{"id":"https://openalex.org/W7224119464","doi":"https://doi.org/10.1186/s40795-026-01530-x","title":"Associations of homocysteine levels and implantation failure in the first embryo transfer: a retrospective study","display_name":"Associations of homocysteine levels and implantation failure in the first embryo transfer: a retrospective study","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224119464","doi":"https://doi.org/10.1186/s40795-026-01530-x"},"language":"en","primary_location":{"id":"doi:10.1186/s40795-026-01530-x","doi":"https://doi.org/10.1186/s40795-026-01530-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40795-026-01530-x","pdf_url":null,"source":{"id":"https://openalex.org/S2765040563","display_name":"BMC Nutrition","issn_l":"2055-0928","issn":["2055-0928"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s40795-026-01530-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160030272","display_name":"Ying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","Department of Reproductive Medicine, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China","Reproductive Medicine Center, the University of Hong Kong-Shenzhen Hospital, Futian District, No. 1 Haiyuan Road, Shenzhen, 518053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Department of Reproductive Medicine, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210164332"]},{"raw_affiliation_string":"Reproductive Medicine Center, the University of Hong Kong-Shenzhen Hospital, Futian District, No. 1 Haiyuan Road, Shenzhen, 518053, China","institution_ids":["https://openalex.org/I4210141719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160010783","display_name":"Wenjun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159991797","display_name":"Haiyan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Lin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160035540","display_name":"Xiaohui Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Ji","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101675621","display_name":"Shuai Fu","orcid":"https://orcid.org/0000-0003-1889-3030","observed_orcids":["https://orcid.org/0000-0003-1889-3030"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Fu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160052150","display_name":"Liqiong Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liqiong Zhu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006078361","display_name":"\u5f20\u5c11\u5a23","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaodi Zhang","raw_affiliation_strings":["Reproductive Medicine Center, Henan Provincial People\u2019s Hospital, 7 Weiwu Road, Zhengzhou, 450003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Henan Provincial People\u2019s Hospital, 7 Weiwu Road, Zhengzhou, 450003, China","institution_ids":["https://openalex.org/I4210133534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160041813","display_name":"Qiong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091843","display_name":"Second People's Hospital of Yunnan Province","ror":"https://ror.org/00c639s42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Zhang","raw_affiliation_strings":["Center for Obstetrics and Reproductive Medicine, the Second People\u2019s Hospital of Yunnan Province, the Affiliated Hospital of Yunnan University, 176 Qingnian Road, Kunming, 650021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Obstetrics and Reproductive Medicine, the Second People\u2019s Hospital of Yunnan Province, the Affiliated Hospital of Yunnan University, 176 Qingnian Road, Kunming, 650021, China","institution_ids":["https://openalex.org/I4210091843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158922990","display_name":"Philip C.N. Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Philip C. N. Chiu","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Room 08, 7/F, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Room 08, 7/F, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160007011","display_name":"Yu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I4210164332","display_name":"Shenzhen Second People's Hospital","ror":"https://ror.org/05c74bq69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164332"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","Department of Reproductive Medicine, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China","Reproductive Medicine Center, the University of Hong Kong-Shenzhen Hospital, Futian District, No. 1 Haiyuan Road, Shenzhen, 518053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Department of Reproductive Medicine, Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I4210164332"]},{"raw_affiliation_string":"Reproductive Medicine Center, the University of Hong Kong-Shenzhen Hospital, Futian District, No. 1 Haiyuan Road, Shenzhen, 518053, China","institution_ids":["https://openalex.org/I4210141719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100785574","display_name":"Hui Chen","orcid":"https://orcid.org/0000-0002-3709-6494","observed_orcids":["https://orcid.org/0000-0002-3709-6494"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Chen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, 510000, China"],"raw_orcid":"https://orcid.org/0000-0002-3709-6494","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, 510000, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100785574","https://openalex.org/A5158922990","https://openalex.org/A5160007011"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I180726961","https://openalex.org/I4210097354","https://openalex.org/I4210141719","https://openalex.org/I4210164332","https://openalex.org/I889458895"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78064933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.3334999978542328,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.996999979019165},{"id":"https://openalex.org/keywords/implantation-failure","display_name":"implantation failure","score":0.9929999709129333},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.75},{"id":"https://openalex.org/keywords/implantation-rate","display_name":"implantation