{"id":"https://openalex.org/W7224125656","doi":"https://doi.org/10.3389/fcvm.2026.1907964","title":"Association between metabolic syndrome severity score and coronary artery disease complexity assessed by the SYNTAX score in patients with chronic coronary syndrome","display_name":"Association between metabolic syndrome severity score and coronary artery disease complexity assessed by the SYNTAX score in patients with chronic coronary syndrome","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224125656","doi":"https://doi.org/10.3389/fcvm.2026.1907964"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1907964","doi":"https://doi.org/10.3389/fcvm.2026.1907964","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1907964","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1907964/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1907964/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062782810","display_name":"Mehmet Vatansever","orcid":"https://orcid.org/0009-0002-2019-1214","observed_orcids":["https://orcid.org/0009-0002-2019-1214"]},"institutions":[{"id":"https://openalex.org/I4387152860","display_name":"Trabzon University","ror":"https://ror.org/04mmwq306","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387152860"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet Vatansever","raw_affiliation_strings":["Department of Family Medicine, Trabzon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Trabzon University","institution_ids":["https://openalex.org/I4387152860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070700340","display_name":"Ahmet \u00d6zderya","orcid":"https://orcid.org/0000-0002-4369-6146","observed_orcids":["https://orcid.org/0000-0002-4369-6146"]},"institutions":[{"id":"https://openalex.org/I4387152860","display_name":"Trabzon University","ror":"https://ror.org/04mmwq306","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387152860"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet \u00d6zderya","raw_affiliation_strings":["Department of Cardiology, Trabzon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Trabzon University","institution_ids":["https://openalex.org/I4387152860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159997891","display_name":"Fatma Y\u0131lmaz Tulumcu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152860","display_name":"Trabzon University","ror":"https://ror.org/04mmwq306","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387152860"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatma Y\u0131lmaz Tulumcu","raw_affiliation_strings":["Department of Family Medicine, Trabzon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Trabzon University","institution_ids":["https://openalex.org/I4387152860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085118110","display_name":"Y\u0131lmaz Sezgin","orcid":"https://orcid.org/0000-0002-3626-0264","observed_orcids":["https://orcid.org/0000-0002-3626-0264"]},"institutions":[{"id":"https://openalex.org/I4387152860","display_name":"Trabzon University","ror":"https://ror.org/04mmwq306","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387152860"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Y\u0131lmaz Sezgin","raw_affiliation_strings":["Department of Family Medicine, Trabzon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Trabzon University","institution_ids":["https://openalex.org/I4387152860"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037372751","display_name":"Serap \u00d6zer Yaman","orcid":"https://orcid.org/0000-0002-5089-0836","observed_orcids":["https://orcid.org/0000-0002-5089-0836"]},"institutions":[{"id":"https://openalex.org/I4387152860","display_name":"Trabzon University","ror":"https://ror.org/04mmwq306","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387152860"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Serap \u00d6zer Yaman","raw_affiliation_strings":["Department of Biochemistry, Trabzon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Trabzon University","institution_ids":["https://openalex.org/I4387152860"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037372751","https://openalex.org/A5062782810"],"corresponding_institution_ids":["https://openalex.org/I4387152860"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85781016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome-severity","display_name":"metabolic syndrome severity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.8299999833106995},{"id":"https://openalex.org/keywords/coronary-artery-disease-complexity","display_name":"coronary artery disease complexity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/syntax-score","display_name":"SYNTAX score","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-lesion-complexity","display_name":"coronary lesion complexity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/coronary-risk-stratification","display_name":"coronary artery disease risk stratification","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.574999988079071},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8069999814033508},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6959999799728394},{"id":"https://openalex.org/keywords/coronary-angiography","display_name":"coronary angiography","score":0.6309999823570251},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.4950000047683716},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.878000020980835},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":0.871999979019165},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cardiovascular-risk-assessment","display_name":"cardiovascular risk