{"id":"https://openalex.org/W7224128456","doi":"https://doi.org/10.1002/adhm.71892","title":"Self\u2010Crosslinked Oxidized Xyloglucan Hydrogels Enhance Macrophage Metabolism for Diabetic Wound Healing via the cAMP\u2010PKA Pathway","display_name":"Self\u2010Crosslinked Oxidized Xyloglucan Hydrogels Enhance Macrophage Metabolism for Diabetic Wound Healing via the cAMP\u2010PKA Pathway","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224128456","doi":"https://doi.org/10.1002/adhm.71892","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949815"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.71892","doi":"https://doi.org/10.1002/adhm.71892","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71892","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71892","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71892","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029906275","display_name":"Rui Qiao","orcid":"https://orcid.org/0009-0000-9483-4871","observed_orcids":["https://orcid.org/0009-0000-9483-4871"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Qiao","raw_affiliation_strings":["Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","institution_ids":["https://openalex.org/I4210103957","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101506862","display_name":"Hongyu Zhao","orcid":"https://orcid.org/0000-0003-0477-3820","observed_orcids":["https://orcid.org/0000-0003-0477-3820"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Zhao","raw_affiliation_strings":["Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China"],"raw_orcid":"https://orcid.org/0000-0003-0477-3820","affiliations":[{"raw_affiliation_string":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","institution_ids":["https://openalex.org/I4210103957","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100653087","display_name":"Hao Luo","orcid":"https://orcid.org/0009-0005-1605-7516","observed_orcids":["https://orcid.org/0009-0005-1605-7516","https://orcid.org/0000-0002-5447-6210"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Luo","raw_affiliation_strings":["Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","institution_ids":["https://openalex.org/I4210103957","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434783","display_name":"Qing Wang","orcid":"https://orcid.org/0000-0001-6540-1858","observed_orcids":["https://orcid.org/0000-0001-6540-1858","https://orcid.org/0009-0005-6882-1096"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","institution_ids":["https://openalex.org/I4210103957","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159989775","display_name":"Wei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lin","raw_affiliation_strings":["Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","institution_ids":["https://openalex.org/I4210103957","https://openalex.org/I4210161528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404889","display_name":"Ning Zhang","orcid":"https://orcid.org/0000-0002-9513-9288","observed_orcids":["https://orcid.org/0000-0002-9513-9288","https://orcid.org/0009-0001-7867-8028"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ning Zhang","raw_affiliation_strings":["Musculoskeletal Research Laboratory Department of Orthopaedics & Traumatology The Chinese University of Hong Kong  Hong Kong China"],"raw_orcid":"https://orcid.org/0000-0002-9513-9288","affiliations":[{"raw_affiliation_string":"Musculoskeletal Research Laboratory Department of Orthopaedics & Traumatology The Chinese University of Hong Kong  Hong Kong China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394852","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0002-0024-4561","observed_orcids":["https://orcid.org/0000-0002-0024-4561"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Chen","raw_affiliation_strings":["Institute of Medical Sciences The Second Qilu Hospital & Shandong University Center for Orthopaedics Cheeloo College of Medicine Shandong University  Jinan China"],"raw_orcid":"https://orcid.org/0000-0002-0024-4561","affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences The Second Qilu Hospital & Shandong University Center for Orthopaedics Cheeloo College of Medicine Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957","https://openalex.org/I4210161528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101571951","display_name":"Qingguo Lai","orcid":"https://orcid.org/0000-0002-3926-8595","observed_orcids":["https://orcid.org/0000-0002-3926-8595"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingguo Lai","raw_affiliation_strings":["Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","Research Center of 3D Printing in Stomatology of Shandong University  Jinan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Stomatology The Second Qilu Hospital of Shandong University  Jinan China","institution_ids":["https://openalex.org/I4210103957","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Research Center of 3D Printing in Stomatology of Shandong University  Jinan China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100394852","https://openalex.org/A5101571951"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957","https://openalex.org/I4210161528"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86112707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.746999979019165},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.6439999938011169},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.9200000166893005},{"id":"https://openalex.org/keywords/camp-pka-signaling","display_name":"cAMP/PKA signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/anti-inflammatory-biomaterials","display_name":"anti-inflammatory biomaterials","score":0.8700000047683716},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.5830000042915344},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/extracellular-matrix-mimicry","display_name":"extracellular matrix mimicry","score":0.7250000238418579},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.49399998784065247},{"id":"https://openalex.org/keywords/polysaccharide-hydrogels","display_name":"polysaccharide