{"id":"https://openalex.org/W7224112725","doi":"https://doi.org/10.1016/j.omton.2026.201360","title":"Beyond antigen dependence: Improving the therapeutic window of a signal 1 booster for adoptive cell therapy in solid tumors","display_name":"Beyond antigen dependence: Improving the therapeutic window of a signal 1 booster for adoptive cell therapy in solid tumors","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224112725","doi":"https://doi.org/10.1016/j.omton.2026.201360"},"language":"en","primary_location":{"id":"doi:10.1016/j.omton.2026.201360","doi":"https://doi.org/10.1016/j.omton.2026.201360","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2026.201360","pdf_url":"https://www.cell.com/molecular-therapy-family/oncology/pdf/S2950-3299(26)00236-5.pdf","source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cell.com/molecular-therapy-family/oncology/pdf/S2950-3299(26)00236-5.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135343582","display_name":"Angelis M. Morales Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelis M. Morales Rivera","raw_affiliation_strings":["Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160058824","display_name":"Jiasen He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiasen He","raw_affiliation_strings":["Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071050572","display_name":"Candelaria Gomez\u2010Manzano","orcid":"https://orcid.org/0000-0002-1259-2133","observed_orcids":["https://orcid.org/0000-0002-1259-2133"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candelaria Gomez-Manzano","raw_affiliation_strings":["Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038824430","display_name":"Juan Fueyo-Margareto","orcid":"https://orcid.org/0000-0001-6941-2335","observed_orcids":["https://orcid.org/0000-0001-6941-2335"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Fueyo","raw_affiliation_strings":["Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066812528","display_name":"Hong Jiang","orcid":"https://orcid.org/0000-0003-4668-5319","observed_orcids":["https://orcid.org/0000-0003-4668-5319"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hong Jiang","raw_affiliation_strings":["Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-4668-5319","affiliations":[{"raw_affiliation_string":"Department of Neuro-Oncology, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066812528"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81494996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"4","first_page":"201360","last_page":"201360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.399399995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/t-cell-engineering","display_name":"T cell engineering","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.5109999775886536},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.5659999847412109},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.8140000104904175},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5932999849319458},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49619999527931213},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49050000309944153},{"id":"https://openalex.org/C2908856526","wikidata":"https://www.wikidata.org/wiki/Q16252627","display_name":"Antibody therapy","level":4,"score":0.4717000126838684},{"id":"https://openalex.org/C203165030","wikidata":"https://www.wikidata.org/wiki/Q741745","display_name":"Booster (rocketry)","level":2,"score":0.4602999985218048},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.40630000829696655},{"id":"https://openalex.org/C2778751112","wikidata":"https://www.wikidata.org/wiki/Q835016","display_name":"Window (computing)","level":2,"score":0.3840999901294708},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.37560001015663147},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.37380000948905945},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.36160001158714294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.352400004863739},{"id":"https://openalex.org/C46622094","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic window","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.3303999900817871},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.31459999084472656},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C3019217517","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor associated antigen","level":4,"score":0.26420000195503235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.omton.2026.201360","doi":"https://doi.org/10.1016/j.omton.2026.201360","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2026.201360","pdf_url":"https://www.cell.com/molecular-therapy-family/oncology/pdf/S2950-3299(26)00236-5.pdf","source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.omton.2026.201360","doi":"https://doi.org/10.1016/j.omton.2026.201360","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2026.201360","pdf_url":"https://www.cell.com/molecular-therapy-family/oncology/pdf/S2950-3299(26)00236-5.pdf","source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312194","display_name":"ChadTough Foundation","ror":"https://ror.org/04ak25x77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224112725.pdf","grobid_xml":"https://content.openalex.org/works/W7224112725.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W2034526634","https://openalex.org/W2085424263","https://openalex.org/W2651055861","https://openalex.org/W2743510679","https://openalex.org/W3163599487","https://openalex.org/W4220766575","https://openalex.org/W4388035659","https://openalex.org/W4405892700"],"related_works":["https://openalex.org/W7172218847","https://openalex.org/W4415899180","https://openalex.org/W4253934779","https://openalex.org/W4404064366","https://openalex.org/W4409629738","https://openalex.org/W2397269171","https://openalex.org/W1615058699","https://openalex.org/W2419271439","https://openalex.org/W1970431825","https://openalex.org/W2064448261"],"abstract_inverted_index":{"CAR":[0,75],"T":[1,26,37,58,76],"cell":[2,27,38,59,77],"therapy":[3],"has":[4],"transformed":[5],"the":[6],"treatment":[7],"of":[8,21],"several":[9],"hematologic":[10],"malignancies,":[11],"yet":[12],"comparable":[13],"success":[14],"in":[15],"solid":[16],"tumors":[17],"remains":[18],"elusive":[19],"because":[20],"heterogeneous":[22],"antigen":[23,49],"expression,":[24],"restricted":[25],"trafficking,":[28],"and":[29,42,55,73],"an":[30],"immunosuppressive":[31],"tumor":[32,48],"microenvironment":[33],"(TME)":[34],"that":[35],"limits":[36],"activation,":[39],"expansion,":[40],"persistence,":[41],"effector":[43],"function.1,2":[44],"Insufficient":[45],"access":[46],"to":[47,69],"can":[50],"further":[51],"limit":[52],"signal":[53],"1":[54],"compromise":[56],"engineered":[57],"fitness.":[60],"Pharmacologically":[61],"inducible":[62],"MyD88/CD40":[63],"signaling":[64],"modules":[65],"have":[66],"been":[67],"developed":[68],"provide":[70],"controlled":[71],"activation":[72],"enhance":[74],"activity.":[78]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-29T00:00:00"}