assessment","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.853600025177002},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7896000146865845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7461000084877014},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6601999998092651},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6319000124931335},{"id":"https://openalex.org/C60048249","wikidata":"https://www.wikidata.org/wiki/Q37437","display_name":"Syntax","level":2,"score":0.4778999984264374},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.36800000071525574},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.36000001430511475},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fcvm.2026.1907964","doi":"https://doi.org/10.3389/fcvm.2026.1907964","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1907964","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1907964/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7f29ba61f7d5434792e45cd53d24e229","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7f29ba61f7d5434792e45cd53d24e229","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1907964","doi":"https://doi.org/10.3389/fcvm.2026.1907964","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1907964","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1907964/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224125656.pdf","grobid_xml":"https://content.openalex.org/works/W7224125656.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2038429516","https://openalex.org/W2057074602","https://openalex.org/W2103714496","https://openalex.org/W2108466510","https://openalex.org/W2129448542","https://openalex.org/W2143104968","https://openalex.org/W2581982962","https://openalex.org/W2594679043","https://openalex.org/W2605228899","https://openalex.org/W2624397236","https://openalex.org/W2894614049","https://openalex.org/W2902734739","https://openalex.org/W3006116566","https://openalex.org/W3113859820","https://openalex.org/W3128373745","https://openalex.org/W3191082251","https://openalex.org/W4206980299","https://openalex.org/W4223968562","https://openalex.org/W4225384308","https://openalex.org/W4249825849","https://openalex.org/W4319072973","https://openalex.org/W4385663817","https://openalex.org/W4386442485","https://openalex.org/W4390837189","https://openalex.org/W4400327943"],"related_works":["https://openalex.org/W7134230491","https://openalex.org/W4293585415","https://openalex.org/W4397037716","https://openalex.org/W2051329087","https://openalex.org/W3092222124","https://openalex.org/W2158975114","https://openalex.org/W2374316812","https://openalex.org/W2551814222","https://openalex.org/W4402879847","https://openalex.org/W2027701520"],"abstract_inverted_index":{"Background":[0],"Metabolic":[1],"syndrome":[2,20,42,78],"represents":[3],"a":[4],"cluster":[5],"of":[6,33,250,315],"interrelated":[7],"cardiometabolic":[8],"abnormalities":[9],"associated":[10,48,275,289,297],"with":[11,49,62,75,220,276,290,298,306],"coronary":[12,50,64,77,81,97,300,308,338],"artery":[13,51,301],"disease.":[14],"However,":[15],"conventional":[16,323],"definitions":[17],"evaluate":[18,151],"metabolic":[19,41,94,317],"categorically":[21],"and":[22,90,114,125,135,144,156,169,196,199,247,270,282],"may":[23,321],"not":[24,287],"adequately":[25],"reflect":[26],"its":[27,334],"cumulative":[28,316],"severity.":[29],"The":[30,232],"primary":[31],"objective":[32],"this":[34],"study":[35,71],"was":[36,46,84,100,217,237,295],"to":[37,122,150,332],"assess":[38],"whether":[39],"the":[40,57,103,129,152,157,162,176,208,221,251,254,277],"severity":[43],"Z-score":[44],"(MetS-Sz)":[45],"independently":[47,274,296],"disease":[52,302],"complexity,":[53],"as":[54],"quantified":[55],"by":[56],"SYNTAX":[58,104,158,197,222,255,278],"score,":[59,279],"in":[60,175,207,253,304,337],"patients":[61,74,305],"chronic":[63,76,307],"syndrome.":[65,309],"Methods":[66],"This":[67],"single-center":[68],"retrospective":[69],"cross-sectional":[70],"included":[72],"156":[73,163],"who":[79],"underwent":[80],"angiography.":[82],"MetS-Sz":[83,119,155,178,210,216,294,320],"calculated":[85],"using":[86,102,319],"age-,":[87],"sex-,":[88],"race-,":[89],"body":[91,183,265],"mass":[92,184,266],"index-based":[93],"variables,":[95],"whereas":[96,280],"lesion":[98],"complexity":[99,303],"assessed":[101],"score.":[105,159],"Participants":[106],"were":[107,138,148,167,172,273,286],"categorized":[108],"into":[109],"lower":[110,200,209],"(MetS-Sz":[111,116],"<":[112,214,230,245],"0)":[113,118],"higher":[115,177,182],"\u2265":[117],"groups,":[120],"corresponding":[121],"values":[123],"below":[124],"at":[126],"or":[127],"above":[128],"reference":[130],"population":[131],"mean.":[132],"Clinical,":[133],"anthropometric,":[134],"biochemical":[136],"characteristics":[137],"compared":[139],"between":[140,154],"groups.":[141],"Correlation":[142],"analysis":[143],"multiple":[145,233],"linear":[146,234],"regression":[147,235],"performed":[149],"association":[153],"Results":[160],"Of":[161],"participants,":[164],"123":[165],"(78.8%)":[166],"men":[168],"33":[170],"(21.2%)":[171],"women.":[173],"Patients":[174],"group":[179,211],"had":[180],"significantly":[181,288],"index,":[185,267],"triglyceride,":[186],"total":[187],"cholesterol,":[188,191,264],"low-density":[189,262],"lipoprotein":[190,202,263],"glucose,":[192],"diastolic":[193,283],"blood":[194,284],"pressure,":[195],"scores":[198],"high-density":[201],"cholesterol":[203],"levels":[204],"than":[205],"those":[206],"(all":[212],"p":[213,229,244],"0.05).":[215],"positively":[218],"correlated":[219],"score":[223,256],"(":[224,240],"r":[225],"s":[226],"=":[227,242,259],"0.675,":[228],"0.001).":[231],"model":[236],"statistically":[238],"significant":[239],"F":[241],"22.84,":[243],"0.001)":[246],"explained":[248],"51.9%":[249],"variance":[252],"(R":[257],"2":[258],"0.519).":[260],"MetS-Sz,":[261],"triglyceride":[268],"level,":[269],"smoking":[271],"status":[272],"diabetes":[281],"pressure":[285],"it.":[291],"Conclusions":[292],"Higher":[293],"greater":[299],"These":[310],"findings":[311],"suggest":[312],"that":[313],"assessment":[314],"burden":[318],"complement":[322],"cardiovascular":[324],"risk":[325,339],"evaluation.":[326],"Prospective,":[327],"multicenter":[328],"studies":[329],"are":[330],"required":[331],"confirm":[333],"potential":[335],"role":[336],"stratification.":[340]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}