{"id":"https://openalex.org/W7224127789","doi":"https://doi.org/10.5472/marumj.2070845","title":"Clinical characteristics and outcomes of syndromic children with ventricular septal defect: A single-center study","display_name":"Clinical characteristics and outcomes of syndromic children with ventricular septal defect: A single-center study","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224127789","doi":"https://doi.org/10.5472/marumj.2070845"},"language":"en","primary_location":{"id":"doi:10.5472/marumj.2070845","doi":"https://doi.org/10.5472/marumj.2070845","is_oa":true,"landing_page_url":"https://doi.org/10.5472/marumj.2070845","pdf_url":"https://dergipark.org.tr/en/download/article-file/6596852","source":{"id":"https://openalex.org/S2764960455","display_name":"Marmara medical journal","issn_l":"1019-1941","issn":["1019-1941","1309-9469"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318381","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/P4310318381"],"host_organization_lineage_names":["Marmara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marmara Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/6596852","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082543024","display_name":"Selen Karag\u00f6zl\u00fc","orcid":"https://orcid.org/0000-0002-9542-1937","observed_orcids":["https://orcid.org/0000-0002-9542-1937"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Selen Karagozlu","raw_affiliation_strings":["MARMARA \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-9542-1937","affiliations":[{"raw_affiliation_string":"MARMARA \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028535250","display_name":"Mehmet G\u00f6khan Ramo\u011flu","orcid":"https://orcid.org/0000-0002-4117-0685","observed_orcids":["https://orcid.org/0000-0002-4117-0685"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet G\u00f6khan Ramo\u011flu","raw_affiliation_strings":["ANKARA \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-4117-0685","affiliations":[{"raw_affiliation_string":"ANKARA \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159998665","display_name":"Kerem Omer Ozcan","orcid":"https://orcid.org/0009-0004-6342-5046","observed_orcids":["https://orcid.org/0009-0004-6342-5046"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kerem Omer Ozcan","raw_affiliation_strings":["ANKARA \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0009-0004-6342-5046","affiliations":[{"raw_affiliation_string":"ANKARA \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081499104","display_name":"Tayfun U\u00e7ar","orcid":"https://orcid.org/0000-0003-3386-0691","observed_orcids":["https://orcid.org/0000-0003-3386-0691","https://orcid.org/0000-0003-1206-5103"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tayfun U\u00e7ar","raw_affiliation_strings":["ANKARA \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0003-3386-0691","affiliations":[{"raw_affiliation_string":"ANKARA \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082543024"],"corresponding_institution_ids":["https://openalex.org/I74897591"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85575719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"3","first_page":"234","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventricular-septal-defect","display_name":"ventricular septal defect","score":0.984000027179718},{"id":"https://openalex.org/keywords/syndromic-congenital-heart-disease","display_name":"syndromic congenital heart disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.7009999752044678},{"id":"https://openalex.org/keywords/spontaneous-closure","display_name":"spontaneous closure","score":0.4909999966621399},{"id":"https://openalex.org/keywords/muscular-ventricular-septal-defect","display_name":"muscular ventricular septal defect","score":0.824999988079071},{"id":"https://openalex.org/keywords/genetic-syndromes","display_name":"genetic syndromes","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcatheter-interventions","display_name":"transcatheter interventions","score":0.7250000238418579},{"id":"https://openalex.org/keywords/surgical-treatment","display_name":"surgical treatment","score":0.7099999785423279},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9764999747276306},{"id":"https://openalex.org/C2909602630","wikidata":"https://www.wikidata.org/wiki/Q179630","display_name":"Genetic syndromes","level":2,"score":0.7084000110626221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.573199987411499},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5291000008583069},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4424999952316284},{"id":"https://openalex.org/C2777010224","wikidata":"https://www.wikidata.org/wiki/Q16934669","display_name":"Heart septal defect","level":2,"score":0.4357999861240387},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.40149998664855957},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.3652999997138977},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.36149999499320984},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C2994486495","wikidata":"https://www.wikidata.org/wiki/Q939364","display_name":"Heart defect","level":3,"score":0.32170000672340393},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C2992981700","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital