{"id":"https://openalex.org/W7224113158","doi":"https://doi.org/10.1002/advs.78512","title":"Phase\u2010Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar\u2010Reduced Regeneration of Burn Wounds","display_name":"Phase\u2010Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar\u2010Reduced Regeneration of Burn Wounds","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224113158","doi":"https://doi.org/10.1002/advs.78512","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13715928"},"language":"en","primary_location":{"id":"doi:10.1002/advs.78512","doi":"https://doi.org/10.1002/advs.78512","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78512","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.78512","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023757757","display_name":"Yongnian Zeng","orcid":"https://orcid.org/0000-0003-2615-4000","observed_orcids":["https://orcid.org/0000-0003-2615-4000"]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongnian Zeng","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","Key Laboratory of Advanced Pharmaceutics School of Health China Three Gorges University  Yichang People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-2615-4000","affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]},{"raw_affiliation_string":"Key Laboratory of Advanced Pharmaceutics School of Health China Three Gorges University  Yichang People's Republic of China","institution_ids":["https://openalex.org/I161350542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124431241","display_name":"Zhigang Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Chu","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135529493","display_name":"Huiyuan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiyuan Yang","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101596272","display_name":"Wen Zhang","orcid":"https://orcid.org/0000-0001-9607-9259","observed_orcids":["https://orcid.org/0000-0001-9607-9259"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Zhang","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-9607-9259","affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135446677","display_name":"Peng Jiang","orcid":"https://orcid.org/0009-0002-7366-8194","observed_orcids":["https://orcid.org/0009-0002-7366-8194"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Jiang","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0002-7366-8194","affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007821757","display_name":"Jiapeng Lei","orcid":"https://orcid.org/0009-0009-9199-762X","observed_orcids":["https://orcid.org/0009-0009-9199-762X"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiapeng Lei","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0009-9199-762X","affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152727043","display_name":"Siyu Zhang","orcid":"https://orcid.org/0000-0002-8177-8919","observed_orcids":["https://orcid.org/0000-0002-8177-8919"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Zhang","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-8177-8919","affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103907152","display_name":"Qiongfang Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiongfang Ruan","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135494934","display_name":"Shuhua Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuhua Liu","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052226698","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-0789-0320","observed_orcids":["https://orcid.org/0000-0002-0789-0320","https://orcid.org/0000-0001-6669-6977","https://orcid.org/0000-0002-9339-7267"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210138122","display_name":"Wuhan Third Hospital","ror":"https://ror.org/04743aj70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138122"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","Taikang Center for Life and Medical Sciences Wuhan University  Wuhan People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-9339-7267","affiliations":[{"raw_affiliation_string":"Department of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital) School of Pharmaceutical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"]},{"raw_affiliation_string":"Taikang Center for Life and Medical Sciences Wuhan University  Wuhan People's Republic of China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052226698","https://openalex.org/A5135494934"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210138122"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82738095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burn-wound-healing","display_name":"burn wound healing","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hydrogen-release","display_name":"hydrogen release","score":0.5630000233650208},{"id":"https://openalex.org/keywords/ammonia-borane","display_name":"ammonia borane","score":0.9100000262260437},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.6100000143051147},{"id":"https://openalex.org/keywords/biofilm-eradication","display_name":"biofilm eradication","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sulfobutylether-beta-cyclodextrin","display_name":"sulfobutylether-\u03b2-cyclodextrin","score":0.878000020980835},{"id":"https://openalex.org/keywords/plga","display_name":"PLGA","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/redox-modulation","display_name":"redox modulation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.34299999475479126},{"id":"https://openalex.org/keywords/skin-appendage-regeneration","display_name":"skin appendage regeneration","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7192999720573425},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5504000186920166},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.512499988079071},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.49410000443458557},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.45820000767707825},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.42809998989105225},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.33059999346733093},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3089999854564667},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C2777722557","wikidata":"https://www.wikidata.org/wiki/Q4841341","display_name":"Bafilomycin","level":4,"score":0.29319998621940613},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28299999237060547},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.27410000562667847},{"id":"https://openalex.org/C3019879682","wikidata":"https://www.wikidata.org/wiki/Q170518","display_name":"Burn