{"id":"https://openalex.org/W7224123084","doi":"https://doi.org/10.4274/abcr.2026.26456","title":"Longitudinal Optical Coherence Tomography Angiography Assessment of Retinal Microvascular Changes in Patients Receiving Oral Isotretinoin","display_name":"Longitudinal Optical Coherence Tomography Angiography Assessment of Retinal Microvascular Changes in Patients Receiving Oral Isotretinoin","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224123084","doi":"https://doi.org/10.4274/abcr.2026.26456"},"language":"en","primary_location":{"id":"doi:10.4274/abcr.2026.26456","doi":"https://doi.org/10.4274/abcr.2026.26456","is_oa":true,"landing_page_url":"https://doi.org/10.4274/abcr.2026.26456","pdf_url":"https://abcresearch.net/pdf/0fdb9ffe-e838-45c0-b564-25a52c51df96/articles/ABCR.2026.26456/256-262.pdf","source":{"id":"https://openalex.org/S4210218045","display_name":"Archives of Basic and Clinical Research","issn_l":"2687-4482","issn":["2687-4482","2687-4520"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Basic and Clinical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://abcresearch.net/pdf/0fdb9ffe-e838-45c0-b564-25a52c51df96/articles/ABCR.2026.26456/256-262.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041878142","display_name":"Ahmet Mehmet Somuncu","orcid":"https://orcid.org/0009-0008-0304-5278","observed_orcids":["https://orcid.org/0009-0008-0304-5278"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Mehmet Somuncu","raw_affiliation_strings":["Clinic of Ophthalmology , University of Health Sciences T\u00fcrkiye , Trabzon Kanuni Training and Research Hospital , Trabzon , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Ophthalmology , University of Health Sciences T\u00fcrkiye , Trabzon Kanuni Training and Research Hospital , Trabzon , T\u00fcrkiye","institution_ids":["https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064655555","display_name":"Erel \u0130\u00e7el","orcid":"https://orcid.org/0000-0001-7150-5581","observed_orcids":["https://orcid.org/0000-0001-7150-5581"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]},{"id":"https://openalex.org/I4403386742","display_name":"\u0130zmir \u015eehir Hastanesi","ror":"https://ror.org/03rcf8m81","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4403386742"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erel \u0130\u00e7el","raw_affiliation_strings":["Clinic of Ophthalmology , University of Health Sciences T\u00fcrkiye , \u0130zmir City Hospital , \u0130zmir , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Ophthalmology , University of Health Sciences T\u00fcrkiye , \u0130zmir City Hospital , \u0130zmir , T\u00fcrkiye","institution_ids":["https://openalex.org/I4210128276","https://openalex.org/I4403386742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160022974","display_name":"M\u00fcge G\u00f6re Karaali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00fcge G\u00f6re Karaali","raw_affiliation_strings":["Dermatology Specialist, Private Practice , Tekirda\u011f , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Specialist, Private Practice , Tekirda\u011f , T\u00fcrkiye","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8877288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"256","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/retinal-microvasculature","display_name":"retinal microvasculature","score":0.9409999847412109},{"id":"https://openalex.org/keywords/retinal-microvascular-changes","display_name":"retinal microvascular changes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/oral-retinoids","display_name":"oral retinoids","score":0.6600000262260437},{"id":"https://openalex.org/keywords/retinal-vessels","display_name":"retinal vasculature","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8546000123023987},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.6215000152587891},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5837000012397766},{"id":"https://openalex.org/C2985858981","wikidata":"https://www.wikidata.org/wiki/Q60760969","display_name":"Optical coherence tomography angiography","level":3,"score":0.5616000294685364},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5181999802589417},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.4447999894618988},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4049000144004822},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.3617999851703644},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C2776285725","wikidata":"https://www.wikidata.org/wiki/Q287029","display_name":"Isotretinoin","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3068999946117401},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C2781116099","wikidata":"https://www.wikidata.org/wiki/Q3842207","display_name":"Maculopathy","level":4,"score":0.2689000070095062},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4274/abcr.2026.26456","doi":"https://doi.org/10.4274/abcr.2026.26456","is_oa":true,"landing_page_url":"https://doi.org/10.4274/abcr.2026.26456","pdf_url":"https://abcresearch.net/pdf/0fdb9ffe-e838-45c0-b564-25a52c51df96/articles/ABCR.2026.26456/256-262.pdf","source":{"id":"https://openalex.org/S4210218045","display_name":"Archives of Basic and Clinical Research","issn_l":"2687-4482","issn":["2687-4482","2687-4520"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Basic and Clinical Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:15db622be4334e06b7684cbea3c8f855","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/15db622be4334e06b7684cbea3c8f855","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Basic and Clinical Research, Vol 8, Iss 3, Pp 256-262 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4274/abcr.2026.26456","doi":"https://doi.org/10.4274/abcr.2026.26456","is_oa":true,"landing_page_url":"https://doi.org/10.4274/abcr.2026.26456","pdf_url":"https://abcresearch.net/pdf/0fdb9ffe-e838-45c0-b564-25a52c51df96/articles/ABCR.2026.26456/256-262.pdf","source":{"id":"https://openalex.org/S4210218045","display_name":"Archives of Basic and Clinical Research","issn_l":"2687-4482","issn":["2687-4482","2687-4520"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Basic and Clinical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224123084.pdf","grobid_xml":"https://content.openalex.org/works/W7224123084.