{"id":"https://openalex.org/W7224123017","doi":"https://doi.org/10.3389/fphys.2026.1926267","title":"Microglia guide stepwise retinal vascular sprouting and remodeling in postnatal CX3CR1-GFP mice: a spatiotemporal observation from P1 to P30","display_name":"Microglia guide stepwise retinal vascular sprouting and remodeling in postnatal CX3CR1-GFP mice: a spatiotemporal observation from P1 to P30","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224123017","doi":"https://doi.org/10.3389/fphys.2026.1926267"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2026.1926267","doi":"https://doi.org/10.3389/fphys.2026.1926267","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1926267","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1926267/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1926267/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160005375","display_name":"Jiaojiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210155322","display_name":"Henan Provincial Eye Hospital","ror":"https://ror.org/051jybk56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155322"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiaojiao Wang","raw_affiliation_strings":["Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou","institution_ids":["https://openalex.org/I4210133534","https://openalex.org/I4210155322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159995225","display_name":"Qian Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210155322","display_name":"Henan Provincial Eye Hospital","ror":"https://ror.org/051jybk56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Liu","raw_affiliation_strings":["Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou","institution_ids":["https://openalex.org/I4210133534","https://openalex.org/I4210155322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025652960","display_name":"Pingling Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210155322","display_name":"Henan Provincial Eye Hospital","ror":"https://ror.org/051jybk56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingling Shi","raw_affiliation_strings":["Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou","institution_ids":["https://openalex.org/I4210133534","https://openalex.org/I4210155322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066303898","display_name":"Yange Wang","orcid":"https://orcid.org/0000-0001-7216-7430","observed_orcids":["https://orcid.org/0000-0001-7216-7430"]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210155322","display_name":"Henan Provincial Eye Hospital","ror":"https://ror.org/051jybk56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155322"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yange Wang","raw_affiliation_strings":["Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou","institution_ids":["https://openalex.org/I4210133534","https://openalex.org/I4210155322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5160005375"],"corresponding_institution_ids":["https://openalex.org/I4210133534","https://openalex.org/I4210155322"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88315886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.382099986076355,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.382099986076355,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.31200000643730164,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-vascular-development","display_name":"retinal vascular development","score":0.8980000019073486},{"id":"https://openalex.org/keywords/retinal-microglia","display_name":"retinal microglia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cx3cr1-gfp-mice","display_name":"CX3CR1-GFP mice","score":0.8169999718666077},{"id":"https://openalex.org/keywords/retinal-angiogenesis","display_name":"retinal angiogenesis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/retinal-vascular-remodeling","display_name":"retinal vascular remodeling","score":0.7099999785423279},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.5249999761581421},{"id":"https://openalex.org/keywords/retinal-vascular-disease","display_name":"retinal vascular disease","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.8378999829292297},{"id":"https://openalex.org/C31179232","wikidata":"https://www.wikidata.org/wiki/Q14911549","display_name":"CX3CR1","level":5,"score":0.7736999988555908},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7373999953269958},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.7300999760627747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5026000142097473},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.49059998989105225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42080000042915344},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.3801000118255615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3314000070095062},{"id":"https://openalex.org/C3019347889","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Vascular