{"id":"https://openalex.org/W7224124569","doi":"https://doi.org/10.64898/2026.10.25.761662","title":"Glutamine-derived NADH fuels lactate production to maximize ATP yield under oxygen consumption constraints in head and neck cancer","display_name":"Glutamine-derived NADH fuels lactate production to maximize ATP yield under oxygen consumption constraints in head and neck cancer","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224124569","doi":"https://doi.org/10.64898/2026.10.25.761662"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.25.761662","doi":"https://doi.org/10.64898/2026.10.25.761662","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.761662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.25.761662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.25.761662.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092420621","display_name":"Christoff Odendaal","orcid":"https://orcid.org/0000-0003-2199-5070","observed_orcids":["https://orcid.org/0000-0003-2199-5070"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christoff Odendaal","raw_affiliation_strings":["Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2199-5070","affiliations":[{"raw_affiliation_string":"Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022598010","display_name":"Rianne Dalhuisen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rianne Dalhuisen","raw_affiliation_strings":["Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands","Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","institution_ids":["https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114519475","display_name":"Milou Hoving","orcid":"https://orcid.org/0009-0007-5591-612X","observed_orcids":["https://orcid.org/0009-0007-5591-612X"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Milou Hoving","raw_affiliation_strings":["Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138358588","display_name":"Mingjia Zhang","orcid":"https://orcid.org/0000-0002-8706-1572","observed_orcids":["https://orcid.org/0000-0002-8706-1572"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mingjia Zhang","raw_affiliation_strings":["Laboratory of Pediatrics, University of Groningen, Medical Centre Groningen, 9731GZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pediatrics, University of Groningen, Medical Centre Groningen, 9731GZ, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032066520","display_name":"Marijke van Walsum","orcid":"https://orcid.org/0000-0003-3972-3460","observed_orcids":["https://orcid.org/0000-0003-3972-3460"]},"institutions":[{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marijke Stigter-van Walsum","raw_affiliation_strings":["Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","institution_ids":["https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036070069","display_name":"Dennis P. J. Botman","orcid":"https://orcid.org/0000-0002-4679-3013","observed_orcids":["https://orcid.org/0000-0002-4679-3013"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dennis Botman","raw_affiliation_strings":["Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4679-3013","affiliations":[{"raw_affiliation_string":"Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068054218","display_name":"Albert Gerding","orcid":"https://orcid.org/0000-0002-6004-2398","observed_orcids":["https://orcid.org/0000-0002-6004-2398"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Albert Gerding","raw_affiliation_strings":["Laboratory of Pediatrics, University of Groningen, Medical Centre Groningen, 9731GZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pediatrics, University of Groningen, Medical Centre Groningen, 9731GZ, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037043919","display_name":"Jos B. Poell","orcid":"https://orcid.org/0000-0003-1776-3779","observed_orcids":["https://orcid.org/0000-0003-1776-3779"]},"institutions":[{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos B. Poell","raw_affiliation_strings":["Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","institution_ids":["https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064034989","display_name":"Barbara M. Bakker","orcid":"https://orcid.org/0000-0001-6274-3633","observed_orcids":["https://orcid.org/0000-0001-6274-3633","https://orcid.org/0000-0002-6384-5778"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Barbara M. Bakker","raw_affiliation_strings":["Laboratory of Pediatrics, University of Groningen, Medical Centre Groningen, 9731GZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pediatrics, University of Groningen, Medical Centre Groningen, 9731GZ, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070958079","display_name":"Bas Teusink","orcid":"https://orcid.org/0000-0003-3929-0423","observed_orcids":["https://orcid.org/0000-0003-3929-0423"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bas Teusink","raw_affiliation_strings":["Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077403448","display_name":"Ruud H. Brakenhoff","orcid":"https://orcid.org/0000-0003-3251-5378","observed_orcids":["https://orcid.org/0000-0003-3251-5378"]},"institutions":[{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ruud H. Brakenhoff","raw_affiliation_strings":["Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3251-5378","affiliations":[{"raw_affiliation_string":"Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, 1081BT, The Netherlands","institution_ids":["https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Otolaryngology/Head and Neck Surgery, Amsterdam UMC Location VUmc, 1081HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018863308","display_name":"Jurgen R. Haanstra","orcid":"https://orcid.org/0000-0001-9652-0219","observed_orcids":["https://orcid.org/0000-0001-9652-0219"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jurgen R. Haanstra","raw_affiliation_strings":["Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9652-0219","affiliations":[{"raw_affiliation_string":"Systems Biology Lab/A-LIFE, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018863308"],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.8059999942779541},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.7580000162124634},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.5090000033378601},{"id":"https://openalex.org/keywords/atp-yield","display_name":"ATP yield","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.652999997138977},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7039999961853027},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7459999918937683},{"id":"https://openalex.org/keywords/carbon-source-utilization","display_name":"carbon source