{"id":"https://openalex.org/W7224112612","doi":"https://doi.org/10.1021/acsomega.6c07029","title":"Cryptococcus deuterogattii Lung Infection Leads to a Prothrombotic State Revealed by Proteomics and Functional Analysis","display_name":"Cryptococcus deuterogattii Lung Infection Leads to a Prothrombotic State Revealed by Proteomics and Functional Analysis","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224112612","doi":"https://doi.org/10.1021/acsomega.6c07029"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c07029","doi":"https://doi.org/10.1021/acsomega.6c07029","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c07029","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07029/69014075/acsomega.6c07029.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07029/69014075/acsomega.6c07029.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045235061","display_name":"Laura Rascovetzki Saciloto-de-Oliveira","orcid":"https://orcid.org/0000-0001-9472-6037","observed_orcids":["https://orcid.org/0000-0001-9472-6037"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laura Rascovetzki Saciloto-de-Oliveira","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","Universidade de Campinas (Unicamp) , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-9472-6037","affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"Universidade de Campinas (Unicamp) , , , ,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160007442","display_name":"Markus Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Markus Berger","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148042262","display_name":"Luana Carolina Cardozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luana Cardozo","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144125873","display_name":"Camila Innocente-Alves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Innocente-Alves","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051207605","display_name":"David Driemeier","orcid":"https://orcid.org/0000-0003-3766-0654","observed_orcids":["https://orcid.org/0000-0003-3766-0654"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"David Driemeier","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029671362","display_name":"John R. Yates","orcid":"https://orcid.org/0000-0001-5267-1672","observed_orcids":["https://orcid.org/0000-0001-5267-1672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R. Yates","raw_affiliation_strings":["Scripps Research , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5267-1672","affiliations":[{"raw_affiliation_string":"Scripps Research , , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068190041","display_name":"Marilene Henning Vainstein","orcid":"https://orcid.org/0000-0002-3914-2300","observed_orcids":["https://orcid.org/0000-0002-3914-2300"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marilene Henning Vainstein","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012460777","display_name":"Jorge A. Guimar\u00e3es","orcid":"https://orcid.org/0000-0001-6354-6789","observed_orcids":["https://orcid.org/0000-0001-6354-6789"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jorge Almeida Guimara\u0303es","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001212874","display_name":"Luc\u00e9lia Santi","orcid":"https://orcid.org/0000-0002-5698-7006","observed_orcids":["https://orcid.org/0000-0002-5698-7006"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luce\u0301lia Santi","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-5698-7006","affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033817468","display_name":"Walter O. Beys\u2010da\u2010Silva","orcid":"https://orcid.org/0000-0001-8329-7839","observed_orcids":["https://orcid.org/0000-0001-8329-7839"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Walter Orlando Beys-da-Silva","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) , , , ,","institution_ids":["https://openalex.org/I130442723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033817468"],"corresponding_institution_ids":["https://openalex.org/I130442723"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84843342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-deuterogattii","display_name":"Cryptococcus deuterogattii","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cryptococcosis","display_name":"cryptococcosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/thrombin-activity","display_name":"thrombin activity","score":0.777999997138977},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":1.0},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7820000052452087},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6765999794006348},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6148999929428101},{"id":"https://openalex.org/C201267052","wikidata":"https://www.wikidata.org/wiki/Q414446","display_name":"Thrombomodulin","level":4,"score":0.5217000246047974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5131999850273132},{"id":"https://openalex.org/C2779413141","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcosis","level":2,"score":0.5080000162124634},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.49799999594688416},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.46959999203681946},{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.45159998536109924},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4300999939441681},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4146000146865845},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.41370001435279846},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.36160001158714294},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.3206000030040741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30480000376701355},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.29260000586509705},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28679999709129333},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C159973064","wikidata":"https://www.wikidata.org/wiki/Q3740205","display_name":"Platelet factor 4","level":3,"score":0.2694000005722046}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsomega.6c07029","doi":"https://doi.org/10.1021/acsomega.6c07029","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c07029","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07029/69014075/acsomega.6c07029.