{"id":"https://openalex.org/W7224120656","doi":"https://doi.org/10.2147/dddt.s637358","title":"Targeted-Release Budesonide in Chinese Patients with IgA Nephropathy: A Real-World Retrospective Cohort Study","display_name":"Targeted-Release Budesonide in Chinese Patients with IgA Nephropathy: A Real-World Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224120656","doi":"https://doi.org/10.2147/dddt.s637358","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13724032"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s637358","doi":"https://doi.org/10.2147/dddt.s637358","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s637358","pdf_url":"https://www.dovepress.com/article/download/121467","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121467","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126705246","display_name":"Xinyan Yang","orcid":"https://orcid.org/0009-0000-8875-9916","observed_orcids":["https://orcid.org/0009-0000-8875-9916"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyan Yang","raw_affiliation_strings":["Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0000-8875-9916","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160003568","display_name":"Mengting Luo","orcid":"https://orcid.org/0009-0002-7283-7021","observed_orcids":["https://orcid.org/0009-0002-7283-7021"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengting Luo","raw_affiliation_strings":["Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0002-7283-7021","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160033943","display_name":"Shuman Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuman Zhao","raw_affiliation_strings":["Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160041663","display_name":"Yuan Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160010166","display_name":"Hongyu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Chen","raw_affiliation_strings":["Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057360304","display_name":"xue Jiang","orcid":"https://orcid.org/0000-0001-9672-4377","observed_orcids":["https://orcid.org/0000-0001-9672-4377"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xue Jiang","raw_affiliation_strings":["Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-9672-4377","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]},{"raw_affiliation_string":"Key Laboratory of Precise Prevention and Treatment of Rheumatism Syndrome of Renal Wind Disease, Hangzhou, People's Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057360304"],"corresponding_institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83541092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 20","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iga-nephropathy","display_name":"IgA nephropathy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.8629999756813049},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.6880000233650208},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.6629999876022339},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6039999723434448},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.7620000243186951},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.9107000231742859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9000999927520752},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6977999806404114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6272000074386597},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4846000075340271},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4803999960422516},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.41839998960494995},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41440001130104065},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4097999930381775},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3792000114917755},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C2776136866","wikidata":"https://www.wikidata.org/wiki/Q422212","display_name":"Budesonide","level":3,"score":0.36059999465942383},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.31700000166893005},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.29089999198913574},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26030001044273376}],"mesh":[{"descriptor_ui":"D000095225","descriptor_name":"East Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005922","descriptor_name":"Glomerulonephritis, IGA","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019819","descriptor_name":"Budesonide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019819","descriptor_name":"Budesonide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.2147/dddt.s637358","doi":"https://doi.org/10.2147/dddt.s637358","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s637358","pdf_url":"https://www.dovepress.com/article/download/121467","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13724032","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724032/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724032/pdf/DDDT-20-637358.