utilization","score":0.45899999141693115},{"id":"https://openalex.org/keywords/fadh2","display_name":"FADH2","score":0.6790000200271606},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7483999729156494},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.7164000272750854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6549000144004822},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.548799991607666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5455999970436096},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.5174999833106995},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.49320000410079956},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4814000129699707},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.477400004863739},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.4763000011444092},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.45239999890327454},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.4189000129699707},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.41659998893737793},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.4165000021457672},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C71995715","wikidata":"https://www.wikidata.org/wiki/Q78574842","display_name":"Flavoprotein","level":3,"score":0.32519999146461487},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C2777179333","wikidata":"https://www.wikidata.org/wiki/Q213580","display_name":"Pyruvic acid","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2793000042438507},{"id":"https://openalex.org/C2780523633","wikidata":"https://www.wikidata.org/wiki/Q380709","display_name":"Labelling","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C2778160063","wikidata":"https://www.wikidata.org/wiki/Q1532402","display_name":"Glutaminolysis","level":4,"score":0.27570000290870667},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.27320000529289246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.25.761662","doi":"https://doi.org/10.64898/2026.10.25.761662","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.761662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.25.761662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.25.761662","doi":"https://doi.org/10.64898/2026.10.25.761662","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.761662","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/28/2026.10.25.761662.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224124569.pdf","grobid_xml":"https://content.openalex.org/works/W7224124569.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W3184720497","https://openalex.org/W4389890717","https://openalex.org/W7113896064"],"related_works":["https://openalex.org/W2760505998","https://openalex.org/W2094706596","https://openalex.org/W2184384535","https://openalex.org/W2805205703","https://openalex.org/W3203109344","https://openalex.org/W1996365670","https://openalex.org/W3035034091","https://openalex.org/W2101027575","https://openalex.org/W2328385764","https://openalex.org/W4254593809"],"abstract_inverted_index":{"Abstract":[0],"Metabolic":[1],"reprogramming":[2],"is":[3,13,18,63,88,161,296,309,319,359],"one":[4],"of":[5,8,28,37,60,70,203,237,300,313,322,370],"the":[6,14,35,58,68,94,120,129,192,208,248,284,298,301,306,320],"hallmarks":[7],"cancer.":[9],"A":[10],"well-known":[11],"change":[12],"Warburg":[15],"effect:":[16],"glucose":[17,280],"consumed":[19,64,90],"at":[20],"increased":[21,142,164,249],"rates":[22],"and":[23,47,79,91,125,172,263,347,366],"fermented":[24],"to":[25,31,104,118,194],"lactate":[26,61,105,123,143,198,226,250,271,303,308,323,341],"instead":[27],"being":[29],"respired":[30],"carbon":[32,56,72,221],"dioxide,":[33],"despite":[34,180],"presence":[36,69],"sufficient":[38],"oxygen":[39],"(O":[40],"2":[41,137,159,171,175,231,239,352],").":[42],"We":[43,328],"show":[44,85,132,287],"that":[45,86,153,219,294,336],"head":[46],"neck":[48,264],"squamous":[49,265],"cell":[50,266],"carcinoma":[51,267],"(HNSCC)":[52,268],"cells":[53,269,285],"excrete":[54],"more":[55,201],"in":[57,93,257,273,325,364],"form":[59],"than":[62,184,276],"as":[65,147],"glucose,":[66],"indicating":[67],"additional":[71],"sources":[73,222],"for":[74,225,247],"lactate.":[75],"Amino":[76],"acid":[77,96],"uptake":[78],"[U-":[80],"13":[81,291],"C]-glutamine":[82],"labelling":[83],"data":[84],"glutamine":[87,126,146,165,204,289,315,344],"highly":[89],"oxidized":[92],"tricarboxylic":[95],"(TCA)":[97],"cycle,":[98],"but":[99],"remarkably":[100],"does":[101],"not":[102,297,310],"contribute":[103],"carbon.":[106,304],"To":[107],"explain":[108],"these":[109],"observations,":[110],"we":[111,131,217],"generated":[112],"a":[113,244,253,311,330,360],"cell-line":[114],"specific":[115],"metabolic":[116,332],"model":[117,151,333],"understand":[119],"link":[121],"between":[122],"production":[124,144,155,227,242,251,324,342],"metabolism.":[127,373],"In":[128],"model,":[130],"how":[133],"low":[134],"cellular":[135],"O":[136,158,230,238,351],"consumption":[138,160,232,281,353],"capacity":[139],"can":[140,176,188,277],"cause":[141],"with":[145],"NADH":[148,185,187,339],"source.":[149],"The":[150],"suggests":[152],"ATP":[154,183,210,241,348],"under":[156,228,350],"limited":[157],"augmented":[162],"by":[163,197,340],"oxidation":[166,345],"which":[167,334],"yields":[168],"ATP,":[169],"FADH":[170,174],"NADH.":[173],"only":[177],"be":[178,189,195],"respired,":[179],"yielding":[181],"less":[182],"respiration.":[186],"exported":[190],"from":[191,279],"mitochondrion":[193],"reoxidized":[196],"dehydrogenase,":[199],"permitting":[200],"cycles":[202],"oxidation,":[205,316],"thereby":[206],"increasing":[207],"total":[209],"yield.":[211],"By":[212],"experimentally":[213],"inhibiting":[214],"mitochondrial":[215,338],"respiration,":[216],"confirmed":[218],"non-glucose":[220],"are":[223],"used":[224],"decreased":[229],"capacity.":[233],"This":[234,355],"unexpected":[235],"feature":[236],"-constrained":[240],"provides":[243],"credible":[245],"mechanism":[246],"via":[252],"novel":[254,356],"redox":[255,357],"cycle":[256,358],"HNSCC":[258,326,365],"cells.":[259],"Significance":[260],"Statement":[261],"Head":[262],"exhibit":[270],"overproduction,":[272],"amounts":[274],"higher":[275],"originate":[278],"alone.":[282],"While":[283],"also":[286],"high":[288],"consumption,":[290],"C-labelling":[292],"showed":[293],"this":[295],"origin":[299],"extra":[302],"If":[305],"surplus":[307],"product":[312],"partial":[314],"then":[317],"what":[318],"role":[321],"cells?":[327],"built":[329],"cell-specific":[331],"indicated":[335],"recycling":[337],"increases":[343],"flux":[346],"yield":[349],"constraints.":[354],"potential":[361],"therapeutic":[362],"target":[363],"advances":[367],"our":[368],"knowledge":[369],"rewired":[371],"cancer":[372]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
