{"id":"https://openalex.org/W7224110357","doi":"https://doi.org/10.64898/2026.10.26.26366494","title":"Deep Learning-Based Spatial Profiling Identifies MET-Associated Immune Exclusion and Therapeutic Vulnerability Underlying Racial Disparities in Head and Neck Cancer","display_name":"Deep Learning-Based Spatial Profiling Identifies MET-Associated Immune Exclusion and Therapeutic Vulnerability Underlying Racial Disparities in Head and Neck Cancer","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224110357","doi":"https://doi.org/10.64898/2026.10.26.26366494"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.26.26366494","doi":"https://doi.org/10.64898/2026.10.26.26366494","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.26.26366494","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.10.26.26366494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158481882","display_name":"Xinyu Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyu Cui","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051687774","display_name":"FANGHUI CHEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fanghui Chen","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002909143","display_name":"Ashley A. McCook\u2010Veal","orcid":"https://orcid.org/0000-0001-5368-4977","observed_orcids":["https://orcid.org/0000-0001-5368-4977"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley McCook-Veal","raw_affiliation_strings":["Department of Biostatistics & Bioinformatics, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Bioinformatics, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160033224","display_name":"Yuan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Liu","raw_affiliation_strings":["Department of Biostatistics & Bioinformatics, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Bioinformatics, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057995830","display_name":"Nicole Cherie Schmitt","orcid":"https://orcid.org/0000-0002-0571-3531","observed_orcids":["https://orcid.org/0000-0002-0571-3531"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole C. Schmitt","raw_affiliation_strings":["Department of Otolaryngology \u2013 Head and Neck Surgery, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":"https://orcid.org/0000-0002-0571-3531","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology \u2013 Head and Neck Surgery, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016127308","display_name":"Christine H. Chung","orcid":"https://orcid.org/0000-0001-5199-4306","observed_orcids":["https://orcid.org/0000-0001-5199-4306"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine H. Chung","raw_affiliation_strings":["Department of Head and Neck-Endocrine Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck-Endocrine Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112962788","display_name":"Conor E. Steuer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conor E. Steuer","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050371536","display_name":"Dong Mun Shin","orcid":"https://orcid.org/0009-0001-4772-7843","observed_orcids":["https://orcid.org/0009-0001-4772-7843"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong M. Shin","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036672833","display_name":"Nabil F. Saba","orcid":"https://orcid.org/0000-0003-4972-1477","observed_orcids":["https://orcid.org/0000-0003-4972-1477"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabil F. Saba","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159987871","display_name":"Yong Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Teng","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA","Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.8939999938011169},{"id":"https://openalex.org/keywords/met-expression","display_name":"MET expression","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immune-exclusion","display_name":"immune exclusion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cabozantinib","display_name":"cabozantinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/spatial-profiling","display_name":"spatial profiling","score":0.49000000953674316},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.6669999957084656},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5410000085830688},{"id":"https://openalex.org/keywords/black-patients","display_name":"Black patients","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6834999918937683},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6758999824523926},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5722000002861023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5461999773979187},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.534500002861023},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4221000075340271},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40400001406669617},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36079999804496765},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3425999879837036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33809998631477356},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3273000121116638},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2948000133037567},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