wound","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.26510000228881836},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.2646999955177307},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.259799987077713}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.78512","doi":"https://doi.org/10.1002/advs.78512","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78512","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42949795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13715928","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13715928/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/advs.78512","doi":"https://doi.org/10.1002/advs.78512","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78512","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1986308133","https://openalex.org/W1989522391","https://openalex.org/W2550090579","https://openalex.org/W2756243705","https://openalex.org/W2792944830","https://openalex.org/W2914291352","https://openalex.org/W3000263665","https://openalex.org/W3004097028","https://openalex.org/W3007202813","https://openalex.org/W3037597889","https://openalex.org/W3108729041","https://openalex.org/W3130982306","https://openalex.org/W3144518705","https://openalex.org/W3172433406","https://openalex.org/W3176137376","https://openalex.org/W3210821280","https://openalex.org/W3213502693","https://openalex.org/W4200389601","https://openalex.org/W4289593840","https://openalex.org/W4304813456","https://openalex.org/W4307574219","https://openalex.org/W4310437438","https://openalex.org/W4311824266","https://openalex.org/W4312077185","https://openalex.org/W4323351879","https://openalex.org/W4327917745","https://openalex.org/W4361217281","https://openalex.org/W4377093830","https://openalex.org/W4377565240","https://openalex.org/W4386245055","https://openalex.org/W4387439603","https://openalex.org/W4388942105","https://openalex.org/W4388993353","https://openalex.org/W4389524913","https://openalex.org/W4390056640","https://openalex.org/W4391955889","https://openalex.org/W4392519216","https://openalex.org/W4393144087","https://openalex.org/W4399260468","https://openalex.org/W4399379628","https://openalex.org/W4399947190","https://openalex.org/W4401710630","https://openalex.org/W4402884031","https://openalex.org/W4404125618","https://openalex.org/W4404744022","https://openalex.org/W4408549457","https://openalex.org/W4408665748","https://openalex.org/W4409893045","https://openalex.org/W4410489983","https://openalex.org/W4410631631","https://openalex.org/W4411193148","https://openalex.org/W4413276091","https://openalex.org/W6903103554","https://openalex.org/W7154159057"],"related_works":["https://openalex.org/W7163136875","https://openalex.org/W7148558282","https://openalex.org/W4380184651","https://openalex.org/W4416018637","https://openalex.org/W7161572773","https://openalex.org/W7171788989","https://openalex.org/W4410278255","https://openalex.org/W4404624684","https://openalex.org/W7140875708","https://openalex.org/W7167361331"],"abstract_inverted_index":{"ABSTRACT":[0],"Burn":[1],"wounds":[2],"complicated":[3],"by":[4],"bacterial":[5,145],"infection":[6,20],"and":[7,24,45,52,66,97,104,121,133,144,150,177,190],"fibrotic":[8],"scarring":[9],"remain":[10],"a":[11,30,58,67,165],"major":[12],"clinical":[13],"challenge,":[14],"demanding":[15],"therapeutics":[16],"capable":[17],"of":[18,41,92,198],"coordinated":[19],"control,":[21],"inflammation":[22,143],"modulation,":[23,187],"tissue":[25],"regeneration.":[26],"Here,":[27],"we":[28],"report":[29],"phase\u2010programmed":[31],"microneedle":[32],"(MN)":[33],"patch":[34],"(QR/AB\u2010MNs)":[35],"that":[36,162],"enables":[37],"spatiotemporally":[38],"controlled":[39],"release":[40],"ammonia":[42],"borane":[43],"(AB)":[44],"quercetin":[46],"(QR)":[47],"to":[48,81,193],"achieve":[49,194],"synergistic":[50],"antimicrobial":[51],"anti\u2010fibrotic":[53,167],"therapy.":[54],"The":[55],"MNs":[56],"comprise":[57],"poly":[59],"(lactic\u2010co\u2010glycolic":[60],"acid)":[61],"(PLGA)":[62],"shell":[63],"encapsulating":[64],"QR":[65,116],"sulfobutylether\u2010\u03b2\u2010cyclodextrin":[68],"(SBECD)":[69],"core":[70],"loaded":[71],"with":[72,154],"the":[73,82,87],"H":[74],"2":[75,95],"\u2010releasing":[76],"prodrug":[77],"AB.":[78],"Upon":[79],"exposure":[80],"mildly":[83],"acidic":[84],"wound":[85,140],"microenvironment,":[86],"system":[88],"triggers":[89],"sustained":[90],"generation":[91],"hydrogen":[93],"(H":[94],")":[96],"AB":[98],"degradation":[99,113],"products,":[100],"effectively":[101],"eliminating":[102],"bacteria":[103],"biofilms":[105],"while":[106],"mitigating":[107],"oxidative":[108],"stress.":[109],"Subsequently,":[110],"gradual":[111],"PLGA":[112],"ensures":[114],"prolonged":[115],"release,":[117],"suppressing":[118],"fibroblast":[119],"hyperproliferation":[120],"TGF\u2010":[122],"\u03b2":[123],"mediated":[124],"collagen":[125,156,178],"deposition,":[126],"thereby":[127],"preventing":[128],"hypertrophic":[129],"scarring.":[130],"In":[131],"murine":[132],"rabbit":[134],"burn":[135,200],"models,":[136],"QR/AB\u2010MNs":[137,163],"markedly":[138],"accelerated":[139],"closure,":[141],"reduced":[142],"burden,":[146],"restored":[147],"skin":[148],"appendages,":[149],"yielded":[151],"scar\u2010reduced":[152],"regeneration":[153],"native\u2010like":[155],"architecture.":[157],"Transcriptomic":[158],"profiling":[159],"further":[160],"revealed":[161],"orchestrate":[164],"broad":[166],"transcriptional":[168],"program,":[169],"concurrently":[170],"attenuating":[171],"pro\u2010fibrotic":[172],"signaling,":[173],"cell\u2010extracellular":[174],"matrix":[175,191],"interactions,":[176],"synthesis.":[179],"Collectively,":[180],"this":[181],"programmable":[182],"MN":[183],"platform":[184],"integrates":[185],"redox":[186],"anti\u2010infective":[188],"therapy,":[189],"remodeling":[192],"comprehensive,":[195],"scarless\u2010like":[196],"healing":[197],"infected":[199],"wounds.":[201]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-29T00:00:00"}