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c07029","doi":"https://doi.org/10.1021/acsomega.6c07029","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c07029","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c07029/69014075/acsomega.6c07029.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224112612.pdf","grobid_xml":"https://content.openalex.org/works/W7224112612.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1603713747","https://openalex.org/W1782255168","https://openalex.org/W1879198795","https://openalex.org/W1965671620","https://openalex.org/W1969353942","https://openalex.org/W1977877780","https://openalex.org/W1984375997","https://openalex.org/W1987620367","https://openalex.org/W1996406153","https://openalex.org/W2012833122","https://openalex.org/W2018552263","https://openalex.org/W2021540990","https://openalex.org/W2070374666","https://openalex.org/W2088579185","https://openalex.org/W2089545220","https://openalex.org/W2106996349","https://openalex.org/W2117714031","https://openalex.org/W2144814738","https://openalex.org/W2159675211","https://openalex.org/W2166151208","https://openalex.org/W2196345157","https://openalex.org/W2611696724","https://openalex.org/W2734979627","https://openalex.org/W2743857398","https://openalex.org/W2784146546","https://openalex.org/W2789502013","https://openalex.org/W2791501425","https://openalex.org/W2805579785","https://openalex.org/W2901470592","https://openalex.org/W2920820434","https://openalex.org/W2923086212","https://openalex.org/W2949751711","https://openalex.org/W2959326650","https://openalex.org/W2968378385","https://openalex.org/W2972729230","https://openalex.org/W2980543550","https://openalex.org/W3000322482","https://openalex.org/W3007268252","https://openalex.org/W3014420184","https://openalex.org/W3017390707","https://openalex.org/W3025328549","https://openalex.org/W3035856993","https://openalex.org/W3083482298","https://openalex.org/W3086016073","https://openalex.org/W3089092821","https://openalex.org/W3092637456","https://openalex.org/W3096655896","https://openalex.org/W3107972000","https://openalex.org/W3167408212","https://openalex.org/W3193381896","https://openalex.org/W4220672779","https://openalex.org/W4220815932","https://openalex.org/W4220831425","https://openalex.org/W4229374775","https://openalex.org/W4308834893","https://openalex.org/W4313503849","https://openalex.org/W4318065352","https://openalex.org/W4318476604","https://openalex.org/W4319657176","https://openalex.org/W4324368797","https://openalex.org/W4362636634","https://openalex.org/W4378416981","https://openalex.org/W4381480434","https://openalex.org/W4388221959","https://openalex.org/W4390919957","https://openalex.org/W4400952238","https://openalex.org/W4402964244","https://openalex.org/W4403479110","https://openalex.org/W4404458588","https://openalex.org/W4405466070","https://openalex.org/W4410105787","https://openalex.org/W7128720521"],"related_works":["https://openalex.org/W4414919583","https://openalex.org/W4414512471","https://openalex.org/W96492125","https://openalex.org/W2972729230","https://openalex.org/W4410877310","https://openalex.org/W1997824320","https://openalex.org/W3212263526","https://openalex.org/W2882983888","https://openalex.org/W2249839489","https://openalex.org/W4307341888"],"abstract_inverted_index":{"Abstract":[0],"Cryptococcosis":[1],"caused":[2],"by":[3,66],"Cryptococcus":[4],"deuterogattii":[5,68,160],"is":[6],"a":[7,97,136,191],"life-threatening":[8],"fungal":[9,22],"infection":[10,32,51,189],"increasingly":[11],"reported":[12],"in":[13,47,55,61,100,172,211],"immunocompetent":[14],"individuals.":[15],"Although":[16],"clinical":[17],"evidence":[18,186],"suggests":[19,140],"that":[20,202],"invasive":[21],"diseases":[23],"could":[24],"impact":[25],"coagulation,":[26],"the":[27,101,106,167,170,183],"molecular":[28,185],"mechanisms":[29],"linking":[30,187],"cryptococcal":[31,188],"to":[33,58,190],"hemostatic":[34,193],"dysregulation":[35],"remain":[36],"unexplored.":[37],"In":[38],"this":[39],"study,":[40],"we":[41],"employed":[42],"an":[43],"integrative":[44],"approach":[45],"combining":[46],"vivo":[48],"rat":[49],"lung":[50,76],"model,":[52],"proteomics,":[53],"and":[54,63,71,78,92,112,130,176,200],"vitro":[56],"assays":[57,82],"investigate":[59],"alterations":[60],"coagulation":[62,204],"hemostasis":[64],"induced":[65],"C.":[67,159],"R265.":[69],"Morphological":[70],"histological":[72],"evaluations":[73],"revealed":[74],"progressive":[75],"damage":[77],"cryptococcoma":[79],"formation.":[80],"Functional":[81],"showed":[83],"early":[84],"thrombocytopenia,":[85],"increased":[86,162],"thrombin":[87],"activity,":[88],"reduced":[89],"prothrombin":[90],"time,":[91],"enhanced":[93],"platelet":[94,109],"aggregation,":[95],"indicating":[96],"procoagulant":[98],"state":[99],"infection.":[102],"Proteomic":[103],"analysis":[104],"identified":[105],"upregulation":[107],"of":[108,124,143,155,169],"activation":[110],"pathways":[111,205],"key":[113],"prothrombotic":[114],"proteins":[115],"at":[116],"3":[117],"days":[118],"post-inoculation":[119],"(dpi),":[120],"along":[121],"with":[122,151,158],"downregulation":[123,139],"anticoagulant":[125],"regulators":[126],"such":[127],"as":[128],"thrombomodulin":[129],"antithrombin":[131],"III.":[132],"At":[133],"14":[134],"dpi,":[135],"widespread":[137],"protein":[138],"systemic":[141],"collapse":[142],"host":[144],"functions.":[145],"Data":[146],"are":[147],"available":[148],"via":[149],"ProteomeXchange":[150],"identifier":[152],"PXD077765.":[153],"Coculture":[154],"A7R5":[156],"cells":[157],"confirmed":[161],"tissue":[163],"factor":[164],"expression,":[165],"reinforcing":[166],"role":[168],"fungus":[171],"triggering":[173],"thrombo-inflammatory":[174],"responses":[175],"validating":[177],"proteomics":[178],"data.":[179],"Our":[180],"results":[181],"provide":[182],"first":[184],"dysregulated":[192],"profile,":[194],"shedding":[195],"light":[196],"on":[197],"host\u2013pathogen":[198],"interaction":[199],"suggesting":[201],"targeting":[203],"may":[206],"offer":[207],"novel":[208],"therapeutic":[209],"avenues":[210],"cryptococcosis":[212],"management.":[213]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-29T00:00:00"}