disease","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2655999958515167},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.25839999318122864},{"id":"https://openalex.org/C2993153387","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic diagnosis","level":3,"score":0.2572000026702881}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5472/marumj.2070845","doi":"https://doi.org/10.5472/marumj.2070845","is_oa":true,"landing_page_url":"https://doi.org/10.5472/marumj.2070845","pdf_url":"https://dergipark.org.tr/en/download/article-file/6596852","source":{"id":"https://openalex.org/S2764960455","display_name":"Marmara medical journal","issn_l":"1019-1941","issn":["1019-1941","1309-9469"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318381","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/P4310318381"],"host_organization_lineage_names":["Marmara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marmara Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/2070845","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/marumj/article/2070845","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marmara Medical Journal, Vol. 39 No. 3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.5472/marumj.2070845","doi":"https://doi.org/10.5472/marumj.2070845","is_oa":true,"landing_page_url":"https://doi.org/10.5472/marumj.2070845","pdf_url":"https://dergipark.org.tr/en/download/article-file/6596852","source":{"id":"https://openalex.org/S2764960455","display_name":"Marmara medical journal","issn_l":"1019-1941","issn":["1019-1941","1309-9469"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318381","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/P4310318381"],"host_organization_lineage_names":["Marmara University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marmara Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224127789.pdf","grobid_xml":"https://content.openalex.org/works/W7224127789.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W44429629","https://openalex.org/W1969360167","https://openalex.org/W2012517517","https://openalex.org/W2120404937","https://openalex.org/W2128988606","https://openalex.org/W2166829331","https://openalex.org/W2315651635","https://openalex.org/W2413057973","https://openalex.org/W2884265917","https://openalex.org/W2884736044","https://openalex.org/W2905553926","https://openalex.org/W2945647511","https://openalex.org/W2972778322","https://openalex.org/W3006217676","https://openalex.org/W3211998856","https://openalex.org/W4253835536","https://openalex.org/W4293163031","https://openalex.org/W4321181671","https://openalex.org/W4385514688","https://openalex.org/W4391428867","https://openalex.org/W4392383935","https://openalex.org/W4393120092","https://openalex.org/W4406324283","https://openalex.org/W7162763050"],"related_works":["https://openalex.org/W4405440131","https://openalex.org/W2979295330","https://openalex.org/W4382790218","https://openalex.org/W2001903666","https://openalex.org/W2037586329","https://openalex.org/W2754989021","https://openalex.org/W2040737109","https://openalex.org/W2999207259","https://openalex.org/W4390427399","https://openalex.org/W2965033984"],"abstract_inverted_index":{"Objective:":[0],"Ventricular":[1],"septal":[2],"defect":[3,11,162],"(VSD)":[4],"is":[5],"the":[6,21,88,106,113,156,166],"most":[7,89,114],"common":[8,90],"congenital":[9],"heart":[10],"and":[12,28,36,57,67,82,99,109,151,161,176,185],"frequently":[13],"accompanies":[14],"genetic":[15,68,77,149],"syndromes.This":[16],"study":[17,41],"aimed":[18],"to":[19],"evaluate":[20],"demographic":[22],"characteristics,":[23],"VSD":[24,48,63,70,104,142,159],"morphology,":[25],"associated":[26],"syndromes,":[27],"clinical":[29,81],"outcomes":[30,71],"ofsyndromic":[31],"children":[32,45,139],"with":[33,46,75,140,147],"isolated":[34,47,62,141],"VSD.Patients":[35],"Methods:":[37],"This":[38],"retrospective":[39],"single-center":[40],"included":[42],"88":[43],"syndromic":[44,96],"followed":[49,93],"at":[50],"a":[51,144],"tertiarypediatric":[52],"cardiology":[53],"center":[54],"between":[55],"1991":[56],"2024":[58],"(8.8%":[59],"of":[60],"all":[61],"cases).":[64],"Clinical,":[65],"echocardiographic":[66],"dataand":[69],"were":[72,112,164],"reviewed.":[73],"Patients":[74],"suspected":[76],"syndromes":[78,101],"underwent":[79],"stepwise":[80],"molecular":[83],"geneticevaluation.Results:":[84],"Down":[85,153],"syndrome":[86,154],"was":[87,105,118,126,155,173],"diagnosis":[91],"(48.9%),":[92],"by":[94],"unclassified":[95],"conditions":[97],"(18.2%)":[98],"raregenetic":[100],"(20.5%).":[102],"Muscular":[103],"predominant":[107,157],"subtype,":[108],"small":[110],"defects":[111],"common.":[115],"Pulmonaryhypertension":[116],"(PHT)":[117],"present":[119],"in":[120,128,134],"20.5%.":[121],"Surgical":[122],"or":[123],"transcatheter":[124],"intervention":[125],"required":[127],"20.5%,":[129],"while":[130],"spontaneous":[131,169],"VSDclosure":[132],"occurred":[133],"27.3%":[135],"during":[136],"follow-up.Conclusion:":[137],"Syndromic":[138],"represent":[143],"heterogeneous":[145],"population":[146],"diverse":[148],"diagnoses":[150],"variableoutcomes;":[152],"syndrome.":[158],"anatomy":[160],"size":[163],"among":[165],"main":[167],"determinantsof":[168],"closure,":[170],"whereas":[171],"PHT":[172],"an":[174],"important":[175],"often":[177],"multifactorial":[178],"concern.":[179],"These":[180],"findings":[181],"may":[182],"facilitate":[183],"clinicalsurveillance":[184],"management.":[186]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}