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2561160082","https://openalex.org/W3210643671","https://openalex.org/W2592479105","https://openalex.org/W2920518389","https://openalex.org/W2885567008","https://openalex.org/W3176037679","https://openalex.org/W2741517942","https://openalex.org/W3139513970","https://openalex.org/W1504046067","https://openalex.org/W2913369856"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"determine":[2],"whether":[3],"oral":[4,54,309],"isotretinoin":[5,55,310],"therapy":[6],"is":[7],"associated":[8],"with":[9,127,301],"longitudinal":[10],"changes":[11,320],"in":[12,208],"retinal":[13,313,342],"structure":[14],"and":[15,41,48,72,138,153,162,175,190,261,295],"microvasculature":[16],"measured":[17],"by":[18],"optical":[19,81],"coherence":[20,82],"tomography":[21,83],"angiography":[22],"(OCTA).Methods:":[23],"This":[24],"prospective,":[25],"longitudinal,":[26],"bilateral-eye":[27],"study":[28,92],"was":[29,106,125,140,144,180,206,216,253,272],"conducted":[30],"at":[31,107],"an":[32,199],"anonymized":[33],"Erzincan":[34],"Binali":[35],"Y\u0131ld\u0131r\u0131m":[36],"University":[37],"Meng\u00fccek":[38],"Gazi":[39],"Training":[40],"Research":[42],"Hospital":[43],"between":[44,258],"01":[45,49],"June":[46,50],"2021":[47],"2022.Fifty-four":[51],"patients":[52,63,186],"receiving":[53],"for":[56,134,218,326],"acne":[57],"were":[58,86,100,122,156,188,299],"enrolled;":[59],"of":[60,308,341],"these,":[61],"34":[62,171],"(68":[64],"eyes)":[65],"completed":[66],"baseline,":[67],"month":[68,70,73],"1,":[69],"3,":[71,235],"6":[74,260,306],"visits,":[75],"forming":[76],"the":[77,89,103,147,159,254,276,284,302],"complete-case":[78],"sample.All":[79],"quantitative":[80],"(OCT)/OCTA":[84],"examinations":[85],"performed":[87],"on":[88],"Nidek":[90],"retinopathy":[91],"(RS)-3000":[93],"advance":[94],"platform":[95],"after":[96,275,324],"topical":[97],"tropicamide-induced":[98],"dilation.Acquisitions":[99],"repeated":[101],"until":[102],"image-quality":[104],"index":[105],"least":[108],"0.70;":[109],"scans":[110],"that":[111,321],"did":[112,242],"not":[113,243,273],"reach":[114],"this":[115,240],"threshold":[116],"or":[117,195,283,315],"had":[118],"clinically":[119],"relevant":[120],"artifacts":[121],"excluded.Longitudinal":[123],"change":[124,205],"analyzed":[126],"patientclustered":[128],"Gaussian":[129],"generalized":[130],"estimating":[131],"equations,":[132],"adjusted":[133],"eye":[135],"laterality,":[136],"age,":[137],"sex.Time":[139],"modeled":[141],"categorically.Endpointlevel":[142],"multiplicity":[143],"controlled":[145],"using":[146,158],"Benjamini-Hochberg":[148],"false-discovery":[149],"rate":[150],"(FDR)":[151],"procedure,":[152],"pairwise":[154,251],"contrasts":[155],"assessed":[157],"Holm":[160,278],"procedure":[161],"a":[163],"global":[164,285],"FDR":[165,245,286],"correction.Results:":[166],"The":[167],"analytic":[168],"dataset":[169],"included":[170],"patients,":[172],"68":[173],"eyes,":[174],"272":[176],"eye-time":[177],"observations.Mean":[178],"age":[179],"20.71":[181],"\u00b1":[182],"3.33":[183],"years;":[184],"22":[185],"(64.7%)":[187],"women":[189],"12":[191],"(35.3%)were":[192],"men.No":[193],"OCT":[194],"OCTA":[196,316],"endpoint":[197],"showed":[198],"FDR-confirmed":[200],"time":[201],"effect;":[202],"no":[203,312],"significant":[204,274,323],"detected":[207],"any":[209],"parameter.The":[210],"lowest":[211],"omnibus":[212],"time-effect":[213],"P":[214],"value":[215],"observed":[217],"inner-nasal":[219],"Early":[220],"Treatment":[221],"Diabetic":[222],"Retinopathy":[223],"Study":[224],"9":[225],"(ETDRS9)":[226],"perfusion":[227,257],"(Wald":[228],"\u03c7":[229],"2":[230],"=":[231,234,237,248,264,266,269,281,289],"9.786,":[232],"df":[233],"p":[236,268],"0.0205),":[238],"but":[239],"finding":[241],"survive":[244],"adjustment":[246],"(q":[247,288],"0.5284).The":[249],"smallest":[250],"contrast":[252],"inner-temporal":[255],"ETDRS9":[256],"months":[259,307],"1":[262],"(difference":[263],"1.338,SE":[265],"0.532,":[267],"0.0119),":[270],"which":[271],"within-endpoint":[277],"correction":[279,287,325],"(p":[280],"0.0715)":[282],"0.5934).Patient-averaged":[290],"models,":[291],"non-parametric":[292],"repeated-measures":[293],"tests,":[294],"time-by-eye":[296],"interaction":[297],"models":[298],"consistent":[300],"primary":[303],"analysis.Conclusion:":[304],"Over":[305],"therapy,":[311],"structural":[314],"microvascular":[317,343],"parameters":[318],"exhibited":[319],"remained":[322],"multiple":[327],"testing.Small":[328],"nominal":[329],"fluctuations":[330],"should":[331],"be":[332],"interpreted":[333],"as":[334],"exploratory":[335],"signals":[336],"rather":[337],"than":[338],"confirmatory":[339],"evidence":[340],"toxicity.":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}