network","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.28700000047683716},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.26510000228881836},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fphys.2026.1926267","doi":"https://doi.org/10.3389/fphys.2026.1926267","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1926267","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1926267/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f6da84db890c4ed4a91ed67602fbc7dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f6da84db890c4ed4a91ed67602fbc7dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2026.1926267","doi":"https://doi.org/10.3389/fphys.2026.1926267","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2026.1926267","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1926267/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224123017.pdf","grobid_xml":"https://content.openalex.org/works/W7224123017.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1089052599","https://openalex.org/W1980705285","https://openalex.org/W1992112921","https://openalex.org/W1992159395","https://openalex.org/W2003438800","https://openalex.org/W2005215351","https://openalex.org/W2007375983","https://openalex.org/W2017607366","https://openalex.org/W2040965438","https://openalex.org/W2063751953","https://openalex.org/W2067581018","https://openalex.org/W2074196937","https://openalex.org/W2074479550","https://openalex.org/W2090281391","https://openalex.org/W2090494985","https://openalex.org/W2141816935","https://openalex.org/W2147317687","https://openalex.org/W2759608040","https://openalex.org/W2915527064","https://openalex.org/W2932856647","https://openalex.org/W2977656056","https://openalex.org/W2994615204","https://openalex.org/W2997961245","https://openalex.org/W3008535867","https://openalex.org/W3025363008","https://openalex.org/W3027991843","https://openalex.org/W3038464575","https://openalex.org/W3046622690","https://openalex.org/W3117064465","https://openalex.org/W3169728976","https://openalex.org/W7095266456"],"related_works":["https://openalex.org/W2090494985","https://openalex.org/W7125428848","https://openalex.org/W3030845392","https://openalex.org/W2915527064","https://openalex.org/W4206601711","https://openalex.org/W4319812189","https://openalex.org/W4407620365","https://openalex.org/W7100172331","https://openalex.org/W3041361526","https://openalex.org/W3089202372"],"abstract_inverted_index":{"Introduction":[0],"Retinal":[1,183],"vessel":[2,60,179,189],"formation":[3,22,180,190],"is":[4],"a":[5,112,126,199],"complex":[6],"process":[7],"that":[8,82,168],"may":[9,196],"be":[10],"affected":[11],"by":[12],"multiple":[13],"etiological":[14],"factors.":[15],"This":[16],"study":[17],"aimed":[18],"to":[19,39,95],"investigate":[20],"the":[21,76,87,90,96,107,118,152,159,172,175],"of":[23,52,57,89,117,136,149,174],"retinal":[24,40,83,188,206],"vessels":[25,70,84,120],"in":[26,151,187],"CX3CR1":[27,33],"gfp/gfp":[28,34],"mice":[29,36],"after":[30],"birth.":[31],"Methods":[32],"transgenic":[35],"were":[37,62,73],"subjected":[38],"vascular":[41,108,128,207],"examination":[42],"at":[43,102,105,132,158,171,181],"eight":[44],"different":[45],"time":[46],"points":[47],"during":[48,75],"development.":[49,192],"The":[50,65,115,134,147],"differentiation":[51],"arteries":[53],"and":[54,59,71,93,142,164,177,191],"veins,":[55],"branching":[56],"vessels,":[58],"length":[61,116],"thoroughly":[63],"examined.":[64],"potential":[66],"correlation":[67],"between":[68,162],"developmental":[69,77],"microglia":[72,150,169,184],"examined":[74],"process.":[78],"Results":[79],"We":[80,166],"found":[81,167],"developed":[85],"from":[86,123,140],"center":[88],"optic":[91],"papilla":[92],"radiated":[94],"peripheral":[97],"retina.":[98],"Vascular":[99],"remodeling":[100],"began":[101],"P7.":[103],"Subsequently,":[104],"P14,":[106],"network":[109,129],"consolidated":[110],"with":[111],"honeycomb-like":[113],"architecture.":[114],"large":[119],"increased":[121,139],"gradually":[122],"P14":[124],"until":[125,145],"complete":[127],"was":[130,155],"formed":[131],"P17.":[133],"number":[135],"primary":[137],"branches":[138],"P17":[141],"then":[143],"decreased":[144],"P30.":[146,165],"density":[148],"central":[153],"retina":[154,161,176],"higher":[156],"than":[157],"edge":[160,173],"P1":[163],"appeared":[170],"preferred":[178],"P1.":[182],"are":[185],"involved":[186],"Discussion":[193],"These":[194],"findings":[195],"serve":[197],"as":[198],"reference":[200],"database":[201],"for":[202],"therapeutic":[203],"trials":[204],"on":[205],"diseases.":[208]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