29330000281333923},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2680000066757202},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2558000087738037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.26.26366494","doi":"https://doi.org/10.64898/2026.10.26.26366494","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.26.26366494","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.26.26366494","doi":"https://doi.org/10.64898/2026.10.26.26366494","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.26.26366494","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7578999996185303}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1498931318","https://openalex.org/W1563129071","https://openalex.org/W1983517349","https://openalex.org/W1986241711","https://openalex.org/W2039123767","https://openalex.org/W2060765762","https://openalex.org/W2096796899","https://openalex.org/W2100945326","https://openalex.org/W2102979753","https://openalex.org/W2151087797","https://openalex.org/W2578528809","https://openalex.org/W2586267950","https://openalex.org/W2792883124","https://openalex.org/W2891533221","https://openalex.org/W2901379455","https://openalex.org/W2993803798","https://openalex.org/W3000339487","https://openalex.org/W3045570573","https://openalex.org/W3046305306","https://openalex.org/W3082770049","https://openalex.org/W3084362113","https://openalex.org/W3099369238","https://openalex.org/W3125429777","https://openalex.org/W3146559848","https://openalex.org/W3166362230","https://openalex.org/W3190202966","https://openalex.org/W4200247705","https://openalex.org/W4212827976","https://openalex.org/W4220694418","https://openalex.org/W4220746348","https://openalex.org/W4228997235","https://openalex.org/W4247814033","https://openalex.org/W4281661302","https://openalex.org/W4310954837","https://openalex.org/W4311203636","https://openalex.org/W4317435826","https://openalex.org/W4320484983","https://openalex.org/W4361222620","https://openalex.org/W4362521833","https://openalex.org/W4385987383","https://openalex.org/W4386572423","https://openalex.org/W4392713922","https://openalex.org/W4393033732","https://openalex.org/W4393935425","https://openalex.org/W4399360899","https://openalex.org/W4400913862","https://openalex.org/W4401725355","https://openalex.org/W4407360292","https://openalex.org/W4412493430","https://openalex.org/W4414183212","https://openalex.org/W4417164932","https://openalex.org/W7126426900","https://openalex.org/W7160216254","https://openalex.org/W7160232135","https://openalex.org/W7162945569"],"related_works":["https://openalex.org/W3045570573","https://openalex.org/W4415898675","https://openalex.org/W2908414896","https://openalex.org/W4393088575","https://openalex.org/W4362586201","https://openalex.org/W4409691595","https://openalex.org/W4386784024","https://openalex.org/W7117293508","https://openalex.org/W4401007914","https://openalex.org/W4387709158"],"abstract_inverted_index":{"ABSTRACT":[0],"Black/African":[1],"American":[2],"(BAA)":[3],"patients":[4],"with":[5,53,59,99,126,138,145,164],"head":[6],"and":[7,17,49,85,112,141,168,183],"neck":[8],"squamous":[9],"cell":[10,79,103],"carcinoma":[11],"(HNSCC)":[12],"experience":[13],"more":[14],"aggressive":[15],"disease":[16],"poorer":[18],"survival":[19],"outcomes":[20],"than":[21],"White":[22],"patients;":[23],"however,":[24],"the":[25,146,165],"tumor":[26,110,115],"immune":[27,47,69,82,166],"microenvironmental":[28],"features":[29],"underlying":[30],"these":[31],"racial":[32,54,178],"disparities":[33,55,179],"remain":[34],"poorly":[35],"characterized.":[36],"Here,":[37],"we":[38],"identify":[39],"MET":[40,88,94,133,162],"as":[41],"a":[42,67,106,119,156],"potential":[43],"molecular":[44],"link":[45],"between":[46,108],"exclusion":[48],"therapeutic":[50,169],"response":[51,140],"associated":[52,98,137],"in":[56,71,118,180],"HNSCC.":[57],"Compared":[58],"White-derived":[60],"tumors,":[61,73],"deep":[62],"learning-based":[63],"spatial":[64,87,132],"profiling":[65],"revealed":[66],"distinct":[68],"landscape":[70],"BAA-derived":[72],"characterized":[74],"by":[75],"reduced":[76,100],"CD8\u207a":[77,101],"T":[78,102],"infiltration,":[80,104],"increased":[81],"checkpoint":[83],"expression,":[84],"elevated":[86],"expression.":[89],"Across":[90],"independent":[91],"cohorts,":[92],"higher":[93,130],"expression":[95,134,163],"was":[96,135],"consistently":[97],"supporting":[105],"relationship":[107],"MET-associated":[109,173],"biology":[111,174],"an":[113],"immune-excluded":[114],"microenvironment.":[116],"Importantly,":[117],"phase":[120],"2":[121],"clinical":[122,143],"trial":[123],"cohort":[124],"treated":[125],"pembrolizumab":[127],"plus":[128],"cabozantinib,":[129],"predicted":[131],"strongly":[136],"treatment":[139,184],"improved":[142],"outcomes,":[144],"association":[147],"particularly":[148],"pronounced":[149],"among":[150],"BAA":[151],"patients.":[152],"This":[153],"study":[154],"establishes":[155],"spatially":[157],"resolved":[158],"framework":[159],"linking":[160],"tumor-intrinsic":[161],"microenvironment":[167],"response,":[170],"suggesting":[171],"that":[172],"may":[175],"contribute":[176],"to":[177],"HNSCC":[181],"progression":[182],"outcomes.":[185]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-29T00:00:00"}