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmid:42968938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aa3372d8b9bf4ffbb8ace29c6f118708","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aa3372d8b9bf4ffbb8ace29c6f118708","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol Volume 20, Iss Issue 1, Pp 1-13 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121467","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/targeted-release-budesonide-in-chinese-patients-with-iga-nephropathy-a-peer-reviewed-fulltext-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s637358","doi":"https://doi.org/10.2147/dddt.s637358","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s637358","pdf_url":"https://www.dovepress.com/article/download/121467","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224120656.pdf","grobid_xml":"https://content.openalex.org/works/W7224120656.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2101794801","https://openalex.org/W2120366573","https://openalex.org/W2155965977","https://openalex.org/W2159666276","https://openalex.org/W2600347335","https://openalex.org/W2602196428","https://openalex.org/W2741457765","https://openalex.org/W2937346600","https://openalex.org/W3027793481","https://openalex.org/W3084942492","https://openalex.org/W3200553460","https://openalex.org/W3206281990","https://openalex.org/W4211021420","https://openalex.org/W4247172809","https://openalex.org/W4280590173","https://openalex.org/W4306757577","https://openalex.org/W4385803938","https://openalex.org/W4388304602","https://openalex.org/W4389001266","https://openalex.org/W4389199403","https://openalex.org/W4403243630","https://openalex.org/W4403759533","https://openalex.org/W4404510806","https://openalex.org/W4405212181","https://openalex.org/W4410278007","https://openalex.org/W4411394620","https://openalex.org/W4412981740","https://openalex.org/W7125487667"],"related_works":["https://openalex.org/W7222145849","https://openalex.org/W7128012080","https://openalex.org/W4404574614","https://openalex.org/W4415426701","https://openalex.org/W7207724353","https://openalex.org/W2600347335","https://openalex.org/W4415756328","https://openalex.org/W7140335456","https://openalex.org/W2775322345","https://openalex.org/W4398233267"],"abstract_inverted_index":{"Background:":[0],"Although":[1],"the":[2,38,89,149,183,194],"NefIgArd":[3],"trial":[4],"demonstrated":[5],"efficacy":[6],"of":[7,30,40,66,116,147],"targeted-release":[8],"budesonide":[9],"(TRF-budesonide)":[10],"in":[11,17,42,92,191,227],"IgA":[12],"nephropathy":[13],"(IgAN),":[14],"real-world":[15,234],"effectiveness":[16,39],"Chinese":[18,44,68,233],"patients":[19,69],"with":[20,55,70,78,141,165,239,247],"advanced":[21],"or":[22],"highly":[23],"active":[24],"disease":[25],"remains":[26],"undefined,":[27],"and":[28,46,51,108,123,175,182,202,242,260],"predictors":[29],"response":[31,151],"are":[32],"underexplored.":[33],"We":[34,59],"aimed":[35],"to":[36,47,102,249,257],"evaluate":[37],"TRF-budesonide":[41,75,236],"routine":[43],"practice":[45],"identify":[48],"baseline":[49,103,209],"clinical":[50,104],"histopathologic":[52],"features":[53],"associated":[54,164,238],"treatment":[56,106,157,219,258],"response.":[57],"Methods:":[58],"conducted":[60],"a":[61,142,166,187],"single-center":[62],"retrospective":[63],"cohort":[64],"study":[65],"106":[67],"biopsy-proven":[71],"IgAN":[72],"who":[73],"received":[74],"(16":[76],"mg/day)":[77],"optimized":[79],"supportive":[80],"care":[81],"for":[82,208],"6":[83,114,245],"months.":[84],"The":[85],"primary":[86],"endpoint":[87],"was":[88,154,163,237],"percentage":[90],"change":[91],"24-hour":[93],"proteinuria":[94,119,177,192,214,241],"from":[95,161],"baseline.":[96],"Subgroup":[97],"analyses":[98],"were":[99,200,203,225],"performed":[100],"according":[101],"features,":[105],"regimen,":[107],"Oxford":[109,261],"MEST-C":[110],"classification.":[111],"Results:":[112],"After":[113],"months":[115],"treatment,":[117],"median":[118,144],"decreased":[120],"by":[121,130],"38.77%":[122],"urinary":[124],"red":[125],"blood":[126],"cell":[127],"(uRBC)":[128],"count":[129],"52.86%":[131],"(both":[132],"P":[133,172],"<":[134],"0.001),":[135],"while":[136],"kidney":[137,252],"function":[138],"remained":[139],"stable,":[140],"modest":[143],"eGFR":[145],"increase":[146],"4.80%;":[148],"overall":[150],"rate":[152],"(ORR)":[153],"37.74%.":[155],"Earlier":[156],"initiation":[158],"(<4":[159],"years":[160],"biopsy)":[162],"higher":[167],"ORR":[168,212],"(53.06%":[169],"vs":[170],"24.56%,":[171],"=":[173,180],"0.005)":[174],"deeper":[176],"reduction":[178,190,215],"(P":[179],"0.009),":[181],"T0":[184],"subgroup":[185,198],"showed":[186],"numerically":[188],"larger":[189],"than":[193],"T1+2":[195],"subgroup.":[196],"These":[197],"associations":[199],"exploratory":[201],"not":[204],"confirmed":[205],"after":[206],"adjustment":[207],"differences.":[210],"Neither":[211],"nor":[213],"differed":[216],"significantly":[217],"between":[218],"regimens.":[220],"No":[221],"major":[222],"safety":[223],"events":[224],"documented":[226],"available":[228],"records.":[229],"Conclusion:":[230],"In":[231],"this":[232],"cohort,":[235],"reduced":[240],"hematuria":[243],"over":[244],"months,":[246],"stable":[248],"modestly":[250],"improved":[251],"function.":[253],"Exploratory":[254],"signals":[255],"related":[256],"timing":[259],"T":[262],"score":[263],"require":[264],"prospective":[265],"validation":[266],"before":[267],"they":[268],"can":[269],"guide":[270],"patient":[271],"selection.":[272]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-29T00:00:00"}