{"id":"https://openalex.org/W7224112708","doi":"https://doi.org/10.21037/tcr-2026-1049","title":"A novel tumor cell origin-based risk score (TCOMRS) to predict liver metastasis and guide treatment in colon adenocarcinoma","display_name":"A novel tumor cell origin-based risk score (TCOMRS) to predict liver metastasis and guide treatment in colon adenocarcinoma","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224112708","doi":"https://doi.org/10.21037/tcr-2026-1049","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743213"},"language":"en","primary_location":{"id":"doi:10.21037/tcr-2026-1049","doi":"https://doi.org/10.21037/tcr-2026-1049","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1049","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/tcr-2026-1049","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160043249","display_name":"Liping Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Gao","raw_affiliation_strings":["Department of Oncology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003144567","display_name":"Lingxiu Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134626604","display_name":"Jiujiang University","ror":"https://ror.org/0066vpg85","country_code":"CN","type":"education","lineage":["https://openalex.org/I134626604"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingxiu Zeng","raw_affiliation_strings":["Department of Gastroenterology, Jiujiang University Affiliated Hospital, Jiujiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiujiang University Affiliated Hospital, Jiujiang, China","institution_ids":["https://openalex.org/I134626604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160061771","display_name":"Yabing Huo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113795","display_name":"Hubei University of Arts and Science","ror":"https://ror.org/0212jcf64","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113795"]},{"id":"https://openalex.org/I4210119234","display_name":"Xiangyang Central Hospital","ror":"https://ror.org/02dx2xm20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yabing Huo","raw_affiliation_strings":["Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China","institution_ids":["https://openalex.org/I4210113795","https://openalex.org/I4210119234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160031859","display_name":"Hao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119183","display_name":"The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture","ror":"https://ror.org/01s12ye51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119183"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Department of Integrated Traditional Chinese and Western Medicine Oncology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Traditional Chinese and Western Medicine Oncology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China","institution_ids":["https://openalex.org/I4210119183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160039594","display_name":"Jing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160021449","display_name":"Yong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Li","raw_affiliation_strings":["Department of Oncology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5160021449"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8079405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"10","first_page":"756","last_page":"756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.38989999890327454,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-cell-of-origin","display_name":"tumor cell of origin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fabp1","display_name":"FABP1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.6930000185966492},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade-response","display_name":"immune checkpoint blockade response","score":0.8579999804496765},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7039999961853027},{"id":"https://openalex.org/keywords/metastatic-colonization","display_name":"metastatic colonization","score":0.6359999775886536},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7319999933242798},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6888999938964844},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6672999858856201},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6274999976158142},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5752000212669373},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5293999910354614},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5202999711036682},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.5187000036239624},{"id":"https://openalex.org/C2993158029","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colon adenocarcinoma","level":4,"score":0.4618000090122223},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.44359999895095825},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.44350001215934753},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.3921999931335449},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33970001339912415},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.3375999927520752},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3357999920845032},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3174000084400177},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3160000145435333},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3158999979496002},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.3034000098705292},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2818000018596649},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C137345334","wikidata":"https://www.wikidata.org/wiki/Q7303350","display_name":"Recursive partitioning","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25380000472068787},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.25360000133514404},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2508000135421753},{"id":"https://openalex.org/C3017561025","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastatic tumor","level":4,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21037/tcr-2026-1049","doi":"https://doi.org/10.21037/tcr-2026-1049","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1049","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},{"id":"pmid:42997878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/tcr-2026-1049","doi":"https://doi.org/10.21037/tcr-2026-1049","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1049","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403294167","https://openalex.org/W4410991318","https://openalex.org/W7163933806","https://openalex.org/W4394869977","https://openalex.org/W7221006629","https://openalex.org/W4403086067","https://openalex.org/W7143482156","https://openalex.org/W7153247907","https://openalex.org/W3046948258","https://openalex.org/W3044340755"],"abstract_inverted_index":{"Background:":[0],"Liver":[1],"metastasis":[2,38],"(LM)":[3],"is":[4],"a":[5,34,88,182,208,217],"major":[6],"determinant":[7],"of":[8,104,118,152,185],"poor":[9],"prognosis":[10],"in":[11,47,56,170,228],"colon":[12],"adenocarcinoma":[13],"(COAD),":[14],"yet":[15],"reliable":[16],"biomarkers":[17],"for":[18,42,211,224],"identifying":[19],"patients":[20,155],"at":[21],"high":[22],"metastatic":[23,58,191,200],"risk":[24,39,212],"remain":[25],"limited.":[26],"This":[27],"study":[28],"aimed":[29],"to":[30,50,73,162],"develop":[31],"and":[32,49,69,78,111,134,149,190,199,214],"validate":[33],"tumor":[35,109,147],"cell":[36],"origin-based":[37],"score":[40],"(TCOMRS)":[41],"characterizing":[43],"LM-associated":[44,112],"transcriptional":[45],"features":[46],"COAD":[48],"identify":[51,74],"key":[52,183],"molecular":[53],"regulators":[54],"involved":[55],"liver":[57],"progression.":[59],"Methods:":[60],"Single-cell":[61],"RNA":[62],"sequencing":[63],"(scRNA-seq)":[64],"profiles":[65],"from":[66,100],"primary":[67,108],"tumors":[68],"LM":[70],"were":[71],"integrated":[72],"distinct":[75],"malignant-cell":[76],"subpopulations":[77],"delineate":[79],"their":[80],"cellular":[81],"origins.":[82],"TCOMRS":[83,119,138,158,198,206],"was":[84,120,139,179],"constructed":[85],"based":[86],"on":[87],"one-class":[89],"logistic":[90],"regression":[91],"(OCLR)":[92],"algorithm":[93],"trained":[94],"with":[95,142,156,197],"4,512":[96],"malignant":[97,113],"cells":[98,110],"derived":[99],"LM,":[101,186],"enabling":[102],"assessment":[103],"the":[105,150],"similarity":[106],"between":[107],"phenotypes.":[114],"The":[115,127],"clinical":[116],"relevance":[117],"validated":[121],"across":[122],"multiple":[123],"independent":[124],"cohorts,":[125],"including":[126],"Cancer":[128],"Genome":[129],"Atlas":[130],"(TCGA)-COAD,":[131],"GSE39582,":[132],"GSE38832,":[133],"GSE161158.":[135],"Results:":[136],"Elevated":[137],"consistently":[140],"associated":[141],"unfavorable":[143],"overall":[144],"survival,":[145],"increased":[146],"stemness,":[148],"presence":[151],"LM.":[153],"Moreover,":[154],"low":[157],"demonstrated":[159],"improved":[160],"responsiveness":[161],"immune":[163],"checkpoint":[164],"blockade":[165],"therapy,":[166],"suggesting":[167],"potential":[168],"utility":[169],"therapeutic":[171,219],"decision-making.":[172],"Mechanistically,":[173],"fatty":[174],"acid-binding":[175],"protein":[176],"1":[177],"(FABP1)":[178],"identified":[180],"as":[181,207,216],"driver":[184],"facilitating":[187],"epithelial-mesenchymal":[188],"transition":[189],"colonization.":[192],"FABP1":[193,215],"expression":[194],"correlated":[195],"strongly":[196],"propensity.":[201],"Conclusions:":[202],"Our":[203],"findings":[204],"establish":[205],"robust":[209],"biomarker":[210],"stratification":[213],"promising":[218],"target,":[220],"offering":[221],"valuable":[222],"insights":[223],"personalized":[225],"treatment":[226],"strategies":[227],"COAD.":[229]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-29T00:00:00"}
