academic.oup.com/rheumap/advance-article-pdf/doi/10.1093/rap/rkag133/72556272/rkag133.pdf","source":{"id":"https://openalex.org/S2735938563","display_name":"Rheumatology Advances in Practice","issn_l":"2514-1775","issn":["2514-1775"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology Advances in Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1777800410","display_name":"Genetic factors of interstitial lung disease associated with polymyositis and dermatomyositis.","funder_award_id":"15K09543","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3437691786","display_name":"Genetic Association Study on HLA with Interstitial Lung Diseases in Rheumatoid Arthritis Patients.","funder_award_id":"24791018","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3877387429","display_name":"Elucidation of the genetic factors and the mechanisms of adverse effects by anti-rheumatic drugs.","funder_award_id":"26293123","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G465001623","display_name":"The regulation of the expression of SH2D1A gene in systemic lupus erythematosus.","funder_award_id":"22591090","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6344911603","display_name":"The important roles of a common protective allele HLA-DRB1*13:02 in collagen diseases.","funder_award_id":"18K08402","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320310030","display_name":"Takeda Pharmaceuticals U.S.A.","ror":"https://ror.org/03bygaq51"},{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"},{"id":"https://openalex.org/F4320310759","display_name":"Nakatomi Foundation","ror":"https://ror.org/0196vdc40"},{"id":"https://openalex.org/F4320310762","display_name":"Mitsui Sumitomo Insurance Welfare Foundation","ror":"https://ror.org/032vsjs50"},{"id":"https://openalex.org/F4320310945","display_name":"Abbott Japan","ror":"https://ror.org/04v748538"},{"id":"https://openalex.org/F4320312288","display_name":"Asahi Kasei Pharma Corporation","ror":"https://ror.org/018wp0236"},{"id":"https://openalex.org/F4320321627","display_name":"Dainippon Sumitomo Pharma","ror":"https://ror.org/04sapgw72"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320323515","display_name":"Daiwa Securities Health Foundation","ror":"https://ror.org/007pxvx88"},{"id":"https://openalex.org/F4320326474","display_name":"Teijin Pharma","ror":"https://ror.org/001144c36"},{"id":"https://openalex.org/F4320327566","display_name":"Mitsubishi Tanabe Pharma Corporation","ror":"https://ror.org/038ehsm73"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320333002","display_name":"Pfizer Japan","ror":"https://ror.org/05pm71w80"},{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224129012.pdf","grobid_xml":"https://content.openalex.org/works/W7224129012.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214312087","https://openalex.org/W4318671228","https://openalex.org/W4388733980","https://openalex.org/W4313267790","https://openalex.org/W3046573191","https://openalex.org/W4225640539","https://openalex.org/W3161245500","https://openalex.org/W4399355579","https://openalex.org/W4409335650","https://openalex.org/W7165639156"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"Extra-articular":[2],"manifestations":[3],"commonly":[4],"complicate":[5],"rheumatoid":[6],"arthritis":[7],"(RA)":[8],"and":[9,83,153,161,172,190],"include":[10],"chronic":[11],"lung":[12,18],"diseases":[13],"(CLD),":[14],"for":[15,120],"example,":[16],"interstitial":[17],"disease":[19],"or":[20,35,117],"emphysema":[21],"(EMP).":[22],"These":[23],"confer":[24],"a":[25,52],"poor":[26],"prognosis.":[27],"Genetic":[28],"studies":[29,44],"of":[30,73,181],"idiopathic":[31],"pulmonary":[32],"fibrosis":[33],"(IPF)":[34],"EMP":[36,46,64,82,97,173,187],"were":[37,192],"conducted.":[38,89],"However,":[39],"there":[40],"are":[41],"limited":[42],"genetic":[43],"on":[45],"in":[47,65,75,98,138,176,188],"RA.":[48,178],"We":[49],"examined":[50],"whether":[51],"single":[53,183],"nucleotide":[54,184],"variant":[55,185],"associated":[56,62,95,135],"with":[57,81,149],"susceptibility":[58],"to":[59,63,96,101],"IPF":[60,137,191],"was":[61,88,93,133,165,174],"Japanese":[66,177],"RA":[67,79,85,99,162,189],"patients.":[68],"Methods":[69],"rs199526":[70,160,171],"[C/G]":[71],"genotyping":[72],"LRRC37A2":[74,91,159],"samples":[76],"from":[77],"88":[78],"patients":[80],"425":[84],"lacking":[86],"CLD":[87],"Results":[90],"rs199526C":[92],"significantly":[94],"according":[100],"an":[102,146],"allele":[103],"model":[104,119],"(p":[105,123],"=":[106,124],"0.0083,":[107],"odds":[108],"ratio":[109],"[OR]":[110],"1.72,":[111],"95%":[112,128],"confidence":[113],"interval":[114],"[CI]":[115],"1.14-2.59)":[116],"recessive":[118],"major":[121],"alleles":[122],"0.0139,":[125],"OR":[126],"1.82,":[127],"CI":[129],"1.13-2.94),":[130],"although":[131],"it":[132],"protectively":[134],"against":[136],"European":[139],"populations.":[140],"Multiple":[141],"logistic":[142],"regression":[143],"analyses":[144],"revealed":[145],"independent":[147],"association":[148,157,169],"age,":[150],"Steinbrocker":[151,154],"stage,":[152],"class.":[155],"An":[156,168],"between":[158,170,186],"per":[163],"se":[164],"detected.":[166],"Conclusion":[167],"noted":[175],"Differential":[179],"roles":[180],"the":[182],"suggested.":[193]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}