rate","score":0.718999981880188},{"id":"https://openalex.org/keywords/endometrial-receptivity-array","display_name":"endometrial receptivity array","score":0.5899999737739563},{"id":"https://openalex.org/keywords/endometrial-receptivity-index","display_name":"endometrial receptivity index","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9140999913215637},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6920999884605408},{"id":"https://openalex.org/C3020098204","wikidata":"https://www.wikidata.org/wiki/Q266500","display_name":"Implantation failure","level":4,"score":0.6421999931335449},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5659000277519226},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.5479000210762024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5404999852180481},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.5164999961853027},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.510699987411499},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42489999532699585},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.33009999990463257},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C2909731803","wikidata":"https://www.wikidata.org/wiki/Q28693","display_name":"Early Pregnancy Loss","level":4,"score":0.30649998784065247},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3061000108718872},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.2867000102996826},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2653999924659729}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s40795-026-01530-x","doi":"https://doi.org/10.1186/s40795-026-01530-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40795-026-01530-x","pdf_url":null,"source":{"id":"https://openalex.org/S2765040563","display_name":"BMC Nutrition","issn_l":"2055-0928","issn":["2055-0928"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nutrition","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s40795-026-01530-x","doi":"https://doi.org/10.1186/s40795-026-01530-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40795-026-01530-x","pdf_url":null,"source":{"id":"https://openalex.org/S2765040563","display_name":"BMC Nutrition","issn_l":"2055-0928","issn":["2055-0928"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5666999816894531}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362737825","https://openalex.org/W4386168358","https://openalex.org/W1988702412","https://openalex.org/W4408276904","https://openalex.org/W2305616898","https://openalex.org/W4408837781","https://openalex.org/W7204575092","https://openalex.org/W4220727474","https://openalex.org/W2029313529","https://openalex.org/W2019118677"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Homocysteine":[2],"(Hcy)":[3],"has":[4],"been":[5],"associated":[6,200,316,331],"with":[7,14,23,79,98,108,121,176,201,232,279,304,317,332,344],"adverse":[8],"pregnancy":[9,166],"outcomes,":[10],"but":[11,270],"its":[12],"association":[13,175],"implantation":[15,45,69,90,129,157,177,318],"failure":[16,46,91,130,178,319],"in":[17,77,221,230,237,272],"the":[18,73,222,238,252,273],"first":[19,50],"embryo":[20,51],"transfer":[21,52,61,86,116],"and":[22,62,76,102,155,164,251,320,351],"endometrial":[24,339],"characteristics":[25],"remains":[26,37],"unclear.":[27],"Whether":[28],"nutritional":[29,284],"supplementation":[30,226,285,329],"is":[31],"linked":[32,288],"to":[33,289],"these":[34],"outcomes":[35],"also":[36,199],"unclear":[38],"Methods":[39],"Among":[40,277],"1770":[41],"participants":[42],"without":[43],"established":[44],"risk":[47],"factors":[48],"undergoing":[49],"(Jan":[53],"2015\u2013May":[54],"2025),":[55],"589":[56],"had":[57],"Hcy":[58,80,99,109,122,194,233,242,257,280,305,314],"measured":[59,81,110,306],"before":[60,85,115,311,354],"were":[63],"analyzed.":[64],"The":[65,174],"primary":[66],"outcome":[67],"was":[68,198,227,286,315,330],"failure.":[70],"Results":[71],"In":[72,106,302],"overall":[74,223,239],"cohort":[75,240],"patients":[78,97,107,120,231,278,303,343],"within":[82],"one":[83,309],"year":[84,114,310],"(\u2264":[87],"1-year":[88,118,254,275],"subgroup),":[89,119],"rates":[92,167],"did":[93],"not":[94,271],"differ":[95],"between":[96],"\u2265":[100,123,195,234,281],"8":[101,104,124,196,235,282],"<":[103,268],"\u03bcmol/L.":[105],"more":[111,228,307],"than":[112,308],"1":[113],"(>":[117],"\u03bcmol/L":[125,197,236],"exhibited":[126],"a":[127,138,202,321,333],"higher":[128,334],"rate":[131],"(53.4%":[132],"vs.":[133,150,159,169,245,249,260,264],"36.5%,":[134],"P":[135,152,161,171,191,218,267,298],"=":[136,153,162,172,192,219,299],"0.026),":[137],"lower":[139,156,203,322],"prevalence":[140,204,335],"of":[141,205,324,336],"type":[142,206,290,325,337],"A":[143,207,291,326,338],"endometrium":[144,208],"on":[145,209],"hCG":[146,210],"trigger":[147,211],"day":[148,212],"(76.3%":[149],"93.8%,":[151],"0.046),":[154],"(32.8%":[158],"49.0%,":[160],"0.010)":[163],"clinical":[165,355],"(46.6%":[168],"63.5%,":[170],"0.026).":[173],"remained":[179],"significant":[180],"after":[181],"multivariable":[182],"adjustment":[183],"[adjusted":[184],"OR":[185],"(aOR)":[186],"1.3,":[187],"95%":[188,215,295],"CI":[189,216,296],"1.1\u20131.6,":[190],"0.0033].":[193],"(aOR":[213,293],"0.5,":[214],"0.2\u20130.9,":[217],"0.0288)":[220],"cohort.":[224],"Methylcobalamin":[225],"common":[229],"(after":[241,256],"measurement:":[243,258],"9.9%":[244],"1.5%;":[246],"pre-transfer:":[247,262],"9.4%":[248],"0.3%)":[250,265],"\u2264":[253],"subgroup":[255],"11.0%":[259],"1.4%;":[261],"12.7%":[263],"(all":[266],"0.001),":[269],">":[274],"subgroup.":[276],"\u03bcmol/L,":[283],"positively":[287],"pattern":[292],"2.9,":[294],"1.2\u20136.7,":[297],"0.0153).":[300],"Conclusions":[301],"transfer,":[312],"elevated":[313,345],"likelihood":[323],"endometrium.":[327],"Nutritional":[328],"pattern,":[340],"even":[341],"among":[342],"Hcy.":[346],"These":[347],"findings":[348],"are":[349],"hypothesis-generating":[350],"require":[352],"confirmation":[353],"application.":[356],"Trial":[357],"registration":[358],"Not":[359],"applicable.":[360]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}
