{"id":"https://openalex.org/W7224110672","doi":"https://doi.org/10.21037/tcr-2026-1297","title":"Development and internal validation of a prognostic nomogram for cancer-specific survival in Ewing sarcoma: a SEER-based study","display_name":"Development and internal validation of a prognostic nomogram for cancer-specific survival in Ewing sarcoma: a SEER-based study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224110672","doi":"https://doi.org/10.21037/tcr-2026-1297","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743235"},"language":"en","primary_location":{"id":"doi:10.21037/tcr-2026-1297","doi":"https://doi.org/10.21037/tcr-2026-1297","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1297","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/tcr-2026-1297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160002538","display_name":"Shilong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shilong Wang","raw_affiliation_strings":["Shandong Medical and Pharmaceutical University, Binzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Medical and Pharmaceutical University, Binzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112487872","display_name":"Long Jia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Long Jia","raw_affiliation_strings":["Shandong Medical and Pharmaceutical University Hospital, Binzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Medical and Pharmaceutical University Hospital, Binzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112487872"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"10","first_page":"749","last_page":"749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-nomogram","display_name":"prognostic nomogram","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cancer-specific-survival","display_name":"cancer-specific survival","score":1.0},{"id":"https://openalex.org/keywords/personalized-prognosis","display_name":"individualized prognosis","score":0.5699999928474426},{"id":"https://openalex.org/keywords/tnm-staging","display_name":"TNM staging","score":0.8799999952316284},{"id":"https://openalex.org/keywords/decision-curve-analysis","display_name":"decision curve analysis","score":0.703000009059906},{"id":"https://openalex.org/keywords/net-clinical-benefit","display_name":"net clinical benefit","score":0.546999990940094},{"id":"https://openalex.org/keywords/lasso","display_name":"LASSO","score":0.5350000262260437},{"id":"https://openalex.org/keywords/seer-database","display_name":"SEER database","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.9714999794960022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8069000244140625},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6722000241279602},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5853999853134155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5580999851226807},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4250999987125397},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4153999984264374},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.37959998846054077},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C2993277928","wikidata":"https://www.wikidata.org/wiki/Q7248370","display_name":"Prognostic model","level":3,"score":0.3346000015735626},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.3068999946117401},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3050000071525574},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2987804222","wikidata":"https://www.wikidata.org/wiki/Q5376582","display_name":"End point","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C172400760","wikidata":"https://www.wikidata.org/wiki/Q332796","display_name":"Survivorship curve","level":3,"score":0.26460000872612}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/tcr-2026-1297","doi":"https://doi.org/10.21037/tcr-2026-1297","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1297","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},{"id":"pmid:42997920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13743235","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13743235/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21037/tcr-2026-1297","doi":"https://doi.org/10.21037/tcr-2026-1297","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-1297","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2911997073","https://openalex.org/W3217365231","https://openalex.org/W2954036960","https://openalex.org/W3102468219","https://openalex.org/W3199055385","https://openalex.org/W3103971595","https://openalex.org/W4280501350","https://openalex.org/W4307091983","https://openalex.org/W4404878967","https://openalex.org/W4293460182"],"abstract_inverted_index":{"Background:":[0],"Ewing":[1,57,68,246],"sarcoma":[2,69],"is":[3,263],"a":[4,47,93,147,179,239],"rare":[5],"and":[6,22,26,44,73,85,90,113,171,192,198,201,219,236,253],"aggressive":[7],"malignancy":[8],"with":[9,56,65,121,178,205,257],"substantial":[10],"survival":[11,52],"heterogeneity.":[12],"Conventional":[13],"tumor-node-metastasis":[14],"(TNM)":[15],"staging":[16,207],"provides":[17],"limited":[18],"individualized":[19,242],"prognostic":[20,48],"assessment,":[21],"previous":[23],"Surveillance,":[24],"Epidemiology,":[25],"End":[27],"Results":[28],"(SEER)-based":[29],"nomograms":[30],"have":[31],"rarely":[32],"reported":[33],"optimism-corrected":[34,127],"performance":[35,100,255],"or":[36],"clinical":[37,221,266],"utility.":[38],"This":[39],"study":[40],"aimed":[41],"to":[42,125],"develop":[43],"internally":[45,237],"validate":[46],"nomogram":[49,185,210,240],"for":[50,136,241],"cancer-specific":[51],"(CSS)":[53],"in":[54,245],"patients":[55,64],"sarcoma.Methods:":[58],"Using":[59],"the":[60,109,209],"SEER":[61],"database,":[62],"720":[63,140],"pathologically":[66],"confirmed":[67],"diagnosed":[70],"between":[71],"2004":[72],"2015":[74],"were":[75,79],"identified.":[76],"Candidate":[77],"predictors":[78],"selected":[80],"using":[81,103,226],"least":[82],"absolute":[83],"shrinkage":[84],"selection":[86],"operator":[87],"(LASSO)":[88],"regression":[89],"incorporated":[91],"into":[92],"multivariable":[94],"Cox":[95],"proportional":[96],"hazards":[97],"model.":[98],"Model":[99],"was":[101,119,134,176],"assessed":[102],"Harrell\u2019s":[104],"C-index,":[105],"time-dependent":[106],"area":[107],"under":[108],"curve":[110,115],"(AUC),":[111],"calibration,":[112],"decision":[114],"analysis.":[116],"Internal":[117],"validation":[118,262],"performed":[120],"1,000":[122],"bootstrap":[123],"resamples":[124],"estimate":[126],"performance.":[128],"Multiple":[129],"imputation":[130,228],"by":[131],"chained":[132],"equations":[133],"used":[135],"sensitivity":[137],"analysis.Results:":[138],"Among":[139],"patients,":[141],"258":[142],"CSS":[143,243],"events":[144],"occurred":[145],"during":[146],"mean":[148],"follow-up":[149],"of":[150,182],"89.3":[151],"months.":[152],"The":[153,173,184,248],"final":[154],"model":[155,249],"included":[156],"age,":[157],"sex,":[158],"race,":[159],"primary":[160],"tumor":[161],"site,":[162],"T":[163],"stage,":[164,166,168],"N":[165],"M":[167],"surgery,":[169],"radiation,":[170],"chemotherapy.":[172],"apparent":[174],"C-index":[175,181],"0.736,":[177,217],"bootstrap-corrected":[180],"0.721.":[183],"demonstrated":[186],"good":[187],"discrimination":[188,213,252],"at":[189],"3,":[190],"5,":[191],"10":[193],"years":[194],"(AUCs:":[195],"0.795,":[196],"0.784,":[197],"0.780,":[199],"respectively)":[200],"acceptable":[202],"calibration.":[203],"Compared":[204],"TNM":[206,258],"alone,":[208],"showed":[211,229,250],"improved":[212,254],"(C-index":[214],"0.680":[215],"vs.":[216],"P<0.001)":[218],"greater":[220],"net":[222],"benefit.":[223],"Sensitivity":[224],"analysis":[225],"multiple":[227],"generally":[230],"consistent":[231],"predictor":[232],"effects.Conclusions:":[233],"We":[234],"developed":[235],"validated":[238],"prediction":[244],"sarcoma.":[247],"moderate":[251],"compared":[256],"staging.":[259],"However,":[260],"external":[261],"required":[264],"before":[265],"application.":[267]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-10-29T00:00:00"}