hydrogels","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8513000011444092},{"id":"https://openalex.org/C2779741953","wikidata":"https://www.wikidata.org/wiki/Q1132297","display_name":"Xyloglucan","level":3,"score":0.8235999941825867},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6133000254631042},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5410000085830688},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5195000171661377},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.513700008392334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48570001125335693},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4602000117301941},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3853999972343445},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3783000111579895},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.36059999465942383},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.36010000109672546},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.33079999685287476},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2590999901294708},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.71892","doi":"https://doi.org/10.1002/adhm.71892","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71892","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71892","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:42949815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/adhm.71892","doi":"https://doi.org/10.1002/adhm.71892","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71892","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.71892","source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2675867054","display_name":null,"funder_award_id":"ZR2023ZD24","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G34554725","display_name":null,"funder_award_id":"22475121","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224128456.pdf","grobid_xml":"https://content.openalex.org/works/W7224128456.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W2014282275","https://openalex.org/W2108382420","https://openalex.org/W2573514138","https://openalex.org/W2594813491","https://openalex.org/W2756183719","https://openalex.org/W2883325680","https://openalex.org/W2897968865","https://openalex.org/W2997658354","https://openalex.org/W3017453968","https://openalex.org/W3033348713","https://openalex.org/W3049203712","https://openalex.org/W3089482192","https://openalex.org/W3116757665","https://openalex.org/W3193219480","https://openalex.org/W4220759222","https://openalex.org/W4250254619","https://openalex.org/W4285678546","https://openalex.org/W4296849524","https://openalex.org/W4309720948","https://openalex.org/W4365459086","https://openalex.org/W4378515609","https://openalex.org/W4380319434","https://openalex.org/W4390704525","https://openalex.org/W4391451604","https://openalex.org/W4393313450","https://openalex.org/W4393320664","https://openalex.org/W4399046463","https://openalex.org/W4400033876","https://openalex.org/W4400882171","https://openalex.org/W4401834588","https://openalex.org/W4402291076","https://openalex.org/W4402496802","https://openalex.org/W4402808802","https://openalex.org/W4403853942","https://openalex.org/W4404554429","https://openalex.org/W4410795170","https://openalex.org/W4412488726","https://openalex.org/W4413257606","https://openalex.org/W4413466428","https://openalex.org/W4414409217","https://openalex.org/W4415363925","https://openalex.org/W7089190883","https://openalex.org/W7154382506"],"related_works":["https://openalex.org/W7135025272","https://openalex.org/W7214804744","https://openalex.org/W7140291891","https://openalex.org/W7166852763","https://openalex.org/W7127582718","https://openalex.org/W4400882171","https://openalex.org/W4391097014","https://openalex.org/W7201860254","https://openalex.org/W4412662563","https://openalex.org/W7159841627"],"abstract_inverted_index":{"Xyloglucan,":[0],"an":[1,81],"immunomodulatory":[2],"hemicellulose,":[3],"shows":[4],"potential":[5],"for":[6,67,194],"promoting":[7],"chronic":[8,181],"wound":[9,139],"healing.":[10],"However,":[11],"tunable":[12],"hydrogels":[13],"composed":[14],"solely":[15],"of":[16,169,176],"xyloglucan":[17,35],"with":[18,42,155],"a":[19,30,85,125,151,156,170,189],"defined":[20],"anti-inflammatory":[21,40,158,192],"mechanism":[22,159],"remain":[23],"elusive.":[24],"To":[25],"address":[26],"this,":[27],"we":[28],"developed":[29],"single-component,":[31],"inherently":[32],"bioactive":[33],"oxidized":[34],"(OXG)":[36],"hydrogel":[37,48,108,153],"that":[38,105],"integrates":[39],"functionality":[41],"extracellular":[43],"matrix":[44],"(ECM)-mimetic":[45],"properties.":[46],"The":[47],"forms":[49],"autonomously":[50],"via":[51],"dynamic":[52],"hemiacetal":[53],"crosslinking":[54],"between":[55],"aldehyde":[56],"and":[57,83,93,100,113,128,143,166,197],"hydroxyl":[58],"groups":[59],"on":[60],"the":[61,65,106,119,162,177],"OXG":[62,76,107,187],"backbone,":[63],"eliminating":[64],"need":[66],"exogenous":[68,132],"crosslinkers":[69],"or":[70],"drug":[71],"loading.":[72],"This":[73,148],"strategy":[74],"enables":[75],"to":[77,124],"function":[78],"both":[79],"as":[80,84,188],"immunomodulator":[82],"supportive":[86],"scaffold,":[87],"exhibiting":[88],"tissue":[89,146,195],"adhesion,":[90],"injectability,":[91],"self-healing,":[92],"stability":[94],"in":[95,101,180],"physiological":[96],"environments.":[97],"In":[98],"vitro":[99],"vivo":[102],"results":[103],"demonstrated":[104],"promotes":[109],"M2":[110],"macrophage":[111],"polarization":[112],"suppresses":[114],"pro-inflammatory":[115],"responses":[116],"by":[117,160],"activating":[118],"cAMP-PKA":[120],"signaling":[121],"pathway,":[122],"leading":[123],"metabolic":[126],"shift":[127],"inflammation":[129],"resolution":[130],"without":[131],"cytokines.":[133],"These":[134,184],"actions":[135],"collectively":[136],"accelerated":[137],"diabetic":[138,182],"closure,":[140],"enhanced":[141],"angiogenesis,":[142],"facilitated":[144],"orderly":[145],"regeneration.":[147],"work":[149],"established":[150],"drug-free":[152],"dressing":[154],"well-defined":[157],"leveraging":[161],"inherent":[163],"biological":[164],"activity":[165],"self-gelling":[167],"capability":[168],"single":[171],"polysaccharide,":[172],"achieving":[173],"active":[174],"remodeling":[175],"immune":[178],"environment":[179],"wounds.":[183],"findings":[185],"position":[186],"promising":[190],"natural":[191],"biomaterial":[193],"engineering":[196],"therapeutics.":[198]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-29T00:00:00"}